「kb」の検索結果

Detects A/B chromatin compartments from balanced Hi-C contact matrices via eigenvector decomposition of the distance-normalized, Pearson-correlated cis matrix with cooltools (eigs_cis), then orients (phases) the compartment eigenvector against a GC or gene-density track so the active (A) sign is not arbitrary. Covers the eigenvector-is-a-choice problem (per-arm view_df to remove the centromere gradient; picking the eigenvector by max correlation with activity, not by eigenvalue), GC phasing with bioframe.frac_gc, resolution choice (100kb-1Mb), saddle plots and saddle_strength for compartmentalization strength, the cohesin-loss-strengthens-compartments result, subcompartments (SNIPER/Calder/dcHiC), and cross-condition compartment switching. Use when calling A/B compartments, computing E1/eigenvectors, phasing the eigenvector, building saddle plots, choosing a compartment resolution, quantifying compartment strength, or comparing compartmentalization across conditions.

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Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.

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Queries PharmGKB / CPIC / DPWG for drug-gene interactions; calls CYP2D6/CYP2C9/CYP2C19/DPYD/TPMT/NUDT15/UGT1A1/SLCO1B1 star alleles and phenotype with PharmCAT, Cyrius (CYP2D6 structural variants), Aldy, Stargazer; applies Caudle 2020 activity-score translation. Use when implementing pharmacogenomic-guided prescribing, applying CPIC vs DPWG guidance, screening HLA risk alleles for ICI / antiepileptics / abacavir, or interpreting compound TPMT+NUDT15 thiopurine risk.

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Constructs and validates polygenic risk scores using LDpred2-auto, SBayesRC, MegaPRS, PRS-CS, PROSPER, MUSSEL, BridgePRS, JointPRS, PRSmix, or PGS Catalog Calculator with ancestry-aware reference panels (HapMap3, UKB-LD), ancestry-conditional calibration, and PRS-RS reporting standards. Use when computing PRS for cohorts, applying absolute-risk transformation, assessing cross-ancestry portability (Martin 2017 / Ding 2023 continuous ancestry), or auditing PRS manuscripts against the 22-item PRS-RS reviewer checklist.

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Performs ML-based protein-ligand pose prediction and scoring using DiffDock-L (diffusion-based), Boltz-1 / Boltz-2 (foundation model with affinity), Chai-1, AlphaFold3 ligand, EquiBind, TANKBind, NeuralPLexer, and hybrid workflows (DiffDock pose + GNINA rescore + PoseBusters QC). Explicit handling of when ML beats classical docking, when classical beats ML, the PB-invalid pose problem, and rescoring as the standard production hybrid. Use when modern docking is needed: foundation-model ligand-pose prediction, AI rescoring of classical poses, or scaffold-hopping in cross-docking scenarios.

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Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.

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Align protein structures using Foldseek 3Di, TM-align, US-align, DALI, or Foldmason for structural MSA. Predict, score, and superpose backbone coordinates when sequence identity is below the twilight zone or remote-homology detection is required. Use when sequence MSA fails (<25% identity), when the dark proteome is the target, when AlphaFoldDB / ESM Atlas search is needed, or when structural superposition is the goal.

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Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

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Append a GitHub issue link and its Linear ticket to the current PR's description. Use when asked to "link issue to pr", "fill in issue and linear in pr", "add issue refs to pr", or when given a GitHub issue URL and asked to attach it to the current PR. Resolves the Linear ticket automatically from the issue's linear-linkback comment.

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Adds Excel Online (Business) connector to a Power Apps code app. Use when reading or writing Excel workbook data from OneDrive or SharePoint.

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Use when sculpting in Blender through Python: sculpt a head, face or bust, a stylized or cartoon character, a creature or a realistic portrait; block out from primitives; cut planes, a jaw or gonial angle, cheekbones; fix a jaw or face that looks like a ball or balloon; stylized hair clumps; eyelids; an expression or smirk; plan remesh or multires resolution; reproduce Clay Strips, Crease, Draw Sharp, Scrape, Grab or mask moves without a tablet; final clay renders; or when a sculpt operator crashes headless.

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Generate food and beverage video prompts for Seedance 2.0 on Higgsfield. Use whenever the user wants food videos, recipe content, restaurant promos, beverage ads, cooking videos, food ASMR, menu showcases, food delivery ads, café content, or any food/drink video. Triggers on: food video, recipe, cooking, restaurant, beverage, food ad, food ASMR, menu, café, cocktail, food photography video, appetite appeal, food styling, mukbang, or any food/drink video request. Use even for "make my food look delicious" or "restaurant promo video.

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为 Seedance 2.0（Higgsfield）生成时尚造型书、模特展示和风格视频提示。在用户想要时尚视频内容、造型书视频、模特走秀、服装展示、风格指南、时尚活动、跑道片段、街头风格内容或任何时尚/服装视频时使用。在以下情况下触发：时尚视频、造型书、模特展示、服装、风格指南、时尚活动、跑道、街头风格、系列发布、时尚广告、服装视频、OOTD、时尚电影或任何时尚/模特视频请求。即使是"展示这件服装"或"为我的品牌提供时尚内容"也适用。

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Designing quizzes, personality assessments, and recommendation tools that segment users into actionable categories rather than generating clicks for clicks' sake. Question architecture, scoring algorithms, result categorization, recommendation mapping, lead capture integration. Honest about clickbait-quiz (engagement only), vanity-result (entertaining, not useful), and actionable-segmentation (genuine categorization that drives next-step recommendations) patterns. Triggers on quiz, assessment, personality test, recommendation tool, scorecard, diagnostic, fit evaluator, what-type-of-X-are-you, persona quiz. Also triggers when an audience needs a categorization-driven lead magnet, when a vanity quiz is producing engagement but no qualified leads, or when an assessment is being scoped for the first time.

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Pre-publish QA framework for content. Brief adherence, voice consistency, fact accuracy, structure and clarity, AI-content audit, SEO and AEO compliance, internal linking and schema validation, QA at scale via sampling, the QA workflow, and the discipline that distinguishes catch-problems QA from checkbox QA. Triggers on editorial QA, content review, pre-publish review, content audit, content QA process, AI-content audit, hallucination check, content sampling, programmatic QA, voice consistency check, brief adherence check. Also triggers when a content team is shipping sloppy work, when AI-co-authored content is reaching publish unaudited, when a QA process burns reviewers out, or when a programmatic SEO set needs sampling discipline. On a voice consistency check, this skill owns checking a draft against an existing voice system at the publish gate; use `brand-voice` when the voice system itself needs defining or documenting.

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Expert guidance for FedRAMP certification and compliance under CR26 (FedRAMP Consolidated Rules for 2026). Use this skill whenever a user asks about FedRAMP authorization, ATO (Authority to Operate), cloud security for federal government, NIST SP 800-53 controls, CSP compliance, or any of the core FedRAMP document types: SSP, SAP, SAR, POA&M, CIS/CRM workbooks. Also trigger for questions about FedRAMP Certification Classes (A, B, C, D — new baseline labels: A = pilot/transitional, B = LI-SaaS/Low, C = Moderate, D = High, per NTC-0004), FedRAMP 20x (now the primary authorization pathway), OSCAL mandate (September 2026), 3PAO assessments, continuous monitoring (ConMon), gap assessments, system boundary definition, or architecture reviews for federal cloud. FedRAMP Ready retired July 28, 2026 (Legacy FedRAMP Ready). When in doubt, use this skill — it covers the full FedRAMP lifecycle from readiness through continuous monitoring.

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Expert guidance for FedRAMP certification and compliance under CR26 (FedRAMP Consolidated Rules for 2026). Use this skill whenever a user asks about FedRAMP authorization, ATO (Authority to Operate), cloud security for federal government, NIST SP 800-53 controls, CSP compliance, or any of the core FedRAMP document types: SSP, SAP, SAR, POA&M, CIS/CRM workbooks. Also trigger for questions about FedRAMP Certification Classes (A, B, C, D — new baseline labels: A = pilot/transitional, B = LI-SaaS/Low, C = Moderate, D = High, per NTC-0004), FedRAMP 20x (now the primary authorization pathway), OSCAL mandate (September 2026), 3PAO assessments, continuous monitoring (ConMon), gap assessments, system boundary definition, or architecture reviews for federal cloud. FedRAMP Ready retires July 28, 2026. When in doubt, use this skill — it covers the full FedRAMP lifecycle from readiness through continuous monitoring.

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An animated bottom-tab indicator — Lottie JSON. A Lottie (JSON) animation — portable motion that plays identically on web and app via lottie-web. Honors prefers-reduced-motion (don't autoplay). Reserve Lottie for motion that earns its ~160KB runtime.

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A floating action button that morphs open — Lottie JSON. A Lottie (JSON) animation — portable motion that plays identically on web and app via lottie-web. Honors prefers-reduced-motion (don't autoplay). Reserve Lottie for motion that earns its ~160KB runtime.

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An animated pagination dots indicator — Lottie JSON. A Lottie (JSON) animation — portable motion that plays identically on web and app via lottie-web. Honors prefers-reduced-motion (don't autoplay). Reserve Lottie for motion that earns its ~160KB runtime.

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A heart/favorite icon that animates on toggle — Lottie JSON, portable across web & app. A Lottie (JSON) animation — portable motion that plays identically on web and app via lottie-web. Honors prefers-reduced-motion (don't autoplay). Reserve Lottie for motion that earns its ~160KB runtime.

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Android APK decompiler that converts DEX bytecode to readable Java source code. Use when you need to decompile APK files, analyze app logic, search for vulnerabilities, find hardcoded credentials, or understand app behavior through readable source code.

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Analyze digital and analog captures from Saleae Logic MSO devices. Decode protocols like UART, SPI, I2C from exported binary files. Use when analyzing logic analyzer captures for CTF challenges, hardware reverse engineering, or protocol decoding.

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Advanced file finder with type detection and filesystem extraction for analyzing firmware and extracting embedded filesystems. Use when you need to analyze firmware files, identify file types, or extract ext2/3/4 or F2FS filesystems.

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