「unit」の検索結果

Compare cell-type composition and spatial features across conditions in IMC/MIBI cohorts with the patient as the experimental unit, covering pseudoreplication, per-patient aggregation, mixed models, compositional (Dirichlet/scCODA) differential abundance, diffcyt, per-image-to-patient spatial differential testing (SpaceANOVA), batch covariates, and FDR. Use when testing whether a cell type or spatial niche differs between groups, avoiding cell-level pseudoreplication, choosing a differential-abundance method, or correctly powering an IMC cohort comparison.

日本語の概要は準備中です。原文の説明を表示しています。

Designs genomics experiments so technical nuisance variation (batch, lane, plate, flow cell, operator, reagent lot, processing day) is balanced against the biological variable of interest and therefore estimable rather than confounded, using constrained sample-to-batch assignment (designit, OSAT), the confounder/mediator/collider distinction, and the principle that no post-hoc correction recovers a fully confounded design. Covers detecting hidden batches with surrogate variable analysis, a decision table for downstream correction (ComBat-seq, RUVSeq, SVA) whose execution is deferred to differential-expression/batch-correction, and reproducibility metadata. Use when assigning samples to sequencing batches/lanes/plates, avoiding batch-condition confounding, deciding whether a design is salvageable by correction, choosing a correction method, or estimating the number of hidden batches. For the experimental unit, randomization, and blocking concepts see experimental-design/randomization-blocking.

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Assesses genetic health of populations for conservation with Ne estimation across time horizons (LDNe NeEstimator V2 option-file API + SNeP physical-linkage correction; recent trajectory via GONE/GONE2; deep history via Stairway Plot 2 / dadi / fastsimcoal2 / PSMC), F-statistics, runs of homozygosity binned by length class to date inbreeding, genetic-load decomposition (Bertorelle 2022 realized vs masked), the modern 100/1000 Ne rule (Frankham 2014), Ne/Nc 2-6 orders of magnitude in marine fish (Hauser & Carvalho 2008), tree-sequence forward simulations (SLiM 4 + pyslim + tskit), and the Sukumaran-Knowles caveat against MSC methods for management-unit definition. Use when estimating Ne by time horizon, detecting inbreeding via F_ROH, decomposing genetic load, justifying conservation thresholds, distinguishing ESU/MU/DPS, configuring NeEstimator V2, or correcting LDNe physical linkage.

日本語の概要は準備中です。原文の説明を表示しています。

Differential abundance (DA) and differential state (DS) analysis for flow and mass cytometry - tests which cell populations change in frequency or marker expression between conditions using diffcyt (edgeR/voom/GLMM for DA, limma/LMM for DS), with cydar, CITRUS, and compositional methods (sccomp, scCODA, DCATS) as alternatives. Covers the sample-is-the-experimental-unit principle, design/contrast and mixed-model formulas, compositionality of cluster proportions, and FDR across clusters. Use when comparing populations between groups, choosing a DA method, handling paired/batch designs, or deciding whether compositional correction is needed.

日本語の概要は準備中です。原文の説明を表示しています。

Visualize biological networks (PPI, gene-regulatory, co-expression, pathway) with layout algorithm choice (ForceAtlas2, Fruchterman-Reingold, Kamada-Kawai, hive plots), edge bundling, community-based coloring, and reproducible seeds using NetworkX, PyVis, igraph, and Cytoscape automation. Use when rendering biological networks for static publication, interactive HTML exploration, or Cytoscape-format export.

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Use when a carrier asks about trailer types — dry van, reefer, flatbed, step-deck, conestoga, tanker, dump, lowboy, intermodal chassis, auto-hauler. Covers length / weight rules, common specs, reefer unit options (Carrier vs Thermo King), liftgate options, kingpin setting, and trailer-to-tractor matching.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about refrigerated (reefer) trucking — cold chain compliance, FDA temperature recording requirements, Sanitary Transportation Rule (STR / 21 CFR 1.900-1.934), commodity-specific temperature ranges, refrigeration unit operation, temperature recorder calibration, and how a load is challenged if temperature deviates. Cite 21 CFR Part 1 Subpart Q.

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Use this skill to ensure driver hiring practices comply with Equal Employment Opportunity Commission requirements. Covers Title VII, disability, age, and pregnancy.

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The watch-fix-rerun method for making an existing platform agent or automated process efficient and correct: baseline its ledger, run one unit yourself, fix the class behind every wasted call, rerun, record. Use when asked to improve, optimize, watch, or 'make efficient' an agent, a sandbox session, a sync job, or any recurring automated process.

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End-of-task routine: health checks, fixes, then commit and push. Use when finishing a unit of work, or when the user says 'commit and push', 'ship it', 'get it ready', 'wrap up', or just 'do this' with no push instruction.

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Write content in David Dias's authentic voice. Use when Quill or any agent needs to create tweets, blog posts, emails, marketing copy, or any content that should sound like David wrote it. David's voice is personal and conversational, mixing professional insight with personal anecdotes. He shares failures openly, values community, and speaks directly to readers with honesty and warmth. Not corporate or overly polished.

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Extract and consolidate reusable components, design tokens, and patterns into your design system. Identifies opportunities for systematic reuse and enriches your component library. Use when the user asks to create components, refactor repeated UI patterns, build a design system, or extract tokens.

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Generates PSR-3 Logger implementation for PHP 8.5. Creates LoggerInterface implementations with log levels, context interpolation, and LoggerAwareTrait usage. Includes unit tests.

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Generates Rate Limiter pattern for PHP 8.5. Creates request throttling with token bucket, sliding window, and fixed window algorithms. Includes unit tests.

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Generates PSR-7 HTTP Message implementations for PHP 8.5. Creates Request, Response, Stream, Uri, and ServerRequest classes with immutability. Includes unit tests.

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Generates PSR-20 Clock implementation for PHP 8.5. Creates ClockInterface implementations including SystemClock, FrozenClock, and OffsetClock for time abstraction and testing. Includes unit tests.

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Generates DDD Value Objects for PHP 8.5. Creates immutable, self-validating objects with equality comparison. Includes unit tests.

日本語の概要は準備中です。原文の説明を表示しています。

Generates Read Model/Projection for PHP 8.5. Creates optimized query models for CQRS read side with projections and denormalization. Includes unit tests.

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Generates PSR-18 HTTP Client implementation for PHP 8.5. Creates ClientInterface with request sending and exception handling. Includes unit tests.

日本語の概要は準備中です。原文の説明を表示しています。

Generates ADR Responder classes for PHP 8.5. Creates HTTP response builders with PSR-7/PSR-17 support. Includes unit tests.

日本語の概要は準備中です。原文の説明を表示しています。

Generates Saga pattern components for PHP 8.5. Creates Saga interfaces, steps, orchestrator, state management, and compensation logic with unit tests.

日本語の概要は準備中です。原文の説明を表示しています。

Generates Retry pattern for PHP 8.5. Creates resilience component with exponential backoff, jitter, and configurable retry strategies. Includes unit tests.

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Generates State pattern for PHP 8.5. Creates state machines with context, state interface, and concrete states for behavior changes. Includes unit tests.

日本語の概要は準備中です。原文の説明を表示しています。

Generates Application Use Cases for PHP 8.5. Creates orchestration services that coordinate domain objects, handle transactions, and dispatch events. Includes unit tests.

日本語の概要は準備中です。原文の説明を表示しています。