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Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.

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Comprehensive backend development guide for Langfuse's Next.js 14/tRPC/Express/TypeScript monorepo. Use when creating tRPC routers, public API endpoints, BullMQ queue processors, services, or working with tRPC procedures, Next.js API routes, Prisma database access, ClickHouse analytics queries, Redis queues, OpenTelemetry instrumentation, Zod v4 validation, env.mjs configuration, tenant isolation patterns, or async patterns. Covers layered architecture (tRPC procedures → services, queue processors → services), dual database system (PostgreSQL + ClickHouse), projectId filtering for multi-tenant isolation, traceException error handling, observability patterns, and testing strategies (Jest for web, vitest for worker).

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Disciplined diagnosis loop for hard bugs and performance regressions. Reproduce → minimise → hypothesise → instrument → fix → regression-test. Use when user says "diagnose this" / "debug this", reports a bug, says something is broken/throwing/failing, or describes a performance regression.

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Generate songs, instrumentals, lyrics, podcasts using Mureka AI.

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Expert-level seismology covering earthquake seismology, seismic wave propagation, seismometer instrumentation, earthquake source parameters, seismic hazard, and induced seismicity.

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Expert-level analytical chemistry knowledge. Use when working with chromatography, spectroscopy, electroanalytical methods, sample preparation, quantitative analysis, calibration, statistics, or instrumental analysis. Also use when the user mentions 'HPLC', 'GC', 'mass spectrometry', 'atomic absorption', 'ICP', 'titration', 'calibration curve', 'detection limit', 'NMR', 'chromatography', 'electrochemistry', 'sample preparation', or 'method validation'.

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Use when validation needs entry, business-logic, environment, and instrumentation guards so a bad value cannot reach the failure point — turns a local bug fix into a structural one.

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Use when adding logging, metrics, tracing, or alerting to production code, or when a past incident lacks diagnostic data.

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Instrument browser/web apps with the Application Insights JavaScript SDK (@microsoft/applicationinsights-web). Use for Real User Monitoring (RUM) — page views, clicks, AJAX/fetch dependencies, exceptions, custom events...

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Generate AI music and songs with Diffrythm, Tencent Song Generation via inference.sh CLI. Models: Diffrythm (fast song generation), Tencent Song Generation (full songs with vocals). Capabilities: text-to-music, song generation, instrumental, lyrics to song, soundtrack creation. Use for: ba...

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Detects and analyzes malicious behavior in mobile applications through behavioral analysis, permission abuse detection, network traffic monitoring, and dynamic instrumentation. Use when analyzing suspicious mobile applications for data exfiltration, command-and-control communication, credential stealing, SMS interception, or other malware indicators. Activates for requests involving mobile malware analysis, app behavior monitoring, trojan detection, or suspicious app investigation.

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Knowledge base from MIL-HDBK-61B, the DoD Configuration Management (CM) guidance handbook (7 April 2020, cataloged with Change 1, 2025). Use for defense CM across the acquisition and sustainment life cycle: the five CM functions (planning, identification, control/change management, status accounting, verification & audit), the three configuration baselines (FBL/ABL/PBL) and FCD→ACD→PCD documentation, configuration items (CIs/HWCI/CSCI), change instruments (ECP/NOR/RFV), the CCB and Class I/II classification, CDCA/AA authority, FCA/PCA audits, data management and data rights (CDRL/DID, DFARS rights ladder, master/authoritative source), and tailoring CM by phase (EIA-649-1 R/T/NR matrix, Appendix C templates), plus digital-era CM (digital twin, viewpoints, MOSA). NOTE: 61B is advisory guidance that adopts and points to the SAE EIA-649 / EIA-649-1 / GEIA-HB-649 suite for the authoritative CM requirements — this pack names and describes that suite but does not reproduce its copyrighted requirement text. Thin on: the EIA-649 requirement clauses themselves, form-level detail (DD-form field instructions, full DID content), and non-DoD/commercial CM frameworks.

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Knowledge base from the NASA Digital Engineering Acquisition Framework Handbook (NASA-HDBK-1004). Use for acquiring digital/model-based data under contract: the Data Requirements Description (DRD) instrument and the Appendix A DRD suite (TDP, MBx, CDMP, CSA, CR, FCA/PCA, SDT, EMDAL, REF, MRI); the Data Type 1-5 control scale; SOW/RFP/Cost-Volume contract language and data rights (FAR/DFARS, Table 3 license categories); the Requirements Exchange Format (REF/ReqIF, UUID schema) and Master Records Index; model-based data definition (MBSE, CAD/PMI, M&S credibility, BOM, release-state mapping, PLM); digital data collaboration, the four owned architectures, and interoperability standards (MIL-STD-31000, STEP/ISO 10303, ASME Y14); the four MBE interoperability use cases; and MBE Plan development. Scope is the acquisition and contracting side of digital engineering. Does not reproduce ISO/STEP/ASME/MIL-STD/SAE standard text, and the companion NASA-HDBK-1009A carries the deeper digital-engineering practitioner detail this handbook defers to.

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Checks an extracted PFD register as a process model and returns findings and unknowns only: connectivity closure, stream numbering, presence of design conditions, equipment duty text, phase and service labels, package and off-sheet scope, boundaries, operating cases, and agreement between the drawing and attached process documents, then holds at gate G2. Creates no design values. Use when the user asks to "check the process model", "verify connectivity" or "is the PFD ready for enrichment" after gate G1 and before enrichment. Do not use for extraction from the drawing, use pfd-intake-and-extraction instead; do not use to propose lines or instruments, use piping-enrichment. Drafts for human review; never approves, authorises or signs off.

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Instrument browser/web apps with the Application Insights JavaScript SDK (@microsoft/applicationinsights-web).

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Instrument AI agents with tracing, token metrics, latency, and cost visibility. Use for reliability and debugging.

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Use when the user asks to "monitor my launch", "track our Product Hunt / Hacker News ranking", or "watch the launch window"; runs the T-0 to T+30 window watch — pre-launch instrumentation verification (UTM/event checks, the upstream of RAMP P1), HN rank/points/comments polling with a comments-over-points flamewar early-warning (Estimated heuristic), PH votes/featured status, store charts and reviews, news echo, D0/W1/M1 KPI snapshots vs targets, spike-vs-sustain and owned-capture reads, and alert thresholds against the launch-tier KPI targets. Not for launch-day go/rollback calls — use launch-day-conductor; not for metric deep-dives — use performance-analyzer; not for SEO rank tracking — use rank-tracker. 发布监控/排名轮询/火焰战比/spike-sustain

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Improve conversion performance on marketing pages and forms through diagnosis, message hierarchy, friction analysis, proof, UX hypotheses, instrumentation and experiments.

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Marketing analytics and data-driven optimization for B2B SaaS campaigns. Use this skill when analyzing marketing performance, optimizing conversion rates, running A/B tests, conducting customer research, creating marketing dashboards, building attribution models, analyzing funnel metrics, or storytelling with data. Also triggers on: marketing ops, performance analytics, CRO, A/B testing, data storytelling, customer insights, tracking plan, event taxonomy, UTM taxonomy, GA4 audit, consent mode, instrumentation contract, sample size calculation, minimum detectable effect, test duration, not enough traffic to A/B test, statistical significance, Bayesian vs frequentist, sample ratio mismatch, experiment feasibility, martech stack, marketing tech stack audit, tool consolidation, build vs buy, vendor evaluation, shadow IT tools, ESP/CRM/platform migration, switching cost, cutover plan, suppression list migration, data portability, customer interviews, survey design, sampling frame, non-response bias, how many people should I interview, thematic saturation, voice of customer, jobs-to-be-done, buyer persona research, is this finding real, data enrichment, which enrichment provider should we buy, waterfall enrichment, contact data quality, match rate, our list data is bad, email verification, catch-all domain, accept-all, bounce rate from bad data, B2B data decay, how often should we re-verify contacts, ZoomInfo vs Apollo vs Clearbit evaluation, cost per usable record, where did this list come from, GDPR Article 14 notice, purchased list compliance, suppression screening, TAM list building, demand planning, marketing plan, how many leads do we need, what pipeline target should marketing carry, funnel model, top-down vs bottom-up plan, plan of record, annual marketing planning, quarterly planning, pipeline coverage we have to create, sales cycle lag, our leads cannot close this quarter, carry-in pipeline, scenario planning, conservative moderate aggressive forecast, stretch target, reforecast, re-forecast triggers, assumption register, capacity ceiling, addressable audience ceiling, marginal cost per lead, blended CPL is wrong, we missed plan and nobody knows why.

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Builds native iOS apps in Swift — SwiftUI and UIKit screens, state and data flow, NavigationStack, lists, forms and accessibility; networking with URLSession and Codable, persistence with SwiftData, Core Data, files and the Keychain; permissions, push notifications, universal links, background tasks, widgets, App Intents and StoreKit 2 purchases; performance with Instruments and MetricKit; and release with signing, TestFlight and App Store Connect. Use when writing or changing native iOS code, adding a platform feature, preparing a build for TestFlight or the App Store, or when the user asks how to do something on iOS, even if they do not name the framework.

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Azure Monitor OpenTelemetry Distro for Python. Use for one-line Application Insights setup with auto-instrumentation.

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Instrument applications with Azure Monitor and OpenTelemetry for JavaScript (@azure/monitor-opentelemetry). Use when adding distributed tracing, metrics, and logs to Node.js applications with Appli...

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Next.js 16.2.4 with TypeScript — App Router, Server Components, use cache directive, Turbopack dev, Server Actions, ISR, SSR, SSG, MCP devtools, metadata API, route handlers, instrumentation.

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Improve AI application with evaluation-driven development. Define eval criteria, instrument the application, build golden datasets, observe and evaluate application runs, analyze results, and produce a concrete action plan for improvements. ALWAYS USE THIS SKILL when the user asks to set up QA, add tests, add evals, evaluate, benchmark, fix wrong behaviors, improve quality, or do quality assurance for any Python project that calls an LLM model.

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