「method」の検索結果

Checks cyclomatic complexity, nesting, long methods, god classes, method signatures, O(n²), N+1 queries, constants management. Returns findings.

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Core statistical methodology and pedagogical approach for all Inquiro analyses. Always loaded to maintain teaching quality and reproducibility standards.

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Application of Six Sigma quality methodology to AI agent process improvement and reliability

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GOMS cognitive modeling methodology for analyzing human-computer interaction task performance

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Analytical methods for decomposing expert performance into cognitive and physical task components

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Cognitive Systems Engineering design methodology for joint cognitive systems and human-centered automation

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Integration of BDI agent architecture with soft systems methodology for complex organizational problem-solving

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Methodology for eliciting expert knowledge about cognitive processes, decisions, and mental models in complex tasks

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Systematic methodology for eliciting, representing, and operationalizing expert cognitive skills—pattern recognition, situation assessment, mental simulation—from practitioners without requiring research training. Bridges academic rigor and practical usability.

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Up-to-date Zig programming language patterns for version 0.17.0-dev (0.16.0 stable APIs plus the 0.17 deltas). Use when writing, reviewing, or debugging Zig code, working with build.zig and build.zig.zon files, or using comptime metaprogramming. Critical for avoiding outdated patterns from training data - especially std.net→std.Io.net (requires Io instance), std.time timestamps removed (use clock_gettime), std.Thread.Mutex/Condition/sleep removed (use pthreads), std.crypto.random removed, build system APIs (root_module, Compile methods→Module methods), I/O APIs (buffered writer pattern), container initialization (.empty/.init), allocator selection (DebugAllocator), ArrayList now unmanaged by default, @typeInfo lowercase fields (.@"struct" not .Struct), and removed language features (async/await, usingnamespace). Also covers 0.17.0-dev deltas: b.args→run_cmd.addPassthruArgs(), std.gpu→std.spirv, @bitCast logical-bit (endian-agnostic) semantics, build configurer/maker split, and the zig-pkg/ package directory. Also covers quality tooling Zig does not ship: coverage with kcov (and why in-file tests wreck the denominator), detecting unused private functions (neither the compiler nor zlint's unused-decls finds them), duplicate detection with jscpd, zlint (NOT the same-named X.509 linter in Homebrew), and the built-in fuzzer whose testOne now takes *std.testing.Smith rather than []const u8.

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Calls m6A peaks from MeRIP-seq / m6A-seq paired IP-vs-input data using exomePeak2 (transcript-aware, GC-bias-corrected Poisson GLM), MeTPeak (HMM over sliding windows), MACS3/MACS2 with --nomodel --broad --keep-dup all (genome-wide broad alternative), and DRACH motif enrichment via HOMER or ggseqlogo as a sanity check (NOT a filter). Covers BED12 vs narrowPeak output, exonic vs intronic peak handling, multi-tool reconciliation (intersection vs union), the m6A-vs-m6Am ambiguity at 5'UTR peaks that antibody methods cannot resolve, and orthogonal validation (miCLIP/GLORI/m6A-SAC-seq/m6Anet). Use when calling peaks from paired IP/input genome BAMs, choosing exomePeak2 (transcript-aware default) vs MACS3 (broad genomic) vs MeTPeak (HMM-smoothed low-coverage), confirming DRACH enrichment as a sanity check on the peak set, reconciling differing peak sets across tools, validating MeRIP peaks against single-base methods, interpreting 5' peaks where m6Am contamination is possible, or recommending a consensus strategy.

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Differential abundance (DA) and differential state (DS) analysis for flow and mass cytometry - tests which cell populations change in frequency or marker expression between conditions using diffcyt (edgeR/voom/GLMM for DA, limma/LMM for DS), with cydar, CITRUS, and compositional methods (sccomp, scCODA, DCATS) as alternatives. Covers the sample-is-the-experimental-unit principle, design/contrast and mixed-model formulas, compositionality of cluster proportions, and FDR across clusters. Use when comparing populations between groups, choosing a DA method, handling paired/batch designs, or deciding whether compositional correction is needed.

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Infer gene regulatory networks from bulk or general expression data with mutual-information (ARACNe) and tree-ensemble (GENIE3, GRNBoost2) methods, and infer transcription-factor protein activity from regulons with VIPER and msVIPER. Covers the activity-not-edges paradigm, the undirected-association caveat, the DREAM5 wisdom-of-crowds and method-complementarity result, AUPRC-over-AUROC evaluation, and gold-standard incompleteness. Use when inferring a regulatory network from a bulk expression matrix, finding master regulators, or scoring TF activity from a signature. For single-cell motif-pruned regulons see scenic-regulons; for co-expression modules see coexpression-networks.

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Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.

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Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates across robust methods.

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Selects the aldosterone-to-renin ratio (ARR) method over hypokalemia for screening hypertensive patients for primary aldosteronism. Use when a clinician asks what test to use for screening hypertensive patients with resistant hypertension or unexplained hypokalemia for PA.

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Expert-level dynamics covering kinematics and kinetics of particles and rigid bodies, Newton-Euler equations, energy methods, impulse-momentum, and vibrations.

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Expert-level geophysics covering seismic methods, gravity and magnetics, electromagnetic methods, heat flow, Earth structure, and exploration geophysics.

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Expert-level analytical chemistry knowledge. Use when working with chromatography, spectroscopy, electroanalytical methods, sample preparation, quantitative analysis, calibration, statistics, or instrumental analysis. Also use when the user mentions 'HPLC', 'GC', 'mass spectrometry', 'atomic absorption', 'ICP', 'titration', 'calibration curve', 'detection limit', 'NMR', 'chromatography', 'electrochemistry', 'sample preparation', or 'method validation'.

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Expert-level differential equations knowledge. Use when working with ordinary differential equations, partial differential equations, systems of ODEs, Laplace transforms, Fourier methods, boundary value problems, stability analysis, or numerical methods for ODEs. Also use when the user mentions 'ODE', 'PDE', 'initial value problem', 'boundary value problem', 'Laplace transform', 'separation of variables', 'eigenvalue problem', 'heat equation', 'wave equation', 'Laplace equation', 'stability', or 'phase plane'.

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Use when you need to inspect NuGet package APIs, list public types, or decompile method/property signatures. Keywords: inspect package API, list types, decompile type, method signatures, NuGet interface.

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copy_tuner_client v2.0.0 への移行で、削除された独自ヘルパー tt の呼び出しを Rails 標準の t（translate）へ 置換するスキル。tt は PR #122 で存在理由を失い gem から削除されたため、残った tt(...) は NoMethodError に なる。大半は機械的に tt( → t( で済むが、訳文を文字列加工している箇所（→ I18n.t へ）と label 系ヘルパーの 第一引数に渡している箇所（→ 引数構造を分離）だけは別扱いで、開発環境のマーカートークン残留バグを避けるため 1 件ずつ確認する。対象は app 配下の .rb / .haml / .erb。

Codex adapter for Garry Tan's full gstack methodology across CEO/product pressure, CTO architecture, design, engineering, QA, security, shipping, documentation, and retrospectives. Use when the 总控/CEO or 架构/CTO role needs gstack method routing, implementation-plan hardening, or the user says gstack should help a role.

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Cloudflare Durable Objects の実装とレビューに使用する。チャットルーム、マルチプレイ、予約システムなどの状態を持つ協調処理、RPC methods、SQLite storage、alarms、WebSockets、Workers統合、wrangler設定、Vitestでのテストを扱う。事前学習の知識より最新のCloudflare docsの取得を優先する。