333 件 ・ 関連度順
概要と使いどころ
Evaluates and implements age estimation and verification technologies for online services. Covers facial age estimation, digital ID verification, self-declaration with risk assessment, AI-based age estimation, and the accuracy versus privacy tradeoff. Includes ICO guidance and euCONSENT framework. Keywords: age verification, age estimation, facial analysis, digital ID, children, online safety.
日本語の概要は準備中です。原文の説明を表示しています。
Read a Japanese job posting closely and report what it actually states: base pay separated from fixed overtime allowance, the range converted to an hourly basis, required versus preferred requirements, and the terms left ambiguous. Use when a user wants a 求人票 or job description examined before applying, wants two postings compared on the same basis, or wants questions prepared about pay and working conditions; do not use to judge whether the user will be hired, to infer duties the posting does not state, or to evaluate the employer's reputation.
日本語の概要は準備中です。原文の説明を表示しています。
Bead-based signal normalization and cross-batch harmonization for CyTOF and high-parameter cytometry - EQ four-element bead normalization of instrument sensitivity drift (CATALYST normCytof, premessa), and reference-anchor cross-batch normalization (CytoNorm, per-cluster quantile splines). Covers the distinction between within-run drift correction and between-batch correction, the mandatory anchor/reference sample, why normalization is per-cluster with many quantiles, and the over-correction risk. Use when correcting CyTOF signal drift, harmonizing multi-batch or multi-site studies, or deciding whether to normalize data versus model batch in the design.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.
日本語の概要は準備中です。原文の説明を表示しています。
Resolve subclonal copy number, whole-genome doubling, and copy-number tumor evolution from bulk sequencing with Battenberg, TITAN, and MEDICC2. Covers clonal versus subclonal copy-number states, haplotype phasing for subclonal resolution, cancer cell fraction, whole-genome-doubling detection and timing relative to mutations, mirrored subclonal allelic imbalance, and copy-number phylogenies. Use when a tumor is heterogeneous and bulk data shows non-integer copy number, when calling subclonal CNAs, detecting or timing whole-genome doubling, reconstructing copy-number evolution, or deciding between Battenberg and TITAN.
日本語の概要は準備中です。原文の説明を表示しています。
Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.
日本語の概要は準備中です。原文の説明を表示しています。
Detect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allele-specific callers. Use when calling CNVs from hybrid-capture panels or exomes, deciding whether CNVkit (depth-only) is the right tool versus an allele-specific caller, building a panel of normals, diagnosing flat-reference false positives, or interpreting log2 ratios into copy-number states.
日本語の概要は準備中です。原文の説明を表示しています。
Bead-based signal normalization and cross-batch harmonization for CyTOF and high-parameter cytometry - EQ four-element bead normalization of instrument sensitivity drift (CATALYST normCytof, premessa), and reference-anchor cross-batch normalization (CytoNorm, per-cluster quantile splines). Covers the distinction between within-run drift correction and between-batch correction, the mandatory anchor/reference sample, why normalization is per-cluster with many quantiles, and the over-correction risk. Use when correcting CyTOF signal drift, harmonizing multi-batch or multi-site studies, or deciding whether to normalize data versus model batch in the design.
日本語の概要は準備中です。原文の説明を表示しています。
Resolve subclonal copy number, whole-genome doubling, and copy-number tumor evolution from bulk sequencing with Battenberg, TITAN, and MEDICC2. Covers clonal versus subclonal copy-number states, haplotype phasing for subclonal resolution, cancer cell fraction, whole-genome-doubling detection and timing relative to mutations, mirrored subclonal allelic imbalance, and copy-number phylogenies. Use when a tumor is heterogeneous and bulk data shows non-integer copy number, when calling subclonal CNAs, detecting or timing whole-genome doubling, reconstructing copy-number evolution, or deciding between Battenberg and TITAN.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.
日本語の概要は準備中です。原文の説明を表示しています。
Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.
日本語の概要は準備中です。原文の説明を表示しています。
Detect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allele-specific callers. Use when calling CNVs from hybrid-capture panels or exomes, deciding whether CNVkit (depth-only) is the right tool versus an allele-specific caller, building a panel of normals, diagnosing flat-reference false positives, or interpreting log2 ratios into copy-number states.
日本語の概要は準備中です。原文の説明を表示しています。
Generate SEO-optimized competitor comparison and alternatives pages. Covers "X vs Y" layouts, "alternatives to X" pages, feature matrices, schema markup, and conversion optimization. Use when user says "comparison page", "vs page", "alternatives page", "competitor comparison", "X vs Y", "versus", "compare competitors", or "alternative to".
日本語の概要は準備中です。原文の説明を表示しています。
Find and identify the CBaseTrigger::StartTouch and CBaseTrigger::EndTouch overridden virtual functions in the CS2 server binary using IDA Pro MCP. Use this skill when reverse engineering server.dll or libserver.so to locate the trigger-volume touch-list add/remove handlers by RTTI-walking CBaseTrigger's and CBaseEntity's primary vtables and diffing them slot-by-slot to find CBaseTrigger's overrides, then identifying which two overridden slots implement "add pOther to the touching-entities list" (StartTouch) versus "remove pOther from the touching-entities list" (EndTouch). Trigger: CBaseTrigger_StartTouch, CBaseTrigger_EndTouch
日本語の概要は準備中です。原文の説明を表示しています。
Compare cross-border e-commerce shipping options, packaging tactics, customs-risk signals, and speed-versus-cost tradeoffs for sellers, operations teams, and marketplace operators. Use when choosing routes, carriers, declaration practices, or packaging plans for parcel shipments without relying on live carrier APIs.
日本語の概要は準備中です。原文の説明を表示しています。
Hunt TLS/SSL and DNS misconfigurations — missing HSTS (downgrade attack), weak cipher suites, expired/invalid certificates, mTLS bypass, missing SPF/DKIM/DMARC (email spoofing), DNS Zone Transfer (AXFR), dangling CNAME subdomain takeover, CAA records. Most of these are Info/Low on their own — this skill is opinionated about which findings actually pay (spoofable DMARC with delivered-to-inbox proof, AXFR returning internal hosts, dangling-CNAME takeover) versus which get rejected as best-practice noise (missing CAA, missing HSTS with no MitM position). Use during recon to find infrastructure weaknesses, and to TRIAGE them honestly before reporting.
日本語の概要は準備中です。原文の説明を表示しています。
look up and explain llm api pricing across models.dev, openrouter, and official provider pages. use when the user asks for model prices, input/output token costs, cached-token costs, openrouter aliases such as :free, provider-specific pricing, official versus third-party prices, or wants to verify an api call cost log.
日本語の概要は準備中です。原文の説明を表示しています。
Evaluates current go-to-market positioning versus the market. Analyzes website, content, pricing, ICP alignment, and competitive landscape to identify gaps, opportunities, and produce a GTM health report.
日本語の概要は準備中です。原文の説明を表示しています。
Chooses and designs developer surfaces for an agentic product: SDK, CLI, MCP, GUI, API, webhooks, and pd tube-style listener/sender workflows. Use when deciding why a user belongs in an SDK versus CLI/MCP/GUI, planning Python SDK parity, or making agent invocation easy across languages. NOT for implementing the full SDK, generic API docs, or UI visual design.
日本語の概要は準備中です。原文の説明を表示しています。
Author a pull request an AI coding agent can actually get merged: a scoped, coherent diff; a Summary and Test Plan backed by real evidence; correct triage of required-and-blocking CI gates versus external/advisory checks (e.g. a Cloudflare Pages preview build); draft-while-WIP discipline; named fixup commits for real review findings; and a clean landing through a merge queue without force-pushing or bypassing branch protection. Use when opening, updating, triaging red CI on, or landing an agent-authored GitHub PR. NOT for this repo's internal release ceremony, actor embodiments, or contributor mirror-sync mechanics (use port-daddy-internal-dev), tracking backlog/issue lifecycle across a board (use agent-issue-tracker-workflow), or deciding what to build next / sequencing a roadmap (use legible-roadmap-with-sidequests).
日本語の概要は準備中です。原文の説明を表示しています。
Verify every visual-evidence artifact (screenshot/GIF/recording) attached to a PR carries a provenance manifest binding it to real daemon-backed truth — daemon port, run id, transcript head hash, agent node id, commit, and an honest real/fixture/mock source label — and that operator-control-panel PRs cover the required set of proof states. Use when gating a PR's proof artifacts before merge, auditing whether a "LIVE" visual claim is backed by a real daemon run versus a reused or fixture-backed mock, or defining the required state-coverage set for a control-panel change. NOT for the capture technique itself — headless Playwright, `screencapture -x -l`, non-interruptive capture (use port-daddy-agent-skill's visual-evidence doctrine), designing the receipt body schema an artifact attaches to (use agent-work-receipt-designer), or the broader dogfood/Potemkin product-quality bar (use multi-agent-authoring-product-bar).
日本語の概要は準備中です。原文の説明を表示しています。