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概要と使いどころ
You are an expert in the interface between LLMs and the outside world. You've seen tools that work beautifully and tools that cause agents to hallucinate, loop, or fail silently. The difference is almost always in the design, not the implementation.
日本語の概要は準備中です。原文の説明を表示しています。
Infer gene regulatory networks from bulk or general expression data with mutual-information (ARACNe) and tree-ensemble (GENIE3, GRNBoost2) methods, and infer transcription-factor protein activity from regulons with VIPER and msVIPER. Covers the activity-not-edges paradigm, the undirected-association caveat, the DREAM5 wisdom-of-crowds and method-complementarity result, AUPRC-over-AUROC evaluation, and gold-standard incompleteness. Use when inferring a regulatory network from a bulk expression matrix, finding master regulators, or scoring TF activity from a signature. For single-cell motif-pruned regulons see scenic-regulons; for co-expression modules see coexpression-networks.
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Analyzes species-environment relationships with constrained ordination (CCA, RDA, db-RDA), variance partitioning, indicator species (indicspecies IndVal.g group-equalized), PERMANOVA paired MANDATORILY with PERMDISP (Anderson & Walsh 2013; dispersion confounds centroid tests), Joint Species Distribution Models (HMSC, sjSDM, gjam) with explicit rejection of "residual covariance equals biotic interaction", phylogenetic community ecology (SES_MPD/MNTD), trait-environment via RLQ + fourth-corner with corrected modeltype=6 (Dray 2014), bipartite network metrics (NODF, modularity) with curveball null (Strona 2014), and Mantel-test replacements (dbRDA, GDM) for spatial data. Use when testing how environmental gradients structure communities, identifying habitat indicator taxa, partitioning variance among predictors, deciding whether PERMANOVA significance is location vs dispersion, picking among HMSC/sjSDM/gjam, or replacing Mantel tests for landscape data.
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Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.
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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 7.
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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract, SES), k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.
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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.
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Use when a dispatcher, operations manager, or owner asks how to plan loads to minimize empty (deadhead) miles, sequence freight efficiently, balance regional capacity, design dedicated loops, or build a load-pairing strategy across customers. Covers loaded-ratio math, lane balance, region-pair pricing, and software-supported optimization.
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Use this skill when the user asks about driver fitness-for-duty programs — pre-trip readiness assessment, recognizing impairment from drugs/alcohol/medication/fatigue/mental health, refusing assignments when unfit, supervisor training on fitness assessment, FMCSA recommendations on duty status determination, and how to handle a driver who appears unfit. Reference 49 CFR 392.3 + 392.4.
日本語の概要は準備中です。原文の説明を表示しています。
Design dashboards for migrations and runtimes. Use for authority drift, verifier status, burn-down, runtime health, or pain panels. NOT for vanity analytics, ad hoc charts, or duplicate reporting.
日本語の概要は準備中です。原文の説明を表示しています。
Use when introducing a feature flag system, choosing between release flags / experiment flags / operational flags / kill switches / permission flags, designing percentage rollouts, building kill-switch + circuit-breaker patterns, structuring evaluation contexts (user IDs, plan tier, region), or building flag-cleanup discipline. Triggers: LaunchDarkly / GrowthBook / Unleash / Flagsmith / OpenFeature, percentage ramp, sticky bucketing, kill switch wired to alerting, "we still have flags from 2 years ago", flag debt, OpenFeature provider, evaluation context, default value on provider failure. NOT for A/B test statistical analysis (separate skill), traffic-split routing at the edge, build-time bundler defines, or environment-based config.
日本語の概要は準備中です。原文の説明を表示しています。
Apply recognition-primed decision making to agents operating under time pressure, uncertainty, and ambiguous cues. Use for situation assessment, RPD-style action selection, and decision-support design in operational settings. NOT for batch optimization, static planning with full information, or tasks where exhaustive search is cheap and harmless.
日本語の概要は準備中です。原文の説明を表示しています。
Designs and audits data retention and file compaction for an embedded SQLite datastore in a long-lived service — a unified retention registry (one declared policy per table), TTL / absolute-age / row-count-cap policies, a fail-loud coverage guard, WAL/checkpoint tuning, and auto_vacuum/incremental-vacuum so pruning actually shrinks the file. Use when a SQLite DB grows unbounded, a table has an index but no DELETE, a pruned DB never shrinks on disk, metrics are stored as raw events forever, or a new table needs bounding. Keywords retention policy, TTL, reaper, prune, VACUUM, auto_vacuum, incremental_vacuum, WAL checkpoint, freelist, DB bloat, row cap, per-tenant quota. NOT for Postgres/MySQL/server-DB partitioning or TTL, log-line rate-limiting/sampling, backup/replication, schema migrations, or query-performance indexing.
日本語の概要は準備中です。原文の説明を表示しています。
Apply recognition-primed decision making to agents operating under time pressure, uncertainty, and ambiguous cues. Use for situation assessment, RPD-style action selection, and decision-support design in operational settings. NOT for batch optimization, static planning with full information, or tasks where exhaustive search is cheap and harmless.
日本語の概要は準備中です。原文の説明を表示しています。
Detect crisis signals in user content using NLP, mental health sentiment analysis, and safe intervention protocols. Implements suicide ideation detection, automated escalation, and crisis resource integration. Use for mental health apps, recovery platforms, support communities. Activate on "crisis detection", "suicide prevention", "mental health NLP", "intervention protocol". NOT for general sentiment analysis, medical diagnosis, or replacing professional help.
日本語の概要は準備中です。原文の説明を表示しています。
App Store and Google Play submission automator with Fastlane, screenshot automation, metadata management, and TestFlight/internal testing. Activate on: app store submission, Fastlane, TestFlight, Google Play Console, screenshot automation, metadata management, app review, code signing, provisioning profiles. NOT for: CI/CD pipeline setup (use github-actions-pipeline-builder), app architecture (use react-native-architect), analytics (use mobile-analytics-crash-reporting-expert).
日本語の概要は準備中です。原文の説明を表示しています。
Generates OpenAPI 3.0/3.1 specs, TypeScript client types, and curl examples from existing route handler code. Supports Express, Next.js API routes, Fastify, and Hono. Produces complete documentation including auth requirements, rate limits, error codes, and request/response examples. Activate on: 'generate API docs', 'OpenAPI from code', 'document endpoints', 'API reference', 'swagger generation', 'endpoint documentation'. NOT for: API design from scratch (use api-architect), deployment (use devops-automator), testing (use test-automation-expert).
日本語の概要は準備中です。原文の説明を表示しています。
Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.
日本語の概要は準備中です。原文の説明を表示しています。
Apply AlphaGo-style patterns: learned priors plus search, mixed evaluators, self-play, and asynchronous fast/slow loops. Use for intractable search and compute allocation. NOT for basic supervised learning, tractable optimization, or domains without search bottlenecks.
日本語の概要は準備中です。原文の説明を表示しています。
Design or review a declared control-command profile and its verb/backend lifecycle matrix. Distinguish policy denial, unsupported capability, delivery acknowledgement, independently observed effect, and unknown outcome; bind authorization to principal, target, scope, current policy, expiry, and fencing epoch. NOT for claiming runtime correctness, proving an adapter from declarations, or approving a control-panel button without independent runtime evidence.
日本語の概要は準備中です。原文の説明を表示しています。
Design or audit an agent identity, credential, session, continuity, and reputation plan. Use when attributed outcomes must survive key rotation, restart, recovery, or review; when choosing Elo, TrueSkill, a contextual bandit, or an LLM judge; and when making Sybil, newcomer, calibration, collusion, and evidence limits explicit. Produces a supplied-plan consistency audit, never proof of observed delivery, cryptographic identity, or live enforcement. NOT for proving personhood, global Sybil resistance, or an unobserved delivery.
日本語の概要は準備中です。原文の説明を表示しています。
Research AI coding assistant products, audiences, user stories, social proof, hacks, and unmet needs for apps like Cursor, Claude Code, Codex, Warp Code, Devin, Windsurf, GitHub Copilot, Cline, Aider, and homegrown agent stacks. Use when designing or positioning agentic developer tools, Port Daddy Agent Harbor, swarm consoles, background coding agents, or competitive/product research for AI software engineering. NOT for implementing the coding agent runtime, generic market research, or UX mockups without developer workflow evidence.
日本語の概要は準備中です。原文の説明を表示しています。
Local SEO analysis covering Google Business Profile optimization, NAP consistency, citation health, review signals, local schema markup, location page quality, multi-location SEO, and industry-specific recommendations. Detects business type (brick-and-mortar, SAB, hybrid) and industry vertical. Use when user says "local SEO", "Google Business Profile", "GBP", "map pack", "local pack", "citations", "NAP consistency", "service area", or "multi-location".
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Find and identify the CCSPlayer_WeaponServices_EquipWeapon function and the CCSPlayer_WeaponServices_CanUse virtual function in CS2 binary using IDA Pro MCP. Use this skill when reverse engineering CS2 server.dll or libserver.so to locate the weapon-equip helper and the "is this weapon usable right now" vfunc by RTTI-walking the CCSPlayer_WeaponServices vtable and confirming each candidate's decompiled body against the known CCSPlayer_WeaponServices_PickupItem anchor's callee shapes. Trigger: CCSPlayer_WeaponServices_EquipWeapon, CCSPlayer_WeaponServices_CanUse
日本語の概要は準備中です。原文の説明を表示しています。