「esp」の検索結果

Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use when batch-converting Ensembl IDs to other namespaces (HGNC, RefSeq, UniProt, Entrez), pulling gene coordinate tables for thousands of genes, building ortholog wide-tables across species, or replacing slow Ensembl REST loops with one-shot bulk export. Encodes BioMart's XML query format, R biomaRt vs Python pybiomart trade-off, mart-vs-dataset hierarchy, and the URL endpoint that's BioMart-specific (separate from rest.ensembl.org).

日本語の概要は準備中です。原文の説明を表示しています。

Search NCBI databases using Biopython Bio.Entrez (ESearch, EInfo, EGQuery, ESpell). Use when finding records by keyword, building reproducible field-qualified queries, navigating the Entrez Query Translator, exploiting the history server for large result sets, handling retmax caps, or interpreting weekly index lag. Covers PubMed, Nucleotide, Protein, Gene, SRA, GEO, Assembly, Taxonomy, ClinVar, dbSNP.

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Detect syntenic blocks and structural rearrangements between genomes using MCScanX (Wang 2012), JCVI/MCScan (Tang 2008 Python), GENESPACE (Lovell 2022) for orthology-anchored riparian visualization, SyRI for structural variation, AnchorWave for sequence-level synteny, i-ADHoRe 3.0 for highly diverged species, SynNet for synteny networks, and ntSynt for multi-genome macrosynteny. Use when identifying collinear gene blocks across species, distinguishing macrosynteny from microsynteny, detecting inversions/translocations/duplications, anchoring orthology in WGD lineages, producing publication riparian plots, computing synteny block age via Ks (cross-references whole-genome-duplication), or running synteny-aware ortholog inference in polyploids.

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Identifies super-enhancers from H3K27ac, MED1, or BRD4 ChIP-seq using ROSE, ROSE2, LILY, HOMER -style super, and ENCODE dELS cross-referencing. Handles peak stitching parameters, ranking choices, hockey-stick inflection, marker choice (H3K27ac vs MED1/BRD4), and cross-condition comparison with spike-in normalization. Constructs core regulatory circuitry (Saint-Andre 2016) from SE-encoded TFs. Use when identifying cell-identity / cancer-associated regulatory domains, comparing super-enhancers between conditions, identifying master transcription factor networks, or predicting BET-inhibitor responsiveness.

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Performs 3D shape-based similarity searching using ROCS (OpenEye), USRCAT (ultra-fast), Open3DAlign (RDKit), ESPSim (electrostatic), and ShaEP with explicit handling of Tanimoto-Combo (shape + color), shape vs ECFP4 complementarity, conformer-ensemble searching, alignment optimization, and scaffold hopping. Use when searching for shape-mimicking compounds with different scaffolds, identifying bioisosteric replacements, prospective scaffold hopping, or expanding hit series beyond 2D similarity.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

日本語の概要は準備中です。原文の説明を表示しています。

Use when users need bioinformatics analysis on the NCPGR cluster, especially when converting analysis requests into local software choices, resource plans, and LSF job scripts.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a driver has been involved in a crash — regardless of preventability or injury — and the carrier needs to handle the immediate, post-investigation, and return-to-work phases. Covers trauma response, post-accident testing under 49 CFR 382.303, paid time off, retraining, light duty, and re-entry planning.

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Use this skill when the user asks about logging / log hauling operations — short-haul exemption specifics for logging, log truck securement, axle weights, state-by-state logging permits (especially OR, WA, ID, BC), bunk + stake configurations, and how logging fits into FMCSA + state rules. Reference 49 CFR 393 for cargo securement of logs.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when a driver receives an out-of-service (OOS) violation. Covers the immediate compliance, paperwork retention, and CSA impact.

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Use this skill to understand the 6 levels of FMCSA roadside inspections and what each covers. Helps drivers know what to expect and helps carriers respond to inspection types.

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Use this skill when the user asks about hazardous materials (hazmat) transportation under 49 CFR 171-180 — placarding requirements, segregation tables, hazmat employee training (49 CFR 172 Subpart H), Hazmat Safety Permit (HMSP), shipping papers, packaging groups, emergency response phone, security plans, hazmat endorsement on CDL, and bulk vs non-bulk distinctions. Cite specific 49 CFR section.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about Environmental Health & Safety (EHS) for trucking — fuel spill response, hazmat release reporting, EPA + state environmental reporting, emergency contact information (CHEMTREC), environmental impairment liability insurance, and how to handle a CMV-related environmental incident. Cite 40 CFR + 49 CFR 174.6.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to respond to an FMCSA audit document request efficiently. Covers organization, file labeling, secure transmission.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about cybersecurity for a trucking carrier — protecting ELD data, customer information, financial systems, EDI integrations, fleet telematics, ransomware risk, vendor / shipper data sharing, incident response, and FMCSA cyber-recommendations. Reference NIST + CISA cybersecurity frameworks.

日本語の概要は準備中です。原文の説明を表示しています。

Multi-page Lighthouse audit via the MIT-licensed Unlighthouse CLI. Free-tier alternative to running PageSpeed against every URL on a site, no API quota burn, runs locally.

日本語の概要は準備中です。原文の説明を表示しています。

Image optimization analysis for SEO and performance. Checks alt text, file sizes, formats, responsive images, lazy loading, CLS prevention, image SERP rankings (via DataForSEO), and image file optimization (WebP/AVIF conversion, IPTC/XMP metadata injection). Use when user says "image optimization", "alt text", "image SEO", "image size", "image audit", "optimize images", "image metadata", "image SERP", "convert to webp", or "image file optimize".

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user wants to design, redesign, shape, critique, audit, polish, clarify, distill, harden, optimize, adapt, animate, colorize, extract, or otherwise improve a frontend interface. Covers websites, landing pages, dashboards, product UI, app shells, components, forms, settings, onboarding, and empty states. Handles UX review, visual hierarchy, information architecture, cognitive load, accessibility, performance, responsive behavior, theming, anti-patterns, typography, fonts, spacing, layout, alignment, color, motion, micro-interactions, UX copy, error states, edge cases, i18n, and reusable design systems or tokens. Also use for bland designs that need to become bolder or more delightful, loud designs that should become quieter, live browser iteration on UI elements, or ambitious visual effects that should feel technically extraordinary. Not for backend-only or non-UI tasks.

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Printing and PDF export for AI response blocks and messages via @ai-matrx/print. Use when adding a print button or BlockPrinter to a render block, wiring PrintOptionsDialog/usePrintOptions, captureBlockElement, or useDomCapturePrint, or when a print window shows no images or a print fails silently.

日本語の概要は準備中です。原文の説明を表示しています。

The universal v3 right-click menu (EditableContextMenu / NonEditableContextMenu). Use when adding a right-click menu to a surface, fixing a fake menu with no Copy or Export, a missing Download as Markdown, or a bespoke per-surface menu. NOT for an assigned rollout shard (use context-menu-rollout).

日本語の概要は準備中です。原文の説明を表示しています。

iOS-native mobile web UX rules. Use when building any UI component, fixing mobile issues, reviewing responsive code, or touching viewport heights (dvh vs h-screen), safe areas, Dialog vs Drawer, tabs on mobile, touch targets, or input zoom.

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Bringing an existing table onto the platform base standard. Use when asked to canonicalize, retrofit, or 'Wave 3' a table, run apply_rls or an org backfill, retire a bespoke *_versions table, or move it onto platform comments/associations/permissions. NOT for a schema move (use db-move-table-schema).

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Use when implementing features or fixing bugs with strict Test-Driven Development (TDD). Activate for coding tasks that require new functionality, refactoring, or comprehensive test coverage, especially when the user mentions TDD or Test Driven Development.

日本語の概要は準備中です。原文の説明を表示しています。

Builds simple Three.js web apps with scene setup, lighting, geometry, materials, animation, and responsive rendering. Use when creating or prototyping 3D web scenes with modern Three.js (r150+).

日本語の概要は準備中です。原文の説明を表示しています。