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Annotate genetic variants (GWAS hits, eQTLs, rare variants) with ENCODE functional data to interpret non-coding variation. Use when the user has variants of interest and wants to understand their regulatory context, identify causal variants from GWAS loci, assess variant impact on regulatory elements, perform enrichment testing of variant sets in tissue-specific annotations, or link variants to target genes through enhancer-gene maps. Handles the full post-GWAS workflow from variant set → tissue mapping → functional annotation → fine-mapping awareness → enrichment → variant-to-gene → prioritization. Use this skill for ANY variant interpretation task involving ENCODE chromatin, accessibility, TF binding, or 3D genome data.

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Integrate multiple ENCODE data types (RNA-seq, ATAC-seq, Histone ChIP-seq, TF ChIP-seq) for a tissue/cell type to build a comprehensive regulatory landscape. Use when the user wants to answer "what are the enhancers, promoters, and regulatory elements active in my tissue, and which transcription factors control them?" by layering expression, chromatin accessibility, histone marks, and TF binding data. Follows the Mawla et al. 2023 framework for cross-assay integration of islet cell type-specific data. Handles chromatin state annotation (ChromHMM), enhancer-gene linkage, TF motif enrichment, and cell type-specific regulatory element identification. Use for ANY multi-omic analysis, enhancer discovery, regulatory network construction, or epigenomic characterization using ENCODE data.

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Build comprehensive epigenomic profiles for tissues or cell types using ENCODE data. Use when the user wants to characterize chromatin states, assemble histone modification panels, create epigenomic landscapes, run ChromHMM segmentation, identify super-enhancers or bivalent domains, profile regulatory elements across a biosample, or understand epigenetic regulation in a specific biological context. Covers histone marks, chromatin accessibility, TF binding, transcription, DNA methylation, and 3D genome structure.

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Plan and execute integrative analysis combining multiple ENCODE experiments for cross-dataset or multi-omic workflows. Use when the user wants to combine experiments, perform cross-dataset comparison, multi-omic integration, peak overlap analysis, differential binding, signal correlation, chromatin state segmentation, enhancer-gene linkage, or any analysis that requires merging or comparing data from two or more ENCODE experiments. Covers same-assay cross-sample, multi-omic same-sample, cross-organism, and perturbation integration designs. Guides compatibility checks, batch effect detection, normalization, integration strategy selection, and provenance documentation.

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Interactive Claude Code environment setup wizard. Detects existing configuration, guides through best-practice setup for Global CLAUDE.md, project scaffolding, MCP servers, hooks, custom agents, keybindings, and settings. Use when user runs /devtools:code-env-setup, mentions "setup claude code", "configure claude", "claude code setup", "environment setup", or "initialize claude code".

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Use when designing, validating, deploying, changing, or troubleshooting Volcengine TLS LogCollector collection on Linux hosts or Kubernetes, including Project, Topic, host group, collector rule, index, binding, heartbeat, parsing, and end-to-end log ingestion checks through volclog. 当用户需要设计、部署、 变更或排查火山引擎日志服务 LogCollector 采集（主机、Kubernetes DaemonSet/Controller、机器组、采集配置、 心跳、解析、日志未入库）时调用。

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Guidance for Tauri v2 IPC with frontend invoke calls, Rust commands, and type-safe bindings.

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Writes, reviews, and debugs idiomatic Rust code with memory safety and zero-cost abstractions. Implements ownership patterns, manages lifetimes, designs trait hierarchies, builds async applications with tokio, and structures error handling with Result/Option. Use when building Rust applications, solving ownership or borrowing issues, designing trait-based APIs, implementing async/await concurrency, creating FFI bindings, or optimizing for performance and memory safety. Invoke for Rust, Cargo, ownership, borrowing, lifetimes, async Rust, tokio, zero-cost abstractions, memory safety, systems programming.

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Three-agent adversarial debate protocol for strategic decisions. Two advocates steelman opposing positions while a moderator identifies risks and synthesizes a binding consensus. Use when choosing between alternatives, evaluating tradeoffs, or making high-stakes decisions.

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ChIP-seq analysis — peak calling, differential binding, motif discovery, and QC with phantom-peak metrics.

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Manages the end-to-end lifecycle of on-demand, temporary access using Privileged Access Manager (PAM). Use when a user asks to create, read, update, or delete PAM entitlements, request temporary access, or approve/deny pending PAM grants. Do NOT use for permanent IAM policy bindings, troubleshooting IAM permission errors, or general Google Cloud resource provisioning.

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Audits, configures, and hardens workload-level security controls for Google Kubernetes Engine (GKE) applications and namespaces. Covers running cluster security audits (`audit_cluster.sh`), configuring Workload Identity Federation (impersonation, KSA/GSA binding, and pod setup), enforcing Network Policies (default-deny and Dataplane V2 logging), isolating high-risk pods inside GKE Sandbox (`gVisor`), enforcing Pod Security Standards (`restricted` labeling), and mounting Secret Manager secrets via CSI (`SecretProviderClass`). Use when auditing cluster security posture, isolating namespaces, applying pod security standards, setting up Workload Identity, or configuring network policies and secret volume mounts. Don't use for cluster-wide control plane security, RBAC hardening, Binary Authorization, Shielded Nodes, or enabling platform-level GKE add-ons (use gke-platform-security instead).

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Plans, configures, and hardens platform-level Google Kubernetes Engine (GKE) cluster security. Covers cluster add-ons (Secret Manager enablement), RBAC hardening (disabling insecure bindings, audit tools), Binary Authorization, enabling Shielded Nodes, GKE Sandbox cluster enablement, GKE IAM roles, and cross-service authentication IAM patterns. Use when securing cluster control planes, hardening GKE RBAC, enabling Shielded Nodes, enabling GKE Sandbox runtime, enabling cluster-wide security add-ons, or managing GKE IAM roles. Don't use for workload-level security (Workload Identity, SecretProviderClass, PSS, NetPol, gVisor pod runtimeClassName; use gke-workload-security instead).

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Mounts Cloud Storage buckets as a POSIX file system with Cloud Storage FUSE (gcsfuse). Use when interacting with gcsfuse: decide whether FUSE, native gs:// reads, or Filestore/Managed Lustre fits a workload, deploy tuned mounts on GKE, Compute Engine, or Cloud Run, enable and size file, stat, and list caches, tune mount flags or config-file settings, apply workload profiles, keep ML checkpointing safe (rename atomicity, hierarchical namespace/HNS, close-time finalization, concurrent writers), or diagnose slow training, low throughput, or bill spikes with gcsfuse metrics. Covers mount semantics, gcsfuse CLI and config files, GKE gcsfuse CSI driver (Workload Identity principal:// bindings, profile StorageClasses, sidecar sizing), and Cloud Run volume mounts. Don't use for bucket administration or data management without a mount (google-cloud-storage-basics) or fully POSIX-compliant shared file systems (Filestore, Managed Lustre).

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Use when overriding the default UI of an Agentforce agent action's Apex input or output with your own Lightning web components via a LightningTypeBundle (schema.json + editor.json/renderer.json, lightning__AgentforceInput / lightning__AgentforceOutput targets, the @apexClassType binding). NOT for standard agent actions with primitive inputs/outputs (only Apex-class input/output can be overridden), NOT for Flow screen custom property editors (use flow/flow-custom-property-editors), and NOT for general LWC-in-Lightning-page work (use lwc/* skills).

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Use when designing how an Agentforce agent extracts structured input parameters (slots) from a user's natural-language utterance to invoke an action. Triggers: 'agent extract date from user', 'agent action argument extraction', 'agentforce slot filling', 'agent invocable input mapping', 'agent fails to fill required parameter'. NOT for action authoring (use agentforce/agent-actions) or for prompt-template variable binding (use agentforce/prompt-builder-templates).

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Use this skill when writing, debugging, or optimizing SAQL queries in CRM Analytics — covering pipeline syntax, aggregation, windowing functions (rank, dense_rank, moving_average), cogroup joins, rollup subtotals, piggyback queries, and REST API execution. NOT for SOQL GROUP BY aggregates in Apex — use apex/apex-aggregate-queries. NOT for dashboard JSON steps and bindings — use admin/analytics-dashboard-json.

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Design, mock up, build and review terminal UIs — full-screen TUIs, interactive CLIs and pickers, and plugin panels or popups inside a host (herdr, tmux, Neovim, k9s, lazygit). Use when designing, reviewing (from code, a live capture or a screenshot) or redesigning a TUI's layout, keybindings, states or colors, including requests that name a known TUI (lazygit, k9s, btop, yazi, helix, fzf); writing terminal mockups; building or fixing one in Ink, Textual, Bubble Tea, Ratatui or gum; mapping a color scheme (Catppuccin, Dracula, Nord, Gruvbox, Tokyo Night, Rosé Pine…) onto a TUI's theme; fixing misaligned glyphs, flicker, NO_COLOR, exit codes, signals, pipes or a broken terminal after exit; suspend or $EDITOR handoff; or profiling a slow TUI. Not for web or native GUIs, terminal-emulator, editor or shell-prompt themes.

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Migrate from manual configuration binding to ASP.NET Core IOptions pattern

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Generate non-binding follow-up action suggestions from lead summaries or lead lists. Use when users ask for next best actions, call list for hot leads, or follow-up draft plan without automatic execution. Recommended chain: summary-generator then action-suggester then supervisor approval. Do not use for parsing, storage, or autonomous action execution.

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Build signal-based forms in Angular v21+ using the new Signal Forms API. Use for form creation with automatic two-way binding, schema-based validation, field state management, and dynamic forms. Triggers on form implementation, adding validation, creating multi-step forms, or building forms with conditional fields. Signal Forms are experimental but recommended for new Angular projects. Don't use for template-driven forms without signals or third-party form libraries like Formly or ngx-formly.

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Generate TUI screen/view with layout, keybindings, state management, and tests

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Manages Rule 30(b)(6) corporate representative deposition workflows — drafting notice topics with reasonable particularity, building examination outlines, defending designees, handling objections, and preserving binding admissions for summary judgment or trial. Use when drafting or responding to 30(b)(6) notices, selecting and preparing designees, building topic-by-topic outlines, or triaging scope and privilege disputes. Trigger keywords: 30(b)(6), corporate representative deposition, topic list, designee, notice analysis, deposition objections, corporate admissions.

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Guides taking and defending Rule 30(b)(6) corporate representative depositions. Drafts topic lists with reasonable particularity, builds examination outlines for binding corporate admissions, analyzes noticed topics for objections, and prepares designees. Use when drafting 30(b)(6) notices, preparing corporate deposition topics, selecting or preparing designees, or defending corporate representative depositions.

日本語の概要は準備中です。原文の説明を表示しています。