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Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, applies the Patel et al 2024 *Nat Biotechnol* failure-mode framework, and validates that normalization is applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.

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Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.

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Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract) with SES scaling, k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

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Use when work produces a deliverable, factual claim, dataset, code change, decision, publication, deployment, automation, or irreversible action whose failure would matter; when the user asks for a quality gate, acceptance criteria, QA, completeness, validation, audit, evidence, preflight, release readiness, or a definition of done; or before claiming completion on medium- or high-risk work. Automatically decide whether a formal gate is warranted, derive task-specific pass/fail criteria, gather evidence, and block unsupported completion. Make sure to use this skill even when the user does not say "quality gate" if consequential work needs acceptance criteria or completion evidence. Skip formal gating for trivial, reversible, low-impact requests.

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Qualify Windows desktop installers in GitHub Actions and promote verified Windows/macOS assets from one frozen SHA. Use for cloud packaging, installer failures, or GitHub Release publication; not local packaging or macOS qualification.

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Use for Electron desktop application implementation, local packaging, and macOS Electron installer builds in GitHub Actions. Covers secure IPC, preload and multi-process architecture, electron-builder/Forge configuration, native modules, signing/notarization setup, DMG/ZIP packaging, mounted packaged smoke, and macOS qualification evidence. For cloud releases, this Skill owns macOS build and qualification; use github-desktop-release for Windows GitHub Actions qualification and for shared artifact promotion, GitHub Release publication, resume, or authoritative readback. Do not use this Skill to build or qualify Windows installers in GitHub Actions.

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Create, revise, and validate publication-ready academic paper figures and tables. Use for LaTeX tables, related-work comparison tables, result tables, notation/dataset/taxonomy tables, precise source-data-driven experiment plots from CSV/JSON/logs, generated conceptual figures such as system overviews/pipelines/architectures/threat models, captions, artifact specs, source-data traceability, and paper-ready PDF/SVG/PNG/LaTeX exports. Do not use for prose-only paper writing, self-review, reviewer response, rebuttal drafting, or external literature-management workflows.

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Use when evaluating, designing, drafting, revising, stress-testing, or preparing academic articles, empirical research reports, literature reviews, systematic reviews, meta-analyses, journal submissions, reviewer responses, research methods, sampling, measurement, analysis, publication readiness, or citation/source audits.

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Create Beamer-style academic PPTX presentations using python-pptx. Produces publication-quality .pptx files with navy-blue Metropolis theme (16:9, frame title bars, progress bar) for conference talks, job market presentations, and seminar slides. Called by /present command.

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Comprehensive results analysis for empirical research: generate publication-quality descriptive statistics and balance tables, interpret regression coefficients with economic magnitude and effect sizes, assess identification assumption diagnostics, and produce structured results memos. Use when asked to create summary statistics, Table 1, balance tests, interpret results, assess economic significance, or write results narratives.

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Nutzerneutrale Prüfung von Repositories vor einer Veröffentlichung oder bei einer erneuten öffentlichen Prüfung. Kontrolliert Privacy, Geheimnisse, Lizenzen, Drittinhalte, Dokumentation und Freigabestatus, ohne die Veröffentlichung selbst vorzunehmen.

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Sweeps a named list of news sources and blogs for items relevant to the user's role and returns a dated digest of 5 to 8 items, each with a one-line so-what, a source URL and a publication date, as a Markdown document or a ready-to-paste email. Use when the user asks to "run my news digest", "do my news sweep", "draft my morning news flash", "what happened in industry news this week" or to monitor vendor or industry news for their role. Do not use for the user's own inbox, calendar and mentions brief, use custom-daily-brief instead. Drafts for human review; never approves, authorises or signs off.

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Drafts one anonymised DRAFT case study (situation, approach, outcome as evidenced, optional lessons) from engagement notes, status reports, closing reports, emails and metrics extracts the user supplies, with a fact trace to the notes, an evidence grade on every result, quotes only where the user supplied them with speaker role and permission, an anonymisation log and a confidentiality checklist that must be completed before publication. Use when the user asks to "write a case study from these notes", "turn this engagement into a customer story", "draft a success story for the website", "anonymise this project write-up" or "prepare a reference case for the proposal". Do not use for redacting identifiers from an existing document, use document-deidentification-pass instead; for checking whether a document's claims are substantiated, use claims-evidence-map. Drafts for human review; never approves, authorises or signs off.

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Proposes redactions of personal identifiers in pasted text or an attached document (names, contact details, identification and account numbers, dates that identify, quasi-identifiers) and returns a DRAFT redacted copy with consistent placeholder tokens plus a redaction table stating what was replaced, where and why, with a confidence level and a blank reviewer decision per row. Use when the user asks to "redact the names in this document", "de-identify this transcript before we share it", "strip personal data from these notes", "anonymise this report for publication" or "what would need redacting here". Do not use for assessing a planned processing activity, use dpia-draft-pack instead; do not use for working out what data an incident exposed, use data-incident-impact-brief instead. Never declares a document anonymised, safe to release or compliant. Drafts for human review; never approves, authorises or signs off.

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Polish, restructure, or translate academic prose into Nature-leaning English using writing-strategy principles, curated Nature/Nature Communications article patterns, and phrase-level support from Academic Phrasebank. Use whenever the user asks to polish a manuscript paragraph, abstract, introduction, results, discussion, conclusion, title, methods section, or Chinese academic draft for publication-quality English. Also covers LaTeX layout/typesetting (排版) fixes — loose or sparse pages, stranded section headings, figures that don't fill the page or split across pages, "Float too large", multi-panel figure arrangement, and Supplementary Information that looks empty — via references/latex-layout.md. Also trigger on general academic/scientific writing requests even without the word "Nature", including academic writing, scientific writing, SCI/paper writing, English manuscript polishing, language editing, proofreading, and Chinese phrasings such as 学术写作、科研写作、论文润色、写paper、SCI写作、英文论文润色、语言润色、润色、改写、学术英语、英文写作.

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Produce publication-style figures from MIKE+ .res1d results via the mike-plus MCP server — a stacked rainfall-runoff hydrograph, a single time series, a network map, a baseline-vs-scenario overlay, or a longitudinal profile (bed / crown / ground / max water level along a pipe string), in the house style (Arial 12, ticks inward, SI units, no title). Use when an agent must render MIKE+ results as a PNG without opening the GUI. No license required.

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Full-funnel paid advertising operations for B2B SaaS. Use this skill for PPC strategy, Google Ads optimization, LinkedIn Ads, social media advertising, programmatic buying, creative strategy, attribution modeling, budget allocation, budget pacing and planned-vs-delivered reconciliation, audience overlap and campaign self-competition audits, suppression lists, ROAS improvement, media spend optimization, and the media no auction sells — newsletter and podcast sponsorships, community and industry-publication placements, paid review-site listings on G2 and Capterra, and pay-per-lead content syndication. Also triggers on: PPC, Google Ads, LinkedIn Ads, social ads, programmatic, ad creative, attribution, media budget, paid campaigns, ROAS, CPA, ad spend, newsletter sponsorship, podcast sponsorship, community sponsorship, sponsor a newsletter, content syndication, pay-per-lead, cost per lead vendor, media kit, rate card, insertion order, direct buy, publisher partnership, make-good, G2 paid listing, Capterra ads, review site advertising, sponsorship ROI, budget pacing, we underspent our budget, are our campaigns competing with each other, audience overlap, self-competition, campaign cannibalization, suppression list, exclusion list, ad frequency across channels, how many ad accounts do we have.

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Run a comprehensive health check on a single Estuary task by combining catalog status, data flow stats, recent errors, and publication history. Use when diagnosing a task that seems broken, slow, or stuck. Use when user says "is my task healthy", "something seems wrong", "check my capture", "check my materialization", "why is data not flowing", "task health check", "diagnose my task", or "what's wrong with my pipeline".

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META Stock Price Activity: Meta stock was up 0.37% at $718.30 at the time of publication Tuesday, ac

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Orchestrator for the full academic research pipeline: research -> write -> integrity check -> review -> revise -> re-review -> re-revise -> final integrity check -> finalize. Coordinates deep-research, academic-paper, and academic-paper-reviewer into a seamless 10-stage workflow with mandatory, coverage-bounded integrity checks, two-stage peer review, and auditable quality-assurance artifacts. Triggers on: academic pipeline, research to paper, full paper workflow, paper pipeline, end-to-end paper, research-to-publication, complete paper workflow, 연구부터 논문까지, 연구 주제 설정부터 논문 완성까지, 논문 전체 워크플로.

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Draft, prepare, publish, and verify personal or project LinkedIn posts through the user's signed-in Chrome session, including audience review, public-safe media uploads, links, action-time confirmation, and post-publication checks.

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Run evaluations for Hugging Face Hub models using inspect-ai and lighteval on local hardware. Use for backend selection, local GPU evals, and choosing between vLLM / Transformers / accelerate. Not for HF Jobs orchestration, model-card PRs, .eval_results publication, or community-evals automation.

日本語の概要は準備中です。原文の説明を表示しています。