「sel」の検索結果

Plan, generate, edit, and quality-check still images with Google's Gemini native image models (Nano Banana), including Gemini 3.1 Flash Image, Gemini 3.1 Flash-Lite Image, Gemini 3 Pro Image, and legacy Gemini 2.5 Flash Image. Use for model and API-route selection, conversational editing, multi-reference composition, thinking and Google Search grounding, resolution/aspect-ratio control, exact-text and brand workflows, SynthID/provenance, safety, privacy, rights, and migration from legacy Gemini or Imagen image endpoints. Do not use for Veo/video generation or Gemini Live/audio work.

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Generate, edit, composite, stream, and production-review still images with OpenAI GPT Image models. Use when an agent must choose between GPT Image 2 and legacy GPT Image/DALL-E integrations, select the Image API or Responses API, build prompts and reference-image workflows, use masks or multiple inputs, preserve identity or brand details, render in-image text, handle output files and partial images, estimate cost and rate limits, migrate deprecated image code, or apply OpenAI image safety, consent, privacy, provenance, and rights requirements. Do not use for OpenAI video or audio generation.

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Select, integrate, and operate multi-model image-generation gateways with model-specific schema discovery, version policy, asynchronous jobs, webhooks, spend approval, safe inputs and artifacts, data-governance review, and billing observability. Use for comparing or building against fal.ai, Replicate, or Together AI image APIs, including controlled failover; do not use for direct model-provider APIs, local inference, training, dedicated endpoint provisioning, video generation, or general image editing.

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Plan, prompt, call, edit, iterate, and productionize Alibaba Cloud Model Studio image generation with current Wan 2.7 Image, Qwen-Image 2.0, and Z-Image Turbo models. Use for Alibaba/DashScope text-to-image, multi-reference generation, instruction editing, character-consistent image sets, typography and layout work, regional authentication, model selection, API integration, cost/rate-limit planning, troubleshooting, safety, rights, privacy, and output QA.

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Production guidance for Kling AI Open Platform Advanced Lip-Sync. Use for identifying/selecting one face in an existing video, assigning URL/Base64 or Kling TTS audio, cropping and inserting audio in milliseconds, mixing original sound, creating and monitoring tasks, downloading expiring results, consent/privacy review, sync QA, and repair. Do not use for still-image avatar generation or ordinary Kling video generation.

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Provider-independent workflow for AI agents producing documentary-style montages, archive-driven timelines, interview-supported sequences, nonprofit or advocacy shorts, historical explainers, and hybrid generated/archive edits. Use for editorial thesis development, research/source logs, fact-checking, archive rights, synthetic reenactment disclosure, chronology, interview selects, lower thirds, generated b-roll direction, music restraint, captions, sensitive subjects, review escalation, delivery variants, and documentary QA.

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Provider-independent production workflow for recutting long talking-head, podcast, interview, webinar, panel, lecture, livestream, founder call, or customer-call footage into short clips, highlight reels, trailers, audiograms, captioned vertical videos, and social cutdowns. Use when an agent must ingest source recordings, transcribe and diarize speakers, select quotes without misrepresentation, preserve context, handle consent/rights/disclosures, clean jump cuts and audio, add captions, graphics, lower thirds, b-roll, platform variants, synthetic-media boundaries, review packets, delivery specs, and recut QA.

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Provider-independent editing and montage direction for AI agents producing generated videos, ads, trailers, social clips, explainers, product videos, documentary-style pieces, and music- or beat-driven cuts. Use when planning, revising, QAing, or handing off an edit: story structure, shot selection, continuity, montage theory, rhythm and pacing, J/L cuts, match cuts, cutaways, transitions, beat sync, platform timing, source/generated asset management, revision workflow, and composition handoff.

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Provider-independent music supervision and scoring direction for AI agents producing generated videos, ads, trailers, explainers, product films, social clips, documentaries, game trailers, and branded content. Use when planning, prompting, selecting, licensing, mixing, repairing, or quality-reviewing music, score, temp tracks, needle drops, AI-generated tracks, cue sheets, stems, loudness, loopability, platform music constraints, and rights-aware audio handoff for visual media.

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Apply clean code principles when generating or modifying implementation code. Enforces function focus, naming clarity, complexity management, error handling, and self-documenting style. Use when the user mentions 'clean code', 'code quality', 'coding guidelines', or 'implementation quality'. Loaded automatically by the code-generating molecules (code-forge, refactor-safely, bug-fix). This skill governs the craft of writing individual code units -- not architecture (see architecture), not security posture (see secure-coding), not test structure (see test-quality), and not refactoring workflows (see refactor-safely).

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End-to-end CRISPR experiment design from target selection to delivery-ready constructs. Covers guide RNA design, off-target assessment, and specialized editing strategies including knockouts, base editing, and HDR knockins. Use when designing complete CRISPR editing experiments for gene knockout, correction, or tagging.

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End-to-end CLIP-seq pipeline from FASTQ to ENCODE-compliant binding sites, single-nucleotide crosslink maps, annotation, motifs, and (optionally) differential binding. Use when running the full Yeo lab eCLIP / iCLIP / iCLIP2 / iCLIP3 / irCLIP / PAR-CLIP analysis with SMInput control, protocol-specific UMI extraction, ENCODE STAR parameters, CLIPper or Skipper peak calling with stringent log2 FC and -log10 p thresholds, IDR rescue and self-consistency QC, and downstream motif registration with mCross or PEKA.

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Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma & Hiller 2017 codon-aware exon projection), LiftOff (Shumate & Salzberg 2020 reference-based annotation transfer), Liftover (UCSC), GeMoMa (Keilwagen 2019 evidence-based projection), and Comparative Annotation Toolkit (CAT). Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.

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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

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Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.

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Run remote BLAST searches against NCBI servers using Biopython Bio.Blast.NCBIWWW. Use when identifying unknown sequences, finding homologs, picking the correct BLAST program (blastn/blastp/blastx/tblastn/tblastx/psiblast/megablast/dc-megablast), interpreting Karlin-Altschul E-values, avoiding the max_target_seqs trap (Shah 2019), choosing composition-based statistics, or limiting searches by organism. Covers RID lifecycle, database choice (nt/nr/refseq_select/swissprot), word-size and CBS taxonomy.

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Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

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Detect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allele-specific callers. Use when calling CNVs from hybrid-capture panels or exomes, deciding whether CNVkit (depth-only) is the right tool versus an allele-specific caller, building a panel of normals, diagnosing flat-reference false positives, or interpreting log2 ratios into copy-number states.

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Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.

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Select colormaps and qualitative palettes for scientific figures using perceptual-uniformity, color-vision-deficiency safety, and luminance-monotonicity criteria. Covers Crameri scientific colormaps, viridis/cividis/magma, Okabe-Ito categorical, ColorBrewer, and the rainbow/jet critique. Use when choosing palettes for heatmaps, scatter, networks, or any encoding where color carries quantitative or categorical meaning.

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Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.

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Trim PCR primers from aligned reads in amplicon-panel BAMs using samtools ampliconclip. Use when processing SARS-CoV-2 ARTIC, hereditary cancer panels, ctDNA hot-spot panels, or any amplicon assay where primer-derived bases would falsely confirm reference at primer footprints.

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Infer integer allele-specific copy number, tumor purity, and ploidy from tumor sequencing by jointly modeling read depth (logR) and B-allele frequency (BAF) with ASCAT, Sequenza, FACETS, PURPLE, and PureCN (tumor-only). Covers the purity-ploidy identifiability problem, the diploid-baseline (dipLogR) anchor, major/minor copy number, loss of heterozygosity, sunrise/contour fit diagnostics, and reconciliation of conflicting fits. Use when tumor analysis needs absolute copy number rather than relative log2, when estimating purity and ploidy, calling LOH or copy-neutral LOH, resolving whole-genome doubling, running tumor-only allele-specific calling, or choosing among ASCAT, Sequenza, FACETS, and PureCN.

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ATAC-seq library quality control -- TSS enrichment, FRiP, fragment-size periodicity, library complexity (NRF/PBC1/PBC2), mitochondrial fraction, and ENCODE 4 thresholds. Use when assessing whether an ATAC-seq library passes ENCODE acceptance criteria, diagnosing transposition artefacts, comparing Omni-ATAC vs standard prep quality, or selecting which replicates to drop before peak calling.

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