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Building or editing Simulink (.slx) models that stream signals in frames using DSP System Toolbox — audio, vibration, radar, comms. Use when the prompt names a Simulink block (Discrete FIR Filter, Buffer, Unbuffer, Rate Transition, Downsample, Upsample, Sample-Rate Converter, FIR Decimation, Time Scope, Spectrum Analyzer, From Multimedia File) or an action (frame-based processing, InputProcessing, buffering, overlap, windowing, STFT, short-time Fourier, decimate, downsample, upsample, resample, multirate, anti-aliasing, tunable filter). Prevents silent numerical errors from sample-vs-frame mismatch, wrong block choice, or missing anti-aliasing.

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Segment single cells from multiplexed IMC/MIBI tissue images using Mesmer/DeepCell, Cellpose, or ilastik+CellProfiler, covering whole-cell vs nuclear segmentation, the summed-membrane-channel decision, nuclear-expansion bias, lateral spillover, resolution-floor parameters, and downstream-proxy evaluation. Use when delineating cells after preprocessing, choosing a segmentation model, building a cell mask for quantification, diagnosing impossible double-positive populations, or troubleshooting over/under-segmentation.

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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

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Produce and interpret PCA, t-SNE, UMAP, and PHATE plots for high-dimensional omics data with rigor about which method preserves what (variance, local structure, manifold, transitions), hyperparameter sensitivity, and the well-documented limits of 2D embeddings. Covers PCA biplot/scree/loadings, t-SNE PCA initialization (Kobak-Berens 2019), UMAP n_neighbors/min_dist trade-offs, and the Chari-Pachter 2023 critique. Use when visualizing high-dimensional data — bulk PCA, single-cell embeddings, multi-omics integration projections.

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Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.

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Model gene-family birth-death dynamics across a species tree using CAFE5 (Mendes et al 2020 Bioinformatics 36:5516 gamma-distributed rate categories), CAFE5-error (annotation-error-aware), Count (Csurös 2010 ancestral state reconstruction), BadiRate (Librado 2012 likelihood + parsimony), DupliPHY-Family, and ALE/AleRax (for per-family DTL; see [[gene-tree-species-tree-reconciliation]]). Test lineage-specific gene-family expansions and contractions, distinguish biological dynamics from annotation artifacts, account for assembly fragmentation, identify functional enrichment in expanded / contracted families. Use when correlating gene-family changes with phenotype evolution, ranking lineages by adaptive gene-family-rate shifts, post-WGD dosage-balance analysis, or building Birth-death models from OrthoFinder presence/absence matrices.

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Implement, diagnose, or review SwiftUI motion using explicit and scoped implicit animations, springs, transitions, PhaseAnimator, KeyframeAnimator, matched geometry or navigation zoom, SF Symbol effects, and custom Animation types. Use when views should animate on state changes, insertion, removal, navigation, or multi-step choreography, or when motion must respect Reduce Motion and Swift concurrency.

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Implement, review, or improve SwiftUI gesture handling. Use when adding tap, long press, drag, magnify, or rotate gestures, composing gestures with simultaneously/sequenced/exclusively, managing transient state with @GestureState, resolving parent/child gesture conflicts with highPriorityGesture or simultaneousGesture, building custom Gesture protocol conformances, or migrating from deprecated MagnificationGesture to MagnifyGesture or using the newer RotateGesture.

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Build SwiftUI layouts using stacks, grids, lists, scroll views, forms, and controls. Covers VStack/HStack/ZStack, LazyVGrid/LazyHGrid, List with sections and swipe actions, ScrollView with ScrollPosition and scroll-driven reveal surfaces, Form with validation, Toggle/Picker/Slider, .searchable, and overlay patterns. Use when building data-driven layouts, collection views, paged detail reveals, settings screens, search interfaces, or transient overlay UI.

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Implement, review, or improve data persistence using SwiftData. Use when defining @Model classes with @Attribute, @Relationship, @Transient, #Unique, or #Index; when querying with @Query, #Predicate, FetchDescriptor, or SortDescriptor; when configuring ModelContainer and ModelContext for SwiftUI or background work with @ModelActor; when planning schema migrations with VersionedSchema and SchemaMigrationPlan; when setting up CloudKit sync with ModelConfiguration; or when coexisting with or migrating from Core Data.

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Generate, verify, refine, and accelerate C/C++ or CUDA code from MATLAB with MATLAB Coder, Embedded Coder, GPU Coder, or MATLAB Test. Also covers writing codegen-ready MATLAB code: language constraints, coder.* directives, and optimization patterns. Triggers on: codegen, MEX, deploy MATLAB as C/C++, GPU Coder, coder.screener, coder.config, coder.gpuConfig, coder.typeof, coder.runTest, matlabtest.coder.TestCase, SIL, embedded config, no dynamic memory, EnableMexProfiling, coder.timeit, coder.perfCompare, %#codegen, writing codegen-ready MATLAB, code generation readiness, coder.varsize, coder.unroll, coder.noImplicitExpansionInFunction, coder.ceval, coder.inline, coder.extrinsic, coder.const, coder.classSignature, class codegen limitations, temporal types codegen, DMA-off, stack-only, host-target InstructionSetExtensions, SIMDAcceleration, OptimizeReductions, host SIMD tuning, host OpenMP, codegen performance.

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Analyze workflow patterns using the Agent Monitor's workflow intelligence API — orchestration DAGs, tool flow transitions, subagent effectiveness, model delegation patterns, error propagation by depth, concurrency lanes, compaction impact, and agent co-occurrence. Produces prioritized optimization recommendations with quantified impact.

日本語の概要は準備中です。原文の説明を表示しています。

Detect recurring patterns using the Agent Monitor's workflow intelligence — toolFlow transitions (tool A → B frequency matrices), recurring workflow patterns, agent co-occurrence pairs, model delegation habits, error propagation paths by agent depth, and compaction triggers. Use to discover habitual usage patterns and anti-patterns.

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Compare two sessions side-by-side using Agent Monitor data — per-model token usage (input/output/cache_read/cache_write + compaction baselines), pricing engine cost breakdowns, workflow intelligence (complexity scores, tool flow transitions, subagent effectiveness), session metadata (thinking_blocks, turn_count, turn_duration_ms, usage_extras), and full event timelines with all 10+ event types.

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Test website responsiveness across viewport widths using browser automation. Resizes a single session through breakpoints, screenshots each width, and detects layout transitions (column changes, nav switches, overflow). Produces comparison reports showing exactly where layouts break. Trigger with 'responsiveness check', 'check responsive', 'breakpoint test', 'viewport test', 'responsive sweep', 'check breakpoints', or 'test at mobile'.

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Modern animation library for React and JavaScript. Create smooth, production-ready animations with motion components, variants, gestures (hover/tap/drag), layout animations, AnimatePresence exit animations, spring physics, and scroll-based effects. Use when building interactive UI components, micro-interactions, page transitions, or complex animation sequences.

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When the user wants to plan go-to-market strategy, GTM framework, or market entry. Also use when the user mentions "GTM," "go-to-market," "market entry," "new market," "repositioning," "PLG," "sales-led," "product-led," "marketing-led," "ICP," "buyer persona," "GTM motion," or "market expansion." For launch checklist, use product-launch.

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Use when animating characters or scenes in Godot 4.7: AnimationPlayer clips and RESET, AnimationTree state machines and blend spaces built in code, Mixamo or glTF import, loop settings, BoneMap retargeting and shared animation libraries, root motion, foot sliding, foot IK with TwoBoneIK3D or custom SkeletonModifier3D, tweens, SpringArm3D cameras, cutscenes; or when a character T-poses, slides, floats, freezes mid-blend or a transition never fires.

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Use when generating or extending video with Google Veo models on Scenario via MCP: text-to-video, image-to-video from a first frame, first and last frame transitions, reference-to-video (R2V) with asset or style reference images, native audio with dialogue, sound effects, and ambience, negative prompts, seeded reruns, extending a 16:9 clip, or choosing a quality, fast, or lite tier. Keywords: Veo 3.1, Veo 3.1 Fast, Veo 3.1 Lite, Extend Video, Google, T2V, I2V, V2V, 720p, 1080p.

日本語の概要は準備中です。原文の説明を表示しています。

Use when generated clips must become a finished video on Scenario via MCP: cutting a shot list together, laying a timeline, concatenating with transitions, overlaying a logo or title card, adding a music bed or voiceover, burning in or exporting captions and subtitles, trimming and splitting, or producing vertical and square variants of one master. Keywords: edit, assemble, stitch, concat, compositor, timeline, layers, overlay, captions, SRT, ad, UGC, social cut.

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Use when creating game art through Scenario MCP: sprites, sprite sheets, icons, props, loot, tilesets and autotile terrain transitions, seamless tiles, isometric buildings, top-down maps, pixel art, UI buttons and panels, parallax background layers or depth planes for side-scrollers, and character or concept art; or when assets need transparent backgrounds, background removal, style-consistent variation batches, upscaling, pixel-grid cleanup, or PNG export for Unity, Godot, or Unreal.

日本語の概要は準備中です。原文の説明を表示しています。

Expert ISO 27701 Privacy Information Management System (PIMS) compliance advisor. Use this skill whenever a user asks about ISO/IEC 27701:2025, ISO/IEC 27701:2019, privacy information management, PIMS certification, PII controller or processor obligations, privacy risk assessment, Statement of Applicability for privacy, privacy by design, data subject rights, DPIA, records of processing activities, transitioning from ISO 27701:2019, GDPR alignment with ISO 27701, or any privacy management system topic. Also trigger for questions about Annex A.1 (controller controls), A.2 (processor controls), A.3 (shared security controls), or implementing a standalone PIMS without ISO 27001. When in doubt, use this skill — it covers the full ISO 27701 lifecycle from gap assessment through certification.

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Expert ISO 27001 compliance assistant for security and compliance teams. Use this skill whenever a user asks about ISO 27001 or ISO/IEC 27001, including any of the following: gap analysis, auditing, compliance assessments, control checklists, policy writing, document generation, Statement of Applicability (SoA), risk assessment, risk registers, risk treatment plans, Annex A controls, ISMS implementation, clause requirements, certification readiness, transitioning from 2013 to 2022, control implementation guidance, incident response policies, access control policies, supplier security, or any information security management system (ISMS) topic. Trigger even if the user doesn't say "skill" — any ISO 27001 or ISMS question should use this skill.

日本語の概要は準備中です。原文の説明を表示しています。