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Analyze and engineer protein glycosylation. Scan sequences for canonical N-glycosylation sequons (N-X-S/T with X not proline, including overlapping sites), predict O-GalNAc hotspots, read glycan notation, and reach the curated external tooling (NetNGlyc, NetOGlyc, GlycoShield, GlycoWorkbench, GlyTouCan, GlyConnect). Use this skill for therapeutic antibody glycoengineering and afucosylation for ADCC, Fc glycan control, glycan shielding in vaccine immunogen design, sequon removal or insertion, and half-life engineering through sialylation. Also trigger on N-glycosylation, sequon, NXS/NXT, O-glycosylation, glycoform heterogeneity, afucosylation, high-mannose, GlyTouCan, or WURCS.

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Turn in vitro potency and animal pharmacokinetics into a defensible human dose projection — the arithmetic that decides whether a compound can reach its target concentration safely. Use this skill for non-compartmental analysis of a concentration-time profile (AUC, Cmax, terminal half-life, clearance, volume of distribution), one- and two-compartment simulation of a dosing regimen, interspecies allometric scaling, human-equivalent dose conversion by body surface area, and the exposure margin between a projected therapeutic concentration and a toxicology no-effect level. Also trigger on non-compartmental analysis, AUC, clearance, volume of distribution, allometric scaling, human equivalent dose, first-in-human, NOAEL, therapeutic index, or exposure margin.

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Cheminformatics toolkit for fine-grained molecular control. Parse and write SMILES, SDF, MOL and InChI; compute descriptors (MW, LogP, TPSA, QED, Bertz); build fingerprints (Morgan/ECFP, RDKit, MACCS, atom pair, torsion) and score Tanimoto, Dice or cosine similarity; run SMARTS substructure search and reaction SMARTS; generate 2D depictions and ETKDG 3D conformers; extract Murcko scaffolds and canonical hashes; control sanitization and stereochemistry directly. Also trigger on rdkit, Chem.MolFromSmiles, rdFingerprintGenerator, SDMolSupplier, SMARTS query, ETKDG, or FilterCatalog. For standard workflows with a simpler interface use the datamol skill, which wraps RDKit; use rdkit for advanced control, custom sanitization, and specialized algorithms.

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Turn a set of structures into absorption, distribution, metabolism, excretion, and toxicity estimates with ADMET-AI, and read them as a developability verdict rather than a table of numbers. Use this skill to run batch prediction over a library, interpret each endpoint against its DrugBank-approved percentile, and flag the liabilities that stop a series — hERG blockade, CYP inhibition, poor Caco-2 permeability, high clearance, and plasma protein binding. Also trigger on ADMET-AI, admet_ai, Chemprop-RDKit, hERG liability, CYP3A4 inhibition, Caco-2, bioavailability prediction, or developability triage.

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List configured models, guide provider setup, verify local Kimi companion readiness, and manage the PreToolUse hook plus optional review gate. Use when asked about available models, subscription/API-key setup, default selection, or explicitly requested to install, check, enable, disable, or uninstall the integration. Codex and Claude Code share one ~/.kimi-code/config.toml but each own a host-scoped block, so $kimi-setup here does not disturb Claude Code's /kimi:setup (and vice-versa).

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Onboarding workflow for cross-library KB query in a consulting practice. Discovers existing user-scope library registrations, prompts for additions, validates each library, helps activate the relevant ones for the current project, runs a smoke test, and reports a clear "ready" or "issues to fix" verdict. Use --verify-only to skip prompting and just validate existing setup (sub-task 23 of

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This skill should be used to spawn specialized OpenAI Codex CLI subagents for code review, debugging, architecture analysis, security audits, refactoring, documentation, comparative evidence adjudication, and autonomous /goal runs. It adds each persona through process-local developer instructions while preserving the project's AGENTS.md chain, including during parallel launches. Supports GPT-6-Astra across low, medium, high, xhigh, max, and ultra reasoning with default or priority service tiers, plus GPT-5.6 and GPT-5.5 models. Triggers on 'delegate to Codex', 'Codex Astra', 'Astra subagent', 'Codex subagent', 'code review agent', 'security audit', 'refactor with Codex', 'goal run', 'autonomous goal', 'have Codex weigh this'.

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Convert Figma designs into production-ready code using MCP server tools. Use this skill when users provide Figma URLs, request design-to-code conversion, ask to implement Figma mockups, or need to extract design tokens and system values from Figma files. Works with frames, components, and entire design files to generate HTML, CSS, React, or other frontend code.

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Slack workspace integration: 9 on-demand scripts (post, read, delete, search, stream, react, upload, channels, users) + dual-token support + RTS API search + chat streaming + AI Block Kit + Session Bridge + Claudicle unified launcher (Claude Agent SDK, soul engine, three-tier memory).

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Build interactive live slide decks with Vite + React 19, TanStack Router, WebGPU shaders, Framer Motion orchestration, 1920x1080, access-gated SPA. 39 components (layout, interaction, graphics, chrome, navigation), direction-aware slide transitions, presenter mode with speaker notes and BroadcastChannel sync, Playwright PNG/PDF export, YAML-driven authoring, Cloudflare/Vercel/Netlify deploy. Triggers on: slide deck, presentation, pitch deck, investor deck, product demo, conference talk, live slides, WebGPU slides, interactive presentation, presenter mode, speaker notes, overwatch deck.

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Generate frontend code drafts using Gemini 3.1 Pro's one-shot UI generation. Use when building React components, HTML/CSS pages, SVG animations, or converting screenshots to code. Produces fast, cheap drafts (7.5x cheaper than Opus) that Claude reviews and refines. Supports design system context loading (1M token window), screenshot-to-code pipeline, and physics-based SVG animation. Trigger: "generate a UI", "screenshot to code", "draft a component", "SVG animation", "convert this design", "gemini forge", "forge a UI".

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Drive a GitHub Copilot (or any bot reviewer) pull-request review to a clean pass without babysitting it: fix each finding in its own commit, reply to the review thread with the fix sha, resolve the thread, re-request the bot, and poll for the async re-review. Covers the thread node-id (PRRT_...) vs comment databaseId distinction, the resolveReviewThread GraphQL mutation, the copilot-pull-request-reviewer[bot] slug, and how to read the bot's verdict (COMMENTED plus a "human review recommended" banner is not a blocking finding). Use when Copilot has left review comments on your PR, when bot review threads must be closed out with an auditable fix-reply-resolve trail before merge, or when you need to verify that a re-review actually landed on the new HEAD rather than the old one.

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Polish cut gemstones to final finish using progressive abrasive sequences. Covers pre-polish sanding, polishing compounds, lap selection, and quality assessment for both cabochons and faceted stones. Use when a cabochon or faceted stone has completed cutting and is ready for polishing, selecting the correct compound and lap for a specific species, troubleshooting a polish that will not reach full lustre (orange peel, haze, scratches), or re-polishing a stone with surface wear.

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Redact reverse-engineering findings for public disclosure while preserving methodology, generalizable patterns, and teaching value. Covers the private-vs-public repo split, deny-list pattern maintenance, orphan-commit publish pattern that prevents `git log` leaks, category-based redaction calibration (methodology/pattern/version-finding/internal), and the `check-redaction.sh`-style CI gate that blocks merges when a deny-listed pattern appears. Use when publishing findings about a CLI harness you don't own, when preparing upstream proposals to an unrelated project, or when archiving a private research repo for public reference.

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Redact rendered visual artifacts — Mermaid diagrams, SVGs, and HTML dashboards — before public disclosure, using an ordered longest-first mapping table (specific label, then namespace label, then catch-all placeholder) that swaps sensitive identifiers for descriptive stand-ins while preserving structure, node ids, and teaching value. Covers whole-word identifier replacement, node-label-vs-node-id discrimination, re-rendering the derived image from the redacted source, and verifying the result through the redaction gate. Use when a diagram or dashboard built from internal findings must ship to a public mirror without leaking the names behind it.

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Organize, extract, prune, and verify Claude Code persistent memory files. Covers MEMORY.md as a concise index, topic extraction to dedicated files, staleness detection, accuracy verification against project state, the dual 200-line / 25KB load cap, and reachability of topic files from the index. Use when MEMORY.md is approaching either load cap, after a session produces durable insights worth preserving, when a topic section has grown beyond 10-15 lines and should be extracted, when project state has changed and memory entries may be stale, or before and after rewriting the index so that no topic file loses its only pointer.

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Plan a comprehensive spectroscopic analysis campaign by defining the analytical question, assessing sample characteristics, selecting appropriate techniques using a decision matrix, planning sample preparation for each technique, sequencing analyses from non-destructive to destructive, and defining success criteria with a cross-validation strategy.

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Maintain the 8 essential garden hand tools through sharpening, handle care, rust prevention, and seasonal storage. Covers bypass secateurs, hori-hori, hand fork, trowel, pruning saw, sharpening stone, watering can, and soil rake. Use after each garden session for quick cleaning, monthly during the growing season for sharpening and oiling, at end of season for winter storage preparation, before spring for pre-season readiness checks, or whenever a tool feels dull, stiff, or shows rust.

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Identify and safely gather edible and useful wild plants. Covers safety rules and deadly plant recognition, habitat reading, multi-feature identification methodology, the universal edibility test, sustainable harvesting practices, preparation methods, reaction monitoring, and building knowledge with beginner-friendly universal species. Use when supplementing food supply in a wilderness or survival setting, needing medicinal or utility plants, identifying plants around camp for safety, or in long-term scenarios where foraging extends available rations.

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AI systematic knowledge acquisition from unfamiliar territory — deliberate model-building with feedback loops. Maps spaced repetition principles to AI reasoning: survey the territory, hypothesize structure, explore with probes, integrate findings, verify understanding, and consolidate for future retrieval. Use when encountering an unfamiliar codebase or domain, when a user asks about a topic requiring genuine investigation rather than recall, when multiple conflicting sources require building a coherent model, or when preparing to teach a topic and deep understanding is required first.

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Decommission a validated computerized system at end-of-life. Covers data retention assessment by regulation, data migration validation (mapping, transformation, reconciliation), archival strategy, access revocation, documentation archival, and stakeholder notification. Use when a validated system is being replaced, reaching end-of-life without replacement, vendor support is discontinued, multiple systems are consolidating, or regulatory changes render a system obsolete.

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Build and maintain a library collection through acquisitions, weeding (deaccessioning), collection assessment, reader advisory, and interlibrary loan coordination. Covers selection criteria, collection development policies, the CREW/MUSTIE method for weeding, usage analysis, and responsive collection management. Use when building a new collection with a defined scope and budget, assessing an existing collection for gaps or outdated materials, when shelves are overcrowded and systematic weeding is needed, or when establishing a formal collection development policy.

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Conduct a structured cross-project code review between two Claude Code instances via the cross-review-mcp broker. Each agent reads its own codebase, reviews the peer's code, and engages in evidence-backed dialogue — with QSG scaling laws enforcing review quality through minimum bandwidth constraints and phase-gated progression.

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Perform a ruler-and-compass construction with step-by-step justification for each operation, producing a constructible geometric figure from given elements. Covers classical Euclidean constructions including perpendicular bisectors, angle bisectors, parallel lines, regular polygons, and tangent lines. Use when given geometric elements (points, segments, angles) and asked to produce a Euclidean construction, verify constructibility, or generate ordered construction steps for educational or documentation purposes.

日本語の概要は準備中です。原文の説明を表示しています。