「logic design」の検索結果

Develop, challenge, and document Chisel processor microarchitecture designs before implementation. Use when discussing or writing design documents for processor pipelines, queues, issue logic, rename, ROB, LSU, caches, MSHRs, forwarding, wakeup, replay, flush, privilege, exceptions, or other cycle-accurate hardware mechanisms; when converting design conversations into stable Markdown specifications; or when reviewing a proposed Chisel CPU design for correctness, timing, area, verification cost, and cross-document consistency.

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Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.

日本語の概要は準備中です。原文の説明を表示しています。

Expert-level VLSI design covering CMOS logic, custom layout, standard cell design, physical design flow, DRC, LVS, and advanced process nodes.

日本語の概要は準備中です。原文の説明を表示しています。

The perception-by-culture lens for psycho-logic — establish HOW a specific region, country, or subculture reads a signal before you send it, because perception is culturally coded and the same move can mean the opposite elsewhere. Use when adapting a product, price, message, or campaign to a new market; when the user asks 'will this work in [country/region]', 'why does this land in X but flop in Y', 'how do people here perceive Z', 'how do we localise/differentiate by region', or is about to copy a US/global playbook into another market. Covers the cultural dimensions that move Sutherland's levers — uncertainty avoidance, individualism/collectivism, status/power distance, high- vs low-context communication, mental-accounting norms, trust locus, and taboo/sacredness — and how each rewires reframing, costly-signaling, and experience-design. Inspired by Rory Sutherland's *Alchemy*. Routed to from psycho-logic; pair with market-recon for live local data. 日本語・中文の相談（「この地域で通用する？」「适合本地市场吗？」）にも使う。

Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.

日本語の概要は準備中です。原文の説明を表示しています。

Detects methodological gaps across study design, analysis, validation, bias control, reproducibility, and implementation readiness within a biomedical research area. Use this skill when a user wants to identify what current studies are still methodologically missing, which weaknesses are most consequential, and what upgrade path would produce a stronger next-step study. Always separate design gaps, analysis gaps, validation gaps, and reproducibility gaps. Never treat technical complexity as methodological rigor.

日本語の概要は準備中です。原文の説明を表示しています。

Design, improve, and review interfaces for websites, apps, dashboards, and components: explore distinct design directions, compare styles side by side, and refine visual hierarchy against real screenshots. Delivers comparison pages, design notes, mockups, or working interfaces. Use for new interface design, style comparison, visual polish, screenshot recreation, or interface review. Not for business logic, APIs, builds, or code cleanup without visible UI changes. If oil-ui-pro is installed, use oil-ui-pro instead. 设计、改进和评审网站、App、后台与组件的界面，完成设计方向探索、多风格同屏比较、视觉层级和基于实际画面的迭代；按请求交付对比页、设计说明、设计稿或可运行界面。当用户需要新界面设计、比较不同设计风格、视觉精修、截图还原或界面评审时使用。只负责设计判断，组件归属、数据流、状态正确性和测试等代码实现质量不在范围内。不用于纯业务逻辑、接口、构建部署、无界面行为变化的代码整理、单独绘制普通插画或操作现有网站。已安装 oil-ui-pro 时交给 oil-ui-pro。

日本語の概要は準備中です。原文の説明を表示しています。

Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

日本語の概要は準備中です。原文の説明を表示しています。

Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

日本語の概要は準備中です。原文の説明を表示しています。

Designing conversational flows for website chatbots and AI agents. Intent recognition architecture, branching logic, fallback handling, escalation to human, conversation analytics. Honest about scripted-bot (rigid trees, fail edge cases), hallucinating-bot (LLM without structure, makes things up), and structured-guided-conversation (LLM-powered with intent architecture and fallback discipline) patterns. Distinguishes chatbot DESIGN (this skill) from chatbot IMPLEMENTATION (engineering and platform work). Triggers on chatbot, conversational AI, AI agent, chat widget, intent design, conversational flow, bot escalation, LLM grounding. Also triggers when a chatbot is hallucinating, when a scripted bot is failing edge cases, or when a chatbot is being scoped for the first time.

日本語の概要は準備中です。原文の説明を表示しています。

Expert blueprint for puzzle games including undo systems (Command pattern for state reversal), grid-based logic (Sokoban-style mechanics), non-verbal tutorials (teach through level design), win condition checking, state management, and visual feedback (instant confirmation of valid moves). Use for logic puzzles, physics puzzles, or match-3 games. Trigger keywords: puzzle_game, undo_system, command_pattern, grid_logic, non_verbal_tutorial, state_management.

日本語の概要は準備中です。原文の説明を表示しています。

We present a statistical simulator, scDesign3, to generate realistic single-cell and spatial omics data, including various cell states, experimental designs, and feature modalities, by learning interpretable parameters from real data. Using a unified probabilistic model for single-cell and spatial omics data, scDesign3 infers biologically meaningful parameters; assesses the goodness-of-fit of inferred cell clusters, trajectories, and spatial locations; and generates in silico negative and positi

日本語の概要は準備中です。原文の説明を表示しています。

Provides design token system and theming framework for consistent, customizable UI styling across all components. Covers complete token taxonomy (color, typography, spacing, shadows, borders, motion, z-index), theme switching (CSS custom properties, theme providers), RTL/i18n support (CSS logical properties), and accessibility (WCAG contrast, high contrast themes, reduced motion). This is the foundational styling layer referenced by ALL component skills. Use when theming components, implementing light/dark mode, creating brand styles, customizing visual design, ensuring design consistency, or supporting RTL languages.

日本語の概要は準備中です。原文の説明を表示しています。

Apply the bioengineering, translational systems biology, and tissue modeling frameworks of Linda Griffith, Professor of Biological Engineering at MIT and tissue engineering pioneer. Use this skill whenever facing decisions, designs, or evaluations in bioengineering, tissue modeling, microphysiological systems (organs-on-chips), synthetic matrix design, disease subtyping, or drug target validation. Reach for this skill when evaluating preclinical models (human vs. animal), reframing overlooked or neglected pathologies into rigorous engineering challenges, selecting biomaterials, designing cell signal processing assays, or diagnosing operational flaws in experimental platforms (e.g., PDMS compound absorption or Matrigel lot variability).

日本語の概要は準備中です。原文の説明を表示しています。

Hardware verification tool for checking functional equivalence between two RTL designs (Verilog). Use when users need to: (1) Verify if two RTL versions are functionally equivalent, (2) Compare original vs. refactored RTL code, (3) Validate design changes or optimizations, (4) Identify semantic vs. cosmetic differences, (5) Generate counterexamples for non-equivalent designs. Analyzes interface alignment, state variables, logic differences, and produces detailed equivalence verdicts with plain language explanations. Particularly effective for design verification, code reviews, and regression testing of RTL modifications.

日本語の概要は準備中です。原文の説明を表示しています。

Designs experiments to minimize and account for batch effects using balanced layouts and blocking strategies. Use when planning multi-batch experiments, assigning samples to sequencing lanes, or designing studies where technical variation could confound biological signals.

日本語の概要は準備中です。原文の説明を表示しています。

Audit whether a paper's EVALUATION DESIGN actually measures what it claims and whether its reporting is complete — the validity layer family D (experiment-forensics) cannot reach. Three patterns: train/test leakage means the reported score may not measure generalization (HP-EVAL-LEAKAGE — adopts the Kapoor & Narayanan 8-type / 3-category leakage taxonomy; the illegitimate-proxy / sampling-bias / pretraining-contamination subtypes hand off as needs_external_check, naming but NEVER running Oren-2023 exchangeability / Shi-2023 Min-K% / Golchin-2023 Time-Travel / BIG-bench canary); a load-bearing LLM judge is conflicted (same model/family as a compared system) or unvalidated (no human-agreement, no bias control) (HP-JUDGE-VALIDITY); a declared condition/metric is dropped or switched to favor the method, or 'best' is chosen with no held-out set (HP-SELECTIVE-REPORTING). Verdict-bearing at L0/L1 from the DESCRIBED protocol — NOT repo-gated like experiment-forensics; L2 only CONFIRMS against split/preprocessing/result files. A fresh cross-model reviewer (gpt-5.6-sol xhigh, read-only, fresh thread per pass) PROPOSES findings, each span-anchored to a ledger claim_id; tools/adjudicate_findings.py DECIDES the verdict. Leakage and under-reporting are usually HONEST methodological errors — every finding describes a discrepancy to CHECK, never an accusation. An LLM generating GROUND-TRUTH labels is HP-FAKE-GT (experiment-forensics) — routed there, not here. Emits eval-design-forensics.findings.json; computes NO verdict. Detect-only. Triggers: "eval design audit", "evaluation validity", "train/test leakage", "data leakage", "is the score measuring generalization", "LLM judge bias", "is the judge validated", "selective reporting", "cherry-picked results", "评估设计审计", "评测有效性", "数据泄漏", "训练测试集泄漏", "裁判模型有没有验证", "选择性报告".

日本語の概要は準備中です。原文の説明を表示しています。

Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

日本語の概要は準備中です。原文の説明を表示しています。

Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

日本語の概要は準備中です。原文の説明を表示しています。

Expert-level digital electronics covering Boolean algebra, combinational and sequential logic, FPGA design, HDL programming, timing analysis, and digital system design.

日本語の概要は準備中です。原文の説明を表示しています。

Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

日本語の概要は準備中です。原文の説明を表示しています。