「tia」の検索結果

Compares Hi-C contact maps between conditions across the right scale -- differential bin-pair contacts (multiHiCcompare, diffHic), differential A/B compartments (dcHiC), differential TAD boundaries (delta insulation), and differential loops (diffloop, DiffHiChIP) -- with distance-stratified between-sample normalization, replicate-aware NB-GLM FDR, HiCRep SCC reproducibility gating, and CNV correction for cancer/aneuploid samples. Use when comparing Hi-C between treatment and control, finding differential contacts/compartments/boundaries/loops, normalizing two maps of unequal depth, choosing a replicate-aware test, gating replicates with SCC, or correcting copy-number artifacts before a tumor-vs-normal comparison.

日本語の概要は準備中です。原文の説明を表示しています。

Compare gene co-expression and regulatory networks between biological conditions to find rewired relationships using DiffCorr, DiffCoEx, DINGO/iDINGO, and CoDiNA. Covers the differential-connectivity-is-not-differential-expression distinction, the pairwise multiple-testing explosion, marginal vs partial (direct) rewiring, and the underpowered-rewiring failure mode. Use when comparing co-expression networks between disease vs control, treatment, or developmental stages, or finding hub genes that rewire without changing mean expression. For single-condition modules see coexpression-networks; for differential expression of means see differential-expression/de-results.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 with `bam_ip` + `bam_input` (control arm) and `bam_treated_ip` + `bam_treated_input` (treatment arm) for integrated GC-bias-aware differential calling (Liu 2022 *NAR Genom Bioinform* 4:lqac046), QNB beta-binomial test (Liu 2017 *BMC Bioinformatics* 18:387), MeTDiff HMM-based differential bundled with MeTPeak, RADAR (Zhang 2019 *Genome Biol* 20:294) with its `filterBins -> diffIP -> reportResult` workflow, and the defensible paired-symmetric case of edgeR / DESeq2 on featureCounts-on-peaks matrices when batch / lot covariates need explicit fixed-effect handling (exomePeak2's top-level API does NOT accept arbitrary covariates). Covers paired vs unpaired vs interaction designs, batch confounding (antibody lot, RNA prep, sequencing run) and the per-lot meta-analysis strategy when exomePeak2 is the primary caller, the stoichiometry-vs-expression-vs-IP-efficiency confound that all MeRIP differential methods inherit, normalisation choice (size factor on IP, on input, on per-sample IP/input ratio), the McIntyre 2020 reproducibility caveat, effect-size filtering as a guardrail against under-powered N=2 designs, and orthogonal-validation routes for absolute stoichiometry (GLORI / SAC-seq / m6Anet `mod_ratio`). Use when comparing m6A levels across two or more conditions, choosing between exomePeak2 / QNB / RADAR / MeTDiff for a given design, handling batch confounding when exomePeak2's API is too rigid, normalising against input properly, distinguishing real hyper- / hypo-methylation from expression-level shifts, applying effect-size thresholds, interpreting volcano plots of differential peaks, or planning a follow-up orthogonal stoichiometry validation.

日本語の概要は準備中です。原文の説明を表示しています。

Compares Hi-C contact maps between conditions across the right scale -- differential bin-pair contacts (multiHiCcompare, diffHic), differential A/B compartments (dcHiC), differential TAD boundaries (delta insulation), and differential loops (diffloop, DiffHiChIP) -- with distance-stratified between-sample normalization, replicate-aware NB-GLM FDR, HiCRep SCC reproducibility gating, and CNV correction for cancer/aneuploid samples. Use when comparing Hi-C between treatment and control, finding differential contacts/compartments/boundaries/loops, normalizing two maps of unequal depth, choosing a replicate-aware test, gating replicates with SCC, or correcting copy-number artifacts before a tumor-vs-normal comparison.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 with `bam_ip` + `bam_input` (control arm) and `bam_treated_ip` + `bam_treated_input` (treatment arm) for integrated GC-bias-aware differential calling (Liu 2022 *NAR Genom Bioinform* 4:lqac046), QNB beta-binomial test (Liu 2017 *BMC Bioinformatics* 18:387), MeTDiff HMM-based differential bundled with MeTPeak, RADAR (Zhang 2019 *Genome Biol* 20:294) with its `filterBins -> diffIP -> reportResult` workflow, and the defensible paired-symmetric case of edgeR / DESeq2 on featureCounts-on-peaks matrices when batch / lot covariates need explicit fixed-effect handling (exomePeak2's top-level API does NOT accept arbitrary covariates). Covers paired vs unpaired vs interaction designs, batch confounding (antibody lot, RNA prep, sequencing run) and the per-lot meta-analysis strategy when exomePeak2 is the primary caller, the stoichiometry-vs-expression-vs-IP-efficiency confound that all MeRIP differential methods inherit, normalisation choice (size factor on IP, on input, on per-sample IP/input ratio), the McIntyre 2020 reproducibility caveat, effect-size filtering as a guardrail against under-powered N=2 designs, and orthogonal-validation routes for absolute stoichiometry (GLORI / SAC-seq / m6Anet `mod_ratio`). Use when comparing m6A levels across two or more conditions, choosing between exomePeak2 / QNB / RADAR / MeTDiff for a given design, handling batch confounding when exomePeak2's API is too rigid, normalising against input properly, distinguishing real hyper- / hypo-methylation from expression-level shifts, applying effect-size thresholds, interpreting volcano plots of differential peaks, or planning a follow-up orthogonal stoichiometry validation.

日本語の概要は準備中です。原文の説明を表示しています。

Compare gene co-expression and regulatory networks between biological conditions to find rewired relationships using DiffCorr, DiffCoEx, DINGO/iDINGO, and CoDiNA. Covers the differential-connectivity-is-not-differential-expression distinction, the pairwise multiple-testing explosion, marginal vs partial (direct) rewiring, and the underpowered-rewiring failure mode. Use when comparing co-expression networks between disease vs control, treatment, or developmental stages, or finding hub genes that rewire without changing mean expression. For single-condition modules see coexpression-networks; for differential expression of means see differential-expression/de-results.

日本語の概要は準備中です。原文の説明を表示しています。

Locate CBaseIssue::CountPotentialVoters in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the local gamedata entry "CBaseIssue::CountPotentialVoters" (symbol CBaseIssue_CountPotentialVoters). This is a non-virtual function - emit a byte signature (func_sig), not an offset. Locate it via cross-references, distinctive constants/strings in its body, or callers of related symbols; verify by decompilation before committing to a candidate. Trigger: CBaseIssue_CountPotentialVoters, CBaseIssue::CountPotentialVoters

日本語の概要は準備中です。原文の説明を表示しています。

Tactical negotiation framework based on Chris Voss's "Never Split the Difference." Use when preparing for negotiations, during live negotiation scenarios, analyzing counterpart behavior, crafting responses to difficult conversations, handling objections, salary/contract negotiations, or when asked about negotiation techniques like mirroring, labeling, calibrated questions, or the Ackerman method.

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive secrets extraction methodology targeting CI/CD environments across all major platforms. Covers environment variable extraction from build contexts, exploitation of vault and secrets-manager misconfigurations (HashiCorp Vault, AWS Secrets Manager, Azure Key Vault, GCP Secret Manager), runner and agent token abuse for lateral movement, OIDC federation attacks exploiting trust relationships between CI/CD providers and cloud platforms, build log leakage analysis for inadvertently exposed credentials, cache poisoning techniques for credential exfiltration, platform-specific credential store exploitation (GitHub Actions secrets, GitLab CI variables, Jenkins credential providers), service connection and service account abuse in Azure DevOps and GCP, and Docker registry credential theft from build environments. Maps to MITRE ATT&CK T1552 (Unsecured Credentials) and its sub-techniques. Each section provides enumeration procedures, extraction techniques, and post-exploitation pivoting guidance for usi...

日本語の概要は準備中です。原文の説明を表示しています。

TypeScriptのテストで使う型の強制指定を専用関数に置き換え、必要な項目だけのデータや意図的に型を外したデータを扱いやすくするスキル。

• テスト内のasを置き換えたいとき
• 必要な項目だけでテストデータを作成
• 不正な入力によるエラーテスト

Scan source code repositories, CI/CD pipelines, and configuration files for exposed AWS credentials using TruffleHog, git-secrets, and AWS-native detection. Use when integrating secrets scanning into CI/CD, auditing repositories (including git history) for historically committed AWS keys, responding to a GuardDuty alert about credential use from an unexpected location, or verifying credential rotation removed all exposed keys.

日本語の概要は準備中です。原文の説明を表示しています。

Extract and decrypt Windows DPAPI-protected secrets (Credential Manager, browser logins/cookies, Wi-Fi credentials, KeePass keys) online or offline using SharpDPAPI, SharpChrome, Mimikatz, or Impacket's dpapi.py, including domain-wide decryption via the DPAPI backup key. Use during authorized red-team credential-access engagements after gaining a foothold or when triaging DPAPI blobs pulled from a host.

日本語の概要は準備中です。原文の説明を表示しています。

Python library for working with geospatial vector data including shapefiles, GeoJSON, and GeoPackage files. Use when working with geographic data for spatial analysis, geometric operations, coordinate transformations, spatial joins, overlay operations, choropleth mapping, or any task involving reading/writing/analyzing vector geographic data. Supports PostGIS databases, interactive maps, and integration with matplotlib/folium/cartopy. Use for tasks like buffer analysis, spatial joins between datasets, dissolving boundaries, clipping data, calculating areas/distances, reprojecting coordinate systems, creating maps, or converting between spatial file formats.

日本語の概要は準備中です。原文の説明を表示しています。

Gets AWS credentials for CLI/SDK access via `aws login`. Activates when a developer needs to authenticate to AWS for local development, when an AWS operation fails due to missing or expired credentials, or when someone asks about setting up AWS access. Triggers: "set up AWS", "configure AWS", "aws login", "get credentials", "authenticate", "session expired", "token expired", "no credentials", "AccessDeniedException" with no configured credentials.

日本語の概要は準備中です。原文の説明を表示しています。

Organization-grade identity-fabric mapping: tenant/federation fingerprinting and the pre-auth user-ENUMERATION oracle methodology — enumeration and fingerprint only, never credential submission. Covers domain-to-tenant resolution (Microsoft getuserrealm.srf Managed/Federated namespace check, Entra OIDC metadata tenant-GUID extraction, Autodiscover v2), keyless Microsoft tenant-federation mapping (GetFederationInformation SOAP -> sibling-domain discovery, discover-only ROE, FEDERATED_WITH provenance edge held out of attack-path pivoting), Okta org-slug derivation + OIDC fingerprint + governed custom-domain enumeration, ADFS passive/active fingerprint + version inference, Google Workspace MX-correlated detection, generic OIDC (Auth0/Keycloak/Ping Identity/OneLogin/Duo) discovery, SAML metadata (5 paths), Azure AD Seamless-SSO Negotiate-challenge detection, Microsoft Defender for Identity (MDI) sensor-API presence check, the user-enumeration oracle methodology for Microsoft GetCredentialType (IfExistsResult semantics: exists / doesn't-exist / exists-in-federated-tenant / throttled) and Okta /api/v1/authn (errorCode differential), Medium-detectability discipline with a hard 20-candidate-per-tenant cap and admin/role interest-based ranking, and name x confirmed-email-pattern login-candidate synthesis that FAILS CLOSED with zero output when no org pattern is confirmed. Grounded directly in a production ASM implementation's sso_idp.py, tenant_recon.py, and core/email_patterns.py modules. Deepens — does not duplicate — offensive-osint skill's Identity Fabric endpoint reference with the tenant-federation MAP, the oracle WORKFLOW, and the candidate-SYNTHESIS methodology that reference lacks. Use when fingerprinting an organization's identity provider, mapping its tenant/federation boundary, running an authorized pre-auth user-enumeration pass, or synthesizing login candidates from harvested names to feed that oracle — never for password spray, credential submission, or auth bypass.

日本語の概要は準備中です。原文の説明を表示しています。

Institutional-quality equity research initiation reports for A-share companies. Covers company analysis, financial modeling, valuation, chart preparation, and final report assembly. Adapted from the original initiating-coverage skill for Chinese market conventions, CAS accounting, and AkShare data sources. Triggers on "A股首次覆盖", "首次评级", "initiate coverage China", "initiate on [company]", "A股研究报告", or "start research on [company]".

日本語の概要は準備中です。原文の説明を表示しています。

SpatialDE is a method to find spatially variable genes (SVG) from spatial transcriptomics data. This package provides wrappers to use the Python SpatialDE library in R, using reticulate and basilisk.

日本語の概要は準備中です。原文の説明を表示しています。

Expert knowledge for Azure Confidential Ledger development including troubleshooting, decision making, security, integrations & coding patterns, and deployment. Use when configuring ACL auth/attestation, integrating with Blob/Cosmos, using MST payloads, or deploying via ARM/Terraform, and other Azure Confidential Ledger related development tasks. Not for Azure Confidential Computing (use azure-confidential-computing), Azure Key Vault (use azure-key-vault), Azure Dedicated HSM (use azure-dedicated-hsm), Azure Payment Hsm (use azure-payment-hsm).

日本語の概要は準備中です。原文の説明を表示しています。

薪资谈判教练。模拟前 FAANG 招聘官 + 薪酬策略师，把「拿到 offer → 签字」这一步拆成 6 个动作：Offer 诊断（Base / RSU / Sign-on / Bonus 每项标 LOW/MED/HIGH leverage）→ 谈判杠杆图（我的力量 / 招聘官的力量 / 弱点）→ 策略排序（Base → RSU → Sign-on → Bonus，按 context 调整）→ 脚本生成（电话 / 邮件 / 招聘官回话模拟）→ Counter 模拟（"这是最好的了" / "预算固定" / "会考虑其他候选人" 三种硬回答）→ 最终建议（要什么 / 别推什么 / 何时停）。三步：贴 offer → 说 context（有没有竞争 offer / deadline / 级别 / 风险偏好 / 最看重什么）→ 自动生成并打开一份 HTML Negotiation Playbook。关键词：salary negotiation, offer negotiation, comp negotiation, RSU, sign-on, base salary, counter offer, competing offer, TC, total comp, 薪资谈判, offer 谈判, 谈薪, 反 offer, 加薪, 谈 package, levels.fyi, 招聘官话术, recruiter script。

日本語の概要は準備中です。原文の説明を表示しています。

Geospatial vector analysis extending pandas. Read/write spatial formats (Shapefile, GeoJSON, GeoPackage, Parquet, PostGIS), CRS handling, geometric ops (buffer, simplify, centroid, affine), spatial analysis (joins, overlays, dissolve, clipping, distance), visualization (choropleth, interactive maps, basemaps). Use for spatial joins, overlays, CRS transforms, area/distance, maps.

日本語の概要は準備中です。原文の説明を表示しています。

Expert sales negotiation strategist for B2B deal-making. Use when planning negotiation strategy, handling discount requests, closing deals, navigating procurement, or structuring win-win agreements. Covers anchoring, framing, BATNA development, multi-party negotiations, and contract terms. Use for enterprise deals, pricing discussions, and high-stakes negotiations.

日本語の概要は準備中です。原文の説明を表示しています。

Authentication and credential security assessment. Tests password brute-force, credential stuffing, password spraying, default credential testing, credential harvesting, lockout analysis, MFA bypass, OAuth/OIDC abuse, session token entropy, Kerberos attacks, and intelligent wordlist generation. Uses hydra, john, ncrack, medusa, cewl, crunch, netexec, impacket, kerbrute, and nuclei default-login templates. Covers OWASP A07:2021 Identification and Authentication Failures.

日本語の概要は準備中です。原文の説明を表示しています。

Process, analyze, and visualize geospatial data at scale. Handles drone imagery, GPS tracks, GeoJSON optimization, coordinate transformations, and tile generation. Use for mapping apps, drone data processing, location-based services. Activate on "geospatial", "GIS", "PostGIS", "GeoJSON", "map tiles", "coordinate systems". NOT for simple address validation, basic distance calculations, or static map embeds.

日本語の概要は準備中です。原文の説明を表示しています。

Implement iOS authentication patterns including Sign in with Apple (ASAuthorizationAppleIDProvider, ASAuthorizationController, ASAuthorizationAppleIDCredential), credential state checking, identity token validation, ASWebAuthenticationSession for OAuth and third-party auth flows, ASAuthorizationPasswordProvider for AutoFill credential suggestions, and biometric authentication with LAContext. Use when implementing Sign in with Apple, handling Apple ID credentials, building OAuth login flows, integrating Password AutoFill, checking credential revocation state, or validating identity tokens server-side.

日本語の概要は準備中です。原文の説明を表示しています。