565 件 ・ 関連度順
概要と使いどころ
Think and work like an expert Marine Biologist. Use when a task calls for Marine Biologist judgment. Reasons from water-mass stratification, CTD–Niskin and CalCOFI-style net tows, BRUV, and MiFish/COI eDNA through OBIS/WoRMS/GBIF and ARGO/BGC-Argo; treats mesopelagic DVM, hypoxia/Ω_aragonite constraints, fluorometer quenching, BRUV MaxN bias, and transect pseudoreplication as first-class failure modes.
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Think and work like an expert Molecular Pathologist. Use when a task calls for Molecular Pathologist judgment. Reasons from tumor cellularity, assay-specific LOD, and AMP/ASCO/CAP Tier I–IV classification; validates IHC (CAP ≥90% concordance), FISH (HER2/ALK break-apart), and NGS oncology panels under CAP/CLIA MM09 while treating FFPE deamination, HER2-low/ultralow scoring, PD-L1 TPS vs CPS, and ctDNA CHIP as first-class failure modes.
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Think and work like an expert Microbiome Scientist. Use when a task calls for Microbiome Scientist judgment. Reasons from compositional and longitudinal stats (MaAsLin2, ANCOM-BC2), STORMS pre-analytics, FMT/LBP and diet trials, and multi-omics integration; treats PPI/antibiotic confounders, kitome contamination, host-DNA swamping, and HMA causality overclaim as first-class failure modes.
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Think and work like an expert Medical Geneticist. Use when a task calls for Medical Geneticist judgment. Reasons from pedigree priors, HPO phenotype match, and ACMG/ClinGen variant classification; integrates exome/genome, CMA, RNA splicing, NBS ACT pathways, Tier 3 carrier screening, SF v3.3, and CPIC pharmacogenomics while treating VUS overcall, CPM/NIPT discordance, mtDNA heteroplasmy sampling, and SpliceAI-only splicing claims as first-class failure modes.
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Think and work like an expert Genome Engineering (CRISPR) Scientist. Use when a task calls for Genome Engineering (CRISPR) Scientist judgment. Reasons from NHEJ/HDR/MMEJ competition and editor modality choice through CRISPick/CRISPResso2 guide design, LOCK/lssDNA and RNP HDR, base and prime editing (PE4/PE5, epegRNA), CAST-Seq/UDiTaS on-target SV assessment, clonal genotyping, and FDA/IBC-bound off-target and genome-integrity analytics.
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Think and work like an expert Epigeneticist. Use when a task calls for Epigeneticist judgment. Reasons from chromatin state, DNA methylation, histone marks, accessibility, and 3D genome topology through ChIP/CUT&RUN, ATAC-seq, WGBS/EM-seq, Hi-C, and dCas9-DNMT3A/KRAB perturbation while treating cell-composition shifts, batch confounding, antibody nonspecificity, Tn5 bias, and incomplete bisulfite conversion as first-class failure modes.
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Think and work like an expert Environmental Microbiologist. Use when a task calls for Environmental Microbiologist judgment. Reasons from spatial patchiness, redox thermodynamic ceilings, and process-over-taxonomy guild function through DADA2/QIIME2 amplicons keyed to SILVA/GTDB/PR2/UNITE, metaSPAdes/MetaBAT2 MAGs vetted by CheckM/GUNC, and SIP/qSIP rate assays paired with IC/GC/ICP-MS chemistry, while treating extraction-batch effects, relic and extracellular DNA, primer-window bias, and core pseudoreplication as first-class failure modes.
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Think and work like an expert Conservation Biologist. Use when a task calls for Conservation Biologist judgment. Reasons from IUCN Red List A–E and Green Status recovery metrics, PVA/Ne, occupancy and distance sampling (unmarked, msocc, RMark), prioritizr/Marxan SCP, Conservation Evidence and ROSES synthesis, counterfactual impact evaluation, METT/SMART PAME, and eDNA false-positive models while treating pseudoreplication, GBIF effort bias, offset baselines, and Red List≠priority conflation as first-class failure modes.
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Think and work like an expert Biological Oceanographer. Use when a task calls for Biological Oceanographer judgment. Reasons from light-nutrient-grazing coupling, the microbial loop, and size-structured export through CTD/MOCNESS sampling, 14C and O2/Ar production with 234Th export flux, imaging and flow cytometry enumeration, and SILVA/PR2 metabarcoding while treating spatial patchiness, diel-migration tow aliasing, CDOM-biased chlorophyll algorithms, and eDNA-detection-as-abundance as first-class failure modes.
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Think and work like an expert Botanist. Use when a task calls for Botanist judgment. Reasons from morphology, floras (FNA/Jepson/eFlora), voucher herbarium specimens (Darwin Core, Index Herbariorum), nomenclature (IPNI/POWO/Madrid Code), APG IV phylogeny, DNA barcoding (rbcL/matK/ITS2), community ecology (vegan adonis2/betadisper, TRY traits), and CITES/ABS ethics; treats vegetative mis-ID, pseudoreplication, PERMDISP confounds, and unvouchered GBIF records as first-class failure modes.
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Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin. Extracts nucleosome positioning patterns, fragment ratios, and DELFI-style fragmentation profiles for cancer detection. Use when leveraging fragment patterns for tumor detection or tissue-of-origin analysis.
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End-to-end DNA sequencing workflow from FASTQ files to variant calls. Covers QC, alignment with BWA, BAM processing, and variant calling with bcftools or GATK HaplotypeCaller. Use when calling variants from raw sequencing reads.
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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.
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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
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Trim PCR primers from aligned reads in amplicon-panel BAMs using samtools ampliconclip. Use when processing SARS-CoV-2 ARTIC, hereditary cancer panels, ctDNA hot-spot panels, or any amplicon assay where primer-derived bases would falsely confirm reference at primer footprints.
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Analyze DNA/RNA/protein sequences. Use when the user provides a sequence and asks for analysis, translation, GC content, ORFs, motifs, restriction sites, or primer design. Triggers on "sequence", "translate", "GC content", "ORF", "primer", "restriction", "complement", "reverse complement".
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Review SDS-PAGE or protein purification gel images using DNA sequence, protein sequence, base-pair length, expected protein size, and lane labels. Use when the user wants to judge whether a gel ran well, whether the main band matches the expected product, or whether there may be impurities, degradation, aggregation, or low expression.
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Cell-free protein synthesis (CFPS) planning and optimization guidance. Use when: (1) Planning CFPS experiments, (2) Troubleshooting low yield or aggregation, (3) Optimizing DNA template design for CFPS, (4) Expressing difficult proteins (disulfide-rich, toxic, membrane).
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Guidance for cell-free protein synthesis (CFPS) optimization. Use when: (1) Planning CFPS experiments, (2) Troubleshooting low yield or aggregation, (3) Optimizing DNA template design for CFPS, (4) Expressing difficult proteins (disulfide-rich, toxic, membrane).
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An inspired interpretation of Shopifi's design language — a cinematic commerce platform that runs two parallel design tracks. The marketing-hero and product-narrative pages live on near-black canvases with full-bleed photography of merchants, giant Neue Haas Grotesk display type at thin weights, and a single black-pill CTA stroked in white. The transactional pages (pricing, signup, dashboards) flip to a cream-mint canvas with pastel aloe and pistachio greens, the same pill button vocabulary, and Inter for UI body. The two tracks share typographic DNA but diverge sharply in canvas polarity — and that choice is the brand.
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The ultimate brand asset: a consistent, explorable universe generated by AI. This skill covers creating coherent brand worlds, consistent characters, architectural spaces, and visual universes that serve as the foundation for all marketing content. Traditional brand building creates guidelines. AI world building creates explorable realities. Characters with consistent personalities across thousands of images. Environments that feel like real places. Visual languages so coherent that any new asset feels like it belongs. This is where AI generation meets universe design. The practitioners of this skill don't just create images—they create the DNA that generates infinite consistent images. They build the source code for visual worlds. Use when "world building, brand world, universe, consistent character, character design, visual language, brand universe, style bible, world bible, coherent assets, character sheet, environment design, world-building, universe, character-design, consistency, visual-language, brand-world, style-guide" mentioned.
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招聘与猎头 (招聘与猎头 (Recruiting & Executive Search) — 面向甲方招聘负责人/HR 与市场化猎头顾问「双侧视角」的『把一个模糊的用人需求，变成一个来得了、干得好、留得住的人』的判断体系；不是候选人一侧的求职与简历面经（那是 job-hunting-coach 的范围），也不是薪酬绩效/员工关系/组织发展的泛 HR 全模块，更不是劳动法条文解读。覆盖：(a) 第一性张力 —— 这行的核心世界观分歧：**需求诊断优先 ⇄ 快速供给优先**（用人经理提来的岗位需求几乎总是一张愿望清单，资深招聘先开 intake 会把『必须有』与『最好有』拆开、把画像逼成可证伪的成功标准；但按成单计酬的猎头把诊断时间压不进单价里，于是行业里同时存在『先诊断再搜寻』和『先扔简历再说』两种作业习惯）；**结构化面试 ⇄ 看人的直觉**（工业与组织心理学近一个世纪的效度元分析一致指向：结构化面试、工作样本、认知能力测验的预测效度明显高于非结构化面谈与经验年限，但一线用人经理绝大多数仍相信自己聊两句就能看准人——这是本行最大的知行落差，也是所有循证招聘流派的出发点；顺带一提，业内长期奉为圭臬的 Schmidt-Hunter 效度排序近年被重新校正，工作样本的效度被下调，这场修正本身就是本行必须如实呈现的争议）；**能力素质 ⇄ 文化匹配**（culture fit 既是最常被写在拒信里的理由，也是被批评得最凶的偏见外壳，Google 一派主张改口叫 culture add，看的是这个人补上了团队缺的东西，而不是像不像我们）；**主动寻访 sourcing ⇄ 被动投递漏斗**（高端与稀缺技能岗只有 outbound 人才地图一条路；量大岗位靠渠道效率、转化率与自动化，两条路的技能树几乎不重叠）；**人才地图是资产 ⇄ 人才地图是浪费**（保留制猎头把 mapping 当交付物的一部分，成功付费猎头认为地图做完单子已经黄了）；**保留制 retained ⇄ 成功付费 contingency**（按阶段预付、独家、深度地图 vs 多家赛马、入职才收钱、速度压倒深度；两种商业模式塑造出两种截然不同的作业节奏、候选人对待方式与职业道德边界，比如 off-limits 不挖回自己安置过的人）；**内部招聘团队 ⇄ 外部猎头与 RPO**（成本、速度、知识沉淀、雇主品牌归属谁的长期争论；embedded recruiter 是近年的折中）；**候选人体验 ⇄ 筛选效率**（漏斗越严体验越差，被拒者也是客户与口碑）；**AI 筛选的效率 ⇄ 合规与偏见**（简历解析、AI 面试评分、自动排序已在大规模使用，同时被监管盯上：纽约市 Local Law 144 要求自动化决策工具做偏见审计并公示、欧盟 AI 法案把招聘划为高风险场景、伊利诺伊州对 AI 视频面试单独立法；业内既离不开它，也在诉讼与审计里学做记录）；**offer 谈判的锚定 ⇄ 薪酬透明**（多地薪酬区间披露立法把谈判起点从『你现在多少』改成『这个岗位值多少』，问薪酬历史在不少法域已被禁止）；**counter-offer 该不该接**（猎头几乎一致反对，认为留下来的人多数一年内还是会走，但这条业内定论的证据基础本身也在被质疑）；**入职后早期流失算谁的**（保证期与退款条款把这场争论直接写进了合同）。(b) 工具栈 —— 申请人追踪系统 ATS（Greenhouse、Lever、Ashby、Workday Recruiting、SmartRecruiters、iCIMS、Taleo，中国侧 Moka、北森、大易、e成）、猎头 CRM 与交付系统（Bullhorn、Vincere、Loxo、Clockwork、Recruit CRM）、寻访与触达（LinkedIn Recruiter、SeekOut、hireEZ、Amazing Hiring、GitHub 与学术检索，中国侧 BOSS 直聘、猎聘、脉脉、拉勾、牛客）、评估与测评（HackerRank、CodeSignal、CoderPad、结构化面试题库与 scorecard 评分卡、Hogan、SHL、Predictive Index、Criteria、案例作业与工作样本）、面试调度与视频（GoodTime、Calendly、HireVue、Spark Hire）、背景调查与合规（HireRight、Checkr、Sterling，中国侧 i背调、八方锦程，以及个人信息保护法与 GDPR 下的授权链、FCRA 的不利行动通知）、数据与漏斗分析（time to fill 与 time to hire 的口径差异、offer 接受率、通过率与转化漏斗、quality of hire 的度量困境、招聘成本 cost per hire 的口径战争）、以及最被低估的纸笔工具（intake 提纲、成功标准清单、scorecard、人才地图表格、Boolean 检索式、一页纸的岗位价值主张）—— 选型的真正分岔从来不是功能清单，而是『你的岗位是靠触达赢还是靠转化赢』。(c) 心智模型层 —— 招聘是一次双向销售而不是一场考试；岗位画像要写成结果（这个人半年内要做成什么）而不是资历清单；信号与噪音（公司名与学历是弱信号，工作样本与具体行为证据是强信号）；结构化与评分卡的意义在于让判断可比而不是显得严谨；漏斗每一层都在丢人，所以要从入职倒推触达量；稀缺人才不看招聘广告，只在熟人与私域里流动；offer 是谈判也是承诺，谈崩与反悔的代价高度不对称；招聘的质量要到入职之后才结算。(d) 工作流 —— intake 需求诊断会、岗位画像与成功标准、渠道策略与人才地图 mapping、Boolean 与主动触达、简历筛选与电话初筛、结构化面试与 debrief 定校准、工作样本与技术评估、reference check 与背调、offer 设计与谈判、counter-offer 应对、入职前 no-show 防范与 pre-boarding、试用期与早期留存复盘、招聘漏斗与数据复盘、以及岗位关闭或撤销时的收尾。(e) 表达 DNA、质量基准（什么算一次好的招聘）、反模式（外行与新手最容易犯的错：照抄 JD、面试问脑筋急转弯、用薪酬历史锚定、把候选人当库存、背调走过场、offer 口头承诺）、智识谱系（工业与组织心理学的效度学派、循证与结构化招聘派、保留制高管寻访派、增长型 sourcing 与招聘运营派、雇主品牌与候选人体验派、中国互联网大厂的人才盘点与赛马派）。) Master OS — automated mastery of 招聘与猎头 (Recruiting & Executive Search) — 面向甲方招聘负责人/HR 与市场化猎头顾问「双侧视角」的『把一个模糊的用人需求，变成一个来得了、干得好、留得住的人』的判断体系；不是候选人一侧的求职与简历面经（那是 job-hunting-coach 的范围），也不是薪酬绩效/员工关系/组织发展的泛 HR 全模块，更不是劳动法条文解读。覆盖：(a) 第一性张力 —— 这行的核心世界观分歧：**需求诊断优先 ⇄ 快速供给优先**（用人经理提来的岗位需求几乎总是一张愿望清单，资深招聘先开 intake 会把『必须有』与『最好有』拆开、把画像逼成可证伪的成功标准；但按成单计酬的猎头把诊断时间压不进单价里，于是行业里同时存在『先诊断再搜寻』和『先扔简历再说』两种作业习惯）；**结构化面试 ⇄ 看人的直觉**（工业与组织心理学近一个世纪的效度元分析一致指向：结构化面试、工作样本、认知能力测验的预测效度明显高于非结构化面谈与经验年限，但一线用人经理绝大多数仍相信自己聊两句就能看准人——这是本行最大的知行落差，也是所有循证招聘流派的出发点；顺带一提，业内长期奉为圭臬的 Schmidt-Hunter 效度排序近年被重新校正，工作样本的效度被下调，这场修正本身就是本行必须如实呈现的争议）；**能力素质 ⇄ 文化匹配**（culture fit 既是最常被写在拒信里的理由，也是被批评得最凶的偏见外壳，Google 一派主张改口叫 culture add，看的是这个人补上了团队缺的东西，而不是像不像我们）；**主动寻访 sourcing ⇄ 被动投递漏斗**（高端与稀缺技能岗只有 outbound 人才地图一条路；量大岗位靠渠道效率、转化率与自动化，两条路的技能树几乎不重叠）；**人才地图是资产 ⇄ 人才地图是浪费**（保留制猎头把 mapping 当交付物的一部分，成功付费猎头认为地图做完单子已经黄了）；**保留制 retained ⇄ 成功付费 contingency**（按阶段预付、独家、深度地图 vs 多家赛马、入职才收钱、速度压倒深度；两种商业模式塑造出两种截然不同的作业节奏、候选人对待方式与职业道德边界，比如 off-limits 不挖回自己安置过的人）；**内部招聘团队 ⇄ 外部猎头与 RPO**（成本、速度、知识沉淀、雇主品牌归属谁的长期争论；embedded recruiter 是近年的折中）；**候选人体验 ⇄ 筛选效率**（漏斗越严体验越差，被拒者也是客户与口碑）；**AI 筛选的效率 ⇄ 合规与偏见**（简历解析、AI 面试评分、自动排序已在大规模使用，同时被监管盯上：纽约市 Local Law 144 要求自动化决策工具做偏见审计并公示、欧盟 AI 法案把招聘划为高风险场景、伊利诺伊州对 AI 视频面试单独立法；业内既离不开它，也在诉讼与审计里学做记录）；**offer 谈判的锚定 ⇄ 薪酬透明**（多地
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Universal coding standards, best practices, and patterns for TypeScript, JavaScript, React, and Node.js development.
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Use this skill when the user explicitly asks for TDD or a tests-first workflow, or when developing a new feature with a test coverage requirement. Provides a structured red-green-refactor workflow with unit, integration, and E2E test guidance.
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