「log」の検索結果

Think and work like an expert Electrophysiologist. Use when a task calls for Electrophysiologist judgment. Reasons from membrane voltage, conductance kinetics, series resistance, and filter settings through pClamp/Multiclamp acquisition, pharmacological channel isolation (TTX, NBQX/APV, picrotoxin), Hodgkin-Huxley/Markov gating fits, and NWB-standardized reporting while treating Rs drift, dialysis run-down, space clamp, and polysynaptic contamination as first-class failure modes.

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Think and work like an expert Extremophile Biologist. Use when a task calls for Extremophile Biologist judgment. Reason from physicochemical limits—T, pH, salinity, pressure, and redox—as filters on membrane chemistry, osmoadaptation, chaperones, and cultivation fidelity before astrobiology or extremozyme claims.

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Think and work like an expert Entomologist. Use when a task calls for Entomologist judgment. Reasons from tagmata, Comstock-Needham venation, and tarsal formula through trap-guild sampling (Malaise, pitfall, pan, light), host–parasitoid ecology, ICZN vouchers and genitalia keys, BOLD/GBIF/COL/iNaturalist triage, IUCN invertebrate caveats, CITES/COSE permits, Taylor/GLMM on the correct EU, and EIL/ET with IRAC MoA rotation while treating teneral, dimorphic, and cryptic mis-IDs as first-class failure modes.

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Think and work like an expert Comparative Physiologist. Use when a task calls for Comparative Physiologist judgment. Reason from the Krogh principle and oxygen cascade through intermittent-flow respirometry, SMR/BMR/MMR scope, Q10 and heterothermy, hemoglobin P50, allometry and PGLS, while treating chamber drift, activity artifacts, phylogenetic pseudoreplication, and SMR definition mismatch as first-class failure modes.

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Think and work like an expert Ecosystem Ecologist. Use when a task calls for Ecosystem Ecologist judgment. Reasons from NEE/NEP mass balance, ecological stoichiometry, and u*-filtered eddy covariance; processes with ONEFlux/REddyProc, NEON DP4.00200, and CENTURY/DayCent while treating gap-fill partitioning artifacts, chamber pressure pulses, harvest omission, and footprint shifts as first-class failure modes.

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Think and work like an expert Cell Biologist. Use when a task calls for Cell Biologist judgment. Reasons from compartment thermodynamics, membrane electrophysics, and necessity-plus-sufficiency logic through STR authentication, confocal/TIRF imaging, CRISPR and siRNA perturbation with rescue, and Western blot, treating mycoplasma, passage and serum-lot drift, edge effects, antibody cross-reactivity, siRNA seed off-targets, and well-as-n pseudoreplication as first-class failure modes.

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Think and work like an expert Climatologist. Use when a task calls for Climatologist judgment. Characterizes climate via WMO CLINO baselines (1991–2020 vs 1961–1990), ETCCDI indices, and teleconnection modes; bridges ERA5 climatology to CMIP6/ScenarioMIP SSP deltas (xsdba/QDM), optimal-fingerprint attribution, AR6 ERF/ECS/TCR, and proxy reconstructions (CPS/EIV, PAGES2k, MXD divergence)—distinct from weather forecasting and generic physical-climate narration.

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Think and work like an expert Cancer Biologist. Use when a task calls for Cancer Biologist judgment. Reasons from hallmark capabilities, clonal evolution, and TME context; separates driver from passenger, cell-autonomous from stromal mechanisms, and 2D artifacts from PDO/PDX-validated dependencies using TCGA, DepMap, OncoKB, and REMARK-grade biomarker logic.

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Think and work like an expert Clinical Epidemiologist. Use when a task calls for Clinical Epidemiologist judgment. Clinical epidemiology expert for causal study design, observational bias control, GRADE/EBM synthesis, and principled reporting (CONSORT/STROBE/PRISMA).

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Think and work like an expert Chemical Biologist. Use when a task calls for Chemical Biologist judgment. Reasons from chemical genetics, ABPP/TPP/CETSA chemoproteomics, and SGC/Portal probe criteria; deconvolves phenotypic hits with PAINS/aggregator triage, inactive analogs, and genetic epistasis while treating colloidal aggregation, probe promiscuity, and degrader DC50/Dmax tag artifacts as first-class failure modes.

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Think and work like an expert Clinical Pharmacologist. Use when a task calls for Clinical Pharmacologist judgment. Reasons from exposure–response, popPK (NONMEM), DDI (ICH M12), TDM/NTI windows, and renal/hepatic/allometric adjustment; aligns dose finding with ICH E4 and FDA clinical pharmacology labeling.

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Think and work like an expert Agricultural Entomologist. Use when a task calls for Agricultural Entomologist judgment. Reasons from pest population dynamics, economic injury levels and thresholds, and degree-day phenology through systematic scouting, IRAC mode-of-action rotation, RCBD efficacy trials, and conservation biocontrol while treating misidentification, secondary pest flares from enemy removal, resistance under repeated MoA, and trap-catch-without-field-verification as first-class failure modes.

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Think and work like an expert Bacteriologist. Use when a task calls for Bacteriologist judgment. Reasons from bacterial growth physiology, selective culture, Gram stain, MALDI-TOF and 16S/WGS identification, EUCAST/CLSI AST, BSL containment, contamination and VBNC, using BacDive and BV-BRC for strain metadata and pathogen genomics.

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Think and work like an expert Astrobiologist. Use when a task calls for Astrobiologist judgment. Reasons from habitability, redox disequilibrium, and Bayesian biosignature frameworks through Mars (Perseverance, Viking perchlorate lessons), Europa Clipper ocean worlds, agnostic signatures and the Ladder of Life Detection, while treating abiotic mimics, preservation, and LUCA phylogenomics as constraints—not templates—for extraterrestrial life.

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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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Assists with managing versioning and changelogs in JavaScript/TypeScript monorepos using Changesets. Use when automating semantic versioning, generating changelogs from PRs, coordinating multi-package releases, or publishing to npm. Trigger words: changesets, versioning, changelog, npm publish, monorepo release, semver.

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Design and implement high-quality blog post and article page layouts with professional typography, spacing, and visual hierarchy. Use when building blog pages, article templates, technical documentation readers, use-case pages, or long-form content layouts. Covers dark and light themes.

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The craft of communicating technical concepts clearly to developers. Developer communications isn't marketing—it's about building trust through transparency, accuracy, and genuine utility. The best devrel content helps developers solve real problems. This skill covers technical documentation, developer tutorials, API references, changelog writing, developer blog posts, and developer community engagement. Great developer communications treats developers as peers, not leads to convert. Use when "documentation, docs, tutorial, getting started, API reference, changelog, release notes, developer guide, devrel, developer relations, code examples, SDK docs, README, documentation, devrel, tutorials, api-docs, developer-experience, technical-writing, getting-started, changelogs" mentioned.

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The craft of creating and maintaining cohesive brand identity systems. Branding translates brand strategy into tangible visual and verbal identity—logos, color systems, typography, imagery, and voice guidelines that work together to make a brand recognizable and memorable. This skill covers logo design, visual identity systems, brand guidelines, naming, verbal identity, and brand application across touchpoints. Great branding is invisible when done right—it feels inevitable, as if the brand couldn't have looked any other way. Use when "logo, branding, brand identity, brand guidelines, visual identity, color palette, typography, brand book, naming, rebrand, brand refresh, brand system, branding, identity, logo, visual-design, guidelines, naming, typography, color" mentioned.

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App Store Changelog workflow skill. Use this skill when the user needs Generate user-facing App Store release notes from git history since the last tag and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

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Monitor blogs and RSS/Atom feeds for updates using the blogwatcher CLI.

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Optimize existing blog posts and web content for GEO (Generative Engine Optimization) — AI search visibility on ChatGPT, Perplexity, Claude, and Google AI Overviews. Use whenever a user provides a blog URL or pastes existing content and asks to optimize it for AI search, rewrite for LLM visibility, improve GEO score, make content answer-first, add FAQ sections, restructure headings for AI retrieval, improve citation potential, or audit content for AI readiness. Also triggers on "GEO optimize this", "make this AI-search ready", "rewrite for Perplexity", "optimize for ChatGPT", "optimize for Google AI Overviews", "improve AI visibility", "reformat for AI search", "make this content citation-worthy", "content isn't showing up in AI search", "why isn't my blog cited by AI", "GEO audit", "answer-first rewrite", "restructure for AI", "make my blog AI-friendly", "improve LLM citability". Do NOT trigger for writing new content from scratch — use geo-content for that.

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Generate editorial calendars for blogs with topic clusters, publishing schedules, content decay detection, freshness update plans, seasonal opportunities, content mix formula, template integration, and distribution scheduling. Plans monthly or quarterly calendars optimized for SEO topic authority and AI citation freshness requirements (30-day update cycles). Use when user says "editorial calendar", "content calendar", "blog calendar", "publishing schedule", "blog plan", "content plan", "what should I write".

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Repurpose blog posts for social media, email, YouTube, Reddit, and LinkedIn. Generates Twitter/X threads, LinkedIn articles, YouTube scripts, Reddit discussion posts, email newsletter excerpts. Adapts tone for each platform. Use when user says "repurpose", "blog repurpose", "share blog", "social media", "twitter thread", "linkedin post", "youtube script", "reddit post".

日本語の概要は準備中です。原文の説明を表示しています。