「firm」の検索結果

First-time Archcore setup. Wires the host (MCP config, hooks, CLAUDE.md/AGENTS.md managed block), measures the authored context the repo already holds, then composes a first-day seed — stack rule, run guide, data-model, integrations, config, entry points, public surface, a linked architecture overview, and specs for the top hotspot modules — shown in ONE preview and created on a single confirm. Modes, named as the first word: init import converts the repo's authored context — CLAUDE.md, AGENTS.md, .cursor/rules and other agent instructions, ADR and RFC folders, contributor docs, internal pages of a published docs site, recoverable git history — into native typed documents with no import marks, staged by a plan when the volume is large; init refresh adds facts that appeared since, or drills into one domain with init refresh <domain>. Use on a fresh clone, empty `.archcore/`, 'set up archcore', 'migrate our CLAUDE.md to archcore', 'import our docs and ADRs', or to wire host configs. Not for individual docs or planning.

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Initialize KERNEL links and AgentDB in a confirmed Vaults directory.

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Set a repo up to prove engineering-task work actually works before it ships. Investigates the repo, ensures a one-command dev stack (`dev-local`) exists, asks whether verification runs locally or in a sandbox (crabbox), confirms/installs the driver (the `playwright-cli` skill for web by default). Outputs three artifacts: a committed `/verify` skill (per-task verification SOP — spawn a verifier sub-agent → drive the app → screenshot/video proof → open a PR with the proof embedded), the `/dev-local` skill + script, and the installed driver skill. Use when someone says "set up verification", "make this repo verifiable", "scaffold a verify skill", "set up the verifier".

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Scan a Kotlin or Compose Multiplatform diff for known footgun shapes and open the matching trap to confirm each hit. Use before committing, when reviewing a Kotlin change, or to audit a codebase.

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ALWAYS invoke this skill when you need the user to act - run a command, paste a secret, click, approve - and whenever they ask how to do something or say they do not know what to do: "step by step", "walk me through it", "what do I do", "what should I do", "I don't understand what to do", "explain what I need to do", in any language. Picking which task comes next is os-whats-next; this skill is for doing the thing in front of you. First earn the ask: try it yourself, find another route, shrink it to the part only they can do. Then one action per step, commands labelled by what they touch, no jargon. Commands are single lines that prompt for any value - typing hidden for secrets - and confirm in plain words. Afterwards verify their step.

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Use as the entry point for any Agricultural Systems (AgSy) manuscript. Routes to the right AgSy sub-skill based on where you are in the lifecycle and which article type (research paper, short communication, perspective, comment, review) fits. AgSy is a systems-science journal, so the router's first job is to confirm there is a real systems question — interactions, hierarchical levels, trade-offs — not a single-factor field trial. It dispatches; it does not draft content.

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Use when drafting the ACM MM (ACM Multimedia) rebuttal — turning multiple anonymous reviews into one focused, anonymous response that fixes factual errors first, adds small confirmatory cross-modal results, concedes calibratedly, and stays inside policy (anonymous, no new external links), written for the area chair who decides.

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Use when stress-testing the LOGIC of an Academy of Management Review (AMR) theory manuscript — checking logical coherence, running thought experiments and counterfactuals, addressing alternative explanations and disconfirming cases, and verifying each proposition follows from its argument. This is ARGUMENT DEVELOPMENT, NOT data analysis; AMR publishes no datasets, no statistics, and no empirical results.

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Mandatory pre-publish review gate for a UGC video render. Transcribes the finished render's AUDIO with Whisper and word-diffs it against the approved spoken script, then gates pinning the final render (video_project_upsert patch.final_render_id) — blocking a render whose generated audio mis-voices a word (e.g. the approved "human-vetted" spoken as "human witted"), says a different number or brand name, flips a negation, drops an approved phrase, or comes back silent. Correct speech written differently ("5mg" said "five milligrams", "30%" said "thirty percent", a spoken URL, "don't" said "do not", "braxleybands" said "braxley bands", a confirmed pronunciation like "AG1" said "A G one") passes. Runnable, gating counterpart to content-goose's review-transcript-integrity atom. Every ugc-video-formats recipe runs this after render and BEFORE pinning the final render.

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Verify phone numbers using SMS one-time codes via the Didit API. Use when you need to confirm a user owns a phone number, implement SMS-based 2FA, or validate phone during signup/onboarding flows.

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Prepare for investor calls by pulling upcoming meetings from Google Calendar, deeply researching each investor and their firm (website scraping, portfolio analysis, thesis extraction), checking for competitor conflicts, and outputting an honest prep sheet with compatibility assessments. Use when asked to prep for investor meetings, fundraising calls, VC meetings, or demo day.

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Render the logo-equation card ad (7s, 9:16) — partner icon + brand icon joined by a plus sign as an equation, a two-line "= outcome" headline, four numbered steps, and a CTA that hard-cuts in at 2s, on a static black card over timelapse b-roll, no voice. render_card.py draws the two card plates with measured geometry and hard guardrails (the user must confirm the integration is real, no partnership/endorsement/ranking words, no comment-bait CTA, no dashes); compose.py lays the card over the b-roll sped up to read as a timelapse, with an optional bed; measure_motion.py gates the b-roll (a real-time shot reads as a photo). Free, local.

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Use when a Simulink model is incompatible with Simulink Design Verifier (sldvcompat returns false, or an SLDV analysis errors out on an unsupported construct) and needs to be made analyzable. Diagnoses the incompatibility, applies the matching fix to a copy, and confirms the copy is compatible; optionally raises confidence the fix preserved behavior via a back-to-back consistency replay (agreement on the generated tests, not a proof of equivalence). Do NOT use for running test generation, design error detection, or requirement verification themselves — only for making a model compatible so those can proceed.

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Optimizes Simulink models for Embedded Coder generated code. Use when asked to optimize or improve generated code, or reduce code metrics for a Simulink model. Targets: execution time, memory footprint (RAM, ROM, stack, data copies), code size, MISRA compliance, or any semantically similar generated-code metric. Works iteratively — measures baseline, suggests changes, applies, and re-measures to confirm improvement. Triggers can be prompts similar to: optimize generated code runtime, reduce runtime, shrink code size, improve code efficiency, reduce memory usage, speed up generated code, follow MISRA compliance and so on. CAUTION: Do NOT attempt to optimize Simulink models for generated code efficiency without following this skill — the iterative measurement, gating, and rollback workflow is essential for safe optimization.

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Configure Simulink models for Embedded Coder (ERT), Simulink Coder (GRT rapid-prototyping), or AUTOSAR code generation. Use when the user asks to generate embedded C or C++ code, run a full build of a model, produce a code generation report, configure a model for production/ECU deployment or rapid-prototyping code, target ARM or x86 hardware, apply MISRA C/C++ compliance (ERT/AUTOSAR only — Simulink Coder does not ship MISRA profiles), or set up GRT, ERT, AUTOSAR, or shared-library targets. Handles target selection, hardware mapping, model hierarchy propagation, and constraint introspection via the configure_for_codegen function. Do NOT use for GRT shared-library variants (grt_malloc.tlc), DDS, or ROS, or for iterative optimization workflows that measure baseline metrics, apply targeted changes, and re-measure to confirm improvement.

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Interactive cell annotation and image QC for IMC/MIBI using napari, napari-imc, Mantis Viewer, and cytomapper, covering the pixels-to-cell-table bridge, overlaying masks to catch segmentation/spillover artifacts, inter-annotator variability as the accuracy ceiling, contrast-as-threshold, and building class-balanced ground-truth label sets. Use when manually labeling cells, generating training data for a classifier, QC-ing segmentation on the image, confirming clusters are spatially real, or choosing an annotation viewer.

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Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.

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Transfers gene annotations between genome assemblies via coordinate liftover (UCSC liftOver, CrossMap for same-species version updates) or feature/sequence projection (Liftoff for same/close species, miniprot for protein-level cross-species, TOGA/GeMoMa/CAT for distant clades). Covers the coordinate-vs-projection decision by divergence, why a successful lift is not biological confirmation, reference bias, the silent-dropping of unmapped features, build/PAR/MHC/inversion hazards, and transfer-vs-de-novo validation. Use when annotating a new assembly of a species with an existing reference, harmonizing coordinates across builds, or mapping annotations across related species.

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Calls m6A peaks from MeRIP-seq / m6A-seq paired IP-vs-input data using exomePeak2 (transcript-aware, GC-bias-corrected Poisson GLM), MeTPeak (HMM over sliding windows), MACS3/MACS2 with --nomodel --broad --keep-dup all (genome-wide broad alternative), and DRACH motif enrichment via HOMER or ggseqlogo as a sanity check (NOT a filter). Covers BED12 vs narrowPeak output, exonic vs intronic peak handling, multi-tool reconciliation (intersection vs union), the m6A-vs-m6Am ambiguity at 5'UTR peaks that antibody methods cannot resolve, and orthogonal validation (miCLIP/GLORI/m6A-SAC-seq/m6Anet). Use when calling peaks from paired IP/input genome BAMs, choosing exomePeak2 (transcript-aware default) vs MACS3 (broad genomic) vs MeTPeak (HMM-smoothed low-coverage), confirming DRACH enrichment as a sanity check on the peak set, reconciling differing peak sets across tools, validating MeRIP peaks against single-base methods, interpreting 5' peaks where m6Am contamination is possible, or recommending a consensus strategy.

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Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.

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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

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Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

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Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).

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Trim PCR primers from aligned reads in amplicon-panel BAMs using samtools ampliconclip. Use when processing SARS-CoV-2 ARTIC, hereditary cancer panels, ctDNA hot-spot panels, or any amplicon assay where primer-derived bases would falsely confirm reference at primer footprints.

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