「elo」の検索結果

Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.

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Align protein structures using Foldseek 3Di, TM-align, US-align, DALI, or Foldmason for structural MSA. Predict, score, and superpose backbone coordinates when sequence identity is below the twilight zone or remote-homology detection is required. Use when sequence MSA fails (<25% identity), when the dark proteome is the target, when AlphaFoldDB / ESM Atlas search is needed, or when structural superposition is the goal.

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Use this skill when the user asks the cost of pulling a Motor Vehicle Record (MVR) in a specific state, or wants to compare MVR fees across multiple states, or is budgeting annual compliance costs for a multi-state fleet. Reference the canonical fee table below; flag that fees change (re-verify with state DMV before annual budget planning).

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Use this skill to develop the capability to investigate crashes internally. Covers what to look for, when to escalate to outside experts, and documentation standards.

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Use this skill when the user asks how to recruit CDL drivers — sourcing channels (CDL schools, job boards, military, returning citizens, owner-operator pools), application + screening process, signing bonus structures, recruitment marketing, fleet ambassador programs, and what's working in the current driver market. Reference ATA Workforce Development.

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Use this skill when the user asks about FMCSA financial assistance + grants — Motor Carrier Safety Assistance Program (MCSAP), High Priority Grants, CMV Operator Apprenticeship Program (CMV-DAP), workforce development funding, hazmat preparedness grants, small carrier financial relief, and state-level grants for trucking infrastructure. Reference fmcsa.dot.gov/grants.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about CDL driver wellness, retention strategies, what causes driver turnover, common health issues (obesity, hypertension, sleep apnea, mental health), benefits packages, home-time policies, and how to build a culture that keeps drivers. Reference ATA Workforce Development + FMCSA Wellness Initiative.

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Use when a carrier asks about autonomous trucks — current state of Level 4 development, major programs (Aurora, Kodiak, Plus, Waymo Via, Embark history), regulatory status, operational implications, hub-to-hub model, driver impact, insurance, and what carriers should be doing now (or not doing) to prepare.

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Analyze development-set disagreements between human annotations and one Coval text LLM judge, then propose a focused prompt revision. Use coval-calibrate-metric for independent trust measurements.

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Validate one Coval judge against independent human labels, with grouped development/test separation, class-specific errors and uncertainty. Use for trust claims or calibration; without real labels, prepare review rather than inventing ground truth.

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Maps intelligence for local SEO: geo-grid rank tracking, GBP profile auditing via API, review intelligence across Google/Tripadvisor/Trustpilot, cross-platform NAP verification, competitor radius mapping, and LocalBusiness schema generation. Three tiers: free (Overpass + Geoapify), DataForSEO, and DataForSEO + Google. Use when user says "maps", "geo-grid", "rank tracking", "GBP audit", "review velocity", "competitor radius", or "SoLV".

日本語の概要は準備中です。原文の説明を表示しています。

Recipe for creating or changing a floating window panel. Use when adding a window, editing a window component, adding persistence, onCollectData, or ephemeral mode, wiring the Tools grid, or a window fails to restore after reload. NOT for WindowPanel drag/resize/tray internals (use window-panels).

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The Platform List: Arman's own register of large platform-level work he chose not to start yet. Use when the reminder hook says a row is due, when Arman says to add, snooze, kill, or finish a row, when you own a row, or when you think something belongs there. NOT for ordinary tasks, defects, or handoffs.

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Follow-up sweep for pending third-party provider access campaigns. Use when the recurring 30-minute Provider Access Launch dispatcher wakes, or for a manual status check of due email threads, developer portals, support cases, or review deadlines.

日本語の概要は準備中です。原文の説明を表示しています。

Working playbook preloaded into the researcher helper; the coach updates its Lessons after each round. Use only when acting as researcher or coaching it. NOT for general research tasks.

日本語の概要は準備中です。原文の説明を表示しています。

Working playbook preloaded into the reviewer helper; the coach updates its Lessons after each round. Use only when acting as reviewer or coaching it. NOT for writing a verifier brief (use subagent-dispatch).

日本語の概要は準備中です。原文の説明を表示しています。

Relocating a live, still-used table to another Postgres schema with every reference intact. Use when asked to move or rehome a table into a schema, or to pull a table out of public into a domain schema. NOT for retiring a table (use db-deprecate-table).

日本語の概要は準備中です。原文の説明を表示しています。

Working playbook preloaded into the browser-tester helper; the coach updates its Lessons after each round. Use only when acting as browser-tester or coaching it. NOT for general UI work (use matrx-frontend's browser-testing doc).

日本語の概要は準備中です。原文の説明を表示しています。

Retiring a dead table by moving it to the deprecated schema and clearing every reference in both repos. Use when asked to deprecate or retire a table, when a table is no longer used, or to take a table offline without dropping it. NOT for relocating a still-used table (use db-move-table-schema).

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Locate CCSPlayer_MovementServices::Pawn in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the local gamedata entry "CCSPlayer_MovementServices::Pawn" (symbol CCSPlayer_MovementServices_Pawn). This is a STRUCT MEMBER OFFSET (schema netvar), not a function. Resolve the CCSPlayer_MovementServices class layout via the schema/network system; the member must satisfy natural alignment. Cross-check with functions that dereference the member. Do not switch output schema: emit the structmember fields below even if the class turns out to be polymorphic - a func_*/vfunc_* payload for this symbol is rejected by canonical_symbol_yaml_bytes. Trigger: CCSPlayer_MovementServices_Pawn, CCSPlayer_MovementServices::Pawn

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Find and identify the CCSPlayer_ItemServices_DropActivePlayerWeapon virtual function in CS2 binary using IDA Pro MCP. Use this skill when reverse engineering CS2 server.dll or libserver.so to locate the "drop the currently held weapon" vfunc by RTTI-walking the CCSPlayer_ItemServices vtable and confirming the candidate reads the player's active weapon and forwards it, with a computed toss velocity, into the weapon's own drop vfunc. Trigger: CCSPlayer_ItemServices_DropActivePlayerWeapon

日本語の概要は準備中です。原文の説明を表示しています。

Locate CCSBot::Profile in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the local gamedata entry "CCSBot::Profile" (symbol CCSBot_Profile). This is a STRUCT MEMBER OFFSET (schema netvar), not a function. Resolve the CCSBot class layout via the schema/network system; the member must satisfy natural alignment. Cross-check with functions that dereference the member. Do not switch output schema: emit the structmember fields below even if the class turns out to be polymorphic - a func_*/vfunc_* payload for this symbol is rejected by canonical_symbol_yaml_bytes. Trigger: CCSBot_Profile, CCSBot::Profile

日本語の概要は準備中です。原文の説明を表示しています。