「uis」の検索結果

Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

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Infer orthologous genes and gene families across species using OrthoFinder3 (HOG-based phylogenetic orthology), SonicParanoid2, Broccoli, ProteinOrtho, OMA / FastOMA hierarchical orthologous groups, eggNOG-mapper, JustOrthologs, and TOGA whole-genome-alignment orthology. Use when building single-copy ortholog sets for phylogenomics, classifying co-orthologs and in/out-paralogs after gene duplication, propagating functional annotation via orthology with awareness of the ortholog conjecture, distinguishing speciation from duplication via gene-tree species-tree reconciliation, computing Quest-for-Orthologs benchmark performance, or running synteny-aware ortholog detection in WGD-affected lineages.

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Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.

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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

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Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.

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Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

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Identify direct miRNA-target interactions from AGO HITS-CLIP, AGO-CLEAR-CLIP (chimeric reads), HEAP (Halo-Ago2 mouse), chimeric eCLIP / miR-eCLIP (deep miRNA-target profiling), or CLASH using chimeric-read processing pipelines, seed-pairing analysis, and 3' auxiliary pairing rules. Use when distinguishing direct miRNA targets from indirect, integrating CLIP-derived target maps with TargetScan / miRDB / DIANA predictions, applying canonical 7mer-8mer seed matching with 3' UTR context, or recovering miRNA-mRNA chimeras at scale.

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Migrate Rust TUIs from ratatui (or cursive, Python textual) to SuperLightTUI v0.20. Use when porting an existing TUI codebase to SLT, or when the user asks "how do I do X from ratatui in SLT". Korean triggers "ratatui 마이그레이션", "SLT로 포팅", "이걸 SLT로".

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Migrate Rust TUIs from ratatui (or cursive, Python textual) to SuperLightTUI v0.23. Use when porting an existing TUI codebase to SLT, or when the user asks "how do I do X from ratatui in SLT". Korean triggers "ratatui 마이그레이션", "SLT로 포팅", "이걸 SLT로".

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Use when the user needs a professional marketer's operating mindset for any marketing, growth, or client-acquisition task — finding first customers, writing an ad or landing page, designing ad creatives and visuals (how the eye works: background, scene, hero, movement), evaluating an idea, deciding whether to do X to get Y, positioning or launching a B2B or SaaS product, running cold outreach, setting up ads, or writing copy — not a tactical template.

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Generate beautiful, distinctive HTML/CSS/JS control panels for MATLAB uihtml components. 8 built-in styles (Clean, Material, Cosmic Dark, Neumorphic Dark, Dashboard Light, Midnight Gradient, Minimal Mono, Warm Dark) plus custom aesthetics. Produces production-grade UI with sliders, buttons, toggles, and panels. Use when building visually polished MATLAB app UIs with uihtml.

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Use when an instructor asks for a setup guide, adoption guide, planning guide, implementation checklist, prerequisite check, MATLAB Course Designer course structure plan, Common Cartridge workflow, Simulink starter and solution model planning, LMS import plan, or starter prompt for creating a MATLAB and Simulink enabled course with the matlab-generate-course skill.

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Wire dependency-cruiser into a TypeScript repo so each package is a deep module, with implementation hidden in subfolders and reachable only through its entry-point files. User-invoked.

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Review and upgrade MetaX model support against a target vLLM revision and installed MACA components, recursively including model-dependent attention and kernels. Establish quantization and cache differences, preserve upstream structure, and distinguish shared upstream bugs from adaptation defects. Use for model support work, not standalone monkey-patch or registry audits.

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Establish the shared environment, source/runtime correspondence, target confirmation and validation evidence for MetaX vLLM upgrades. Use as the common prerequisite of the patch, attention, registry and model upgrade skills, or for an explicitly requested MetaX environment preflight; it does not perform domain-specific adaptations.

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Turn a vague bug report into a VERIFIED minimal reproduction and then a failing regression test, agent-driven end to end. Covers extracting the implicit repro from a thin report (env, build, steps, data), the reproduce-minimize-isolate-capture loop, git bisect to find the introducing commit, building a deterministic minimal repro (fixed seeds, frozen time, stubbed network), writing the failing regression test BEFORE the fix (red) and confirming the fix flips it green, and writing repro evidence back into the ticket. Distinguishes flaky-not-reproducible from environment-specific. Use when: "reproduce this bug," "minimal reproduction," "repro steps," "find the commit that broke it," "git bisect," "make the repro deterministic," "write a failing test for this bug," "regression test for a defect," "can't reproduce this bug." Not for: Classifying/deduplicating/severity-routing existing failures without reproducing them — that is ai-bug-triage. Generating tests from specs rather than from a defect — that is ai-test-generation. Related: ai-bug-triage, ai-test-generation, test-reliability, systematic-debugging, qa-project-context.

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Measure and improve test coverage meaningfully. Covers Istanbul/V8/coverage.py configuration, coverage gap analysis by risk, coverage-as-ratchet in CI (never let it decrease), PR coverage diff checks, mutation testing for assertion quality, and distinguishing meaningful from vanity coverage. Use when: "code coverage," "coverage gap," "Istanbul," "coverage threshold," "coverage report," "branch coverage." Not for: writing the tests that raise coverage — use unit-testing; coverage as a tracked KPI trend over time — use qa-metrics. Related: unit-testing, ci-cd-integration, qa-metrics, ai-qa-review.

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Run the TMDb integration tests against the live TMDb API (the Integration test plan; requires TMDB_API_KEY/USERNAME/PASSWORD). Use before a PR, or after model/fixture changes, to validate against real API responses — delegates to the tooling-runner agent (Haiku) and returns counts + failures, distinguishing genuine failures from transient live-API/env issues. For mocked unit tests, use /test.

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Elixir is a functional language on the Erlang VM (BEAM) for concurrent, fault-tolerant and distributed systems. Use when someone asks to "write Elixir", "build a Phoenix app", "Phoenix LiveView", "GenServer", "supervision tree", "Ecto schema or changeset", "mix project", or needs lightweight processes, "let it crash" reliability and real-time web UIs.

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Style terminal output with Chalk. Use when adding colors to CLI output, formatting log messages, building styled terminal UIs, or creating developer tools with colored output.

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Optimize paid advertising campaigns across Google Ads, Meta, TikTok, LinkedIn, and other platforms. Use when tasks involve bid optimization, audience targeting, creative testing, ROAS improvement, attribution modeling, budget allocation, campaign structure, retargeting strategies, lookalike audiences, or reducing customer acquisition cost. Covers multi-platform campaign management and creative performance analysis.

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Core marketing principles for startups. Covers positioning, messaging, channels, and growth. Focus on what works for resource-constrained teams. Battle scars included: I've watched startups burn $1M on Instagram ads because "that's where competitors are", seen "growth hacks" destroy brand trust overnight, and advised founders who scaled marketing before finding product-market fit. Contrarian take: Most startup marketing advice is backwards. The best marketing doesn't feel like marketing. Distribution comes before product features. And your first 100 customers should never come from paid ads. Use when "marketing strategy, positioning, messaging, customer acquisition, growth channels, brand, go-to-market, " mentioned.

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Expert in designing and optimizing growth loops - self-reinforcing systems where the output of one cycle becomes the input for the next. Covers viral loops, content loops, paid loops, sales loops, and product loops. Knows how to identify, measure, and accelerate the specific loop mechanics that drive sustainable growth. Use when "growth loop, viral loop, content loop, flywheel, compounding growth, acquisition loop, referral loop, " mentioned.

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Acquisition is expensive. Retention is profitable. Customer success is the discipline of ensuring customers achieve their desired outcomes with your product - which leads to retention, expansion, and advocacy. This skill covers onboarding that activates, health scoring that predicts, retention plays that save, and expansion strategies that grow accounts. Use when "keywords, file_patterns, contexts, " mentioned.

日本語の概要は準備中です。原文の説明を表示しています。