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現在のブランチからPull Requestを作成する。生成物の混入チェック、コミット、push、gh pr createまでを実行。「PRを作って」「プルリク出して」と言われたら使う。

Plan a resignation and the move to a new employer: check the intended notice date, last working day, and start date against the notice period the employer's own rules require, count the weekdays left against remaining paid leave, and work through the checklist of handover, documents to receive, items to return, and the insurance, pension, and residual tax steps that a gap between jobs creates. Use when a user has accepted an offer and needs to work out when and how to resign, or wants to know what to confirm before giving notice; do not use to rule on whether they can legally leave, to judge a non-compete clause, to promise the departure will go smoothly, or to notify anyone.

日本語の概要は準備中です。原文の説明を表示しています。

Turn vague preferences about employers into criteria that can actually be used to choose between them: for each one, what would have to be seen to confirm it, whether it comes from firsthand experience or from an untested assumption, whether it is a must, a nice-to-have, or something to avoid, and which pairs of criteria pull against each other while both being treated as required, then test the set against real candidates. Use when a new graduate is working out what to select employers on, when someone who has decided to move needs criteria for where to apply, or when a stated axis like "a place I can grow" needs to be made checkable; do not use to recommend an industry, job, or employer, to score or rank candidates, or to judge someone's stated preferences.

日本語の概要は準備中です。原文の説明を表示しています。

Reply to an applicant for an employer's Otameshi Tenshoku listing: match the application against the listed requirements item by item on what the applicant actually stated, list the questions still open, and draft an invitation, a request for clarification, a hold notice or a decline that sticks to the listed conditions, keeps other applicants and internal notes out, and presents any new work or dates as a proposal rather than an agreed term. Use when a hiring manager, recruiter or small-business owner has applications to answer, wants to know what to ask before inviting, or has to decline; do not use to judge an applicant's aptitude or predict hiring outcomes, to screen on personal attributes unrelated to the work, to design the work (trial-work-design) or the listing (trial-listing-draft), or to send the message or update applicant records on the user's behalf.

日本語の概要は準備中です。原文の説明を表示しています。

Re-analyze an existing GitHub Issue using its current title and body, refresh the implementation plan against the latest code state, and update the Issue in place. Use when the user provides an Issue number (numeric, `#`-prefixed, or Issue URL) and wants to regenerate the code analysis via the explore-agent subagent. For reflecting comment-driven updates, use update-issue. For creating a brand-new Issue from a natural-language task description, use create-issue.

日本語の概要は準備中です。原文の説明を表示しています。

Create an implementation plan and a GitHub Issue based on the task description provided as an argument. Use this when the user supplies a natural-language task description (not an issue number) and wants a new implementation-ready Issue. If the input is an existing issue number, use create-issue-from-issue-number (re-analyze) or update-issue (reflect comments) instead.

日本語の概要は準備中です。原文の説明を表示しています。

Annotates bacterial and archaeal genomes (isolates, MAGs, plasmids) with Bakta (active versioned databases, NCBI-compliant output) or Prokka (legacy), producing GFF3/GenBank/EMBL/FASTA with INSDC locus tags. Covers Bakta-vs-Prokka-vs-PGAP-vs-DFAST choice, light-vs-full database tiers, translation-table selection (11/4/25), archaeal and leaderless-gene caveats, the small-ORF blind spot, pseudogene-vs-phase-variation, the pangenome re-annotation trap, and submission compliance. Use when annotating a newly assembled prokaryotic genome, choosing an annotation tool, re-annotating a collection for pangenomics, or preparing annotations for NCBI/DDBJ submission.

日本語の概要は準備中です。原文の説明を表示しています。

Predicts protein-coding gene structures (exons, introns, UTRs) in eukaryotic genomes with BRAKER3 (RNA-seq + protein evidence), BRAKER1/BRAKER2, GALBA (protein-only), Funannotate (fungi), GeMoMa (homology projection), or Helixer/Tiberius (deep-learning ab initio). Covers the evidence-first tool decision, mandatory soft-masking, the training-set-quality-dominates principle, OrthoDB clade-partition selection, the one-isoform-per-locus and missing-UTR traps, merge/split errors, and reference bias against orphan genes. Use when annotating a newly assembled eukaryotic genome, choosing a gene-prediction pipeline based on available evidence, or diagnosing a poor annotation.

日本語の概要は準備中です。原文の説明を表示しています。

Transfers gene annotations between genome assemblies via coordinate liftover (UCSC liftOver, CrossMap for same-species version updates) or feature/sequence projection (Liftoff for same/close species, miniprot for protein-level cross-species, TOGA/GeMoMa/CAT for distant clades). Covers the coordinate-vs-projection decision by divergence, why a successful lift is not biological confirmation, reference bias, the silent-dropping of unmapped features, build/PAR/MHC/inversion hazards, and transfer-vs-de-novo validation. Use when annotating a new assembly of a species with an existing reference, harmonizing coordinates across builds, or mapping annotations across related species.

日本語の概要は準備中です。原文の説明を表示しています。

Query UniProt's REST API (post-2022 endpoint at rest.uniprot.org) for protein sequences, annotations, GO terms, cross-references, ID mappings, and proteomes. Use when fetching UniProtKB entries, navigating the JSON schema, choosing between UniProtKB/UniRef/UniParc/Proteomes resources, deciding stream vs search endpoint for batch retrieval, running ID-mapping jobs with the async pattern, handling isoform suffixes, or filtering reviewed Swiss-Prot vs auto-annotated TrEMBL. Encodes the legacy URL migration (2022), the new JSON schema layout, and bulk-pull patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

日本語の概要は準備中です。原文の説明を表示しています。

Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

日本語の概要は準備中です。原文の説明を表示しています。

Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.

日本語の概要は準備中です。原文の説明を表示しています。

Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2025 Nat Genet; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.

日本語の概要は準備中です。原文の説明を表示しています。

Builds reusable Convex components with isolated tables and app-facing APIs. Use for new components, reusable backend modules, integrations, or component boundary work.

日本語の概要は準備中です。原文の説明を表示しています。

Create Convex queries, mutations, and actions with proper validation, authentication, and error handling. Use when implementing new API endpoints.

日本語の概要は準備中です。原文の説明を表示しています。

Creates or adds Convex to an app. Use for new Convex projects, npm create convex@latest, frontend setup, env vars, or the first npx convex dev run.

日本語の概要は準備中です。原文の説明を表示しています。

Designs and improves onboarding flows, empty states, and first-run experiences to help users reach value quickly. Use when the user mentions onboarding, first-time users, empty states, activation, getting started, or new user flows.

日本語の概要は準備中です。原文の説明を表示しています。

Read this skill before the first step that uses Claude in Chrome, the browser extension whose tools are named mcp__claude-in-chrome__* (also called Chrome, the browser extension, or the external browser) and which acts in the person's real Chrome with their own sign-ins; before those tools are turned on there may be a single enable__mcp__claude-in-chrome tool instead. It covers loading the tools in one ToolSearch call, checking the person's open tabs and working in a new tab, site permissions, GIF recordings, console logs, dialogs to avoid, and when to stop and ask. It is not for the built-in browser (mcp__Claude_Browser__* or mcp__remote-devices__Claude_Browser__* tools), which has its own skill, and it does not decide which browser to use.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill any time a spreadsheet file is the primary input or output. This means any task where the user wants to: open, read, edit, or fix an existing .xlsx, .xlsm, .xltx, .csv, or .tsv file (e.g., adding columns, computing formulas, formatting, charting, cleaning messy data); create a new spreadsheet from scratch or from other data sources; or convert between tabular file formats. Trigger especially when the user references a spreadsheet file by name or path — even casually (like "the xlsx in my downloads") — and wants something done to it or produced from it. Also trigger for cleaning or restructuring messy tabular data files (malformed rows, misplaced headers, junk data) into proper spreadsheets. The deliverable must be a spreadsheet file. Do NOT trigger when the primary deliverable is a Word document, HTML report, standalone Python script, database pipeline, or Google Sheets API integration, even if tabular data is involved.

日本語の概要は準備中です。原文の説明を表示しています。

Find root cause of errors, crashes, regressions, failing tests before any fix. Not for code review or new features.

日本語の概要は準備中です。原文の説明を表示しています。

Create new skills, modify and improve existing skills, and measure skill performance. Use when users want to create a skill from scratch, edit, or optimize an existing skill, run evals to test a skill, benchmark skill performance with variance analysis, or optimize a skill's description for better triggering accuracy.

日本語の概要は準備中です。原文の説明を表示しています。

Read this before the first Google Drive, Docs, Sheets or Slides connector call whenever the task creates or changes a Google file. Use this skill whenever the user wants to create or change a Google Doc, Sheet or Slides file in their Google Drive. Triggers include: a request that names Google Docs, Sheets, Slides or Drive and asks to make, edit, format, copy or rename a file; a docs.google.com link with a request to change that file, even a one-line fix or suggested edits; and any follow-up change to a Google file from earlier in the chat, even "change it" or "add a tab". Includes helper scripts for document positions, cell ranges and slide layout. However, if the user asks for a doc, deck or spreadsheet without naming Google, or gives a Google file only as source material for something new, use Claude's own output type instead. Do NOT use for read-only questions about a Google file, or for Word, Excel, PowerPoint or PDF files.

日本語の概要は準備中です。原文の説明を表示しています。

Sync the current machine's configuration into the dotfiles repo and update the React showcase page. Use this skill whenever the user says "sync dotfiles", "update dotfiles", "sync config", "actualizar dotfiles", "sincronizar config", "update the repo with my current setup", or anything about pulling their current machine state into the dotfiles repo. Also trigger when the user mentions updating the toolkit page, adding new tools to the page, syncing Claude Code or Codex config (AGENTS.md, codex agents/skills/hooks), or keeping the dotfiles repo in sync with what's actually installed.

日本語の概要は準備中です。原文の説明を表示しています。