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Design MVPs, validated learning experiments, and pivot-or-persevere decisions using Build-Measure-Learn. Use when the user mentions "MVP scope", "validated learning", "pivot or persevere", "vanity metrics", "test assumptions", "innovation accounting", "build-measure-learn", "minimum viable experiment", "should we pivot", "test a business idea cheaply", or "build the smallest version first". Also trigger when deciding what to include in a first version, measuring startup progress, or evaluating whether to change direction on a product bet. Covers innovation accounting and actionable metrics. For 5-day prototype testing, see design-sprint. For customer motivation analysis, see jobs-to-be-done.

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Build lean, opinionated products using the 37signals philosophy from "Getting Real", "Rework", and "Shape Up". Use when the user mentions "Getting Real", "Rework", "Shape Up", "37signals", "Basecamp method", "six-week cycles", "fixed time variable scope", "appetite vs estimates", "betting table", "breadboarding", "fat marker sketch", "build less", "underdo the competition", "opinionated software", "we have too many meetings", "how do we ship faster", or "stop overbuilding". Also trigger when cutting scope to ship sooner, running a small team, or avoiding long-term roadmaps. Covers shaping, betting, building, and the art of saying no. For MVP validation, see lean-startup. For design sprints, see design-sprint.

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Turns rough intent or a weak prompt into a reliable one — diagnosing why output is inconsistent, restructuring the instruction, and adapting it across models. Use this when a prompt is not producing what was wanted, when output varies run to run, when writing a prompt for a repeated task, when moving a prompt between models, or when someone describes what they want an AI to do and needs it written properly.

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Keeps production assets available — ranking equipment by consequence of failure, setting preventive and predictive intervals, sizing spares, and moving a plant off reactive maintenance. Use this to build or fix a maintenance program, decide what to put on a PM schedule, diagnose repeat failures on one asset, justify spares inventory, or work out why a plant that maintains everything still has unplanned downtime.

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Manages the flow of goods and inputs — sourcing, inventory, lead times, fulfillment, and supply risk. Use this to reduce stockouts or excess inventory, plan for a supplier failure, decide reorder points and safety stock, improve fulfillment reliability, or assess concentration risk in a supply base.

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Negotiates a commercial deal without giving away the terms that matter — preparing your walk-away and theirs, trading concessions rather than conceding them, recognizing the tactics that create false urgency, protecting price by moving other variables, and closing on terms someone can actually deliver. Use this to prepare for a negotiation, respond to a demand mid-deal, work out why discounts keep landing at quarter end, or review terms before they are signed.

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Designs, documents, and fixes operational processes — mapping the current state, finding where work actually stalls, redesigning the flow, and building controls that hold. Use this when the same failure keeps recurring, when a handoff between teams is unreliable, when onboarding a repeated task, when work takes far longer than the work itself, or when deciding whether to automate, standardize, or eliminate a process.

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Builds and operates data pipelines — ingestion, transformation, orchestration, quality testing, and reliability of data delivery. Use this to design or debug a pipeline, decide batch versus streaming, add data quality checks, handle late or duplicate data, or work out why a dashboard's numbers changed without anyone changing the dashboard.

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Establishes ownership, definitions, quality, access, and lineage for the organization's data. Use this when metrics disagree between teams, when nobody knows which dataset is authoritative, when setting up data ownership or access policy, when data quality is unreliable, or before opening a dataset to a wider audience.

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Builds large sets of search-targeted pages from a template and a dataset — the location, comparison, integration, and use-case pages that capture long-tail demand at scale. Use this when there is a repeating query pattern with real volume, when a dataset could answer many similar searches, or to judge whether a programmatic approach is viable before building it.

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Control desktop software (GIMP, Blender, LibreOffice, etc.) through CLI-Anything generated command-line interfaces. Calls real application backends — much more reliable than GUI automation via desktop_* tools.

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Analyzes the feasibility of a proposed Meta-analysis topic by searching for existing Meta-analyses and Clinical Trials on PubMed/ClinicalTrials.gov. Use when you need to evaluate if a topic is viable for a new Meta-analysis.

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Process CRISPR screening data to identify essential genes and hit candidates. Performs quality control, statistical analysis (RRA), and hit calling for pooled CRISPR screens including viability screens and drug resistance/sensitivity studies.

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Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease. Use when testing whether a molecular...

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Use Biopython to read/write/convert biological sequence files (FASTA/GenBank/FASTQ, etc.) and perform basic sequence operations; use when you need reliable sequence I/O, lightweight sequence manipulation, or scalable processing of large sequence datasets.

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1. Confirm the user objective, required inputs, and non-negotiable constraints before doing detailed work. 2. Validate that the request matches the documented scope and stop early if the task would require unsupported as.

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Generate standardized figure legends for scientific figures and charts; use when preparing publication-ready legends that summarize design, variables, sample size, and key statistical notes.

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Generates complete Mendelian randomization study designs from a user-provided exposure and outcome direction. Always use this skill whenever a user wants to design, plan, or build a Mendelian randomization study — even if phrased as "help me write a paper on X", "design an MR study for Y", or "I want to test whether A causally affects B using GWAS". Covers core two-sample MR design, optional bidirectional follow-up, optional multivariable MR, IV selection logic, ancestry alignment, harmonization, IVW as the default primary estimator, weighted median / MR-Egger / MR-PRESSO / leave-one-out sensitivity analyses, Steiger directionality, heterogeneity / pleiotropy checks, and explicit claim-boundary control. Always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, stepwise workflow, method rationale, validation ladder, figure plan, minimal executable version, and strictly verified literature guidance with no fabricated references.

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Designs a structured real-world evidence study using EHR, claims, or registry data, with explicit handling of time zero, eligibility windows, exposure definitions, outcome windows, censoring, confounding control, and target-trial-emulation logic. Use this skill when the user needs study-type design and protocol framing for an observational clinical study based on routine-care data. Do not invent database fields, follow-up completeness, linkage, coding validity, or causal identifiability.

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Generates complete two-sample Mendelian randomization research designs from a user-provided outcome, exposure or exposure family, and robustness direction. Use when a study centers on summary-statistics causal inference with instrument selection, harmonization, IVW-primary estimation, complementary estimators, sensitivity analyses, optional multivariable upgrades, and conservative evidence interpretation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Designs retrospective or prospective clinical cohort study protocols for biomedical and clinical research. Always use this skill when the user needs a cohort-based study plan rather than a general study idea, evidence summary, or mechanistic experiment design. Focus on cohort appropriateness, enrollment logic, baseline time-zero definition, follow-up structure, endpoint definition, variable collection, confounding control, and a coherent primary statistical analysis line. Do not invent data availability, follow-up completeness, outcome ascertainment quality, sample size adequacy, or causal interpretability.

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Generates complete NHANES-style cross-sectional epidemiology + retrospective clinical validation research designs from a user-provided disease and biomarker direction. Always use this skill whenever a user wants to design, plan, or build a population-level biomarker association study using NHANES or similar survey datasets, especially when the article logic includes disease definition, biomarker formula derivation, multivariable logistic regression, restricted cubic spline analysis, subgroup stability testing, and a secondary hospital-based retrospective validation cohort. Covers five study patterns (cross-sectional association, dose-response / RCS, subgroup-stability, NHANES + retrospective validation, preliminary screening-performance) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...

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Designs a realistic, execution-aware biomedical study version under explicit constraints of samples, time, budget, data access, lab capacity, team skill, and validation resources. Always use this skill when the user has a real study idea, a candidate route, or a partially framed project but cannot assume ideal conditions. If critical feasibility inputs are missing, first clarify what resources are currently available, what resources may be obtainable, and what resources are realistically unavailable. Do not invent access, capabilities, collaborations, or validation resources. Focus first on feasibility-constrained study framing, route narrowing, dependency control, and minimum viable study design.

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Collects candidate biomedical literature across multiple databases, adapts search logic by database, preserves source metadata, and organizes results into a structured, screening-ready candidate pool. Always use this skill when a user wants cross-database literature collection, search strategy construction, candidate paper aggregation, or first-pass evidence organization before deduplication, screening, layered reading, or review planning. Requires real and verifiable literature records only. Every formal literature item must include a real link and DOI when available; never fabricate citations, titles, authors, years, journals, abstracts, PMIDs, or DOIs. If a DOI is unavailable or cannot be verified, state that explicitly rather than inventing one.

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