「xp」の検索結果

End-to-end bulk time-course analysis from an expression matrix to temporal gene modules and per-cluster pathway enrichment. Orchestrates temporal DE (limma splines or DESeq2 LRT), Mfuzz/tslearn soft clustering of expression-profile shapes, GAM trajectory fitting, per-cluster GO enrichment against a temporal-gene background, and an OPTIONAL circadian rhythm-detection branch (MetaCycle/CosinorPy) that runs only when the design covers >=2 full cycles with >=6-8 evenly spaced samples per cycle. Use when analyzing a bulk time-series expression experiment from any omics platform and deciding limma-splines vs DESeq2-LRT for temporal DE, soft vs hard clustering, whether the sampling design even licenses rhythm detection, and which background to use for enrichment. Not for single-cell pseudotime (see temporal-genomics/trajectory-modeling for the bulk-vs-pseudotime boundary) or unknown-period discovery (see temporal-genomics/periodicity-detection).

日本語の概要は準備中です。原文の説明を表示しています。

Model interpretability and explainability using SHAP (SHapley Additive exPlanations). Use this skill when explaining machine learning model predictions, computing feature importance, generating SHAP plots (waterfall, beeswarm, bar, scatter, force, heatmap), debugging models, analyzing model bias or fairness, comparing models, or implementing explainable AI. Works with tree-based models (XGBoost, LightGBM, Random Forest), deep learning (TensorFlow, PyTorch), linear models, and any black-box model.

日本語の概要は準備中です。原文の説明を表示しています。

Inngest イベント駆動 Durable Execution プラットフォームリファレンス。 サーバーレス環境での長時間ワークフロー、バックグラウンドジョブ、スケジュールタスク実装。 createFunction, step.run, step.sleep, step.sleepUntil, step.waitForEvent, step.waitForSignal, step.invoke, step.sendEvent, step.fetch, step.ai.infer, step.ai.wrap, inngest.send, serve, connect。 concurrency, throttle, debounce, rate-limit, batching, priority, idempotency, singleton フロー制御。 Realtime（channels, topics, publish, subscribe, useRealtime, subscription tokens）による進捗配信。 Agent Evals, scoring, group.experiment, MCP dev server などエージェント運用機能。 Next.js / Express / Hono / Cloudflare Workers / Vercel / Netlify / DigitalOcean / Render デプロイ対応。

Better Auth (TypeScript 認証フレームワーク) リファレンス。 認証・認可、サインアップ・サインイン、セッション管理、OAuth、パスキー、 二要素認証 (TOTP)、プラグイン (organization, admin, magic-link, anonymous 等)。 betterAuth, createAuthClient, signUp, signIn, getSession。 フレームワーク統合 (Next.js, Nuxt, SvelteKit, Hono, Express, Expo, TanStack 等)。

Rory Sutherland's 'psycho-logic' approach to marketing, product, and business problems — solve the human perception, not just the engineering or economic metric. Use when the obvious 'logical' fix is expensive, slow, or already done by every competitor; when the user asks 'how do we make people want X', 'the product/price/funnel is fine but nobody converts', 'how do we stand out', 'is there a cheaper way to fix this', or mentions behavioral economics, nudges, irrational behavior, perception, or 'it doesn't make sense but it works'. This is the ROUTER skill: it diagnoses the problem in human terms, then dispatches to reframing, costly-signaling, counterintuitive-tests, or experience-design. Inspired by Rory Sutherland's book *Alchemy*. 日本語の相談（「商品はいいのに売れない」「値下げしかない？」「競合と差別化できない」）にも使う。中文咨询（“产品很好却卖不动”“只能降价吗？”“无法差异化”）也适用。For a catalogue of individual biases, use marketing-psychology (separate plugin) instead.

Assemble a Japanese shokumu-keirekisho (career history document) from an experience inventory, choosing between reverse-chronological, chronological, and skills-based layouts, mapping the target posting's requirements to the experiences that can support them, and drafting the summary, work history, skills, and self-PR so that each sentence stays within what its evidence supports and confidential details are abstracted. Use when a user wants to write or rebuild a whole shokumu-keirekisho for a specific posting or as a general version, or wants to decide which experiences to include and in what order; do not use to invent experience, numbers, titles, or qualifications, to predict whether it will pass screening, to fill in a rirekisho form, or to submit it anywhere.

日本語の概要は準備中です。原文の説明を表示しています。

Scan Gmail (default: today's inbox), produce an anonymized summary with action points, then export each email to Linear as an issue with a sensible priority. No personal details — names, email addresses, or company identifiers — ever leave the summary or reach Linear. Use when the user types /gmail-linear-exports, or asks to turn their inbox into Linear issues / export emails to Linear.

日本語の概要は準備中です。原文の説明を表示しています。

Infer gene regulatory networks from bulk or general expression data with mutual-information (ARACNe) and tree-ensemble (GENIE3, GRNBoost2) methods, and infer transcription-factor protein activity from regulons with VIPER and msVIPER. Covers the activity-not-edges paradigm, the undirected-association caveat, the DREAM5 wisdom-of-crowds and method-complementarity result, AUPRC-over-AUROC evaluation, and gold-standard incompleteness. Use when inferring a regulatory network from a bulk expression matrix, finding master regulators, or scoring TF activity from a signature. For single-cell motif-pruned regulons see scenic-regulons; for co-expression modules see coexpression-networks.

日本語の概要は準備中です。原文の説明を表示しています。

Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural splines, maSigPro (Nueda 2014 for RNA-seq), ImpulseDE2 with explicit impulse-model failure modes, DREAM for repeated measures via linear mixed models, pseudoreplication avoidance, conditional vs marginal modeling, and trajectory clustering with DPGP, Mfuzz (with Schwämmle 2010 fuzzifier estimation), and splines+k-means. Use when modeling time-course or longitudinal expression, choosing factor vs spline, handling repeated measures from the same subject, avoiding pseudoreplication, clustering temporal trajectories, or selecting between dedicated time-course tools and pairwise+LRT.

日本語の概要は準備中です。原文の説明を表示しています。

Query and download from NCBI Gene Expression Omnibus (GEO) and EMBL-EBI's BioStudies/ArrayExpress mirror. Use when finding expression datasets, navigating SuperSeries vs SubSeries, choosing between series-matrix (submitter-normalized) and raw supplementary files, downloading via GEOparse (Python) or GEOquery (R/Bioconductor), linking GEO to SRA for raw reads, or distinguishing GSE/GSM/GPL/GDS record types. Encodes the SuperSeries trap, the series-matrix normalization-trust caveat, GEOmetadb deprecation, ArrayExpress migration to BioStudies, and processed-vs-raw decision matrix.

日本語の概要は準備中です。原文の説明を表示しています。

Expert in building 3D experiences for the web - Three.js, React Three Fiber, Spline, WebGL, and interactive 3D scenes. Covers product configurators, 3D portfolios, immersive websites, and bringing depth to web experiences.

日本語の概要は準備中です。原文の説明を表示しています。

Create a delightful, unexpected "wow" experience for the user by dynamically discovering and creatively combining other enabled skills. Triggers when the user says "surprise me" or any request expressing a desire for an unexpected creative showcase. Also triggers when the user is bored, wants inspiration, or asks for "something interesting".

日本語の概要は準備中です。原文の説明を表示しています。

Exporta peças aprovadas do Figma e monta o pacote de entrega — arquivos nomeados, legendas, texto alternativo e instruções de publicação. Use quando o usuário disser "exportar", "baixar as peças", "pacote final", "entregar para publicação", "handoff", "mandar para o social". Só exporta o que passou na revisão.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user wants a PRD exported — 'exportar o PRD', 'gerar o prd.json', 'criar issue com o PRD', 'export PRD to GitHub' — as canonical JSON or as a single GitHub issue. Do NOT use to publish a roadmap with many issues (prd-publish).

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to optimize post-signup onboarding, user activation, first-run experience, or time-to-value. Also use when the user mentions "onboarding flow," "activation rate," "user activation," "first-run experience," "empty states," "onboarding checklist," "aha moment," "new user experience," "users aren't activating," "nobody completes setup," "low activation rate," "users sign up but don't use the product," "time to value," or "first session experience." Use this whenever users are signing up but not sticking around. For signup/registration optimization, see signup-flow-cro. For ongoing email sequences, see email-sequence.

日本語の概要は準備中です。原文の説明を表示しています。

Guide for creating and writing Expo native modules and views using the Expo Modules API (Swift, Kotlin, TypeScript). Covers module definition DSL, native views, shared objects, config plugins, lifecycle hooks, autolinking, and type system. Use when building or modifying native modules for Expo.

日本語の概要は準備中です。原文の説明を表示しています。

Create a delightful, unexpected "wow" experience for the user by dynamically discovering and creatively combining other enabled skills. Triggers when the user says "surprise me" or any request expressing a desire for an unexpected creative showcase. Also triggers when the user is bored, wants inspiration, or asks for "something interesting".

日本語の概要は準備中です。原文の説明を表示しています。

Infer gene regulatory networks from bulk or general expression data with mutual-information (ARACNe) and tree-ensemble (GENIE3, GRNBoost2) methods, and infer transcription-factor protein activity from regulons with VIPER and msVIPER. Covers the activity-not-edges paradigm, the undirected-association caveat, the DREAM5 wisdom-of-crowds and method-complementarity result, AUPRC-over-AUROC evaluation, and gold-standard incompleteness. Use when inferring a regulatory network from a bulk expression matrix, finding master regulators, or scoring TF activity from a signature. For single-cell motif-pruned regulons see scenic-regulons; for co-expression modules see coexpression-networks.

日本語の概要は準備中です。原文の説明を表示しています。

Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural splines, maSigPro (Nueda 2014 for RNA-seq), ImpulseDE2 with explicit impulse-model failure modes, DREAM for repeated measures via linear mixed models, pseudoreplication avoidance, conditional vs marginal modeling, and trajectory clustering with DPGP, Mfuzz (with Schwämmle 2010 fuzzifier estimation), and splines+k-means. Use when modeling time-course or longitudinal expression, choosing factor vs spline, handling repeated measures from the same subject, avoiding pseudoreplication, clustering temporal trajectories, or selecting between dedicated time-course tools and pairwise+LRT.

日本語の概要は準備中です。原文の説明を表示しています。

Query and download from NCBI Gene Expression Omnibus (GEO) and EMBL-EBI's BioStudies/ArrayExpress mirror. Use when finding expression datasets, navigating SuperSeries vs SubSeries, choosing between series-matrix (submitter-normalized) and raw supplementary files, downloading via GEOparse (Python) or GEOquery (R/Bioconductor), linking GEO to SRA for raw reads, or distinguishing GSE/GSM/GPL/GDS record types. Encodes the SuperSeries trap, the series-matrix normalization-trust caveat, GEOmetadb deprecation, ArrayExpress migration to BioStudies, and processed-vs-raw decision matrix.

日本語の概要は準備中です。原文の説明を表示しています。

Expert landscape designer transforming yards through photo mapping, 3D visualization, seasonal planning, and deep plant knowledge. Specializes in fast-growing privacy screens (knows arborvitae pitfalls), architecture-appropriate design, outdoor living spaces, and realistic maintenance expectations. Activate on "landscape design", "yard design", "garden planning", "plant selection", "privacy screen", "outdoor living", "backyard makeover", "arborvitae", "hedge", "fast growing tree", "landscaping ideas". NOT for interior design (use interior-design-expert), hardscape construction (consult contractors), or lawn care chemicals (consult local experts).

日本語の概要は準備中です。原文の説明を表示しています。

Expert in temporal event detection, spatio-temporal clustering (ST-DBSCAN), and photo context understanding. Use for detecting photo events, clustering by time/location, shareability prediction, place recognition, event significance scoring, and life event detection. Activate on 'event detection', 'temporal clustering', 'ST-DBSCAN', 'spatio-temporal', 'shareability prediction', 'place recognition', 'life events', 'photo events', 'temporal diversity'. NOT for individual photo aesthetic quality (use photo-composition-critic), color palette analysis (use color-theory-palette-harmony-expert), face recognition implementation (use photo-content-recognition-curation-expert), or basic EXIF timestamp extraction.

日本語の概要は準備中です。原文の説明を表示しています。