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概要と使いどころ
End-to-end leadership change signal composite. Takes any set of companies, detects recent leadership changes (new VP+, C-suite hires and promotions), evaluates relevance to your product, and drafts personalized outreach. Uses Apollo People Search (free) for fast detection + Apollo Enrichment (1 credit/person) for employment history, start dates, LinkedIn URLs, and verified emails.
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End-to-end champion/buyer/user job change signal composite. Takes a set of known people (past buyers, champions, power users), detects when they move to a new company, researches the new company for ICP fit, and drafts personalized outreach leveraging the existing relationship. Tool-agnostic — works with any people source, detection method, and outreach platform.
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Build a prospect list of companies with decision makers, verified contact info, and hiring/intent signals. Use when asked to find leads by industry, build an account list with specific titles, prospect companies that are actively hiring, or create a targeted outreach list filtered by company size, location, and hiring activity.
日本語の概要は準備中です。原文の説明を表示しています。
Search for job postings across LinkedIn and Indeed. Use when users want to find open roles, monitor hiring signals, identify companies hiring for specific positions, or research competitor hiring activity. Returns job title, company, location, salary, description, seniority level, and direct apply URLs. No login or cookies required.
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Take raw customer inputs — interview transcripts, survey responses, Slack quotes, support tickets, review excerpts — and generate a structured case study draft with problem/solution/result narrative, pull-quotes, metric callouts, and multi-format outputs (full case study, one-pager, social proof snippet, sales deck slide). Pure reasoning skill. Use when a product marketing team has customer signal but no time to write the story.
日本語の概要は準備中です。原文の説明を表示しています。
Scrapes LinkedIn job postings using the JobSpy library (python-jobspy). Use this skill whenever the user wants to find jobs on LinkedIn, search for open roles, pull job listings, build a job pipeline, source job targets for GTM research, or monitor hiring signals. Even if the user just says "find me some jobs" or "what roles is [company] hiring for", use this skill. It runs a local Python script that outputs a CSV of job postings with title, company, location, salary, job type, description, and direct URLs.
日本語の概要は準備中です。原文の説明を表示しています。
Daily industry intelligence scanner. Scans web, social media, news, blogs, and communities for industry-relevant events, trends, and signals. Produces a comprehensive intelligence briefing plus strategic GTM opportunity ideas. Orchestrates existing scraping skills — does not reimplement data collection.
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Reverse-engineer a company's sales and marketing tech stack from public signals. Detects CRMs, cold email tools, people databases, ad pixels, email delivery services, and outbound sending domains via DNS records, website source inspection, Apify technology profiling, blacklist checks, and public spam complaint searches. Works on single companies or batches. Outputs a structured markdown report per company.
日本語の概要は準備中です。原文の説明を表示しています。
Comprehensive GTM analysis of any target company. Researches what a company is currently doing across all go-to-market dimensions — content/blog, founder LinkedIn activity, SEO/traffic, hiring signals, social/community presence, customer acquisition channels, podcast appearances, review sites, competitive positioning, and partnerships. Produces a structured report identifying what's working, what's missing, and where white space exists for new strategies. Use before designing GTM strategies for a client or prospect.
日本語の概要は準備中です。原文の説明を表示しています。
Specify algorithms for Model-Based Design: system specs, architecture specs, implementation plans, test plans. Use when creating specifications for controllers, signal processing, diagnostics, estimators, or other algorithms authored in Simulink, Stateflow, System Composer, or MATLAB Function blocks.
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Configures Simulink simulations non-destructively using SimulationInput objects — parameter overrides without modifying the model, batch sweeps via parsim, custom input signals via Dataset, and simulation data retrieval via logsout. Use when running sim()/parsim() with setVariable, setBlockParameter, setExternalInput, or when performing parameter sweeps and multi-run analysis. Not needed for one-shot simulations without configuration.
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Building or editing Simulink (.slx) models that stream signals in frames using DSP System Toolbox — audio, vibration, radar, comms. Use when the prompt names a Simulink block (Discrete FIR Filter, Buffer, Unbuffer, Rate Transition, Downsample, Upsample, Sample-Rate Converter, FIR Decimation, Time Scope, Spectrum Analyzer, From Multimedia File) or an action (frame-based processing, InputProcessing, buffering, overlap, windowing, STFT, short-time Fourier, decimate, downsample, upsample, resample, multirate, anti-aliasing, tunable filter). Prevents silent numerical errors from sample-vs-frame mismatch, wrong block choice, or missing anti-aliasing.
日本語の概要は準備中です。原文の説明を表示しています。
Author or upgrade Model Advisor checks for Simulink and System Composer models. Covers the full lifecycle: guideline authoring, check specification, Model Advisor check implementation, and qualification testing. Use when creating new checks (edit-time, standard batch, config-parameter, auto-fix), converting legacy StyleOne/StyleTwo/StyleThree checks to modern DetailStyle, creating a guideline for modeling, enforcing a modeling rule, or testing/qualifying a check. Triggers on any modeling constraint (e.g., "blocks shall...", "signals must match...", "parameters shall be set to...").
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Sanitize and anonymize a Simulink model for external sharing. Use when stripping proprietary content, anonymizing block/signal names, removing metadata, or creating a shareable reproduction model for bug reports. Do NOT use for simply copying or sharing a model internally.
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Detects somatic mutations in circulating tumor DNA, treating low-VAF detection as a signal-versus-noise problem set by error suppression and molecules sampled, not by the choice of caller. Distinguishes de novo CALLING (scanning a panel for unknown variants, bounded by per-locus error and multiple testing) from tumor-informed DETECTION (tracking a pre-specified variant set, where panel integration reaches single-ppm). Covers VarDict and Mutect2 for de novo calling, UMI-aware callers, and a pysam-based known-variant VAF tracker, with matched-WBC subtraction as the mandatory defense against clonal hematopoiesis (the dominant false positive). Use when calling or tracking tumor mutations from plasma cfDNA, setting a VAF threshold, or deciding whether a low-VAF call is tumor versus CHIP.
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Extracts cfDNA fragmentomics features (DELFI genome-wide short/long ratios, WPS nucleosome positioning, Griffin GC-corrected accessibility profiles, end-motifs/MDS, OCF) for cancer detection and tissue-of-origin from plasma WGS. Centers on the nuclease-footprint reframe (every feature re-reads one nucleosome object), the mandatory GC correction, and the cross-protocol non-comparability that breaks naive classifiers. Runs FinaleToolkit (real CLI/Python, MIT) and the Griffin Snakemake pipeline; DELFI is a method, not a package. Use when deriving fragment-based signal from cfDNA, choosing a feature family for detection vs subtyping, or diagnosing why a fragmentomic model failed validation.
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Decides how to preprocess plasma cfDNA sequencing data so the recoverable signal survives - library-prep-aware fragment expectations (dsDNA vs ssDNA/adaptase prep), UMI/duplex consensus with fgbio (ExtractUmisFromBam, GroupReadsByUmi --strategy paired for duplex, CallMolecularConsensusReads vs CallDuplexConsensusReads, FilterConsensusReads min-reads "total s1 s2"), the align->group->consensus->RE-align ordering, and the cfDNA dedup trap where naive coordinate dedup collapses nucleosome-coincident independent molecules. Covers when single-strand consensus suffices vs when duplex is mandatory, the singleton/sensitivity tax at low input, and reading the insert-size histogram as a pre-analytical QC instrument. Use when processing plasma cfDNA reads before fragmentomics, ctDNA mutation calling, or tumor-fraction estimation.
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Basecalls raw Oxford Nanopore signal (POD5/FAST5) into reads with Dorado, choosing the chemistry-matched model and accuracy tier (fast/hac/sup), requesting modified bases (5mCG_5hmCG, 6mA, m6A) at basecall time, and handling duplex, demultiplexing, trimming, and HERRO read correction. Covers why the model+version is an irreversible analysis decision, why methylation cannot be recovered later, and why downstream polish/variant models must match the basecaller. Use when converting POD5/FAST5 to reads, picking a Dorado model for R9/R10 or RNA004, enabling methylation calling, basecalling duplex, demultiplexing barcoded runs, or correcting reads for assembly.
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Decides whether and how to polish a draft genome assembly to raise consensus accuracy (QV) with read-type-matched tools - Racon and medaka (ONT consensus), dorado polish, Polypolish and pypolca (Illumina, repeat-aware), Pilon (legacy short-read), NextPolish/NextPolish2, Hapo-G (haplotype-aware), ntEdit, and DeepPolisher/PEPPER-Margin-DeepVariant for human. Covers the do-not-polish-HiFi rule, the medaka basecaller-model footgun, held-out Merqury QV as the only honest stop signal, and the haplotype-collapse trap. Use when correcting homopolymer indels or residual SNPs in a long-read assembly, deciding if a HiFi assembly needs polishing, or choosing an ONT vs hybrid vs short-read polishing chain.
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Estimates time-scaled phylogenies, molecular-clock rates, effective reproduction number R_e, and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict/relaxed clocks; coalescent, Bayesian-Skyline, Skygrid, Birth-Death-Skyline, and sampled-ancestor priors; structured coalescent via MASCOT). Covers root-to-tip clock QC via TempEst, date-randomisation tests, recombination masking via Gubbins/ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction, multi-chain convergence diagnostics, and reconciling phylodynamic R_e with case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline models, diagnosing temporal-signal failure, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.
日本語の概要は準備中です。原文の説明を表示しています。
Quality control for flow, spectral, and mass cytometry - time-based anomaly cleaning (flowAI, flowCut, PeacoQC, flowClean), margin/boundary event removal, signal-drift detection, dead-cell exclusion, CyTOF Gaussian/DNA/event-length checks, instrument calibration/standardization (MESF, CS&T, peak-2), and batch-level outlier flagging. Use when assessing acquisition quality, choosing a cleaning tool, ordering QC relative to compensation, deciding margin removal before density-based steps, or flagging problematic samples before clustering or differential analysis.
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Assigns GO terms, Pfam/InterPro domains, KEGG orthologs, EC numbers, and product names to predicted proteins using eggNOG-mapper (orthology), InterProScan (domain signatures), and KofamScan (KEGG), routing specialized functions to dbCAN/antiSMASH/AMRFinderPlus/SignalP. Covers the orthology-vs-domain-vs-homology paradigms, the annotation-error percolation cascade, domain-presence-is-not-function, GO IEA circularity in enrichment, evidence tiering, and bit-score/coverage thresholds. Use when adding functional annotation to predicted genes, choosing between eggNOG-mapper and InterProScan, or judging how much to trust a functional label.
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Query protein-protein and gene interaction databases (STRING, BioGRID, IntAct, SIGNOR, Reactome, HuRI, HuMAP, OmniPath, ConsensusPathDB, DIP). Use when building PPI networks, choosing between physical vs functional vs genetic interactions, signed/directed vs undirected, high-throughput vs curated, picking confidence thresholds, aggregating across resources, or navigating license constraints. Encodes the database decision matrix, STRING v12 channel semantics, OmniPath as meta-database, SIGNOR for signed signaling, and per-resource rate limits.
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Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.
日本語の概要は準備中です。原文の説明を表示しています。