「hn」の検索結果

Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

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Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

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Quantifies biodiversity from species abundance/incidence tables using Hill numbers (iNEXT) with coverage-based rarefaction-extrapolation (Chao & Jost 2012), asymptotic richness via Chao1/ACE/jackknife as a lower bound, Baselga turnover/nestedness partition with the Podani alternative as sensitivity check, mandatory Hellinger transformation before ordination (Legendre & Gallagher 2001), Faith PD and SES_MPD/SES_MNTD with explicit null-model choice, and Maire 2015 functional-diversity dimensionality optimization. Use when comparing diversity across sites with unequal sampling effort, picking the right richness estimator for singleton-heavy amplicon data, partitioning beta diversity into turnover vs nestedness, reporting Hill-number effective species counts rather than raw entropies, computing SES_MPD with explicit null-model justification, or deciding whether to apply standard metrics to compositional amplicon data. Not for clinical 16S microbiome diversity (see microbiome/diversity-analysis).

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When the user wants to create step-by-step technical tutorials, quickstarts, or code walkthroughs. Trigger phrases include "tutorial," "quickstart," "getting started guide," "walkthrough," "step by step," "how to guide," "hands-on guide," or "code tutorial."

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Standard operating procedure for producing a documentation page end to end — gather source material, classify, draft against the measured corpus profile, then run the reader-level and humanizer passes and both gates. Use for any page on a documentation surface, or when rewriting a page that reads as machine-written. Orchestrates technical-writing, reader-level and humanizer in a fixed order.

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Write technical documentation that matches the measured profile of professionally-written docs. Carries the craft rules derived from 114k words of pre-2022 documentation (SQLite, PostgreSQL, Python, Django, Rust, Go, Pro Git, nginx), the per-Diátaxis-type numeric targets, and the copywriting register for page leads. Use when drafting or rewriting any documentation prose, or when a page is factually right but reads as machine-written.

日本語の概要は準備中です。原文の説明を表示しています。

Write and maintain technical documentation. Trigger with "write docs for", "document this", "create a README", "write a runbook", "onboarding guide", or when the user needs help with any form of technical writing — API docs, architecture docs, or operational runbooks.

日本語の概要は準備中です。原文の説明を表示しています。

生成AIに日本語の技術文書（書籍の章・記事・解説）を作成・推敲させるときの文章規範を適用するスキル。論理的で誠実な日本語テクニカルライティングを生成し、LLM特有の空虚な言い回し・冗長・過剰演出・AI臭の語彙を抑制する。公開前の採点も可能。Triggers: 日本語技術文書, テクニカルライティング, 技術記事を書いて, 解説文を書いて, 技術文書を推敲, 文章を校正, AIっぽい文章を直す, AI臭を消す, 公開前チェック, write Japanese technical doc, japanese tech writing.

Use when receiving code review feedback, before implementing suggestions, especially if feedback seems unclear or technically questionable - requires technical rigor and verification, not performative agreement or blind implementation

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Provide comprehensive techniques for penetration testing AWS cloud environments. Covers IAM enumeration, privilege escalation, SSRF to metadata endpoint, S3 bucket exploitation, Lambda code extraction, and persistence techniques for red team operations.

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AUTHORIZED USE ONLY: This skill contains dual-use security techniques. Before proceeding with any bypass or analysis: > 1.

日本語の概要は準備中です。原文の説明を表示しています。

Write an Architecture Decision Record (ADR) document for a technical decision. Use when documenting a technical choice, architectural decision, or design decision.

日本語の概要は準備中です。原文の説明を表示しています。

Expert-level battery technology covering electrochemistry, lithium-ion battery physics, battery management systems, degradation mechanisms, and next-generation battery chemistries.

日本語の概要は準備中です。原文の説明を表示しています。

Use when receiving code review feedback, before implementing suggestions, especially if feedback seems unclear or technically questionable - requires technical rigor and verification, not performative agreement or blind implementation

日本語の概要は準備中です。原文の説明を表示しています。

Run technical quality checks across accessibility, performance, theming, responsive design, and anti-patterns. Generates a scored report with P0-P3 severity ratings and actionable plan. Use when the user wants an accessibility check, performance audit, or technical quality review.

日本語の概要は準備中です。原文の説明を表示しています。

Technical SEO audit with GEO-specific checks — crawlability, indexability, security, performance, SSR, and AI crawler access

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Use when verifying a story or ticket implementation against its spec and acceptance criteria - per-AC verdicts with file:line evidence and proving tests, code reuse and design conformance, dead code, stale docs, comment discipline. Finds the spec from an explicit path, the ticket key in the branch name, or plan files - and asks rather than guessing. For defect-hunting code review use dotnet-techne-code-review instead. Keywords: story QA, acceptance criteria, spec conformance, AC coverage, definition of done, dead code check, reuse check, comment check, verify story, QA this branch.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user says "write a spec", "create RFC", "write a PRD", or "document this decision". Writes technical specifications, PRDs, RFCs, and ADRs with clear structure.

日本語の概要は準備中です。原文の説明を表示しています。

Biblioteca do Facebook para busca eficiente de similaridade e clustering de vetores densos. Suporta bilhões de vetores, aceleração GPU e vários tipos de índice (Flat, IVF, HNSW). Use para busca k-NN rápida, recuperação de vetores em larga escala ou quando você precisa de busca pura de similaridade sem metadados. Melhor para aplicações de alto desempenho.

日本語の概要は準備中です。原文の説明を表示しています。

Use when generating a single dense technical architecture, reference poster, or system diagram image for a software project. Produces a source-grounded bitmap diagram with topology, primitives, ingest/process flow, core logic, state scopes, tiers/modules, surfaces, runtime cards, and strict semantic color rules.

日本語の概要は準備中です。原文の説明を表示しています。

Use when receiving code review feedback, before implementing suggestions, especially if feedback seems unclear or technically questionable - requires technical rigor and verification, not performative agreement or blind implementation

日本語の概要は準備中です。原文の説明を表示しています。

Run technical quality checks across accessibility, performance, theming, responsive design, and anti-patterns. Generates a scored report with P0-P3 severity ratings and actionable plan. Use when the user wants an accessibility check, performance audit, or technical quality review.

日本語の概要は準備中です。原文の説明を表示しています。

Run technical quality checks across accessibility, performance, theming, responsive design, and anti-patterns. Generates a scored report with P0-P3 severity ratings and actionable plan. Use when the user wants an accessibility check, performance audit, or technical quality review.

日本語の概要は準備中です。原文の説明を表示しています。

Write and maintain Architecture Decision Records (ADRs) following best practices for technical decision documentation. Use when documenting significant technical decisions, reviewing past architectural choices, or establishing decision processes.

日本語の概要は準備中です。原文の説明を表示しています。