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Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

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Process and generate multimedia content using Google Gemini API. Capabilities include analyze audio files (transcription with timestamps, summarization, speech understanding, music/sound analysis up to 9.5 hours), understand images (captioning, object detection, OCR, visual Q&A, segmentation), process videos (scene detection, Q&A, temporal analysis, YouTube URLs, up to 6 hours), extract from documents (PDF tables, forms, charts, diagrams, multi-page), generate images (text-to-image, editing, composition, refinement). Use when working with audio/video files, analyzing images or screenshots, processing PDF documents, extracting structured data from media, creating images from text prompts, or implementing multimodal AI features. Supports multiple models (Gemini 2.5/2.0) with context windows up to 2M tokens.

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Expert security auditor for AI Skills and Bundles. Performs non-intrusive static analysis to identify malicious patterns, data leaks, system stability risks, and obfuscated payloads across Windows, macOS, Linux/Unix, and Mobile (Android/iOS).

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Run a GitHub issue digest for openai/codex by feature-area labels, all areas, and configurable time windows. Use when asked to summarize recent Codex bug reports or enhancement requests, especially for owner-specific labels such as tui, exec, app, or similar areas.

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When shaping a non-trivial migration — rollout phases, dual-write windows, cutover sequencing, deprecation cycles — hands off to the framework-specific migration skill for DDL once locked.

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Before stating any specific fact about an LLM provider's product — models, pricing, limits, context windows, SDK/API — for OpenAI, Gemini, Claude & others, verify against official docs, not memory.

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Híbrido RNN+Transformer com inferência O(n). Tempo linear, contexto infinito, sem cache KV. Treina como GPT (paralelo), infere como RNN (sequencial). Projeto Linux Foundation AI. Produção em Windows, Office, NeMo. RWKV-7 (março de 2025). Modelos até 14B parâmetros.

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Use the Crabbox wrapper for OpenClaw remote validation across Linux, macOS, Windows, and WSL2, including delegated Blacksmith Testbox proof. Report the actual provider and id.

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Use when building or modifying SwiftUI views, settings windows, menu-bar UIs, or any surface for the KIKA app — or any calm, premium app you want to feel the same way. Encodes the KIKA Design System v2 (June 2026) — a calm, premium, modern dark UI with first-class light mode, inspired by Cursor, Linear, and high-quality dev tools — that you can adopt or adapt for your own app. Apply it to keep color, typography, spacing, and component styling consistent.

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Use when designing or implementing the overall macOS app window shell — titlebar, toolbar, sidebar, content, inspector, window sizing, panels, sheets, and menu bar companion windows.

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Audit or update this Windows computer's fixed third-party Codex helper toolchain when the user requests local helper-tool maintenance. Always show the complete registered list and obtain confirmation for each update group; exclude Codex itself and general runtimes unless explicitly added.

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使用 AACT (Aggregate Analysis of ClinicalTrials.gov) PostgreSQL 数据仓库进行批量、历史、聚合性临床试验数据挖掘。Use this skill when the user requests bulk SQL analysis over the full clinical trials data warehouse — historical trial trends, disease landscapes, similar-design matching, or multi-year aggregations across hundreds of thousands of NCT records. 触发场景包括：AACT 查询、临床试验批量分析、PostgreSQL 试验数据、全量 NCT 检索、试验数据挖掘、历史试验分析、clinical trials data warehouse、SQL trials、bulk trial analysis、disease landscape、试验设计相似性匹配、跨年度聚合、sponsor/phase/country 多维统计。**与 clinical-trials-v2 差异**：本 skill 走批量 SQL · 离线大数据（PostgreSQL）；v2 走实时 API · 单查询。两者互补：单条 NCT 实时状态用 v2，百万级历史挖掘用本 skill。支持云端公共 PostgreSQL（aact-db.ctti-clinicaltrials.org · 零部署）和每日 dump 本地还原（高性能 · 离线）两种连接方式，自动检测优先用本地。跨平台（macOS/Linux/Windows）参数化 SQL 防注入，read-only 强制保护。

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剪映 (JianYing) AI自动化剪辑的高级封装 API (JyWrapper)，提供开箱即用的 Python 接口，支持录屏、素材导入、字幕生成、Web 动效合成及项目导出。全面适配 MacOS (Apple Silicon/Intel) 与 Windows，支持 v5.9+ (draft_info.json) 架构、工程自修复、智能配音字幕及录屏变焦。

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Assess Linux and Windows privilege escalation vectors from existing authorized footholds.

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GStack autoplan method for running a broad CEO, design, engineering, and developer-experience review before opening implementation windows.

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Route CEO-first multi-window work into owner-led role loops. Use for 总控/CEO、架构/CTO、内容主编、角色派发与复用、模型路由、来源窗口回调、role-windows 台账、skill 命中统计或 multi-window loop engineering。

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Use the Crabbox wrapper for OpenClaw remote validation across Linux, macOS, Windows, and WSL2, including delegated Blacksmith Testbox proof. Report the actual provider and id.

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MUST USE when the user needs current, online, or web-derived information — news, latest releases, vendor docs, real-world examples, recent changes, or anything not in the model's training set. LLM-neutral skill that exposes a unified web search CLI behind a single command. Runs single or multi-provider in parallel, saves raw + normalized JSON to a temp directory, prints the path so callers can pipe through rg / jq / grep. Zero-config out of the box. Works identically on macOS, Linux, WSL, Git Bash for Windows, and any environment with Python 3.8+. Triggers: 'search the web', 'look up online', 'google this', 'find current information', 'latest news', 'recent docs', 'check the internet', 'web search', 'browser search', 'research this', 'what is the latest', 'who is X', 'find examples of', 'is there documentation for', 'how do people solve', 'web-search', 'web_search'.

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Expert security auditor for AI Skills and Bundles. Performs non-intrusive static analysis to identify malicious patterns, data leaks, system stability risks, and obfuscated payloads across Windows, macOS, Linux/Unix, and Mobile (Android/iOS).

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This skill should be used when the user asks to "attack Active Directory", "exploit AD", "Kerberoasting", "DCSync", "pass-the-hash", "BloodHound enumeration", "Golden Ticket", "Silver Ticket", "AS-REP roasting", "NTLM relay", or needs guidance on Windows domain penetration testing.

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Detect adversary lateral movement across networks using Splunk SPL queries against Windows authentication logs, SMB traffic, and remote service abuse.

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Detect abuse of legitimate Windows binaries (LOLBins) used for living off the land attacks. Monitors process creation, command-line arguments, and parent-child relationships to identify suspicious LOLBin execution patterns.

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Detect NTLM relay attacks through Windows Security Event correlation by analyzing Event 4624 LogonType 3 for IP-to-hostname mismatches, identifying Responder/LLMNR poisoning artifacts, auditing SMB and LDAP signing enforcement across the domain, and detecting NTLM downgrade attacks from NTLMv2 to NTLMv1 using event log analysis.

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Detect privilege escalation attempts including token manipulation, UAC bypass, unquoted service paths, kernel exploits, and sudo/doas abuse across Windows and Linux.

日本語の概要は準備中です。原文の説明を表示しています。