「eth」の検索結果

Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

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ATAC-seq library quality control -- TSS enrichment, FRiP, fragment-size periodicity, library complexity (NRF/PBC1/PBC2), mitochondrial fraction, and ENCODE 4 thresholds. Use when assessing whether an ATAC-seq library passes ENCODE acceptance criteria, diagnosing transposition artefacts, comparing Omni-ATAC vs standard prep quality, or selecting which replicates to drop before peak calling.

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Use this skill when the user asks how to determine whether a CMV operation is interstate vs intrastate, why it matters (federal vs state rules apply), the "continuation of journey" rule, state-specific intrastate exemptions, and what happens when an intrastate carrier picks up an interstate load. Cite 49 CFR 390.5 + state-specific exemptions.

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Use this skill to evaluate whether to switch from annual MVR pulls to continuous monitoring. Covers cost-benefit, intervention timing, and major providers.

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Use this skill when an inspector requests ELD records during a roadside inspection. Covers the three required transfer methods, what data must be transmitted, and common failure modes.

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Use this skill to understand how IFTA quarterly mileage is calculated. Covers measurement methods, manual vs ELD-derived, and verification.

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Use when a carrier asks whether to buy or lease their next tractor (or trailer), comparing full-service lease (Ryder, Penske, NationaLease), capital lease, finance lease, walk-away open-end lease, or cash purchase. Covers tax treatment, residual risk, maintenance bundling, balance-sheet impact, and cash-flow modeling.

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Use this skill when the user asks how to design or improve a fleet safety scorecard — what KPIs to track, how to weight them, telematics signals vs document compliance vs roadside outcomes, monthly cadence, driver-facing vs admin-facing dashboards, gamification considerations, peer-comparison metrics, and how a scorecard ties to insurance premiums + retention. Reference SMS Methodology v3.20 for industry-standard weights.

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Use this skill when re-hiring a driver who has been away from CMV operation for 1+ years. Covers re-qualification, refresh of medical and MVR, and whether prior employer inquiries restart.

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Use this skill to determine whether you need interstate FMCSA authority or just intrastate state authority. Covers the federal/state divide.

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Use this skill to evaluate whether credit reports are appropriate for driver applicant screening. Covers EEOC guidance, FCRA, and common carrier policies.

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An innate exploratory drive that guarantees no graph node remains permanently invisible to an agent population. After a warm-up period (step > 3), each agent fires a coverage scan with probability |unseen_nodes| / |all_nodes|. When triggered, the agent teleports directly to the globally unseen node with the highest belief uncertainty, works it, and returns control to the normal action-selection loop. Probability is self-annealing: it starts near 1.0 when almost everything is unseen and decays toward 0.0 as coverage saturates, requiring no manual schedule. The mechanism is "innate" (hard-coded into the agent step loop) as distinct from the "adaptive" EFE path, which requires local neighbors and learned precision weights. Together they form a two-layer exploration architecture: adaptive for locally-guided foraging, innate for topological completeness.

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Defensive counterpart to federated-harbor-redteam: closes the smells that red team opens against The Federated Harbor whitepaper. Federation-specific defenses for cross-harbor primitives — mechanization commitments, scope hedges, cross-paper dependency formalization, pre-emptive analogies (CT, Macaroons, atomic swaps), and defense-in-depth framing (refuses vs prices). Use during a versioned red-vs-white round; pairs with federated-harbor-redteam. NOT for ad-hoc code review, NOT for the Anchor or Bonded papers (use whitehat-defense).

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Drafting and iterating sections of The Federated Harbor whitepaper — the third paper in the Curiositech sequence after Anchor (local identity) and Bonded Commons (local coordination), extending coordination across machines and administrative domains. Use when authoring a section, rewriting a section after a redteam/whitehat round, or composing a new chapter. NOT for marketing copy, NOT for the other two papers, NOT for production threat response.

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Structured interview and observation techniques for extracting tacit knowledge from domain experts

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Adversarial reviewer for The Federated Harbor whitepaper — the third paper in the Curiositech sequence after Anchor and Bonded Commons. Probes federation-specific threats: trust transitivity, cross-harbor token forgery, federated revocation under partition, cross-harbor Sybil, cross-domain settlement, equivocation, bond-pool draining, cold-start joining, federation-operator Sybil. Use during a versioned red-vs-white round; pairs with federated-harbor-whitehat. NOT for incident response, NOT for the Anchor or Bonded papers (use redteam-review).

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Create and review Cloudflare Durable Objects. Use when building stateful coordination (chat rooms, multiplayer games, booking systems), implementing RPC methods, SQLite storage, alarms, WebSockets, or reviewing DO code for best practices. Covers Workers integration, wrangler config, and testing with Vitest. Biases towards retrieval from Cloudflare docs over pre-trained knowledge.

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Star schema, snowflake schema, SCD types, and Kimball methodology for analytical data modeling. Activate on: dimensional model, star schema, snowflake schema, SCD, fact table, dimension table, Kimball, grain, surrogate key. NOT for: dbt implementation (use dbt-analytics-engineer), warehouse tuning (use data-warehouse-optimizer).

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Domain-Driven Design methodology using bounded contexts, ubiquitous language, and strategic/tactical patterns

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Digital equity and trauma-informed design for marginalized populations. Activate on "accessibility", "offline-first", "trauma-informed", "reentry", "recovery population", "shared device", "unstable phone", "digital equity", "design justice", "low-literacy", "intermittent access". NOT for general UX, marketing optimization, or enterprise SaaS design.

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Review of Cognitive Systems Engineering applications and current practice in safety-critical domains

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Validates agent outputs against schemas and quality criteria, scores confidence, detects hallucinations, monitors convergence, decides when to iterate, and synthesizes actionable feedback. Use when checking if a node's output is acceptable, scoring confidence, detecting fabricated content, deciding whether to re-execute, or generating improvement feedback. Activate on "validate output", "check quality", "confidence score", "hallucination check", "should we iterate", "improvement feedback". NOT for executing DAGs (use dag-runtime), planning DAGs (use dag-planner), or matching skills (use dag-skills-matcher).

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Analyze undirected cycle structure within a valid DAG using the source paper's orientation and contraction method. Use for cycle-basis analysis with explicit graph and reduction choices. NOT for directed feedback loops, workflow deadlocks, or runtime resilience claims.

日本語の概要は準備中です。原文の説明を表示しています。