1.7万 件 ・ 関連度順
概要と使いどころ
Identify and exploit authentication and session management vulnerabilities in web applications. Broken authentication consistently ranks in the OWASP Top 10 and can lead to account takeover, identity theft, and unauthorized access to sensitive systems.
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Azure Communication Services common utilities for Java. Use when working with CommunicationTokenCredential, user identifiers, token refresh, or shared authentication across ACS services.
日本語の概要は準備中です。原文の説明を表示しています。
Turns Hi-C/Micro-C FASTQ into a deduplicated, filtered .pairs file with pairtools and decides whether the library worked. Covers the bwa mem -SP5M / bwa-mem2 / chromap --preset hic alignment idiom (mates mapped as independent single-end reads), pairtools parse vs parse2 and the walks-policy choice (5unique pairwise vs all for Pore-C/Micro-C concatemers), pair-type classification (keep UU and rescued UC), dedup (PCR vs optical/by-tile), select by pair_type/MAPQ/distance, restriction-fragment handling (restrict, Arima dual-enzyme, Micro-C/DNase fragment-free), and allele-specific phasing (pairtools phase to two coolers). The library-QC decision uses % long-range cis as the one-number quality metric, trans as the noise floor, orientation balance as fragment-map-free dangling-end/self-circle QC, and % duplicates as a complexity proxy. Use when processing Hi-C/Micro-C/Omni-C reads into pairs, judging library quality, handling multi-enzyme or restriction-agnostic protocols, or generating allele-specific contacts.
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Aligns and QCs methylated-RNA-immunoprecipitation (MeRIP / m6A-seq) IP and input libraries using STAR or HISAT2 splice-aware mapping, samtools sort/index, IP/input matched-pair tracking, antibody-lot metadata recording, replicate concordance via deepTools multiBamSummary + plotCorrelation, IP enrichment QC via plotFingerprint and per-transcript IP/input ratio distributions, library-complexity saturation curves via PreSeq c_curve / lc_extrap, and the explicit do-NOT-deduplicate convention for standard non-UMI MeRIP. Use when preparing paired IP and input BAM files for exomePeak2 / MeTPeak / MACS3 peak calling, evaluating MeRIP replicate concordance and IP enrichment, deciding whether to deduplicate (standard MeRIP typically NOT — see Tips), choosing genome-vs-transcriptome alignment for downstream peak vs m6Anet workflows, recording antibody clone and lot metadata for downstream cross-batch reconciliation, detecting failed IPs via saturation curves and IP/input distribution shape, or generating IP-over-Input bigWig tracks for downstream visualisation.
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Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.
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Detects m6A modifications from Oxford Nanopore direct-RNA-sequencing (ONT DRS) signal data using m6Anet (Hendra 2022 *Nat Methods* 19:1590; multiple-instance-learning neural network over DRACH 5-mer signal). Covers the required upstream pipeline (Dorado / Guppy basecalling -> minimap2 transcriptome alignment with `-ax map-ont -uf -k14 --secondary=no` -> nanopolish eventalign with `--scale-events --signal-index` (m6Anet-required) plus `--summary` / `--threads` housekeeping -> m6anet dataprep -> m6anet inference), per-site vs per-read probability interpretation including the `mod_ratio` per-site stoichiometry column, the DRACH-only modeling constraint, minimum-coverage thresholds (20-50 reads per site for stable probability estimates), multi-condition comparison via xPore (Pratanwanich 2021 *Nat Biotechnol* 39:1394), Nanocompore (Leger 2021 *Nat Commun* 12:7198), ELIGOS (Jenjaroenpun 2021 *NAR* 49:e7), and Dorado native modification calling (RNA004 chemistry, 2024+), reference-transcriptome version pinning, the cDNA-vs-DRS chemistry distinction (cDNA-Nanopore CANNOT be used for modification detection), and orthogonal validation against MeRIP / GLORI. Use when calling m6A from ONT DRS without immunoprecipitation, choosing m6Anet vs xPore vs Nanocompore vs ELIGOS vs Dorado native, interpreting per-site `probability_modified` vs `mod_ratio` vs per-read modification probabilities, comparing methylation between conditions from ONT data, deciding between m6Anet for known DRACH sites and Dorado/Remora for genome-wide screening, pinning RNA002 vs RNA004 chemistry and basecaller model versions, or troubleshooting eventalign / dataprep failures.
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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.
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Detect syntenic blocks and structural rearrangements between genomes using MCScanX (Wang 2012), JCVI/MCScan (Tang 2008 Python), GENESPACE (Lovell 2022) for orthology-anchored riparian visualization, SyRI for structural variation, AnchorWave for sequence-level synteny, i-ADHoRe 3.0 for highly diverged species, SynNet for synteny networks, and ntSynt for multi-genome macrosynteny. Use when identifying collinear gene blocks across species, distinguishing macrosynteny from microsynteny, detecting inversions/translocations/duplications, anchoring orthology in WGD lineages, producing publication riparian plots, computing synteny block age via Ks (cross-references whole-genome-duplication), or running synteny-aware ortholog inference in polyploids.
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Use this skill when the user asks about CDL driver medical certification — 49 CFR 391.41-49 medical qualifications, medical examiner's certificate (Long Form 5876 + Short Form 5875), National Registry of Certified Medical Examiners (NRCME), medical restrictions, federal disqualifying conditions, exemption programs (vision, diabetes, hearing), the FMCSA Medical Examiner's Handbook, or what to do when a driver's medical cert is downgraded. Cite specific 49 CFR 391 sections.
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Design bounded applications and workflows for an always-on AI agent with episodic memory. Covers product ideas, persistence-dependent workflows, and constructed examples that make delegation, interruption, evidence, and opt-out explicit. Activate on: "what can an always-on agent do", "persistent agent use cases", "agent applications", "proactive agent ideas", "what to build with episodic memory", "always-on agent product", "personal AI assistant ideas", "/always-on-agent-applications". NOT for: building the architecture (use always-on-agent-architecture), designing inputs (use always-on-agent-inputs), safety and privacy (use always-on-agent-safety).
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Retiring a dead table by moving it to the deprecated schema and clearing every reference in both repos. Use when asked to deprecate or retire a table, when a table is no longer used, or to take a table offline without dropping it. NOT for relocating a still-used table (use db-move-table-schema).
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When the user requests to create or customize an academic personal website from a GitHub template repository. This skill handles the complete workflow of forking academic template repositories (like academicpages.github.io), extracting structured personal information from memory or provided data, and systematically updating configuration files (_config.yml), navigation menus (_data/navigation.yml), content pages (_pages/about.md), and publication listings (_publications/). It specifically handles academic profiles including personal details, education background, research experience, publications, skills, and contact information. Triggers include requests to 'fork and customize academic homepage', 'build personal academic website', 'create research portfolio', or 'set up GitHub pages with academic template'.
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Codified expertise for customs documentation, tariff classification, duty optimization, restricted party screening, and regulatory compliance across multiple jurisdictions. Informed by trade compliance specialists with 15+ years experience. Includes HS classification logic, Incoterms application, FTA utilization, and penalty mitigation. Use when handling customs clearance, tariff classification, trade compliance, import/export documentation, or duty optimization.
日本語の概要は準備中です。原文の説明を表示しています。
Identify and exploit authentication and session management vulnerabilities in web applications. Broken authentication consistently ranks in the OWASP Top 10 and can lead to account takeover, identity theft, and unauthorized access to sensitive systems.
日本語の概要は準備中です。原文の説明を表示しています。
Azure Communication Services common utilities for Java. Use when working with CommunicationTokenCredential, user identifiers, token refresh, or shared authentication across ACS services.
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill whenever the user mentions IP geolocation feeds, RFC 8805, geofeeds, or wants help creating, tuning, validating, or publishing a self-published IP geolocation feed in CSV format. Intended user audience is a network operator, ISP, mobile carrier, cloud provider, hosting company, IXP, or satellite provider asking about IP geolocation accuracy, or geofeed authoring best practices. Helps create, refine, and improve CSV-format IP geolocation feeds with opinionated recommendations beyond RFC 8805 compliance. Do NOT use for private or internal IP address management — applies only to publicly routable IP addresses.
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你的班主任成长教练。2026年3月4日到5月22日，Estelle 用66天完成了从心虚到被学生依赖的全过程。现在她把方法、心法、拆过的墙、哭过的夜、踩过的坑，全部放进这个技能里。 - school-management - teacher-tools - international-school - education-technology
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GPU-accelerated data curation for LLM training. Supports text/image/video/audio. Features fuzzy deduplication (16× faster), quality filtering (30+ heuristics), semantic deduplication, PII redaction, NSFW detection. Scales across GPUs with RAPIDS. Use for preparing high-quality training datasets, cleaning web data, or deduplicating large corpora.
日本語の概要は準備中です。原文の説明を表示しています。
Security hardening and best practices for .NET applications. Navigation skill covering OWASP Top 10, authentication, authorization, cryptography, secrets management, and secure coding. For building secure applications. Keywords: security, owasp, authentication, authorization, cryptography, jwt, oauth, secrets, hardening
日本語の概要は準備中です。原文の説明を表示しています。
Exploit PHP type juggling vulnerabilities caused by loose comparison operators to bypass authentication, circumvent hash verification, and manipulate application logic through type coercion attacks.
日本語の概要は準備中です。原文の説明を表示しています。
Exploit misconfigured Active Directory Certificate Services (AD CS) ESC1 vulnerability to request certificates as high-privileged users and escalate domain privileges during authorized red team assessments.
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Detects and analyzes malicious behavior in mobile applications through behavioral analysis, permission abuse detection, network traffic monitoring, and dynamic instrumentation. Use when analyzing suspicious mobile applications for data exfiltration, command-and-control communication, credential stealing, SMS interception, or other malware indicators. Activates for requests involving mobile malware analysis, app behavior monitoring, trojan detection, or suspicious app investigation.
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A Certificate Authority (CA) is the trust anchor in a PKI hierarchy, responsible for issuing, signing, and revoking digital certificates. This skill covers building a two-tier CA hierarchy (Root CA +
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Single entry point for all AEM 6.5 LTS Replication skills. Covers configuring replication agents, activating/deactivating content, using the Replication API programmatically, and troubleshooting distribution issues for Adobe Experience Manager 6.5 LTS.
日本語の概要は準備中です。原文の説明を表示しています。