「controls」の検索結果

Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.

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Corrects fluorophore spillover (conventional compensation) or spectral overlap (spectral unmixing) and applies variance-stabilizing transforms (logicle/biexponential, arcsinh, log) for flow and mass cytometry. Covers spillover-matrix estimation from single-stain controls, AutoSpill, the spillover spreading matrix and why panel design (not compensation) bounds resolution, compensate-then-transform ordering, and arcsinh cofactor choice (5 for CyTOF, ~150 for fluorescence, per-channel via flowVS). Use when correcting spectral overlap, preparing data for gating/clustering, choosing logicle vs arcsinh, deciding a cofactor, or distinguishing compensation from spectral unmixing.

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Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.

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Assesses a patient’s ability to operate an insulin pump and make setting changes, evaluating dexterity, vision, mental health, and cognition for independent or assisted use. Triggered by phrases such as 'Check patient can manipulate pump controls' and 'Evaluate dexterity and vision for pump use'.

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Design production-grade multi-agent workflows with clear pattern choice (sequential, parallel, hierarchical), handoff contracts, failure handling, and cost/context controls. Use when architecting a multi-step agent pipeline, choosing between single-agent vs multi-agent approaches, or refactoring an LLM workflow that suffers from context bloat or unreliable handoffs.

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当用户想简化公司政策、考虑无限假期、对官僚审批流程感到沮丧、或想建立信任文化时触发。基于Netflix取消管控哲学：用原则替代规则，前端灌输上下文，后端审计。

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Expert-level air quality engineering covering pollutant sources, atmospheric dispersion, air quality standards, emission controls, and air quality modeling.

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Use when writing, debugging, or configuring an omp hook or extension — blocking or rewriting tool calls, redacting tool output, reshaping LLM context, registering tools/commands, or wiring modules through config.yml. Covers ExtensionAPI (current) vs HookAPI (legacy), the event catalog, discovery and load order, and disable controls. Not for Claude Code hooks (~/.claude/settings.json) or the shared harness safety guard (~/.agents/harness/hooks/).

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Adaption AI SDK for synthetic data augmentation and dataset adaptation. Use when building data pipelines with the Adaption Python SDK, uploading datasets (local files, Hugging Face, Kaggle), running augmentation/adaptation jobs, configuring brand controls (hallucination mitigation, safety categories, length), recipe specifications (reasoning traces, deduplication, preference pairs, prompt rephrase), evaluating dataset quality, downloading results, or any workflow involving `pip install adaption`, `from adaption import Adaption`, Adaptive Data, or the adaptionlabs.ai API. Also trigger when the user mentions synthetic data generation for fine-tuning, dataset augmentation pipelines, DPO preference pair generation, or grounding-based hallucination reduction on training data.

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Produce 3+ distinct hi-fi design variations — basic to bold, one file with tweak controls — when the user asks for options, alternatives, "show me a few takes". Extends fe-design.

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Before finishing any code (endpoint, query, migration, render, file, infra, dependency, test) — the senior pre-ship checklist of invisible cross-cutting controls AI omits, with backstop greps

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Use this skill whenever the user wants to create, edit, explain, validate, or troubleshoot a proctmux.yaml/procmux.yaml file, add or change proctmux processes, configure lifecycle behavior such as stop signals/on_kill/autostart, customize unified-mode layout/keybindings/style, or enable Makefile/package.json process discovery. Use it even when the user says this casually, such as "add my dev server to proctmux", "fix this proctmux config", "write a config for these services", or "what YAML option controls focus".

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Load this skill whenever the project must support speech input or voice control — dictation, "click by voice" grammars, Dragon NaturallySpeaking, Voice Control (iOS/macOS), Voice Access (Android), or any interface where users activate controls by speaking. Under no circumstances let an aria-label override a visible label without keeping the visible text intact and in order. Absolutely always ensure the accessible name contains the visible label, and load alongside keyboard/SKILL.md since speech tools commonly emulate keyboard and pointer input.

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Load this skill whenever the project contains static or interactive maps, embedded map widgets (Google Maps, Leaflet, Mapbox, OpenStreetMap), or any geographic visualizations. Under no circumstances embed a map without a text-based alternative conveying the same information. Absolutely always ensure map controls are keyboard-accessible and that all meaningful map content is available without the visual map.

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Load this skill whenever the project has personalization features, user preference controls, theme selectors, font size adjusters, motion toggles, contrast settings, or any user-configurable accessibility accommodations. Under no circumstances override or ignore user OS-level accessibility preferences without explicit user consent. Absolutely always persist user preferences, apply them immediately, and respect prefers-reduced-motion, prefers-contrast, and similar media queries.

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Load this skill whenever the project contains text, UI components, icons, form controls, data visualisations, or focus indicators — in short, almost every project. Under no circumstances hard-code colour values without verifying contrast ratios. Absolutely always ensure text meets 4.5:1, large text meets 3:1, and non-text UI elements meet 3:1 against adjacent colours. Test in light mode, dark mode, and forced-colors (high contrast) mode.

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Use when building, refactoring, or debugging a macOS menu bar app with SwiftUI, or when a MenuBarExtra misbehaves — the icon renders wrong or vanishes, the Settings window opens behind other apps, the popover cannot be closed, controls inside a .menu style do not render, the Dock icon comes back, or the app quits when the item is dragged off the menu bar. Triggers include menu bar app, status bar app, tray app, MenuBarExtra, NSStatusItem, LSUIElement, hide Dock icon.

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Use when exposing app features to App Intents, Shortcuts, Siri, Spotlight, widgets, controls, or system actions — small safe AppIntents, AppShortcutsProvider, AppEnum/AppEntity, parameters, and open-vs-background behavior.

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Use when designing, reviewing, or implementing Settings/Preferences for Apple-platform apps — what belongs in Settings vs Inspector/Toolbar, grouped forms, native controls, secure storage, launch at login, and destructive actions.

日本語の概要は準備中です。原文の説明を表示しています。

Coordinate autonomous pentest skills with dependency enforcement, deconfliction, and emergency stop controls.

日本語の概要は準備中です。原文の説明を表示しています。

Assess AWS, Azure, and GCP controls for IAM escalation and cloud service exposure.

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Test Docker and Kubernetes security controls for RBAC abuse, breakout, and secret exposure.

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Test egress and DLP controls using synthetic canary data across authorized exfiltration channels.

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Test authentication and session management controls for bypass and account takeover scenarios.

日本語の概要は準備中です。原文の説明を表示しています。