「compute」の検索結果

Implement electronic signatures compliant with 21 CFR Part 11 Subpart C and EU Annex 11. Covers signature manifestation (signer, date/time, meaning), signature-to-record binding, biometric vs non-biometric controls, policy creation, and user certification requirements. Use when a computerized system requires legally binding electronic signatures for GxP records, when replacing wet-ink signatures in regulated workflows, when implementing batch release or document approval workflows, or when a regulatory gap reveals missing signature controls.

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Fit hidden Markov models using the Baum-Welch (EM) algorithm with model selection, Viterbi decoding for state sequences, and forward-backward probabilities. Use when observations are generated by unobservable latent states, you need to segment a time series into latent regimes (market regimes, speech phonemes, biological sequences), compute sequence probabilities, decode the most likely hidden state path, or compare models with different numbers of hidden states.

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Decommission a validated computerized system at end-of-life. Covers data retention assessment by regulation, data migration validation (mapping, transformation, reconciliation), archival strategy, access revocation, documentation archival, and stakeholder notification. Use when a validated system is being replaced, reaching end-of-life without replacement, vendor support is discontinued, multiple systems are consolidating, or regulatory changes render a system obsolete.

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Conduct a GxP audit of computerized systems and processes. Covers audit planning, opening meetings, evidence collection, finding classification (critical/major/minor), CAPA generation, closing meetings, report writing, and follow-up verification. Use for scheduled internal audits, supplier qualification audits, pre-inspection readiness assessments, for-cause audits triggered by deviations or data integrity concerns, or periodic compliance posture reviews of validated systems.

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Compute and analyze gematria (Hebrew numerical values) using standard, ordinal, and reduced methods. Covers word-to-number conversion, isopsephy comparisons, and interpretive frameworks. Use when computing the numerical value of a Hebrew word or phrase, comparing two words for shared gematria values, studying a biblical verse or divine name for numerical correspondences, or connecting a numerical result to its position on the Tree of Life.

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Compute relative and absolute binding free energies with the Open Free Energy toolkit — the rigorous alchemical alternative to docking scores when a congeneric series needs reliable potency ranking. Use this skill to plan a perturbation network over a ligand set, choose atom mappings, run hybrid-topology or separated-topology protocols, and analyse the result — per-edge ΔΔG with uncertainty, cycle-closure error, and mean unsigned error against measured affinities. Also trigger on OpenFE, alchemical transformation, thermodynamic cycle, RBFE, ABFE, SepTop, lambda window, MBAR, cycle closure, or perturbation map.

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Number antibody variable domains, annotate CDRs, and assess developability from sequence. Use this skill to apply IMGT, Kabat, Chothia, Martin, or AHo numbering with ANARCI, delimit CDRs and framework regions, scan for chemical liabilities (N-glycosylation sequons, deamidation NG, isomerisation DG, oxidation, unpaired cysteine, fragmentation), compute pI, net charge, extinction coefficient and hydrophobicity, and plan humanisation by CDR grafting. Also trigger on antibody, nanobody, VHH, scFv, Fab, CDR, framework, ANARCI, abnumber, IgBLAST, OAS, SAbDab, humanization, Vernier residues, or developability.

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Cheminformatics toolkit for fine-grained molecular control. Parse and write SMILES, SDF, MOL and InChI; compute descriptors (MW, LogP, TPSA, QED, Bertz); build fingerprints (Morgan/ECFP, RDKit, MACCS, atom pair, torsion) and score Tanimoto, Dice or cosine similarity; run SMARTS substructure search and reaction SMARTS; generate 2D depictions and ETKDG 3D conformers; extract Murcko scaffolds and canonical hashes; control sanitization and stereochemistry directly. Also trigger on rdkit, Chem.MolFromSmiles, rdFingerprintGenerator, SDMolSupplier, SMARTS query, ETKDG, or FilterCatalog. For standard workflows with a simpler interface use the datamol skill, which wraps RDKit; use rdkit for advanced control, custom sanitization, and specialized algorithms.

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Hands on the local Mac for any agent - system state (battery, volume, brightness, IP), app launch/quit, open websites and YouTube, media and browser control via keystrokes, screenshots, clipboard, notifications, TTS, and honest mic/speaker hardware tests. Use whenever the user asks to control the computer, change volume or brightness, open an app or site, play or pause media, check battery/IP/running apps, take a screenshot, or test the mic or speakers. Rebuilt from the PC-Automation repo: the agent is the intent brain; this skill is only the hands.

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Use when profiling CUDA with Nsight Systems or Nsight Compute, reading roofline and occupancy metrics, or annotating phases with NVTX. Not for correctness: use cuda-debugging.

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Use when debugging CUDA with cuda-gdb or Compute Sanitizer, reading GPU core dumps, using device printf, or triaging error codes 700, 701, 702, and 719. Not for performance: use cuda-profiling.

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Compute a unified outer hull around a group of hex tiles that includes multiple disconnected sub-clusters separated by 1-tile gaps. Use when: (1) rendering nested hierarchy hulls (e.g. "package" hull wrapping multiple "sub-region" hex islands), (2) the naive boundary trace outlines each island separately instead of as one bag, (3) flood-fill from outside walks THROUGH the 1-hex gaps and marks them exterior, (4) heuristic "non-adjacent same-group neighbours" over-fills L-shape concavities, (5) axial-only opposite-pair filling misses non-axial bridges between islands. Solution: morphological close (dilate + erode) on the hex grid — fills exactly the interior 1-hex gaps without affecting exterior corners, then trace boundary on the closed shape.

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Drive the machine itself, mouse, keyboard and screen, without needing vision

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Geocode an address, find places nearby, or compute a route.

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Verify NowStack Mobile iOS/Expo changes in the Apple Simulator with `xcrun simctl`. Covers single or parallel Metro/device flows, deep-link navigation, preview routes, and OTP sign-in. Use for `ns ios verification`, "test on simulator", or changed `mobile-app/**`; never use computer-use.

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Calculates CRAP (Change Risk Anti-Patterns) score for .NET methods, classes, or files. Use when the user asks to assess test quality, identify risky untested code, compute CRAP scores, or evaluate whether complex methods have sufficient test coverage. Requires code coverage data (Cobertura XML) and cyclomatic complexity analysis. DO NOT USE FOR: writing tests, general test execution unrelated to coverage/CRAP analysis, or general code coverage reporting without CRAP context.

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International journal matcher — performs L3 6-dimensional matching for SCI/SSCI/EI/Scopus journals, computes conditional acceptance probability with review cycle estimation, applies 4-layer weighted ranking, and outputs tiered submission strategy including CAS warning screening and Chinese scholar friendliness analysis.

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Efficiently extract and convert the contents of any local file—such as PDF, DOCX, DOC, ODT, RTF, XLSX, XLS, or HTML—into clean, well-formatted markdown saved to disk. Use this skill whenever the user requests to parse, read, or extract information from a file on their computer, including phrases like “parse this PDF”, “convert this document”, “read this file”, “extract text from”, or when a local file path (not a URL) is provided. This skill offers advanced options like generating AI-powered summaries and answering questions based on the file's content. Prefer this tool over `scrape` when handling local files to deliver precise, structured outputs for downstream tasks.

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Sets up safe working habits and a change log so you always know what Cowork has done to your files — and can undo anything. Use when setting up file protection guardrails, for establishing safe automation habits, during initial access configuration, when granting file permissions for the first time, or when the user says "is cowork safe", "file safety", "what if it deletes my files", "audit trail", "safety setup", "I'm nervous about file access", "how do I trust cowork with my files", "can cowork mess up my computer", "I heard someone lost files", or "how do I stay in control".

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Deploy and manage cloud infrastructure on Cloudflare (Workers, R2, D1, KV, Pages, Durable Objects, Browser Rendering), Docker containers, and Google Cloud Platform (Compute Engine, GKE, Cloud Run, App Engine, Cloud Storage). Use when deploying serverless functions to the edge, configuring edge computing solutions, managing Docker containers and images, setting up CI/CD pipelines, optimizing cloud infrastructure costs, implementing global caching strategies, working with cloud databases, or building cloud-native applications.

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MATLAB R2026a workflow for signal processing, DSP, image processing, computer vision, lidar, medical imaging, deep learning, and AI-assisted reproducible experiments. Use for filters, spectrograms, wavelets, object detection, segmentation, classification, training, inference, and generated figures.

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"Apply meta-analysis to synthesize effect sizes across multiple studies, assess heterogeneity, and evaluate publication bias. Use this skill when the user needs to combine findings from prior research, compare fixed-effect vs random-effects models, compute pooled effect sizes, or when they ask 'what does the overall evidence say', 'how do I combine results across studies', or 'is there publication bias'.".

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"Implement PageRank algorithm to compute web page importance scores using the random surfer model. Use this skill when the user needs to rank pages by link authority, build a simplified search ranking system, or understand how link structure determines page importance — even if they say 'which pages are most important', 'link analysis', or 'page authority score'.".

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"Calculate and benchmark social media engagement rates across platforms and variants. Use this skill when the user needs to compute engagement metrics, compare performance across accounts or posts, or set engagement benchmarks — even if they say 'what is my engagement rate', 'benchmark engagement', or 'social media KPIs'.".

日本語の概要は準備中です。原文の説明を表示しています。