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Maps metabolomics results to biological pathways via over-representation (ORA), metabolite-set enrichment (MSEA/QEA), mummichog/PSEA on raw m/z peaks, and network-diffusion enrichment (FELLA), with correct background-set construction and honest interpretive ceilings. Use when interpreting differential metabolites or an untargeted LC-MS feature table in pathway context, choosing ORA vs MSEA vs mummichog vs topology, or setting the reference/background set. For annotation confidence levels feeding ORA see metabolomics/metabolite-annotation; for gene-set concepts see pathway-analysis/go-enrichment and pathway-analysis/gsea; for joint gene+metabolite pathways see multi-omics-integration/mofa-integration.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Programmatic untargeted LC-MS feature extraction in R with the modern xcms 4.x MsExperiment/XcmsExperiment API, taking raw mzML to a feature table via CentWave peak detection, retention-time alignment, peak-density correspondence, gap-filling, CAMERA redundancy collapse, and built-in QC feature filtering. Use when converting centroided LC-MS runs into a features-by-samples matrix and deciding centWave/grouping/alignment parameters. For drift correction and QC/CV filtering execution see metabolomics/normalization-qc; for metabolite identification see metabolomics/metabolite-annotation; for the MS-DIAL GUI alternative with MS2Dec deconvolution see metabolomics/msdial-preprocessing; for downstream statistics see metabolomics/statistical-analysis.

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Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docking poses, or selecting a docking workflow for a specific scenario.

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Performs 3D shape-based similarity searching using ROCS (OpenEye), USRCAT (ultra-fast), Open3DAlign (RDKit), ESPSim (electrostatic), and ShaEP with explicit handling of Tanimoto-Combo (shape + color), shape vs ECFP4 complementarity, conformer-ensemble searching, alignment optimization, and scaffold hopping. Use when searching for shape-mimicking compounds with different scaffolds, identifying bioisosteric replacements, prospective scaffold hopping, or expanding hit series beyond 2D similarity.

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Analyzes current state and user query to answer BMad questions or recommend the next skill(s) to use. Use when user asks for help, bmad help, what to do next, or what to start with in BMad.

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Stellar standards, ecosystem, and reference. Covers SEPs (Stellar Ecosystem Proposals), CAPs (Core Advancement Proposals), and a quick map for picking the right standard for wallets, anchors, payments, deposits/withdrawals, federation, deep links, and KYC. Also bundles ecosystem references (DeFi protocols, dev tools, wallets, infra, community projects), curated documentation links, and MCP servers (live tools such as Raven). Use when you need to know which SEP applies, or want a starting point for ecosystem integrations, official docs, or live MCP tooling.

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Meta-skill — browse and discover all installed stellar.new skills. Use when a user says "what skills do I have", "show me available skills", "what can I do", "find a skill for X", "which skill should I use", "help me navigate", "what does stellar.new do", or "where do I start". Lists skills by journey phase, surfaces the SKILL_ROUTER trigger phrases, and recommends the next skill given current context.

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Help users discover what to build on Stellar. Use when a user says "what should I build on Stellar", "Stellar app ideas", "I want to build on Stellar but don't know what", "Stellar startup ideas", "find me a Stellar project idea", "I'm new to Stellar and want to build something", or "what's hot on Stellar right now". Interviews user sharply, then proposes ranked ideas grounded in real ecosystem gaps from the LumenLoop 728-project database and current SCF funding patterns.

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Implement tasks from an OpenSpec change. Use when the user wants to start implementing, continue implementation, or work through tasks.

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Start a new OpenSpec change using the experimental artifact workflow. Use when the user wants to create a new feature, fix, or modification with a structured step-by-step approach.

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Guide for implementing smooth, native-feeling animations using React's View Transition API (`<ViewTransition>` component, `addTransitionType`, and CSS view transition pseudo-elements). Use this skill whenever the user wants to add page transitions, animate route changes, create shared element animations, animate enter/exit of components, animate list reorder, implement directional (forward/back) navigation animations, or integrate view transitions in Next.js. Also use when the user mentions view transitions, `startViewTransition`, `ViewTransition`, transition types, or asks about animating between UI states in React without third-party animation libraries.

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Interviews the user section by section to collaboratively produce design documents. Use when creating a design doc, starting feature design, or when the user invokes the design command.

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Implement sprite layers, overlays, render targets, shader prototypes, and visual cleanup without leaking gameplay authority.

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Implement round lifecycle, game rules, objectives, announcements, win conditions, and restart-safe cleanup.

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Validate, migrate, and atomically persist files and configuration with safe fallback and restart coverage.

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Maintain entity references, ownership links, target relationships, deletion cleanup, and network-safe relation state.

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Reproduce failures, trace authoritative flow, prove the broken assumption, and add targeted regression coverage.

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Restructure existing code while preserving observable behavior. Use for targeted technical debt or hotspot work with characterization tests.

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When the user wants to audit, review, or diagnose SEO issues on their site. Also use when the user mentions "SEO audit," "technical SEO," "why am I not ranking," "SEO issues," "on-page SEO," "meta tags review," or "SEO health check." For building pages at scale to target keywords, see programmatic-seo. For adding structured data, see schema-markup.

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Design account-based marketing strategies with targeting. TRIGGERS - Use when user needs help with abm-strategy related tasks.

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Generate a professional offer letter PDF with role, compensation, start date, and company details.

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Extract menu item names, prices, descriptions, and dietary notes from a public restaurant menu page.

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Extract campaign or business KPIs from report documents — metrics, values, periods, and targets.

日本語の概要は準備中です。原文の説明を表示しています。