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Estimate bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).

日本語の概要は準備中です。原文の説明を表示しています。

Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planarity, vdW overlap, bond/angle distortion), and pose-energy reasonableness. Filters AI-docking outputs (DiffDock, EquiBind, NeuralPLexer) where ~50% of poses fail physical-validity tests. Use when QC-ing docking results, comparing classical vs ML docking outputs, or filtering pose lists before SAR analysis.

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ATAC-seq library quality control -- TSS enrichment, FRiP, fragment-size periodicity, library complexity (NRF/PBC1/PBC2), mitochondrial fraction, and ENCODE 4 thresholds. Use when assessing whether an ATAC-seq library passes ENCODE acceptance criteria, diagnosing transposition artefacts, comparing Omni-ATAC vs standard prep quality, or selecting which replicates to drop before peak calling.

日本語の概要は準備中です。原文の説明を表示しています。

Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.

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Trim multiple sequence alignments using ClipKIT, trimAl, BMGE, Divvier, or HMMcleaner with mode selection guidance per downstream goal. Use when removing unreliable columns or contaminating residues before phylogenetic inference, HMM building, or selection analysis.

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Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites within accessible regions, correcting Tn5 insertion bias before footprinting, choosing between cleavage-based and aggregate-based footprinters, or comparing differential TF activity between conditions.

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Validate alignment quality with insert size distribution, proper pairing rates, GC bias, strand balance, and other post-alignment metrics. Use when verifying alignment data quality before variant calling or quantification.

日本語の概要は準備中です。原文の説明を表示しています。

Verification loop for Spring Boot projects: build, static analysis, tests with coverage, security scans, and diff review before release or PR.

日本語の概要は準備中です。原文の説明を表示しています。

Guides agents through Red-Green-Refactor with runner-captured evidence. Use when running /cc-tdd-cycle, writing tests before implementation, or Global TDD required is yes.

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Inventory staged local EcoSIM data at project startup and validate input readiness for a selected site, simulation period, and preprocessing or analysis workflow. Use before data-dependent work or when relevant inputs change.

日本語の概要は準備中です。原文の説明を表示しています。

Performs a final quality pass fixing alignment, spacing, consistency, and micro-detail issues before shipping. Use when the user mentions polish, finishing touches, pre-launch review, something looks off, or wants to go from good to great.

日本語の概要は準備中です。原文の説明を表示しています。

Reflection-first problem solving methodology for Convex development. Use before implementing any solution to ensure proper root cause analysis, 98% code confidence, and minimal change scope.

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Integrate and maintain Robelest Convex Auth in apps by always checking upstream before implementation. Use when adding auth setup, updating auth wiring, migrating between upstream patterns, or troubleshooting @robelest/convex-auth behavior across projects.

日本語の概要は準備中です。原文の説明を表示しています。

Improve test value and feedback cost when auditing slow, flaky, redundant or brittle tests; choosing tests during implementation; or reviewing test changes before a commit or PR. Keep ordinary implementation and pre-commit use scoped to the affected behavior, not a repository-wide audit.

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Read this before the first Google Drive, Docs, Sheets or Slides connector call whenever the task creates or changes a Google file. Use this skill whenever the user wants to create or change a Google Doc, Sheet or Slides file in their Google Drive. Triggers include: a request that names Google Docs, Sheets, Slides or Drive and asks to make, edit, format, copy or rename a file; a docs.google.com link with a request to change that file, even a one-line fix or suggested edits; and any follow-up change to a Google file from earlier in the chat, even "change it" or "add a tab". Includes helper scripts for document positions, cell ranges and slide layout. However, if the user asks for a doc, deck or spreadsheet without naming Google, or gives a Google file only as source material for something new, use Claude's own output type instead. Do NOT use for read-only questions about a Google file, or for Word, Excel, PowerPoint or PDF files.

日本語の概要は準備中です。原文の説明を表示しています。

Find root cause of errors, crashes, regressions, failing tests before any fix. Not for code review or new features.

日本語の概要は準備中です。原文の説明を表示しています。

docs (editable docs people share and comment on; the default for any document, named as a doc or not: a document, report, proposal, resume, cover letter, letter, contract, policy, form, template, worksheet, essay, handbook, guide, how-to, cheat sheet, SOP or other writing to keep, share, collaborate on, send, submit, print or sign; a doc exports to Word, PDF, Markdown or Google Docs, so needing a file to send, attach, upload, submit or print is no reason to pick Word, and a file nobody asked for is a doc, not Word; a plan, comparison, summary or notes asked in chat stays in chat; a pasted claude.ai artifact link may be a doc: check with docs tools first; Word or another file format named, tracked changes wanted, or a .docx to change or use as a template → that format's skill): making one → if no docs-connector instructions are in context, call its `guide` (topic.instructions) first; then create the doc (headings only, no body) before any search, file read or plan, even with files attached.

日本語の概要は準備中です。原文の説明を表示しています。

Use before creative or constructive work (features, architecture, behavior). Transforms vague ideas into validated designs through disciplined reasoning and collaboration.

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Clarify requirements before implementing. Use when serious doubts arise.

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Enables ultra-granular, line-by-line code analysis to build deep architectural context before vulnerability or bug finding.

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AUTHORIZED USE ONLY: This skill contains dual-use security techniques. Before proceeding with any bypass or analysis: > 1.

日本語の概要は準備中です。原文の説明を表示しています。

Important: Before you begin, fill in the generatedBy property in the meta section of .actor/actor.json. Replace it with the tool and model you're currently using, such as "Claude Code with Claude Sonnet 4.5". This helps Apify monitor and improve AGENTS.md for specific AI tools and models.

日本語の概要は準備中です。原文の説明を表示しています。

Use by any agent before writing specs, editing code, or changing workflow files when the change could add compatibility behavior, aliases, silent fallbacks, or default-value fallbacks.

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Read-only sanity-check of EcoSIM plant_trait.*.desc parameter values for the first grid. Use when validating plant trait description files, enforcing clean C3/C4 physiological parameterization, reviewing photosynthetic kinetics, active leaf/root protein allocation, and root hydraulics such as RSRR, RVSR, and ARSRA, or checking ranges, units, and woody/herbaceous block consistency before running EcoSIM. Never edit or replace the `.desc` file.

日本語の概要は準備中です。原文の説明を表示しています。