「fts」の検索結果

Drafts an Adverse Event Reporting Policy compliant with 21 CFR 312.32 (IND safety reporting), 21 CFR 314.80 (postmarketing), and ICH E2A, with multi-jurisdictional overlays (EMA, PMDA, Health Canada). Covers seriousness/causality frameworks, expedited reporting timelines, roles, documentation standards, training mandates, and QA mechanisms. Use when drafting or updating an adverse event reporting policy, pharmacovigilance policy, AE/SAE reporting SOP, or safety reporting framework for a pharmaceutical company, CRO, biotech, or clinical research institution.

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Drafts adverse possession complaints and quiet title pleadings. Structures jurisdictional foundations, legal property descriptions, and element-by-element proof of actual, open, continuous, exclusive, and hostile possession. Use when filing adverse possession claims, quiet title actions, or prescriptive ownership pleadings.

日本語の概要は準備中です。原文の説明を表示しています。

Drafts jurisdiction-specific Advance Health Care Directive packages with agent appointment, living will instructions, HIPAA authorization bridge, organ donation preferences, and execution compliance checklists. Trigger when the user mentions advance directive, healthcare proxy, living will, health care agent, HIPAA authorization, medical power of attorney, end-of-life planning, capacity trigger planning, state-specific directive forms, witness/notary requirements for healthcare documents, or cross-state directive portability.

日本語の概要は準備中です。原文の説明を表示しています。

Drafts U.S. regulatory client advisory summaries translating legal developments into actionable risk and compliance guidance. Use when a client needs a proactive memo, client alert, or legal-update brief for a new law, case, rulemaking, agency guidance, or pending reform. Trigger on requests for "client advisory," "regulatory update," "legal alert," "compliance briefing," "new law summary," or "quarterly advisory."

日本語の概要は準備中です。原文の説明を表示しています。

Drafts franchise advertising fund contribution agreements or addenda governing franchisee obligations to a centralized marketing fund. Trigger when drafting ad fund agreements, marketing fund addenda, or franchise contribution agreements involving fund administration, contribution calculations, or financial reporting.

日本語の概要は準備中です。原文の説明を表示しています。

Drafts U.S. commercial real estate access and indemnity (right-of-entry) agreements for pre-closing due diligence. Covers license grants, non-invasive vs invasive testing gates, insurance/endorsement requirements, indemnity with discovery carve-outs, restoration and lien remedies, confidentiality, and anti-indemnity guardrails. Trigger: access agreement, right of entry, due diligence access, Phase I/II, invasive testing, pre-PSA site inspection.

日本語の概要は準備中です。原文の説明を表示しています。

Drafts an ADA failure-to-accommodate complaint for federal or state court filing. Covers Title I employment (42 U.S.C. § 12112) and Title III public accommodations (42 U.S.C. § 12182), including EEOC exhaustion, interactive process failures, and prayer for relief. Use when drafting an ADA complaint, disability discrimination pleading, failure-to-accommodate lawsuit, or right-to-sue complaint.

日本語の概要は準備中です。原文の説明を表示しています。

Inspect scoped Autodesk data, compare versioned BOMs, and prepare ownership-aware drafts or approved custom-property changes. Not for implicit PLM release, membership changes or CAD geometry editing.

日本語の概要は準備中です。原文の説明を表示しています。

Patterns for vibe coding that produce production-quality output instead of garbage. Covers prompt engineering for AI coding, verification without reading every line, accept/reject/refine decision framework, architectural guardrails, context management (CLAUDE.md, .cursor/rules), TDD-driven vibe coding, screenshot-driven development, diff review discipline, and the anti-patterns that destroy quality. Activate on: "vibe coding", "AI coding quality", "Claude Code workflow", "AI-assisted development", "how to use AI for coding", "coding with AI", "agentic engineering workflow", "AI code quality", "vibe code without garbage", "production quality AI code", "CLAUDE.md setup", "cursorrules setup", "pre-commit hooks for AI", "TDD with AI", "test-driven vibe coding". NOT for: multi-person collaborative coding sessions (use cooperative-vibe-coding), building AI/LLM applications (use ai-engineer), prompt engineering for non-coding LLM use cases (use prompt-engineer).

日本語の概要は準備中です。原文の説明を表示しています。

Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 (GC-bias-aware differential via its bam_ip/bam_input control + bam_treated_ip/bam_treated_input treatment arms), QNB beta-binomial, MeTDiff HMM, and RADAR, plus the paired-symmetric edgeR/DESeq2-on-peak-counts route when batch/lot covariates need fixed-effect handling that exomePeak2's API does not accept. Covers paired vs unpaired vs interaction designs, batch confounding and per-lot meta-analysis, the stoichiometry-vs-expression-vs-IP-efficiency confound, and effect-size filtering against under-powered N=2 designs. Use when comparing m6A across two or more conditions, choosing between exomePeak2/QNB/RADAR/MeTDiff for a design, handling batch confounding when exomePeak2's API is too rigid, distinguishing real hyper/hypo-methylation from expression shifts, applying effect-size thresholds, or planning orthogonal stoichiometry validation (GLORI/SAC-seq/m6Anet mod_ratio).

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Model gene-family birth-death dynamics across a species tree using CAFE5 (Mendes et al 2020 Bioinformatics 36:5516 gamma-distributed rate categories), CAFE5-error (annotation-error-aware), Count (Csurös 2010 ancestral state reconstruction), BadiRate (Librado 2012 likelihood + parsimony), DupliPHY-Family, and ALE/AleRax (for per-family DTL; see [[gene-tree-species-tree-reconciliation]]). Test lineage-specific gene-family expansions and contractions, distinguish biological dynamics from annotation artifacts, account for assembly fragmentation, identify functional enrichment in expanded / contracted families. Use when correlating gene-family changes with phenotype evolution, ranking lineages by adaptive gene-family-rate shifts, post-WGD dosage-balance analysis, or building Birth-death models from OrthoFinder presence/absence matrices.

日本語の概要は準備中です。原文の説明を表示しています。

Detect positive (diversifying / episodic / pervasive) selection using codon dN/dS frameworks. Implements PAML codeml site models (M0/M1a/M2a/M7/M8/M8a), branch models, branch-site model A (Zhang 2005), and HyPhy methods (BUSTED, BUSTED-S, BUSTED-MH, BUSTED-PH, MEME, FEL, FUBAR, aBSREL, SLAC, RELAX, GARD, FUBAR-MH). Includes McDonald-Kreitman framework (asymptotic alpha, impMKT, polyDFE, DFE-alpha, GRAPES) for within-species + divergence inference, RERconverge for trait-correlated rate shifts, CSUBST for convergent substitution, and PhyloAcc for accelerated noncoding evolution. Use when testing adaptive evolution at codons, branches, or full gene; running GARD recombination pre-screen; controlling alignment-error and gBGC false positives; reconciling PAML vs HyPhy results; or performing genome-scale selection scans.

日本語の概要は準備中です。原文の説明を表示しています。

Identify differentially bound regions across CLIP-seq conditions (knockdown vs control, treatment vs vehicle, disease vs healthy) using DEWSeq (sliding-window DESeq2), Flipper (Skipper-downstream), ASpeak, edgeR, or limma-voom. Use when computing condition-level changes in RBP binding intensity, choosing peak-level vs window-level vs crosslink-level testing, designing replicate experiments, or distinguishing biological binding shifts from technical confounders.

日本語の概要は準備中です。原文の説明を表示しています。

Calls ChIP-seq peaks with MACS3, MACS2, HOMER, or SPP across narrow (TF) and broad (histone) modes. Handles input control matching, fragment-size modeling vs --nomodel, effective genome size, ENCODE-style IDR vs naive overlap, hyper-ChIPable artifacts, and aligner-specific shifts. Use when calling peaks from ChIP-seq alignments, choosing between narrow vs broad mode for a histone mark, deciding model vs nomodel for low-depth data, applying ENCODE pseudoreplicate IDR, or reconciling MACS vs HOMER vs SPP results.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

日本語の概要は準備中です。原文の説明を表示しています。

PM-mode brainstorm helper. Captures the requirement via Socratic dialogue before any entry phase (`/intake`, `/spec`, `/tdd`) drafts its artifact. Stage 0 skip-check, Stage 1 gap-analysis, Stage 2 probe-loop, Stage 3 confirm-and-persist. Output lives at `docs/brief/<slug>.md`. Never proposes solutions — Stage 2 dialogue discipline is structurally enforced via `discipline.mjs`.

日本語の概要は準備中です。原文の説明を表示しています。

Autonomous DevSecOps & FinOps Guardrails. Orchestrates Gemini 3 Flash to audit Linux Kernel patches, Terraform cost drifts, and K8s compliance.

日本語の概要は準備中です。原文の説明を表示しています。

Adversarial code review that breaks the self-review monoculture. Use when you want a genuinely critical review of recent changes, before merging a PR, or when you suspect Claude is being too agreeable about code quality. Forces perspective shifts through hostile reviewer personas that catch blind spots the author's mental model shares with the reviewer.

日本語の概要は準備中です。原文の説明を表示しています。

Generate conservative, editable English outreach drafts for foreign-trade sales from structured lead inputs and customer-intel signals. Use when an operator needs a first-touch or follow-up email draft that calls confirmed recent/customer-market signals from the customer-intel Skill, with subject options, review notes, and explicit reminders not to present unconfirmed facts as facts.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a foreign-trade operator already has a small customer list and needs conservative customer grouping, outreach angles, English subject lines, first-email drafts, follow-up cadence, and human review points before any sending happens.

日本語の概要は準備中です。原文の説明を表示しています。

OpenClaw-native version of the foreign-trade outreach email skill. Use structured operator input plus customer-intel source context to generate conservative first-touch or follow-up email drafts without overstating inferred facts or inventing recent customer events.

日本語の概要は準備中です。原文の説明を表示しています。

Generate guided Chinese software copyright application materials from a real project. Use this skill when the user asks for 软件著作权, 软著申请资料, 软著代码材料, 操作手册, 申请表信息, or wants Word/TXT materials for software copyright registration. The workflow analyzes the imported project, extracts real source code, creates Markdown drafts for user confirmation, then uses bundled DOCX tooling to produce final Word documents and TXT.

日本語の概要は準備中です。原文の説明を表示しています。

Use during or right after an incident — frames severity, sets comms cadence, drafts the post-mortem skeleton — even when the user just says 'production is down' or 'wir haben einen Vorfall'.

日本語の概要は準備中です。原文の説明を表示しています。

Use when removing AI-writing tells from deliverable prose — posts, articles, drafts. Triggers on 'make this sound less like AI', 'humanize this draft', 'this reads like ChatGPT wrote it'.

日本語の概要は準備中です。原文の説明を表示しています。