「2025」の検索結果

Use when designing, reviewing, or debugging how an agent's context window gets filled, pruned, or shared — choosing what loads at boot versus on demand, sizing an install or an always-loaded file, fixing an agent that drifts, repeats itself, or forgets constraints mid-task, planning compaction or summarization, deciding single-agent versus subagents, engineering handoffs between agents, or picking a tool loadout. NOT for rewording a prompt's tone, choosing which model to pin, or debugging business logic — those are adjacent moments this skill does not serve. Historical 2024–2025 snapshot; not normative for present-day frontier models — see the Status section.

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Structure prediction for protein, nucleic-acid, and small-molecule complexes with Boltz-2 (Passaro & Wohlwend et al. 2025, github.com/jwohlwend/boltz). Reach for this skill to validate designed binders against a target, to co-fold a protein with a SMILES or CCD ligand, or to get an open-source AlphaFold3 alternative with optional binding-affinity prediction.

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Meme coin and token security audit — rug pull detection (honeypot, hidden mint, fee manipulation, LP lock bypass), Solana SPL token analysis (freeze authority, mint authority, metadata mutability), Token-2022 extension risks (transfer hooks, permanent delegate), DEX liquidity pool attacks (sandwich amplification, LP drain, bonding curve exploits), pump.fun/Raydium/Jupiter integration risks, token_scanner.py automation, and real exploit examples from 2024-2025. Use for any token audit, rug pull assessment, meme coin security review, or pre-investment due diligence.

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Meme coin and token security audit — rug pull detection (honeypot, hidden mint, fee manipulation, LP lock bypass), Solana SPL token analysis (freeze authority, mint authority, metadata mutability), Token-2022 extension risks (transfer hooks, permanent delegate), DEX liquidity pool attacks (sandwich amplification, LP drain, bonding curve exploits), pump.fun/Raydium/Jupiter integration risks, and real exploit examples from 2024-2025. Use for any token audit, rug pull assessment, meme coin security review, or pre-investment due diligence.

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Hunt Microsoft SharePoint Server (2013/2016/2019/Subscription Edition) on-prem farms — anonymous endpoint enumeration, version disclosure, legacy SOAP login bypass (Authentication.asmx), ToolShell precondition chain (CVE-2025-53770), SafeControl reflection enumeration via Picker.aspx, NTLM Type-2 AD topology disclosure, custom-branding module discovery, EoL farm permanent-CVE-window exploitation, FormDigest anonymous issuance, file-extension blocklist NOT-an-oracle pattern, custom-zone Forms auth bridging on-prem AD. Use when target has SharePoint headers (SPRequestGuid, X-MS-InvokeApp, X-SharePointHealthScore, MicrosoftSharePointTeamServices) or paths (/_layouts/15/, /_vti_bin/, /_api/, /_catalogs/).

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STATA code pattern library for empirical archival accounting research. Provides tested syntax from 126 peer-reviewed JAR (Journal of Accounting Research) replication files (2017-2025). Use when the user asks procedural questions like "How do I implement [method]?" or "Show me code for [technique]" — including: entropy balancing, propensity score matching (PSM), difference-in-differences (DiD), regression discontinuity (RDD), instrumental variables (IV), event studies (CAR/BHAR), survival analysis, Fama-MacBeth regressions, bootstrap, quantile regression, reghdfe/xtreg/areg, clustering standard errors, fixed effects, esttab/outreg2 table formatting, winsorization, leads/lags. Users can specify their variables (e.g., treatment, outcomes, controls) and receive adapted syntax. NOTE: This skill provides code patterns from published papers, not research design advice.

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Generate prompts for AI image tools to produce modern ML/RL paper-style figures matching the aesthetic of recent ICLR/NeurIPS/ICML 2024-2025 publications. Key traits — pure white canvas, white panels with soft drop shadow, rounded friendly font (Nunito/Poppins), densely packed but uncluttered floating elements, small pastel token squares, rich inline illustrations, colored keyword text, pill-shaped concept labels. Trigger phrases — "pastel风格论文配图", "现代ML论文配图", "modern ML figure prompt".

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This is a summary the advantages and disadvantages of earthquake event detection and phase picking methods, shared by leading seismology researchers at the 2025 Earthquake Catalog Workshop. Use it when you have a seismic phase picking task at hand.

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Implement mHC (Manifold-Constrained Hyper-Connections) for stabilizing deep network training. Use when implementing residual connection improvements with doubly stochastic matrices via Sinkhorn-Knopp algorithm. Based on DeepSeek's 2025 paper (arXiv:2512.24880).

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Elite AI-powered customer support specialist mastering conversational AI, automated ticketing, sentiment analysis, and omnichannel support experiences. Integrates modern support tools, chatbot platforms, and CX optimization with 2024/2025 best practices. Use PROACTIVELY for comprehensive customer experience management.

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Elite AI context engineering specialist mastering dynamic context management, vector databases, knowledge graphs, and intelligent memory systems. Orchestrates context across multi-agent workflows, enterprise AI systems, and long-running projects with 2024/2025 best practices. Use PROACTIVELY for complex AI orchestration.

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Elite content marketing strategist specializing in AI-powered content creation, omnichannel distribution, SEO optimization, and data-driven performance marketing. Masters modern content tools, social media automation, and conversion optimization with 2024/2025 best practices. Use PROACTIVELY for comprehensive content marketing.

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Elite code review expert specializing in modern AI-powered code analysis, security vulnerabilities, performance optimization, and production reliability. Masters static analysis tools, security scanning, and configuration review with 2024/2025 best practices. Use PROACTIVELY for code quality assurance.

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OWASP Top 10 for LLM Applications (2025) knowledge base for identifying, assessing, and remediating large language model security risks.

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OWASP Top 10 for Web Applications (2025) knowledge base for identifying, assessing, and remediating web application security risks.

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Personal-data-protection compliance reference for engineers building applications subject to Singapore PDPA, Indonesia UU PDP, Thailand PDPA, Malaysia PDPA, Philippines DPA (RA 10173), or Vietnam PDPL (91/2025/QH15). Use when reviewing or modifying code that touches personal data — signup/auth/consent, data export, account deletion, retention/purging, admin access to personal-data stores, third-party processors, breach response, or privacy/T&C documents.

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Tests genotype-environment associations and identifies adaptive loci while correcting for the four-confound landscape (structure, demography, background selection, sampling design) using LFMM2 with mandatory K via sNMF cross-entropy elbow (LEA 3), BayPass Core/AUX/C2/IS with Omega covariance matrix, RDA / pRDA for polygenic adaptation (Forester 2018; requires imputed genotypes), OutFLANK with trimmed FST null, pcadapt, gradient forests (Ellis-Smith-Pitcher 2012, NOT mis-cited Ellis-Manel), Capblancq & Forester 2021 RDA Swiss-army-knife, genomic-offset prediction with Lind & Lotterhos 2025 three-regime caveat, Lotterhos-Whitlock sampling optima, Wang & Bradburd 2014 IBD vs IBE, and Circuitscape + ResistanceGA. Use when identifying adaptive loci across gradients, choosing K for LFMM2, deciding among GEA methods, predicting maladaptation with the novel-environment caveat, distinguishing IBD vs IBE, or optimizing sampling design.

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Designs and analyzes in vivo CRISPR screens in animal tumor models, organoids, and immune-cell adoptive transfers. Covers bottleneck math (250x cells/sgRNA requires ~25M cells implanted; impossible for most syngeneic models, forcing focused libraries), focused library design (Manguso 2017 Nature 547:413 immune screen; Chen 2015 tumor screens), CRISPR-StAR intrinsic-control screening (Uijttewaal 2025 Nat Biotechnol 43:1848), clonal-dynamics-limited detection, tumor-explant DNA recovery, syngeneic vs xenograft vs PDX considerations, and the relationship to downstream MAGeCK / drugZ analysis. Use when designing in vivo CRISPR screens for tumor / immune / metastasis biology, choosing focused vs genome-wide for animal models, addressing bottleneck-induced clonal collapse, picking the syngeneic / xenograft / PDX model, integrating in vivo with in vitro results, or applying CRISPR-StAR for animal experiments.

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Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

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Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pejaver 2022 and Bergquist 2025 calibrated PP3/BP4 thresholds for REVEL/BayesDel/AlphaMissense, Brnich 2020 PS3/BS3 OddsPath, Walker 2023 SpliceAI splicing framework, and AMP/ASCO/CAP 2017 tumor tiers. Use when classifying germline variants P / LP / VUS / LB / B, applying VCEP-specific CSpec rules, computing Whiffin BS1, or assigning cancer Tier I-IV per Li 2017.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.

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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al. 2023), Pharmer / Pharmit for search, and PharmacoForge for protein-pocket-conditioned pharmacophore generation (Flynn et al. 2025), covering ligand-based pharmacophores from active-set alignment and receptor-based pharmacophores from binding-pocket geometry. Explicitly handles feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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