「psi」の検索結果

Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR 2-pass cohort-style alignment, junction saturation curves and discovery plateau detection, novel-vs-known junction ratio diagnostics, junction-overhang distribution, splice-site strength scoring (MaxEntScan intrinsic + SpliceAI context-aware), strandedness verification, GENCODE basic vs comprehensive choice, and rRNA contamination screening. Splicing analysis is more demanding than DGE on read length, depth, library prep, alignment strategy, and annotation choice — failures silently bias PSI estimates and inflate novel-junction false positives. Use when evaluating data suitability for splicing analysis, troubleshooting low event detection, or designing sequencing experiments where AS is a primary endpoint.

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Quantifies alternative splicing as PSI (percent spliced in) from RNA-seq using rMATS-turbo (BAM-based event), SUPPA2 (TPM-based event), MAJIQ V3 (LSV-based Bayesian), leafcutter (annotation-free intron clusters), VAST-TOOLS (cross-species with microexon support), Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage), or IRFinder-S (intron retention coverage-aware). Distinguishes the five canonical event classes (SE, A5SS, A3SS, MXE, RI), special classes (microexons, exitrons, AFE/ALE), intron retention subtypes (canonical RI vs detained introns), and applies effective-length normalization. Use when measuring splice-site usage or isoform inclusion ratios from short-read RNA-seq.

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Use when building or fixing game UI in Unity 6.3: main menu, settings screen (resolution, quality, volume, key rebinding), HUD, health bar, minimap frame; choosing uGUI or UI Toolkit or mixing both; 'UI scales wrong on phones', portrait to 4K, Canvas Scaler, anchors, layout groups collapsing, sort order, UXML/USS, data binding, TextMeshPro or UI Toolkit fonts missing glyphs, localized menus, gamepad navigation, UI draw calls, canvas rebuild spikes, UI tests, or capturing UI to check it.

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Use when a ZBrush sculpt, scan or AI-generated mesh must become production topology and files (ZRemesher and guides, the 2026 Retopo brush, reprojecting detail with Project All, rebuilding subdivision levels, UV Master or native unwrap, normal and displacement maps with Multi Map Exporter, GoZ, OBJ or FBX export, scale and axes, Decimation Master, "clean up an AI mesh in ZBrush"), or when detail is lost after ZRemesher, a map is upside down or an export arrives at the wrong size.

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Use when skinning a character in Maya ("bind skin", "fix the weights", weight painting, Skin Tools or ngSkinTools layers), when deformation looks wrong (pinching, candy-wrapper wrist, collapsing elbow or shoulder, volume loss, clothes poking through), when mirroring, copying or capping skin weights for Unreal or Unity, building blend shapes, corrective shapes or pose space deformation (Pose Editor on IK-driven joints), a face rig with shapes or joints, multiple skinClusters, Delta Mush or the ML Deformer, or running a range-of-motion deformation test.

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mdtraj molecular dynamics trajectory analysis (Python). Reads DCD/XTC/TRR/NetCDF/H5/PDB topologies and trajectories; computes RMSD vs time, radius of gyration, per-residue RMSF, residue-residue contact frequency maps, phi/psi torsions for Ramachandran plots (general + Gly/Pro), and 8-state DSSP secondary structure. Modules: trajectory I/O, geometry (distances/angles/dihedrals), structural analysis (RMSD/Rg/RMSF/SASA), contacts, hydrogen bonds, secondary structure (DSSP), NMR observables. For broader atom-selection grammar use mdanalysis-trajectory; for running MD simulations use OpenMM/GROMACS.

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This skill should be used when the user asks to "write a query letter", "query", "querying", "pitch", "blurb", "back cover copy", "jacket copy", "comp titles", "comparable titles", "synopsis for agents", "submit to agents", "submission tracker", "self-publishing description", "retailer description", "ready to query", "submission readiness check", "submit a short story", "magazine submission", "short-fiction markets", "simultaneous submission", "reprint rights", "order a short story collection", or wants to prepare and track a finished manuscript's submission to agents, publishers, magazines, anthologies, or retailers. NOT for pitching a series of several books (use series-continuity), or self-publishing production, metadata, or book rights deals (use publishing). The blurb, retailer description, and the rights a short-fiction market buys, such as reprint rights, stay here.

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This skill should be used when the user asks to "write a sequel", "write a prequel", "start book two", "continue the series", "companion novel", "spin-off", "link books in a series", "carry characters into the next book", "series continuity", "series bible", "pitch my series", "series pitch", "multi-book pitch", or needs to plan, pitch, or keep canon consistent across multiple Story Skills projects. NOT for a standalone book (use story-init), continuity within one book (use revision-continuity), or a query, pitch, or synopsis for a single book (use submission).

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Design privacy-preserving analytics systems using differential privacy, k-anonymity, l-diversity, and t-closeness. Covers privacy budget allocation with epsilon tracking, references Google DP library, OpenDP, and Apple PPML. Includes Python differential privacy implementation for GDPR-compliant statistical analysis.

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Create original short videos using the 正面撤退｜通道坍缩逼向唯一庇护 Creative DNA for MiniMax H3 or Seedance 2.0. Use when the user wants this causal, camera, motion, rhythm, or payoff structure with new subjects and surfaces.

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Weekly clinical-trial status diff — the 11-category change report over the stored weekly snapshots (spec 055 FR-B03). Surfaces exactly what changed on the trial registry for your coverage: New / Suspended / Withdrawn / Terminated / Recruiting / Recruitment-Complete / Completed / Ahead / Delayed / Upsized / Downsized, every row carrying previous and new values, with risk flags on Terminated and Downsized and re-timing flags on Ahead and Delayed. The stored-previous-value discipline makes each week's diff reproducible.

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Think and work like an expert MLOps Engineer. Use when a task calls for MLOps Engineer judgment. Reasons from data contracts, feature parity, evaluation gates, and rollback-readiness through MLflow/W&B registries, Feast feature stores, KServe/Triton serving, Great Expectations/TFDV validation, and Evidently PSI/KS drift monitors while treating train-serve skew, data leakage, silent degradation, and schema/concept drift as first-class failure modes.

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Think and work like an expert Heat Transfer Engineer. Use when a task calls for Heat Transfer Engineer judgment. Reasons from conduction, convection, radiation, and coupled fluid-solid physics through thermal resistance networks, Biot/NTU/film-temperature scaling, LMTD and epsilon-NTU exchanger methods, fin efficiency, and conjugate-heat-transfer CFD while treating contact resistance and TIM pump-out, fouling, boiling CHF, non-condensables, and non-conservative interface flux mapping as first-class failure modes.

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Think and work like an expert Gene Therapy Scientist. Use when a task calls for Gene Therapy Scientist judgment. Reasons from vector biology, biodistribution, linked potency, and integration risk through ddPCR titer, empty/full analytics, ISA and off-target NGS (GUIDE-seq, CIRCLE-seq), and ICH S12 nonclinical design while treating pre-existing capsid neutralizing antibodies, RCV/RCA/RCR positivity, gonadal vector genome, and oligoclonal VCN expansion as first-class failure modes.

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Think and work like an expert Exoplanet Scientist. Use when a task calls for Exoplanet Scientist judgment. Reasons from Keplerian motion, transit and RV geometry, and degenerate retrieval spaces through TLS/BLS searches, centroid and odd-even vetting, RadVel and GP activity models, and petitRADTRANS retrievals while treating eclipsing-binary blends, stellar-rotation-mimicking RV signals, and look-elsewhere completeness cliffs as first-class failure modes.

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Think and work like an expert Data Scientist. Use when a task calls for Data Scientist judgment. Reasons from CRISP-DM business estimands, leakage-safe sklearn Pipelines and nested CV, SQL/warehouse semantic metrics, A/B power and SRM/AA guardrails, causal DAG covariate discipline, and Model Cards/Datasheets while treating train-test leakage, Simpson's paradox, peeking, and PSI>0.25 drift as first-class failure modes.

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Think and work like an expert Crop Scientist. Use when a task calls for Crop Scientist judgment. Reasons from genotype-by-environment-by-management interaction, yield-component partitioning, and phenology-gated critical periods through MET stability analysis (AMMI, Finlay-Wilkinson, GGE biplots), mixed models (ASReml-R, lme4), N-response curves (quadratic-plateau, MRTN), and crop models (APSIM, DSSAT) while treating pseudo-replicated subsamples, single-site yield champions, uncorrected harvest moisture, and weather-during-anthesis confounding as first-class failure modes.

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Think and work like an expert Developmental Psychologist. Use when a task calls for Developmental Psychologist judgment. Reasons from developmental trajectories, measurement invariance, and familial-environmental context through age-normed instruments (Bayley, WPPSI/WISC, CBCL, MacArthur-Bates CDI), false-belief and violation-of-expectation paradigms, and lme4/lavaan growth models while treating verbal-demand confounding of theory of mind, informative attrition, adult-normed task misapplication, and parent-versus-direct-assessment divergence as first-class failure modes.

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Think and work like an expert Building Science Engineer. Use when a task calls for Building Science Engineer judgment. Reasons from coupled heat-air-moisture transport through ASHRAE 160 moisture-design analysis, WUFI transient simulation, ACH50 leakage mapping, and ISO 10211 psi-values while treating exfiltration condensation, reservoir claddings, and mold-index sensitivity as first-class failure modes.

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Think and work like an expert Bayesian Statistician. Use when a task calls for Bayesian Statistician judgment. Reasons from Bayes' rule, coherent uncertainty, exchangeability, and partial-pooling hierarchy through Stan/PyMC HMC-NUTS fits, prior and posterior predictive checks, PSIS-LOO, and SBC calibration while treating divergent transitions and funnels, weak identifiability and label switching, improper posteriors, and post-hoc prior tuning as first-class failure modes.

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Run remote BLAST searches against NCBI servers using Biopython Bio.Blast.NCBIWWW. Use when identifying unknown sequences, finding homologs, picking the correct BLAST program (blastn/blastp/blastx/tblastn/tblastx/psiblast/megablast/dc-megablast), interpreting Karlin-Altschul E-values, avoiding the max_target_seqs trap (Shah 2019), choosing composition-based statistics, or limiting searches by organism. Covers RID lifecycle, database choice (nt/nr/refseq_select/swissprot), word-size and CBS taxonomy.

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Production-ready CSS transitions for web apps. Use when implementing notification badges, dropdowns, modals, panel reveals, page transitions, card resizes, number pop-ins, text swaps, icon swaps, success checks, avatar group hovers, error state shakes, search/input clear, skeleton loaders, shimmer text, sliding tabs, tooltips, staggered text reveals, card hover tilt, plus-to-menu morph, or accordions. Triggers on "add a transition", "animate the dropdown", "make the modal open smoothly", "swap icon", "page slide", "stagger animation", "open / close transition", "make it animate", "fade between", "success animation", "form error", "shake on invalid", "hover lift", "avatar stack hover", "clear the search", "skeleton loader", "loading shimmer", "shimmer text", "sliding tabs", "segmented control", "tooltip", "reveal text", "tilt card", "3D hover tilt", "cursor glare", "plus to menu", "FAB morph", "accordion", "collapsible", "expand / collapse", "disclosure". Also "motion tokens", "scan for ad-hoc transitions", "replace hardcoded durations with motion tokens", "tokenize my animations", and the commands transitions reveal, transitions review, transitions apply, transitions refine.

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Analyze agricultural climate risk systems for weather impact modeling, crop insurance, drought/flood prediction, soil moisture, and carbon tracking. Use when: 'assess crop climate risk', 'evaluate weather yield models', 'review crop insurance integration', 'audit drought prediction', 'check carbon sequestration tracking', 'analyze farm adaptation planning', 'evaluate DSSAT or APSIM models'.

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Calculus, series, numerical methods, and optimization for computational mathematics. Covers limits (epsilon-delta, L'Hopital, squeeze theorem), derivatives (rules, optimization, related rates), integrals (Riemann sums, Fundamental Theorem of Calculus, integration techniques), series (convergence tests, Taylor and Maclaurin expansions), differential equations (separable, linear, exact), numerical methods (Newton-Raphson, Euler method, Simpson's rule), and computational pitfalls (floating-point arithmetic, catastrophic cancellation, numerical stability). Use when computing derivatives, integrals, limits, series, solving differential equations, or analyzing numerical accuracy.

日本語の概要は準備中です。原文の説明を表示しています。