「significance」の検索結果

Use this skill to compute ESTIMATE immune-related microenvironment scores from a bulk expression matrix, generate an ESTIMATE score heatmap, and optionally generate group-wise ESTIMATE score boxplots plus significance tables when a sample group file is supplied. Trigger keywords: ESTIMATE, immune score, stromal score, tumor microenvironment score. NOT for: immune cell deconvolution, single-cell analysis, differential expression, clinical diagnosis.

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Use when deciding whether an anthropology project fits American Anthropologist (AA) and which section to target. AA is the four-field AAA flagship, so the test is significance across anthropology (sociocultural, archaeology, biological, linguistic), not single-subfield novelty. Helps frame the question and pick a section; it does not collect data or conduct fieldwork.

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Use when targeting Geology (GSA) or deciding whether a short, high-impact geoscience research letter fits this venue. Encodes the journal's broad-significance-in-tight-length fit, the novelty and rapid-communication bar, GSA house style, official-submission re-check, and desk-reject heuristics.

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Use when targeting Nature Food or deciding whether a food-systems manuscript fits this venue. Encodes the journal's fit, the food-systems-significance and transdisciplinary bar, evidence and reproducibility expectations, house style, official-submission re-check, and desk-reject heuristics.

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Use when targeting Nature Plants or deciding whether a plant-science manuscript fits this venue. Encodes the journal's fit, the broad-significance and Nature-framing bar, evidence and reproducibility expectations, house style, official-submission re-check, and desk-reject heuristics.

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Use when targeting the Bulletin of the American Meteorological Society (BAMS) or deciding whether a broad-interest atmospheric/oceanic/hydrologic-sciences contribution fits this venue. Encodes the journal's review-and-community positioning, the broad-audience-significance bar, synthesis and field-campaign expectations, AMS house style, official-submission re-check, and misfit heuristics.

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Use when building or trimming the exhibits of an American Economic Review: Insights (AER: Insights) short-format manuscript to the hard five-exhibit budget, one page each, no significance asterisks. Designs the minimum exhibit set; it does not run the analysis behind them.

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Use when building or revising exhibits for an AEJ: Economic Policy manuscript so they meet AEA house style and carry the policy message — no significance asterisks, a self-contained headline exhibit, and figures that show the policy effect with uncertainty. Designs exhibits; it does not run the estimation or write the surrounding prose.

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Use when an Advanced Materials result is sound but its central advance and significance are not yet sharp, or when a Communication's opening paragraph must double as its abstract. Structures the one-advance narrative; does not run characterization or design figures.

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Use when designing or auditing experiments for an ACL paper, covering tuned LLM baselines, multi-dataset and multilingual evaluation, statistical significance and variance, human evaluation with agreement reporting, contamination and prompt-sensitivity controls, ablations, and error-analysis expectations in NLP reviewing.

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Use when finalizing tables and figures for a 《会计研究》 (Accounting Research) manuscript — keeping the main table lean, reporting coefficients with the right precision, and interpreting economic magnitude (not just significance stars) for accounting measures. Use after robustness is settled.

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Use when designing or auditing AAAI experiments for the broad-AI program committee, including baselines, ablations, statistical significance, robustness, human evaluation, AI-for-Social-Impact and alignment/safety evidence, compute and cost reporting, and reproducibility-checklist alignment for Phase-1 survival.

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Tests whether two genomic interval sets overlap (colocalize) more than expected by chance using a permutation test against a structured-genome null model. Covers bedtools fisher (analytic 2x2 screen), bedtools shuffle + jaccard permutation, GAT (isochore/GC-conditioned simulation with FDR), regioneR (flexible permutation, randomizeRegions vs circularRandomizeRegions, localZScore), LOLA (universe-relative Fisher against a region database), and GREAT/rGREAT (regulatory-domain binomial + hypergeometric for ontology-from-regions). Stresses the universe/background choice, matched background, blacklist exclusion, and multiple-testing control. Use when asking whether peaks/regions are enriched at enhancers/TFBS/features, scoring region-set colocalization or region-set enrichment, comparing CNV/SV concordance, or turning an overlap count into a defensible p-value.

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Analyzes species-environment relationships with constrained ordination (CCA, RDA, db-RDA), variance partitioning, indicator species (indicspecies IndVal.g group-equalized), PERMANOVA paired MANDATORILY with PERMDISP (Anderson & Walsh 2013; dispersion confounds centroid tests), Joint Species Distribution Models (HMSC, sjSDM, gjam) with explicit rejection of "residual covariance equals biotic interaction", phylogenetic community ecology (SES_MPD/MNTD), trait-environment via RLQ + fourth-corner with corrected modeltype=6 (Dray 2014), bipartite network metrics (NODF, modularity) with curveball null (Strona 2014), and Mantel-test replacements (dbRDA, GDM) for spatial data. Use when testing how environmental gradients structure communities, identifying habitat indicator taxa, partitioning variance among predictors, deciding whether PERMANOVA significance is location vs dispersion, picking among HMSC/sjSDM/gjam, or replacing Mantel tests for landscape data.

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Add p-value brackets, significance asterisks, and effect-size annotations to distribution plots using ggpubr, ggsignif, and statannotations with correct test selection (parametric vs non-parametric vs paired), multiple-testing adjustment, and rendering of negative results. Use when a boxplot/violin/raincloud needs in-figure statistical comparisons between groups.

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Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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How to read experiment results without fooling yourself. Confidence intervals, p-values, multiple testing, sequential testing, CUPED, heterogeneous treatment effects, ratio metrics, network effects, dashboard reconciliation, and the interpretation failures that produce confidently wrong shipping decisions. Use this skill whenever the user is reading a finished experiment result panel and about to make a ship, kill, or iterate decision, or when an experiment number does not match the dashboard number. Triggers on read experiment results, result panel, ship or kill decision, p-value, confidence interval, statistical significance, multiple testing, peeking, sequential testing, CUPED, variance reduction, heterogeneous treatment effects, ratio metric, network effects, inconclusive test, experiment versus dashboard mismatch. Use `experiment-design` instead when the test has not run yet and the question is hypothesis, sample size, duration, or what to test.

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Run conversion rate optimization through hypothesis-driven testing including audit, hypothesis generation, test design, statistical analysis, and rollout decisions. Use this skill whenever the user wants to optimize conversion, run A/B tests, audit a funnel, generate test hypotheses, design experiments, or analyze test results. Triggers on conversion optimization, CRO, A/B test, split test, multivariate test, hypothesis, conversion funnel, funnel audit, experiment design, statistical significance, lift, optimization. Also triggers when the user has a conversion problem and isn't sure where to start, or when test results are ambiguous and need interpretation.

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Query ClinVar for genomic variant clinical significance data

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Design and run statistically rigorous A/B tests and experiments. Use when planning experiments, calculating sample sizes, designing test variants, selecting metrics, analyzing results, or when someone says "let's test that."

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Design and analyze A/B tests: sample size, test duration, and statistical significance for conversion experiments. Use when setting up an A/B test, calculating sample size, designing an experiment, or analyzing results.

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Use when the user has changed a prompt (system prompt, RAG template, agent instruction, etc.) and wants to know whether the candidate is better or worse than the baseline. Also use when the user mentions prompt A/B testing, prompt comparison, prompt optimization validation, "did my prompt change help," or prompt regression testing. Outputs per-dimension win rates with statistical significance using OpenJudge PairwiseAnalyzer.

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Builds a litigation chronology from the disclosure bundle itself — every entry attributed to its source document, behind a CPR 31.22 implied-undertaking check, because documents disclosed in English proceedings may only be used for those proceedings. Adds a privilege screen and case-theory significance tagging, so the output is court-facing work product, not a loose timeline. Use when the user asks to build a chronology or timeline from a disclosure bundle, a matter file, or witness statements, or says 'build the chron', 'what happened when', or needs a Statement of Facts ready timeline.

日本語の概要は準備中です。原文の説明を表示しています。