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概要と使いどころ
Query STRING REST API for PPIs (59M proteins, 20B interactions, 5000+ species). Retrieve networks, run GO/KEGG enrichment, find partners, test PPI significance, visualize networks, analyze homology. For chemical interactions use chembl-database-bioactivity; pathways use kegg-database.
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Systematic strategies for searching scientific literature across PubMed, arXiv, Google Scholar, and AI-assisted tools. Covers PICO framework for clinical questions, three-tiered search (database-specific, AI-assisted, content extraction), PubMed field tags and MeSH, boolean query construction, and full-text extraction. Use when planning a literature search or choosing a search tier.
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AiZynthFinder retrosynthetic route planning (CASP) from AstraZeneca Molecular AI. Monte Carlo tree search guided by a template-based neural expansion policy recursively disconnects a target SMILES until precursors are found in a purchasable stock. Covers config.yml (v4 format), aizynthcli batch screening, the AiZynthFinder/AiZynthExpander Python API, one-step disconnections, custom stocks via smiles2stock, scorers, Retro*/breadth-first/DFPN search alternatives, and reading output.json.gz / trees.json. Use for synthesis route planning, synthesizability screening, and building-block/precursor search. For reaction barriers use neb-irc-activation-energy; for 2D reaction scheme drawing use rdkit-chemdraw-cdxml.
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Cheminformatics toolkit for molecular analysis and virtual screening: SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints (Morgan/ECFP, MACCS), Tanimoto similarity, SMARTS substructure filtering, Lipinski drug-likeness, reaction enumeration, 2D/3D coordinates. For simpler API use datamol; use RDKit for fine-grained sanitization, custom fingerprints, or SMARTS/reaction control.
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Query DDInter drug-drug interactions via REST API (1.7M+ interactions, 2,400+ drugs). Search by drug name/ID for severity (major/moderate/minor), mechanisms, and clinical recommendations. No auth. For FDA labeling use dailymed-database; for pharmacogenomics use clinpgx-database.
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Query IUPHAR/BPS Guide to Pharmacology (GtoPdb) for receptor-ligand interactions, target/ligand metadata, families, and approved drugs. Affinities (pKi/pIC50/pKd), action (Agonist/Antagonist/etc.), species, structures (SMILES/InChI). No auth. Always resolve targets via geneSymbol/accession; most metadata lives in sub-resources (/databaseLinks, /structure, /synonyms).
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Advanced GitHub Actions workflow automation with AI swarm coordination, intelligent CI/CD pipelines, and comprehensive repository management
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This skill should be used when the user wants to record bookkeeping entries (仕訳), import transaction data from CSV files, receipts, or invoices, or manage their general ledger. Trigger phrases include: "仕訳を入力", "仕訳登録", "CSVを取り込む", "レシートを読み込む", "請求書を取り込む", "帳簿を付ける", "経費を記録", "売上を記録", "仕訳を修正", "仕訳を検索", "仕訳を削除", "取引を登録", "帳簿の初期化".
Background context for housing loan tax credit (住宅ローン控除) in the shinkoku tax filing plugin. Contains eligibility requirements, credit limits, calculation rules, and interaction with furusato-nozei for the current tax year. This skill is not user-invocable — Claude loads it automatically when responding to housing loan tax credit questions or calculations.
Provides patterns to deploy ECS tasks and services with GitHub Actions CI/CD. Use when building Docker images, pushing to ECR, updating ECS task definitions, deploying ECS services, integrating with CloudFormation stacks, configuring AWS OIDC authentication for GitHub Actions, and implementing production-ready container deployment pipelines. Supports ECS deployments with proper security (OIDC or IAM keys), multi-environment support, blue/green deployments, ECR private repositories with image scanning, and CloudFormation infrastructure updates.
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Provides comprehensive Drizzle ORM patterns for schema definition, CRUD operations, relations, queries, transactions, and migrations. Proactively use for any Drizzle ORM development including defining database schemas, writing type-safe queries, implementing relations, managing transactions, and setting up migrations with Drizzle Kit. Supports PostgreSQL, MySQL, SQLite, MSSQL, and CockroachDB.
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Provides comprehensive React 19 patterns for Server Components, Server Actions, useOptimistic, useActionState, useTransition, concurrent features, Suspense boundaries, and TypeScript integration. Generates executable code patterns, validates security for public endpoints, and optimizes performance with React Compiler or manual memoization. Proactively use when building React 19 applications with Next.js App Router, implementing optimistic UI, or optimizing concurrent rendering.
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Provides Event-Driven Architecture (EDA) patterns for Spring Boot — creates domain events, configures ApplicationEvent and @TransactionalEventListener, sets up Kafka producers and consumers, and implements the transactional outbox pattern for reliable distributed messaging. Use when implementing event-driven systems in Spring Boot, setting up async messaging with Kafka, publishing domain events from DDD aggregates, or needing reliable event publishing with the outbox pattern.
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Match bank transactions to invoices and surface unpaid / unmatched items in a Well workspace. Use when the user asks what's paid vs unpaid, to reconcile the bank, to find missing payments, or to match transactions to invoices.
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Builds and edits PowerPoint decks bound to a company's own .pptx or .potx template, with a consulting-grade storyline and a rendered visual QA pass. Maps the template's masters, layouts, placeholders, theme colors and fonts; drafts a storyboard of action titles (pyramid principle, SCR) for approval; fills the template's own placeholders instead of drawing text boxes; adds native charts in theme colors, tables sized to placeholders, speaker notes and source lines; then renders every slide to PNG and checks text overflow, off-slide and overlapping shapes, off-theme fonts and colors, empty placeholders and weak titles. Use whenever the user says use our template, company deck, brand or corporate template, make slides, build a deck, pptx, potx, consulting-style deck, board or client presentation, action titles, or fix my deck formatting, and whenever an existing deck must be edited without breaking its masters. Complements the generic pptx skill.
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Predicts client renewal likelihood based on health score signals. Analyzes engagement, support, adoption, satisfaction, billing, stakeholder, and usage data to calculate a weighted Health Score (0-100), classify renewal risk, and generate a prioritized action plan with early warning signals and recommended save plays.
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Analyze meeting transcripts to extract decisions, action items, blockers, sentiment, and generate follow-up emails. Use when user provides meeting notes, transcripts, or recordings and needs structured summaries or action tracking.
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Runs small and midsize business bookkeeping operations - categorizes bank and card transactions to a chart of accounts, reconciles a bank or card statement against the ledger, works a month-end close checklist, and produces a close package for the accountant. Works from QuickBooks Online, Xero, bank CSV/OFX, or Mercury exports, and from the Xero, QuickBooks, or Mercury connectors when present. Use it whenever the user says "reconcile", "bank rec", "categorize transactions", "month end close", "close the books", "books don't match the bank", "reconciliation is off by", "uncategorized expenses", or shares a QuickBooks or Xero export or a bank statement CSV, even if they do not name the task. Never plugs a difference; every unreconciled dollar is explained or listed.
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Configures GitHub Actions CI/CD workflows for testing, linting, and deployment. Use when setting up automation for a Python, Rust, or TypeScript project.
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Route DeepKE knowledge extraction workflows across supervised extraction, data prep, triples, LLMs, and MCP tools.
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Validate, lint, audit, fix GitHub Actions workflows (.github/workflows).
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Implement the NIST Privacy Framework IDENTIFY function including ID.BE business environment, ID.DA data actions, ID.IM improvement, and ID.RA risk assessment subcategories. Provides control mapping, gap analysis templates, and implementation workflows for privacy risk identification.
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Build automated PII detection and redaction pipelines using spaCy NER, Microsoft Presidio, and AWS Macie integration. Includes confidence scoring, custom entity type definitions, batch processing workflows, and multi-format document scanning for structured and unstructured data sources.
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Guide for implementing GDPR-valid consent under Article 7 conditions and Article 4(11) definition. Covers five core requirements: freely given, specific, informed, unambiguous, and clear affirmative action. Includes pre-ticked boxes prohibition per Planet49 CJEU C-673/17, consent form audit checklist, and practical implementation patterns.
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