863 件 ・ 関連度順
概要と使いどころ
Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) Predicting binder-target complex structures, (3) Calculating confidence metrics (pLDDT, pTM, ipTM), (4) Self-consistency validation of designs, (5) Multi-chain complex prediction with AlphaFold-Multimer. For faster single-chain prediction, use esm. For QC thresholds, use protein-qc.
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This skill calculates key financial ratios and metrics from financial statement data for investment analysis
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This skill reassesses the insulin plan when discontinuing continuous subcutaneous insulin infusion (CSII) and transitioning to multiple daily injections (MDI). It is triggered by phrases such as 'Review planned basal-bolus regimen after pump' and 'Confirm MDI dose calculations and schedule'.
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This skill recommends obtaining an oncology consultation to direct treatment of the underlying malignancy causing hypercalcemia of malignancy. It is triggered when a clinician diagnoses HCM and seeks guidance on coordinating cancer‑directed therapy.
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The guideline suggests checking serum magnesium and phosphate levels and repleting if low in patients receiving antiresorptive therapy for hypercalcemia of malignancy. Clinicians should consider this when they note electrolyte abnormalities or inquire about supportive care during bisphosphonate or denosumab treatment.
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Adjusts intravenous bisphosphonate dosing and infusion duration for patients with hypercalcemia of malignancy and renal insufficiency (creatinine clearance <60 mL/min). Triggered when a clinician encounters renal impairment and asks how to modify zoledronic acid or pamidronate infusion rates.
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Recommends initiating intravenous bisphosphonate or denosumab for adults with hypercalcemia of malignancy compared with no treatment. Use when a clinician asks about first‑line pharmacologic therapy for HCM or when deciding to start antiresorptive agents.
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This skill suggests using denosumab rather than an intravenous bisphosphonate for adults with hypercalcemia of malignancy. It is triggered when a clinician questions which antiresorptive to choose first or seeks guidance on drug selection for HCM.
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Determines the appropriate zoledronic acid dose (3‑4 mg IV) and infusion duration based on renal function. Triggered when a clinician prepares to prescribe zoledronic acid for hypercalcemia of malignancy and asks about renal‑adjusted administration.
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Determines the appropriate IV pamidronate dose (60‑90 mg) and infusion duration (2‑24 h) for adults with hypercalcemia of malignancy based on renal function. Triggered when a clinician orders pamidronate and asks how to adjust for kidney dysfunction (eGFR < 60 mL/min/1.73 m²).
日本語の概要は準備中です。原文の説明を表示しています。
Calculates the lowest effective glucocorticoid dose (dexamethasone or prednisone) to normalize blood pressure and serum potassium in glucocorticoid-remediable aldosteronism (GRA/FH-I) by titrating to biochemical and clinical targets. Indicated when initiating medical treatment for confirmed GRA, triggered by findings such as early-onset hypertension, family history of stroke before age 40, spontaneous hypokalemia, or suppressed plasma renin activity with elevated aldosterone.
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Suggests using hydrocortisone 15–25 mg or cortisone acetate 20–35 mg daily in two or three divided oral doses for adult primary adrenal insufficiency (PAI) patients initiating glucocorticoid replacement. The highest dose is given upon awakening, with the second dose either early afternoon (≈2 h after lunch) or split into lunch and afternoon doses; consider total daily dose calculation based on chosen formulation and frequency.
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Decide when to order coronary artery calcium (CAC) scoring in a primary-prevention patient and interpret the result per the 2026 ACC/AHA multisociety dyslipidaemia guideline. Covers the Class 1 indication (men ≥40 / women ≥45, borderline / intermediate PREVENT-ASCVD risk, uncertainty about LLT), CAC score interpretation (0, 1–99, 100–299, ≥300, ≥1000), how CAC modifies LDL and non-HDL goals, when to repeat CAC, and pitfalls (incidental CAC on non-cardiac CT, radiation, cost). Use when a clinician asks should I order a CAC score, CAC indications, what does CAC 150 mean, treatment goals with CAC score, repeat CAC frequency, CAC in a smoker, CAC vs CCTA, is CAC useful in intermediate risk. Grounded in the 2026 ACC/AHA multisociety dyslipidaemia guideline.
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Use for Fermi estimation, or when a rough number is needed fast: "roughly how many...", "ballpark the cost", "estimate capacity or market size", "is this even feasible?". Decomposes, uses ranges and sanity-checks. Skip when exact data is available or a precise calculation is wanted.
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Audit social media accounts (TikTok, IG, etc.): scrape profiles, calculate engagement metrics, diagnose performance drops, interpret analytics screenshots.
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Expert-level discrete mathematics knowledge. Use when working with logic, set theory, combinatorics, graph theory, relations, functions, induction, recursion, boolean algebra, or discrete probability. Also use when the user mentions 'combinatorics', 'permutations', 'combinations', 'pigeonhole principle', 'inclusion-exclusion', 'generating functions', 'recurrence relations', 'graph theory', 'trees', 'logic', 'propositional calculus', or 'boolean algebra'.
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Expert-level general relativity knowledge. Use when working with curved spacetime, Einstein field equations, geodesics, black holes, gravitational waves, cosmology, Schwarzschild metric, or tensor calculus. Also use when the user mentions 'Einstein field equations', 'curved spacetime', 'geodesic', 'black hole', 'event horizon', 'Schwarzschild', 'gravitational waves', 'spacetime curvature', 'Riemann tensor', 'metric tensor', 'cosmological constant', or 'gravitational lensing'.
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Calcule la vélocité des sprints terminés (Σ points des tickets feuilles livrés) et recommande la capacité du prochain sprint. À lancer en fin de sprint. Thin wrapper bash sur sprint_velocity.sh, zéro LLM lourd. Usage: /velocity [<titre-sprint>]
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Planifie le prochain sprint : calcule la capacité (vélocité glissante 3 sprints), reporte les tickets non livrés du sprint courant, puis complète depuis le backlog par priorité jusqu'à la capacité. Présente le plan, attend validation, puis assigne les tickets au sprint. Usage: /plan-sprint [<titre-sprint-cible>]
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Creates marketing analytics reports, KPI dashboards, ROI calculations, and performance summaries for SME marketing teams. Handles weekly/monthly reporting, campaign analysis, content performance reviews, and data-driven recommendations. Use when user asks about marketing metrics, reporting, KPIs, dashboards, ROI analysis, performance review, or data-driven marketing decisions.
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Orientação de liderança técnica para equipes de engenharia, decisões de arquitetura e estratégia de tecnologia. Inclui analisador de débito técnico, calculadora de escalabilidade de equipes, frameworks de métricas de engenharia, ferramentas de avaliação de tecnologia e templates de ADR. Use ao avaliar débito técnico, escalar equipes de engenharia, avaliar tecnologias, tomar decisões de arquitetura, estabelecer métricas de engenharia ou quando o usuário menciona CTO, débito técnico, débito técnico, escalabilidade de equipes, decisões de arquitetura, avaliação de tecnologia, métricas de engenharia, métricas DORA ou estratégia de tecnologia.
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Especialista em criar ferramentas geradoras compartilháveis que viralizam - geradores de nomes, criadores de quiz, criadores de avatares, testes de personalidade e ferramentas de calculadora. Abrange a psicologia do compartilhamento, mecânicas virais e construção de ferramentas que as pessoas não conseguem resistir em compartilhar com amigos. Use quando: ferramenta geradora, criador de quiz, gerador de nomes, criador de avatares, ferramenta viral.
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Geração de demanda multi-canal, otimização de mídia paga, estratégia de SEO e programas de parcerias para startups Series A+. Inclui calculadora de CAC, playbooks de canal, integração com HubSpot e táticas de expansão internacional. Use ao planejar campanhas de geração de demanda, otimizar mídia paga, construir estratégias de SEO, estabelecer parcerias, ou quando o usuário menciona demand gen, anúncios pagos, LinkedIn ads, Google ads, CAC, aquisição, geração de leads ou pipeline.
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Quando o usuário quer planejar, avaliar ou construir uma ferramenta gratuita para fins de marketing — geração de leads, valor em SEO ou conscientização de marca. Use também quando o usuário menciona "engenharia como marketing", "ferramenta gratuita", "ferramenta de marketing", "calculadora", "gerador", "ferramenta interativa", "ferramenta de geração de leads", "construir uma ferramenta para leads" ou "recurso gratuito". Esta competência conecta engenharia e marketing — útil para fundadores e profissionais de marketing técnico.
日本語の概要は準備中です。原文の説明を表示しています。