1,492 件 ・ 関連度順
概要と使いどころ
Use when drafting or polishing an Agricultural Systems (AgSy) manuscript so it reads clearly for a systems-science audience, follows the journal's format, and meets front-matter requirements (abstract <= 250 words, Highlights, graphical abstract). Research papers run to about 8,000 words (no hard cap). Tightens prose and format; it does not invent content.
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Use when running the final pre-submission preflight for an Advanced Materials manuscript — article type, format, files, Supporting Information, TOC graphic, ORCID, and metadata for the Wiley submission system. Verifies submission readiness; does not write content.
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Use when anticipating the objections a sophisticated American Economic Journal: Applied Economics (AEJ: Applied) referee will raise, so a manuscript pre-empts them before submission or addresses them in revision. Plans the defense; it does not draft the response letter (aeja-rebuttal) or run the submission preflight (aeja-submission).
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Use when an American Economic Journal: Applied Economics (AEJ: Applied) manuscript's headline estimate must be shown to survive specification, sample, and inference choices before submission or in an R&R. Builds the robustness suite a sophisticated referee expects; it does not establish the primary identification (aeja-identification) or format the exhibits (aeja-tables-figures).
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Use when designing or auditing figures for an Advanced Materials manuscript, including the lead figure, multi-panel characterization figures, and the Table-of-Contents graphic, where visual quality is a house expectation. Designs figure strategy; does not run the analysis or write prose.
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Use when choosing and justifying the research design for an Administrative Science Quarterly (ASQ) manuscript — qualitative (grounded-theory, ethnographic, historical) or quantitative — and setting the rigor bar. Designs the study; it does not run the analysis (see asq-data-analysis).
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Evaluate whether a creator, influencer, or brand account reaches the right audience using public profile, aggregate demographic, geography, language, content, comment, and commerce signals. Use for creator comparisons, sponsorship fit, market fit, and audience-quality research.
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Research a company's ideal customer profiles and build detailed synthetic buyer personas. Identifies 4-6 distinct buyer segments through web research, then creates rich, realistic personas with demographics, motivations, skepticism profiles, decision criteria, and language patterns. Use when you need to understand who your buyers are at a deep level — their motivations, objections, and how they evaluate solutions.
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Portable visual skill pack for the Agent Skills ecosystem (Claude Code, Claude Desktop, Claude Cowork, Claude Design, Goose, Cursor, Codex). Discovers community-published styles + formats via the gooseworks CLI, runs an extract-style workflow on reference images, and exports rendered PNGs via Playwright.
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Search and visualize the world's data - get charts, insights, and embeddable knowledge cards for finance, economics, demographics, sports, and more
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Assemble a premium 3D product-showcase ad from a config — four beat clips (an orbiting hero rotation, a macro push-in, a physics reveal, a typographic close) normalized to the chosen backdrop colour, hard-concatenated in order, closed on a deterministic Playwright brand end card, and mixed under one instrumental bed at loudnorm I=-16 (music-only, no VO). Ships the runnable build_endcard.py + build_masters.py; the rotation/macro clips are create-video-fal i2v seeded on a create-image-fal styled hero, the reveal is Veo3 i2v, and the bed is create-music-elevenlabs. Use for the 3d-product-showcase format.
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Render a punchy ~12s vertical (9:16) music-only direct-response OFFER ad as a 4-beat kinetic-typography film — HEADLINE slam → real PRODUCT drop → CLAIM/proof → CTA pill — from one config of copy slots, a real product photo, a brand palette, fonts, bpm, and beat split. DETERMINISTIC + FREE (a bundled Remotion project; springs + interpolate, no AI-gen for visuals). Backgrounds are engine gradient divs off the palette, props are inline SVG, the ONLY composited bitmap is the REAL product photo (objectFit:contain, never stretched), and ALL headline/claim/CTA/URL/wordmark text is typeset in the engine — never AI-rendered (the format's credibility guard). A driver binds the config to Remotion input props, renders the 9:16 master, and derives a 1:1 center-crop with ffmpeg. Two gating checks run before render (claim verbs must match the product's physical format; the claim beat needs an edge-entry mechanism prop). Use for the motion-graphics-offer-ad format.
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Handles BED-format genomic intervals (BED3 through BED12, narrowPeak/broadPeak) and the coordinate-system substrate the whole interval category rests on, with bedtools (CLI) and pybedtools/pyranges/pandas (Python). Covers the 0-based half-open vs 1-based-closed convention boundary and the start-1/end-unchanged conversion, the silent failures (chrom-name mismatch, CRLF, lexicographic-vs-version sort under -sorted), genome/chrom.sizes generation, sorting contracts, BED12 block invariants, validation, makewindows, cross-assembly liftover (liftOver/CrossMap), and BED<->VCF/BAM/FASTA conversion. Use when reading, creating, validating, sorting, lifting between genome builds, or converting interval files, preparing inputs for bedtools/tabix/bigBed, or debugging an off-by-one or empty-overlap result.
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Designs and ranks guide RNAs (sgRNAs) for CRISPR-Cas9/Cas12a gene knockout by scanning a target for PAM sites (NGG SpCas9, NNGRRT SaCas9, TTTV Cas12a, NG SpCas9-NG, near-PAMless SpRY), enumerating candidate spacers, applying hard filters (Pol-III TTTT terminator, 5' G, GC), ranking on-target activity with the context-appropriate model (Rule Set 2/Azimuth for U6/lentiviral, CRISPRscan for T7/embryo, DeepHF for high-fidelity variants, DeepCpf1 for Cas12a), and predicting the indel/frameshift outcome (Bae out-of-frame score, inDelphi, FORECasT, Lindel). Use when selecting sgRNAs to knock out a gene, choosing a nuclease/PAM for a constrained locus, picking which exon to target, or shortlisting guides before an off-target check. Off-target specificity, base/prime editing, and HDR donors are separate skills.
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Build weighted gene co-expression networks to identify modules of co-regulated genes, relate them to phenotypes, and find hub genes using WGCNA, hdWGCNA, MEGENA, CEMiTool, and Gaussian graphical models. Covers signed-network choice, soft-threshold selection, module preservation, and the marginal-vs-partial-correlation distinction. Use when finding co-expression modules, identifying hub genes, relating gene networks to clinical or experimental traits, or building single-cell co-expression networks. For directed TF-target inference see scenic-regulons and grn-inference; for condition rewiring see differential-networks.
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Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.
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Assigns isolate identity at the right resolution for the question -- ANI/Mash species triage, 7-locus MLST historical comparability, cgMLST/wgMLST outbreak resolution (chewBBACA, BIGSdb, Ridom SeqSphere, EnteroBase HierCC), in-silico serotyping (SISTR/SeqSero2 Salmonella, SerotypeFinder E. coli, Kaptive Klebsiella, SeroBA pneumococcus, spa+SCCmec S. aureus), and lineage callers (TB-Profiler/Mykrobe barcode for MTBC, Pangolin + Nextclade for SARS-CoV-2, PopPUNK GPSC for S. pneumoniae). Use when typing bacterial isolates for surveillance or outbreak investigation, choosing between cgMLST allele distance and core-SNP distance for cluster definition, harmonising calls across schemas/database versions, assigning MTBC lineage with the Napier 90-SNP barcode, calling Salmonella serovar via SISTR with monophasic Typhimurium awareness, running Pangolin UShER mode with pangolin-data version pinning, or selecting a typing resolution to match the surveillance question.
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Build publication-quality figures in R with ggplot2 using the grammar of graphics (data + aesthetics + geometries + scales + facets + themes) with CVD-safe palettes, cairo_pdf TrueType embedding, programmatic aes via tidy evaluation, and the theme_classic publication baseline. Use when producing static figures in R for papers, presentations, or reports.
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Performs subgroup and heterogeneous treatment effect (HTE) analyses for clinical trials. Covers Mantel-Haenszel pooling, Breslow-Day, interaction tests in regression, RERI for additive interaction, modern data-adaptive HTE methods (STEPP, SIDES, causal forests, X/R-learners), Bayesian shrinkage (Dixon-Simon, MAP, EXNEX), graphical multiplicity (Bretz-Maurer), and credibility frameworks (Sun BMJ, EMA 2019). Use when analyzing treatment effects across patient subgroups for regulatory submissions or precision-medicine claims.
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Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, applies the Patel et al 2024 *Nat Biotechnol* failure-mode framework, and validates that normalization is applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.
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Resolves rsIDs, navigates RsMergeArch/SNPHistory merge chains, and converts between rsID, SPDI, HGVS, and VCF representations using the dbSNP Build 156 JSON architecture. Use when normalizing variant identifiers, joining variant databases by cluster ID, or tracking deprecated rsIDs through historical merges.
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Use when working with ANY GPU rendering, Metal, OpenGL migration, shaders, 3D content, RealityKit, AR, USD/USDZ files, or display performance. Covers Metal migration, shader conversion, RealityKit ECS, RealityView, USDKit, ProMotion.
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Implement, review, or improve SwiftUI Liquid Glass effects for iOS 26+. Covers glassEffect modifier, GlassEffectContainer, glass button styles, glass toolbar/tab bar, static status badges vs interactive controls, morphing transitions, tinting, interactive glass, ToolbarSpacer, scrollEdgeEffectStyle, backgroundExtensionEffect, and availability gating. Use when asked about Liquid Glass, glass buttons, glassEffect, GlassEffectTransition, glassEffectID, glassEffectUnion, scroll edge effects, or adopting iOS 26 design.
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Use Apple CryptoKit for Swift cryptographic primitives. Use when hashing with SHA-2 or SHA-3, generating HMACs, encrypting with AES-GCM or ChaChaPoly, signing with P256/P384/P521/Curve25519 or ML-DSA keys, performing ECDH, HPKE, ML-KEM, or X-Wing key exchange, using Secure Enclave CryptoKit keys, or migrating CommonCrypto code to CryptoKit.
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