「ips」の検索結果

Provider-independent workflow for producing SaaS and software product demo videos, including app walkthroughs, feature launches, sales demos, onboarding clips, help-center explainers, website hero demos, and PLG assets. Use when an agent must plan, script, capture, synthesize, edit, localize, review, or QA privacy-safe software demo videos with substantiated claims, accessible captions, screen/cursor direction, CTA variants, and stakeholder approval.

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Provider-independent lighting direction for AI-generated images, video clips, ads, film scenes, avatars, product shots, interviews, beauty work, and social content. Use when an agent must specify, translate, maintain, troubleshoot, or QA motivated lighting, key/fill/back/rim/practical lights, hard or soft light, color temperature, exposure, contrast, time-of-day, continuity, reference strategy, or safety/accessibility risks in generated media.

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Turn any X (Twitter) profile into a 10.3s animated "POSTING LICENSE" card video — a fake driver's license in X's branding: the card slides in over an animated dot-matrix ground, license text types on letter-by-letter, follower / following / post counters tick up, a diagonal glimmer sweeps as the card tilts in 3D, it flips to a fine-print back with a signature write-on, then crouches and leaps out of frame. Trigger on: "X driver's license", "posting license", "make an X license for @handle", "license card video". The whole composition is a finished template — the agent only supplies profile data and renders.

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Track media coverage, press mentions, journalist activity, and industry narrative across news outlets, Twitter, and LinkedIn. Ideal for PR teams monitoring earned media, tracking campaign impact, and identifying journalist relationships.

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Plan and produce short AI videos with SandBase image, video, music, and speech models. Use for commercials, social clips, explainers, short films, storyboards, or multi-shot video generation; use a simpler image or audio skill when no video deliverable is needed.

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Find cross-database references between NCBI databases using Biopython Bio.Entrez (ELink). Use when navigating gene to protein/structure, sequence to publication, PubMed to GEO, BioProject to SRA runs, or discovering all link relationships for a record. Covers linkname semantics, cmd= variants, asymmetric link warnings, neighbor_history for >200 input IDs, and per-database link tables.

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Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

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Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

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Quality control and exploration of RNA-seq count matrices before differential expression. Check for outliers, batch effects, and sample relationships. Use when assessing count matrix quality before DE analysis.

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Compare gene regulatory and co-expression networks between biological conditions to identify rewired regulatory relationships using DiffCorr. Detects gained, lost, and reversed gene-gene correlations between conditions. Use when comparing co-expression networks between disease vs control, treatment conditions, or developmental stages.

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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2025 Nat Genet; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.

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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

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Build weighted gene co-expression networks to identify modules of co-regulated genes and relate them to phenotypes using WGCNA and CEMiTool. Detects hub genes and module-trait relationships from bulk or single-cell expression data. Use when finding co-expression modules, identifying hub genes, or relating gene networks to clinical or experimental variables.

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Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.

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Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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ESM2 protein language model for sequence scoring, embeddings, and plausibility checks. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai1-structure-prediction or boltz-structure-prediction. For QC thresholds, use protein-design-qc.

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ESM2 protein language model for embeddings and sequence scoring. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai or boltz. For QC thresholds, use protein-qc.

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Turn a vague bug report into a VERIFIED minimal reproduction and then a failing regression test, agent-driven end to end. Covers extracting the implicit repro from a thin report (env, build, steps, data), the reproduce-minimize-isolate-capture loop, git bisect to find the introducing commit, building a deterministic minimal repro (fixed seeds, frozen time, stubbed network), writing the failing regression test BEFORE the fix (red) and confirming the fix flips it green, and writing repro evidence back into the ticket. Distinguishes flaky-not-reproducible from environment-specific. Use when: "reproduce this bug," "minimal reproduction," "repro steps," "find the commit that broke it," "git bisect," "make the repro deterministic," "write a failing test for this bug," "regression test for a defect," "can't reproduce this bug." Not for: Classifying/deduplicating/severity-routing existing failures without reproducing them — that is ai-bug-triage. Generating tests from specs rather than from a defect — that is ai-test-generation. Related: ai-bug-triage, ai-test-generation, test-reliability, systematic-debugging, qa-project-context.

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Seed a fresh (greenfield) repository with the PRD-Driven Context Engineering scaffold — PRD.md, SoT/ knowledge files, EPIC templates, domain-profile config, and agent MEMORY starters. Invoked as /prd-ce:init when the plugin is installed. The framework itself (skills, agents, hooks, scripts) ships LIVE in the plugin; this skill only plants the consumer-owned files the plugin cannot carry as behavior. Triggers on "/prd-ce:init", "set up PRD lifecycle here", "scaffold a new PRD-CE project", "initialize the methodology". Outputs a seeded scaffold + a verification report.

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Synthesize behavioral personas from prior stage evidence for journey mapping and marketing during PRD v0.4 User Journeys. Triggers on requests to define personas, create user profiles, identify target users, or when user asks "who are our users?", "define personas", "user profiles", "target users", "persona creation", "who uses this product?". Consumes CFD- (v0.1-v0.3), BR- (targeting from v0.3 Moat), FEA- (v0.3 Feature Value Planning). Outputs PER- entries with behavioral profiles and feature relationships. Feeds v0.4 User Journey Mapping.

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Define how system components connect, establishing boundaries, patterns, and integration approaches during PRD v0.6 Architecture. Triggers on requests to design architecture, create system design, define component relationships, or when user asks "design architecture", "system design", "how do components connect?", "architecture decisions", "technical architecture", "system overview". Consumes TECH- (stack selections), RISK- (constraints), FEA- (features). Outputs ARC- entries documenting architecture decisions with rationale. Feeds v0.6 Technical Specification.

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Stimulus JS framework for Symfony UX -- client-side behavior via HTML data attributes, zero server round-trips. Use when creating controllers for DOM manipulation, handling click/input/submit events, managing targets and values, wiring outlets between controllers, wrapping third-party JS libraries, or building toggles, dropdowns, modals, tabs, clipboard interactions. Code triggers: data-controller, data-action, data-target, data-*-value, data-*-class, data-*-outlet, stimulusFetch lazy, connect(), disconnect(), static targets, static values. Also trigger when the user asks "how do I add a click handler", "how to toggle a class", "how to build a dropdown/modal/tabs", "how to wrap a JS library in Symfony", "add keyboard shortcuts", "lazy-load a controller", "listen to global events", "communicate between controllers". Do NOT trigger for partial page updates without JS (use turbo), server-rendered reactivity (use live-component), or reusable Twig templates (use twig-component).

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Capture durable, project-specific learnings from the work just done into the knowledge/ base — gotchas, implementation quirks, things looked up or web-searched, live-API behaviours, and design decisions (as ADRs). Use before opening a PR (it runs automatically in /deliver), or any time you've learned something worth remembering. Records only non-obvious, reusable facts; skips anything already in the repo, CLAUDE.md, or git history.

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