「pin」の検索結果

Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

日本語の概要は準備中です。原文の説明を表示しています。

Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

日本語の概要は準備中です。原文の説明を表示しています。

Calls HLA class I and class II alleles at 2/4/6/8-field resolution from WGS/WES/RNA-seq/long-read data using OptiType, HLA-LA, T1K, Polysolver, HLA-HD, arcasHLA, StarPhase, or HIBAG imputation. Use when typing for HSCT, solid-organ transplant, neoantigen prediction, PGx screening (B*57:01, B*15:02, etc.), or disease-association studies, with reconciliation across tools and IPD-IMGT/HLA version mismatch handling.

日本語の概要は準備中です。原文の説明を表示しています。

Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sparse loci with SuSiE-inf or FINEMAP-inf, integrating functional priors via PolyFun, fine-mapping across ancestries with SuSiEx, diagnosing LD mismatch via estimate_s_rss and kriging_rss, handling HLA or long-range LD, or feeding credible sets into coloc.susie for colocalization.

日本語の概要は準備中です。原文の説明を表示しています。

Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Provides guidance on acceptable blood sampling conditions for primary aldosteronism screening when ideal early‑morning supine fasting conditions cannot be met. Triggers include when a clinician says “The patient wasn’t fasting/supine” or questions whether non‑ideal sampling affects screening validity.

日本語の概要は準備中です。原文の説明を表示しています。

Determines when adrenal venous sampling (AVS) is indicated for functional subtyping of primary aldosteronism (PA) when surgical treatment is feasible and desired by the patient. Triggered when a clinician confirms PA diagnosis and asks 'Do I need AVS for subtyping?' or evaluates surgical candidacy.

日本語の概要は準備中です。原文の説明を表示しています。

Determines unilateral vs bilateral aldosterone excess based on cortisol-corrected aldosterone ratios from adrenal venous sampling, with ratio >4:1 indicating unilateral excess, ratio 3:1 suggestive of bilateral hypersecretion, and interpretation dependent on cosyntropin stimulation protocol used during sampling. Use when analyzing AVS results to guide surgical vs medical treatment decisions; triggers include 'AVS lateralization ratio', 'cosyntropin-stimulated AVS', 'aldosterone-to-cortisol ratio >4:1', and 'ratio 3:1 suggestive of bilateral disease'.

日本語の概要は準備中です。原文の説明を表示しています。

Suggests using morning cortisol ≤140 nmol/L (5 µg/dL) in combination with ACTH as a preliminary test suggestive of primary adrenal insufficiency when a corticotropin stimulation test is not feasible. Use when patients present with indicative symptoms such as hypotension, hyponatremia, hyperkalemia, or fatigue and corticotropin stimulation testing cannot be performed.

日本語の概要は準備中です。原文の説明を表示しています。

Clinicians educate adrenal insufficiency patients taking nondexamethasone glucocorticoids who initiate enzyme-inducing antiepileptic drugs about early signs of adrenal insufficiency. Trigger when an AI patient on nondexamethasone GC starts an enzyme-inducing AED such as phenytoin, carbamazepine, or oxcarbazepine.

日本語の概要は準備中です。原文の説明を表示しています。

In central hypothyroidism patients receiving levothyroxine who initiate enzyme‑inducing antiepileptic drugs, the guideline recommends checking free T4 at least 6 weeks after AED start and increasing the levothyroxine dose if free T4 falls below the target range. Triggers include: central hypothyroidism patient on levothyroxine starting antiepileptic drug such as phenytoin, carbamazepine, or oxcarbazepine.

日本語の概要は準備中です。原文の説明を表示しています。

Ultra-compressed communication mode. Cuts token usage ~75% by dropping filler, articles, and pleasantries while keeping full technical accuracy. Use when user says "caveman mode", "talk like caveman", "use caveman", "less tokens", "be brief", or invokes /caveman.

日本語の概要は準備中です。原文の説明を表示しています。

Use cloud browser services (Browserbase) for Cloudflare bypass, JavaScript rendering, and stealth scraping when local tools fail

日本語の概要は準備中です。原文の説明を表示しています。

Guides AI agents through Senzing entity resolution workflows using the Senzing MCP server. Covers data mapping to Senzing format, SDK code generation (Python, Java, C#, Rust, TypeScript/Node.js), documentation search, error troubleshooting, sample data access, reporting and visualization, SDK setup guides, and V3-to-V4 migration. Use when working with entity resolution, record matching, record linkage, deduplication, Senzing SDK integration, data mapping for Senzing ingestion, or troubleshooting Senzing error codes. Also use when the user mentions matching records across data sources, finding duplicate entities, identity resolution, master data management, or needs to resolve who is who across datasets.

日本語の概要は準備中です。原文の説明を表示しています。

Expert-level mechanical vibrations covering free and forced vibration, damping, resonance, modal analysis, vibration isolation, and rotating machinery.

日本語の概要は準備中です。原文の説明を表示しています。

Expert-level complex analysis knowledge. Use when working with complex functions, holomorphic functions, Cauchy's theorem, contour integration, Laurent series, residues, conformal mappings, or analytic continuation. Also use when the user mentions 'holomorphic', 'analytic', 'Cauchy theorem', 'residue', 'contour integral', 'Laurent series', 'conformal map', 'Riemann mapping', 'Mobius transformation', 'harmonic function', 'entire function', or 'meromorphic'.

日本語の概要は準備中です。原文の説明を表示しています。

Expert-level quantum mechanics knowledge. Use when working with wave functions, Schrodinger equation, quantum states, operators, uncertainty principle, quantum tunneling, spin, angular momentum, perturbation theory, or quantum entanglement. Also use when the user mentions 'wave function', 'Schrodinger', 'Heisenberg', 'quantum state', 'eigenvalue', 'superposition', 'tunneling', 'spin', 'Hilbert space', 'Dirac notation', 'commutator', or 'quantum measurement'.

日本語の概要は準備中です。原文の説明を表示しています。

When shaping employee onboarding — time-to-productivity, role-by-role program, mentor pairing, 30/60/90 milestones. Triggers on 'design our onboarding', 'why are new hires ramping slow'.

日本語の概要は準備中です。原文の説明を表示しています。

When shaping cadence — evergreen / campaign / reactive split, beat-mapping across channel stages, content-debt management. Triggers on 'plan our content cadence', 'what should we publish'.

日本語の概要は準備中です。原文の説明を表示しています。

Banco de dados vetorial gerenciado para aplicações de IA em produção. Totalmente gerenciado, com auto-scaling, busca híbrida (vetores densos + esparsos), filtragem de metadados e namespaces. Latência baixa (<100ms p95). Use para RAG em produção, sistemas de recomendação ou busca semântica em escala. Ideal para infraestrutura serverless e gerenciada.

日本語の概要は準備中です。原文の説明を表示しています。

Durable categorized record-keeping for any predicate-enabled walk. Trigger when: - Classifying a step's output for recording (decision, finding, debt, feedback). - Promoting a scratch artifact to the ledger, to repo/docs, or to a category home (.ledger/tech-debt/, .ledger/process-feedback/). - Auditing whether a draft is structurally ready for its destination. - Running a zero-context sensibility read before committing to promotion. - Recording a known limitation as a tech-debt entry (not prose in the log). - Recording a friction, miss, improvement, or process amendment. - Prompt contains: /record, record-keeping, promote, ledger note, zettelkasten, scratch-to-ledger, zero-context read, over-strip, classification trigger, tech-debt, process-feedback, amendment.

日本語の概要は準備中です。原文の説明を表示しています。

SOP for the automated refinement loop (/refine) workflow. Trigger when: - Exhaustively auditing and optimizing pre-existing codebase artifacts. - Applying iterative contraction mapping to reduce code entropy. - Prompt contains: /refine, refinement loop, contraction mapping, fixed-point sweep.

日本語の概要は準備中です。原文の説明を表示しています。

Get structured data from catalogued providers instead of scraping pages. Firecrawl Alexandria is a library of official APIs, licensed publishers, and Firecrawl indexes (financial series, company data, government contracts and law, podcasts, listings, research). Use this skill when the user needs records, listings, prices, filings, transcripts, or a dataset, says "is there an API for", "find a data source for", "pull the records", "get the dataset", or when assembling the answer by scraping would take many pages that one provider call returns directly. Discover with search, inspect with find_tools, execute with scrape.

日本語の概要は準備中です。原文の説明を表示しています。

Control and interact with a live browser session on any scraped page — click buttons, fill forms, navigate flows, and extract data using natural language prompts or code. Use when the user needs to interact with a webpage beyond simple scraping: logging into a site, submitting forms, clicking through pagination, handling infinite scroll, navigating multi-step checkout or wizard flows, or when a regular scrape failed because content is behind JavaScript interaction. Also useful for authenticated scraping via profiles. Triggers on "interact", "click", "fill out the form", "log in to", "sign in", "submit", "paginated", "next page", "infinite scroll", "interact with the page", "navigate to", "open a session", or "scrape failed".

日本語の概要は準備中です。原文の説明を表示しています。