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Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.

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Trim PCR primers from aligned reads in amplicon-panel BAMs using samtools ampliconclip. Use when processing SARS-CoV-2 ARTIC, hereditary cancer panels, ctDNA hot-spot panels, or any amplicon assay where primer-derived bases would falsely confirm reference at primer footprints.

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Spring Boot 3 patterns for configuration, DI, and web services. Trigger: When building or refactoring Spring Boot 3 applications.

日本語の概要は準備中です。原文の説明を表示しています。

Choose and review cryptographic usage in your codebase: TLS, hashing, KMS, secret storage. Prefer standard libraries and vetted constructions.

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Guides agents through Red-Green-Refactor with runner-captured evidence. Use when running /cc-tdd-cycle, writing tests before implementation, or Global TDD required is yes.

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Spec-locked TDD with a mutation-testing gate — refine the intent into an immutable Gherkin contract (SHA-256 frozen), implement under the three laws of TDD, pass a judge audit, and merge only if every mutant dies.

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Extract and consolidate reusable components, design tokens, and patterns into your design system. Identifies opportunities for systematic reuse and enriches your component library. Use when the user asks to create components, refactor repeated UI patterns, build a design system, or extract tokens.

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Tones down visually aggressive or overstimulating designs, reducing intensity while preserving quality. Use when the user mentions too bold, too loud, overwhelming, aggressive, garish, or wants a calmer, more refined aesthetic.

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Reflection-first problem solving methodology for Convex development. Use before implementing any solution to ensure proper root cause analysis, 98% code confidence, and minimal change scope.

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Combine React's official "You Might Not Need an Effect" guidance with this project's stricter no direct useEffect stance. Use when writing, reviewing, or refactoring React components that might reach for useEffect, derived state, event relays, reset logic, subscriptions, or client fetching.

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Write or revise MiniMax H3 prompts for text, keyframe, and full-reference modes, preserving mode-specific fields, labels, and timing.

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Use this skill any time a spreadsheet file is the primary input or output. This means any task where the user wants to: open, read, edit, or fix an existing .xlsx, .xlsm, .xltx, .csv, or .tsv file (e.g., adding columns, computing formulas, formatting, charting, cleaning messy data); create a new spreadsheet from scratch or from other data sources; or convert between tabular file formats. Trigger especially when the user references a spreadsheet file by name or path — even casually (like "the xlsx in my downloads") — and wants something done to it or produced from it. Also trigger for cleaning or restructuring messy tabular data files (malformed rows, misplaced headers, junk data) into proper spreadsheets. The deliverable must be a spreadsheet file. Do NOT trigger when the primary deliverable is a Word document, HTML report, standalone Python script, database pipeline, or Google Sheets API integration, even if tabular data is involved.

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Use this skill any time a .pptx or .potx file is involved in any way — as input, output, or both. This includes: creating slide decks, pitch decks, or presentations as PowerPoint (.pptx) files; reading, parsing, or extracting text from any .pptx or .potx file (even if the extracted content will be used elsewhere, like in an email, summary, or creating a different type of slide deck); editing, modifying, or updating existing presentations; combining or splitting slide files; working with templates (.potx), layouts, speaker notes, or comments. Trigger whenever the user asks for a PowerPoint or .pptx file, or references a .pptx or .potx filename, regardless of what they plan to do with the content afterward. However, when the user asks for a deck, slides, a slide deck, or a presentation without naming a file format, default to using a dedicated slide-deck artifact type or a separate slides skill if this session offers one; otherwise, use this skill.

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Extract structured domain knowledge from AI models in-session or from local open-source models via Ollama. No API key needed.

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X-ray any AI model's behavioral patterns — refusal boundaries, hallucination tendencies, reasoning style, formatting defaults. No API key needed.

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Centralized configuration management with feature flags and dynamic refresh.

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Azure Communication Services common utilities for Java. Use when working with CommunicationTokenCredential, user identifiers, token refresh, or shared authentication across ACS services.

日本語の概要は準備中です。原文の説明を表示しています。

Angular performance optimization and best practices guide. Use when writing, reviewing, or refactoring Angular code for optimal performance, bundle size, and rendering efficiency.

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Behavioral guidelines to reduce common LLM coding mistakes. Use when writing, reviewing, or refactoring code to avoid overcomplication, make surgical changes, surface assumptions, and define verifiable success criteria.

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Understand audience demographics, preferences, behavior patterns, and engagement quality across Facebook, Instagram, YouTube, and TikTok.

日本語の概要は準備中です。原文の説明を表示しています。

AI-powered presentation generation via the 2slides API — create slides from text, match a reference image style, summarize documents into decks, add AI voice narration, and export pages/audio. Use for any "make slides", "create a deck", or "slides from this document" request.

日本語の概要は準備中です。原文の説明を表示しています。

Find and fix WCAG 2.2 accessibility issues. Two modes — report (sweep a codebase or page, produce a prioritized written report, no edits) and fix (audit→edit→verify loop on a target). Prefers direct-CDP live-DOM auditing; falls back to a browser-MCP composition or HTML-string audits.

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Forces the laziest solution that actually works, simplest, shortest, most minimal. Channels a senior dev who has been paged at 3am for a factory class that wrapped one function: question whether the task needs to exist at all, reach for the standard library before custom code, native platform features before dependencies, one line before fifty. Supports intensity levels: lite, full, ultra. The default is full. Use on ANY coding task: writing, adding, refactoring, fixing, reviewing, or designing code, and choosing libraries or dependencies. Also use whenever the user says "ponytail", "be lazy", "lazy mode", "simplest solution", "minimal solution", "yagni", "do less", or "shortest path", or complains about over-engineering, bloat, boilerplate, or unnecessary dependencies. Do NOT use for non-coding requests such as general knowledge, prose, translation, summaries, recipes.

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Core coding guidelines for iOS, iPadOS, macOS, watchOS, tvOS, and visionOS app development using SwiftUI and Swift. Use when implementing Views, working with @State/@Binding/@Observable/@StateObject, using NavigationStack/List/LazyVStack, designing components, or asking about SwiftUI patterns (infinite scroll, pull-to-refresh, search). Covers best practices, implementation patterns, and anti-patterns to avoid.

日本語の概要は準備中です。原文の説明を表示しています。