「uis」の検索結果

Paid acquisition strategy, budget allocation, and avoiding common advertising mistakes across platforms

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You are an academic writing expert specializing in scholarly papers, literature reviews, research methodology, and thesis writing. You must adhere to strict academic standards in all outputs.## Core Requirements1. **Output Format**: Use Markdown exclusively for all writing outputs and always wrap the main content of your response within <ama-doc></ama-doc> tags to clearly distinguish the core i...

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Builds production-quality UIs. Use when building or modifying user-facing interfaces. Use when creating components, implementing layouts, managing state, or when the output needs to look and feel production-quality rather than AI-generated.

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Help founders develop a strategy to acquire and sell to the first 100 customers. Use when someone has a product and needs a customer acquisition plan, or is struggling with early sales.

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Prepare Azure environments and prerequisites before deployment. Use this skill when users ask for readiness checks, environment setup, or preflight planning. Covers landing zones, networking, identity, governance, and cost controls per Cloud Adoption Framework.

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Drafts a BSA/AML Risk Assessment for U.S. financial institutions per FinCEN, FFIEC, and OCC standards. Evaluates inherent risks (customer, product, geographic, transaction, third-party), control adequacy, and residual risk. Use when preparing annual BSA compliance assessments, post-acquisition integration reviews, or when business changes trigger reassessment under 31 U.S.C. § 5318(h).

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Produces a practitioner-grade Blue Sky compliance memorandum and execution plan for U.S. securities offerings. Analyzes NSMIA covered securities preemption, classifies offerings under Regulation D/Rule 506 or alternative federal exemptions, maps state jurisdictional nexus distinguishing offers from sales, and generates a state-by-state filing plan with Form D/EFD workflow, fee schedules, amendment triggers, and renewal calendars. Use this skill when advising on private placement Blue Sky compliance, Reg D notice filings, multi-state offering coordination, state securities registration exemptions, Form D filings, EFD submissions, or state fee budgeting. Also trigger when the user mentions covered securities preemption, NSMIA analysis, or asks about state notice filing requirements. Even if the user just says "Blue Sky" or "state filings for our raise," use this skill.

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Drafts a U.S. Asset Purchase Agreement for deals where a buyer acquires specified business assets while avoiding unwanted liabilities. Enforces itemized asset/liability schedules, purchase price mechanics with working capital true-ups, IRS Form 8594 tax allocation, seller and buyer reps and warranties with disclosure schedules, pre- and post-closing covenants, closing conditions and deliveries, and indemnification with basket/cap limits. Use when drafting an asset purchase agreement, APA, asset acquisition, purchase and sale of assets, asset deal, or excluded liabilities agreement.

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Drafts time-limited policy-limits demand letters that create an opportunity-to-settle record for third-party bad faith exposure. Use when the user mentions time-limited demand, policy limits demand, bad faith notice, Stowers demand, civil remedy notice, failure to settle demand, excess exposure letter, insurer settlement opportunity, or needs help with acceptance mechanics for a policy-limits offer. Also trigger for Georgia O.C.G.A. § 9-11-67.1 compliance, Florida statutory bad faith prerequisites, or documenting insurer refusal to settle.

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Drafts privilege-protective, board-ready executive summary memoranda of internal antitrust investigation findings for US federal law. Covers monopolization, vertical restraints, acquisitions, FTC Act Section 5, tech-platform conduct, risk assessment, and remediation. Use when drafting antitrust investigation summaries, board memos on competition risk, or internal compliance investigation reports.

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Writing tests, running validation, and (TDD mode) red-green-refactor. Active in Test + Build phases. NOT for coverage-gap mapping (mk:nyquist) or sprint contracts (mk:sprint-contract).

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Maps test coverage to plan acceptance criteria and flags requirements with no tests. Use during Test/Review phases. NOT for running tests (mk:testing); NOT for structural review (mk:review).

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Use when writing tests, running validation scripts, or (in TDD mode) enforcing red-green-refactor cycle. Activates during Phase 2 (Test) and Phase 3 (Build). NOT for coverage gap mapping (see mk:nyquist); NOT for sprint contract negotiation (see mk:sprint-contract).

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Unified verification: build→lint→test→type-check→coverage. Use for 'is everything green', 'run all checks', 'verify build'. Auto-called by mk:cook. NOT for lint/format only (see mk:lint-and-validate); NOT for test-to-requirement coverage mapping (see mk:nyquist).

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Use when answering factual or explanatory questions about the current project — codebase, architecture, conventions, workflows, constraints — with minimal cited evidence. Triggers on "how does X work here", "what does X mean", "why is X structured this way", "is this claim true in the repo", "explain X with sources". NOT for brainstorming or comparing approaches (mk:brainstorming), trade-off decisions (mk:party), debugging/root cause (mk:investigate), code review (mk:review), plans (mk:plan-creator), security audits (mk:cso), visual explanations/diagrams (mk:preview --explain), test-coverage gaps (mk:nyquist), library docs (mk:docs-finder), or workflow navigation (mk:help).

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Task-sized forensic analysis of Vivado synthesis and routed timing evidence for processor RTL. Use when Codex must trace a named setup or hold path, audit whole-design timing populations, compare implementation runs, map primitive, LUT, CARRY, BRAM, DSP, MUXF, register, and routed-net stages back to Chisel or generated RTL, distinguish logic from routing pressure, identify missing DCP queries, or write an evidence-backed timing report. This skill is read-only by default and stops at ranked modification directions. Use optimize-chisel-fpga-timing for RTL edits and routed A/B implementation closure.

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Use when building server-driven UIs with htmx, designing hx-* attribute compositions, choosing swap strategies (innerHTML/outerHTML/morph), wiring out-of-band updates, integrating with form validation, or migrating from a SPA back to server-rendered HTML. Triggers: hx-get/hx-post setup, hx-target + hx-swap interplay, hx-trigger debouncing, OOB swaps for parts of the page outside the request target, response headers like HX-Trigger and HX-Push-Url, integration with Hyperscript or Alpine.js, accessibility considerations on partial updates. NOT for full SPAs (use React/Vue), framework-specific server libraries (use those skills directly), or non-HTML responses.

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Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 (GC-bias-aware differential via its bam_ip/bam_input control + bam_treated_ip/bam_treated_input treatment arms), QNB beta-binomial, MeTDiff HMM, and RADAR, plus the paired-symmetric edgeR/DESeq2-on-peak-counts route when batch/lot covariates need fixed-effect handling that exomePeak2's API does not accept. Covers paired vs unpaired vs interaction designs, batch confounding and per-lot meta-analysis, the stoichiometry-vs-expression-vs-IP-efficiency confound, and effect-size filtering against under-powered N=2 designs. Use when comparing m6A across two or more conditions, choosing between exomePeak2/QNB/RADAR/MeTDiff for a design, handling batch confounding when exomePeak2's API is too rigid, distinguishing real hyper/hypo-methylation from expression shifts, applying effect-size thresholds, or planning orthogonal stoichiometry validation (GLORI/SAC-seq/m6Anet mod_ratio).

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Designs genomics experiments so technical nuisance variation (batch, lane, plate, flow cell, operator, reagent lot, processing day) is balanced against the biological variable of interest and therefore estimable rather than confounded, using constrained sample-to-batch assignment (designit, OSAT), the confounder/mediator/collider distinction, and the principle that no post-hoc correction recovers a fully confounded design. Covers detecting hidden batches with surrogate variable analysis, a decision table for downstream correction (ComBat-seq, RUVSeq, SVA) whose execution is deferred to differential-expression/batch-correction, and reproducibility metadata. Use when assigning samples to sequencing batches/lanes/plates, avoiding batch-condition confounding, deciding whether a design is salvageable by correction, choosing a correction method, or estimating the number of hidden batches. For the experimental unit, randomization, and blocking concepts see experimental-design/randomization-blocking.

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Corrects fluorophore spillover (conventional compensation) or spectral overlap (spectral unmixing) and applies variance-stabilizing transforms (logicle/biexponential, arcsinh, log) for flow and mass cytometry. Covers spillover-matrix estimation from single-stain controls, AutoSpill, the spillover spreading matrix and why panel design (not compensation) bounds resolution, compensate-then-transform ordering, and arcsinh cofactor choice (5 for CyTOF, ~150 for fluorescence, per-channel via flowVS). Use when correcting spectral overlap, preparing data for gating/clustering, choosing logicle vs arcsinh, deciding a cofactor, or distinguishing compensation from spectral unmixing.

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Quality control for flow, spectral, and mass cytometry - time-based anomaly cleaning (flowAI, flowCut, PeacoQC, flowClean), margin/boundary event removal, signal-drift detection, dead-cell exclusion, CyTOF Gaussian/DNA/event-length checks, instrument calibration/standardization (MESF, CS&T, peak-2), and batch-level outlier flagging. Use when assessing acquisition quality, choosing a cleaning tool, ordering QC relative to compensation, deciding margin removal before density-based steps, or flagging problematic samples before clustering or differential analysis.

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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

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Detects somatic mutations in circulating tumor DNA, treating low-VAF detection as a signal-versus-noise problem set by error suppression and molecules sampled, not by the choice of caller. Distinguishes de novo CALLING (scanning a panel for unknown variants, bounded by per-locus error and multiple testing) from tumor-informed DETECTION (tracking a pre-specified variant set, where panel integration reaches single-ppm). Covers VarDict and Mutect2 for de novo calling, UMI-aware callers, and a pysam-based known-variant VAF tracker, with matched-WBC subtraction as the mandatory defense against clonal hematopoiesis (the dominant false positive). Use when calling or tracking tumor mutations from plasma cfDNA, setting a VAF threshold, or deciding whether a low-VAF call is tumor versus CHIP.

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Delimits putative species boundaries from molecular data within the de Queiroz 2007 unified-lineage framework using ASAP (Puillandre 2021 successor to ABGD), mPTP C++ (Kapli 2017 successor to bPTP; bPTP is Python NOT R), GMYC single/multi-threshold (Pons 2006; Fujisawa 2013), multilocus BPP v4 with prior calibration from data (NOT defaults; Yang 2015), SNAPP + BFD* for SNP delimitation, DELINEATE (Sukumaran 2021) speciation-process modeling to address Sukumaran & Knowles 2017 PNAS critique that MSC delimits structure not species, integrative-taxonomy congruence (Padial 2010; Carstens 2013), Dsuite for introgression testing before sister claims (Malinsky 2021), and Meyer & Paulay 2005 barcoding-gap-absence caveat. Use when delineating species from DNA barcoding data, resolving cryptic complexes, choosing among ASAP/mPTP/BPP/DELINEATE, calibrating BPP priors, distinguishing introgression from ILS, or applying the Sukumaran-Knowles oversplitting correction.

日本語の概要は準備中です。原文の説明を表示しています。