「meta」の検索結果

Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

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Aligns and QCs methylated-RNA-immunoprecipitation (MeRIP / m6A-seq) IP and input libraries using STAR or HISAT2 splice-aware mapping, samtools sort/index, IP/input matched-pair tracking, antibody-lot metadata recording, replicate concordance via deepTools multiBamSummary + plotCorrelation, IP enrichment QC via plotFingerprint and per-transcript IP/input ratio distributions, library-complexity saturation curves via PreSeq, and the explicit do-NOT-deduplicate convention for standard non-UMI MeRIP. Use when preparing paired IP and input BAM files for exomePeak2 / MeTPeak / MACS3 peak calling, evaluating MeRIP replicate concordance and IP enrichment, deciding whether to deduplicate (standard MeRIP typically NOT), choosing genome-vs-transcriptome alignment for downstream peak vs m6Anet workflows, recording antibody clone and lot metadata for cross-batch reconciliation, detecting failed IPs via saturation curves and IP/input distribution shape, or generating IP-over-Input bigWig tracks for visualisation.

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Processes eDNA metabarcoding from raw paired-end reads to species tables, navigating ASV (DADA2, UNOISE3) vs OTU (swarm v2) decision (Callahan 2017 vs Schloss multi-copy-16S critique), marker/primer choice (Leray COI, MiFish 12S, 515F/806R 16S, ITS2) with primer-specific bias, OBITools3 v3 command-name break (obi stats plural; .tar.gz taxonomy), tag-jumping with dual-indexing (Schnell 2015; NovaSeq 10x MiSeq), decontam as screening-not-classifier (Davis 2018), read-counts-not-abundance critique (Lamb 2019), site-occupancy modeling (Ficetola 2015), Naive-Bayes calibration limits (Bokulich 2018), and eDNA decay (Strickler 2015). Use when going from raw eDNA FASTQ to species tables, picking marker + denoising pipeline, deciding whether read counts represent abundance, applying occupancy modeling, configuring OBITools3 v3, or interpreting decontam output. Not for clinical 16S microbiome (see microbiome/amplicon-processing).

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Compute genome-to-genome distances (ANI, AAI, dDDH, k-mer Mash) and assign taxonomic classifications using skani (Shaw 2023), FastANI (Jain 2018), pyani / pyANI ANIb / ANIm, OrthoANI (Lee 2016), AAI (amino-acid identity), dDDH via TYGS / GGDC, GTDB-Tk (Chaumeil 2020 standard prokaryote taxonomy), and Mash MinHash (Ondov 2016). Use when delineating prokaryote species (95% ANI threshold; Jain 2018 Nat Commun 9:5114), assigning genomes to GTDB taxonomy with ANI radius, computing genome similarity matrices for clustering, classifying archaea, evaluating MAG (metagenome-assembled genome) species assignment, applying skani for fast metagenomic ANI screening, or reconciling 16S rRNA-based taxonomy with whole-genome ANI.

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Recommends steroidogenesis inhibitors as second-line treatment after transsphenoidal surgery (TSS) in Cushing's disease, as primary therapy for occult or metastatic ectopic ACTH syndrome (EAS), and as adjunctive cortisol reduction in adrenocortical carcinoma. Use when evaluating CS patients post‑TSS, with occult/metastatic EAS, or ACC; triggers include “persistent hypercortisolism after TSS,” “occult EAS,” and “adjunctive for ACC.”

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Generate hand-drawn 16:9 article illustrations with the Grav character IP, sparse annotations, and absurd but clear visual metaphors.

日本語の概要は準備中です。原文の説明を表示しています。

A meta-skill that understands task requirements, dynamically selects appropriate skills, tracks successful skill combinations using agent-memory-mcp, and prevents skill overuse for simple tasks.

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Expert-level embedded systems covering microcontrollers, RTOS, peripheral interfaces, low-power design, bare-metal programming, and embedded Linux.

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Expert-level biochemistry knowledge. Use when working with proteins, enzymes, metabolism, DNA, RNA, carbohydrates, lipids, cell signaling, or bioenergetics. Also use when the user mentions 'enzyme kinetics', 'metabolism', 'glycolysis', 'Krebs cycle', 'DNA replication', 'protein folding', 'amino acids', 'ATP', 'oxidative phosphorylation', 'gene expression', 'lipid bilayer', or 'signal transduction'.

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Expert-level biochemistry from a biology perspective covering metabolic pathways, enzyme kinetics, bioenergetics, signal transduction, and the biochemical basis of cellular processes.

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Expert-level medicinal chemistry knowledge. Use when working with drug design, structure-activity relationships, ADMET properties, pharmacophores, lead optimization, target identification, drug metabolism, or pharmaceutical development. Also use when the user mentions 'SAR', 'drug design', 'pharmacophore', 'ADMET', 'lead compound', 'hit to lead', 'drug metabolism', 'bioavailability', 'selectivity', 'binding affinity', 'scaffold hopping', or 'bioisostere'.

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Fornece orientação para treinamento RL agentico nativo do PyTorch usando torchforge, biblioteca da Meta que separa infraestrutura de algoritmos. Use quando você quer abstrações limpas de RL, fácil experimentação de algoritmos, ou treinamento escalável com Monarch e TorchTitan.

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Modelo de moderação especializado 7-8B do Meta para filtragem de entrada/saída de LLM. 6 categorias de segurança - violência/ódio, conteúdo sexual, armas, substâncias, automutilação, planejamento criminal. Precisão de 94-95%. Deploy com vLLM, HuggingFace, Sagemaker. Integra com NeMo Guardrails.

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Guidelines and strategies for constructing meaningful test suites, property-based tests, metamorphic relations, and fuzzing harnesses. Trigger when: - Designing verification bounds, writing tests, creating test invariants, or implementing validation gates. - Prompt contains: testing, test design, property-based testing, PBT, metamorphic testing, fuzzing, integration tests, E2E.

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dev-graph node を metadata で検索したいとき、依存・tombstone・completion 状態を副作用なしで確認したいときに使う。

Generate hand-drawn 16:9 article illustrations with the Grav character IP, sparse annotations, and absurd but clear visual metaphors.

日本語の概要は準備中です。原文の説明を表示しています。

A meta-skill that understands task requirements, dynamically selects appropriate skills, tracks successful skill combinations using agent-memory-mcp, and prevents skill overuse for simple tasks.

日本語の概要は準備中です。原文の説明を表示しています。

yt-dlpを使用した動画ダウンロードの専門スキル。YouTube、ニコニコ動画、Twitter/X、TikTok等1000以上のサイトから動画・音声・字幕をダウンロード。フォーマット選択、プレイリスト処理、メタデータ抽出を効率的に支援。Use when downloading videos, extracting audio, getting subtitles, or fetching metadata from YouTube and other video sites.

SF CLI経由でSalesforceレポートを作成するスキル。Metadata APIとREST APIの使い分け、フィールド命名規則、列数制限、レポートタイプ設定を網羅。カスタムオブジェクトレポート作成時の注意点も含む。Use when creating Salesforce reports via CLI, deploying report types, or automating report generation.

Automatically translate and sync App Store metadata (description, keywords, what's new, subtitle) to multiple languages using LLM translation and asc CLI. Use when asked to localize an app's App Store listing, translate app descriptions, or add new languages to App Store Connect.

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Meta-skill: Structured thinking as a 3-phase workflow. Combines analysis (think), ideation (brainstorm), and decision-making (decide) into one continuous process.

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Fetch video transcripts (subtitles) and metadata from online video sources and output them as Markdown, JSON, or plain text. Currently supported: YouTube. Prefers manually created subtitles, falls back to auto-generated ones.

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Meta-/Umbrella-Skill für die Familie „Therapie / Beratung". Kennt alle therapeutischen Skills (Stabilisierung, Methoden-Überblick, Gesprächsführung + deregistrierte Spezialverfahren) und leitet zum passenden weiter. Nutze diesen Skill, wenn unklar ist, welcher Therapie-/Beratungs-Skill passt, ein Überblick über die verfügbaren Verfahren gebraucht wird, oder eine Beratungs-/Krisensituation zuerst eingeordnet werden muss. Auch auslösen bei „welche Therapiemethode passt", „Beratung strukturieren", „Krise — was tun", „therapeutisches Vorgehen wählen".

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Meta-skill for complete Roblox game development with Rojo — the entry point that knows and unifies the three specialist skills `/rojo` (filesystem→Studio sync, project setup), `/rbx-studio` (editor, MCP, assets, malware scan) and `/game-design` (roles, workflows, GDD). Use this skill for ANY Roblox game-dev undertaking: planning/building/setting up a Roblox game, scaffolding a new project, defining code architecture (Main + manager modules, _G.ClientState + HUD, remotes in GameEnums), avoiding Luau/Roblox pitfalls, or when it is unclear which of the Roblox specialist skills fits — routing happens from here. Also trigger on "develop Roblox game", "build Roblox game", "new Roblox project", "Luau project structure", "how do I organize Roblox code", "Roblox dev setup".

日本語の概要は準備中です。原文の説明を表示しています。