「scaffold」の検索結果

Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

日本語の概要は準備中です。原文の説明を表示しています。

Performs molecular similarity searching using Tanimoto, Tversky, Dice, and cosine coefficients on bit/count fingerprints with explicit choice rules for symmetric vs asymmetric measures, scaffold-hopping vs lead-optimization regimes, activity-cliff diagnosis, and large-library nearest-neighbor methods (BulkTanimoto, Annoy MHFP6, USRCAT). Use when ranking compounds by structural resemblance to a query, clustering libraries, finding analogs, or diagnosing activity cliffs.

日本語の概要は準備中です。原文の説明を表示しています。

Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.

日本語の概要は準備中です。原文の説明を表示しています。

Performs ML-based protein-ligand pose prediction and scoring using DiffDock-L (diffusion-based), Boltz-1 / Boltz-2 (foundation model with affinity), Chai-1, AlphaFold3 ligand, EquiBind, TANKBind, NeuralPLexer, and hybrid workflows (DiffDock pose + GNINA rescore + PoseBusters QC). Explicit handling of when ML beats classical docking, when classical beats ML, the PB-invalid pose problem, and rescoring as the standard production hybrid. Use when modern docking is needed: foundation-model ligand-pose prediction, AI rescoring of classical poses, or scaffold-hopping in cross-docking scenarios.

日本語の概要は準備中です。原文の説明を表示しています。

Use when building PHP applications with modern PHP 8.3+ features, Laravel, or Symfony frameworks. Invokes strict typing, PHPStan level 9, async patterns with Swoole, and PSR standards. Creates controllers, configures middleware, generates migrations, writes PHPUnit/Pest tests, defines typed DTOs and value objects, sets up dependency injection, and scaffolds REST/GraphQL APIs. Use when working with Eloquent, Doctrine, Composer, Psalm, ReactPHP, or any PHP API development.

日本語の概要は準備中です。原文の説明を表示しています。

Create new OpenCode skills with the standard scaffold.

日本語の概要は準備中です。原文の説明を表示しています。

Skill for scaffolding, installation, and composition of shadcn-vue components (based on Reka UI v2). Use when you need to install components, understand Vue variants, compose patterns with vee-validate/Zod, or adapt existing components. Stack: Vue 3 + Reka UI v2 + Tailwind CSS.

日本語の概要は準備中です。原文の説明を表示しています。

Scaffold a minimal GNOME-compliant GTK4/libadwaita app from scratch — window, header bar, ViewSwitcher, adaptive breakpoint, menu, preferences, GSettings schema, desktop entry, meson. Use when starting a new GNOME app or when the user asks for a GNOME app template.

日本語の概要は準備中です。原文の説明を表示しています。

Build generative UI apps with OpenUI and OpenUI Lang — the token-efficient open standard for LLM-generated interfaces. Use when mentioning OpenUI, @openuidev, generative UI, streaming UI from LLMs, component libraries for AI, or replacing json-render/A2UI. Covers scaffolding, defineComponent, system prompts, the Renderer, and debugging OpenUI Lang output.

日本語の概要は準備中です。原文の説明を表示しています。

Initialize an Adobe App Builder project end-to-end without Developer Console UI clicks. Creates the Console project and workspace, subscribes APIs (including those needing a product profile), maps user intent to the right template, runs non-interactive `aio app init`, and guides post-init customization. Use whenever the user mentions creating an App Builder app, scaffolding a project, `aio app init`, setting up an Experience Cloud extension, adding actions or web assets, creating a Console project or workspace, adding APIs, or bootstrapping App Builder — even if they don't say "App Builder". Also for SPA templates, AEM extensions, API Mesh, Asset Compute workers, and MCP server projects. Also handles debugging init failures — template not found, `aio app init` hangs or times out, Node version mismatches, npm install failures, post-init build errors, `aio login` issues, `aio app run` showing nothing, or `aio console project create` / `workspace create` / `workspace api add` errors.

日本語の概要は準備中です。原文の説明を表示しています。

Generate and run tests for Adobe App Builder actions and UI components. Scaffolds Jest unit tests, integration tests against deployed actions, contract tests for Adobe API interactions, and React component tests using Testing Library. Provides mock helpers for State, Files, Events SDKs, @adobe/aio-lib-* clients, ExC Shell context (@adobe/exc-app), and UIX Guest SDK (@adobe/uix-guest). Use this skill whenever the user mentions testing App Builder actions, writing unit tests for Runtime actions, creating integration tests, mocking Adobe SDKs, setting up test fixtures, running aio app test, or wants to verify action behavior before deployment. Also trigger when users mention Jest configuration for App Builder, test coverage, CI test setup, React component test, Testing Library, UI test, Provider wrapper, test my page, test my form, test my table, test my component, mock shell context, mock extension context, debug test failures, or fix Jest errors.

日本語の概要は準備中です。原文の説明を表示しています。

Create, implement, deploy, and debug Adobe Runtime actions with consistent layout, validation, and error handling. Use this skill whenever the user needs to add actions to an App Builder project, understand action structure (params, response format, web/raw actions), configure actions in the manifest, use App Builder SDKs (State, Files, Events, database), deploy and invoke actions via CLI, debug action issues, or implement patterns such as webhook receivers, custom event providers, journaling consumers, large payload redirects, action sequence pipelines, and Asset Compute workers. Also trigger when users mention serverless functions in Adobe context, action logging, IMS authentication for actions, or cron-style scheduled actions.

日本語の概要は準備中です。原文の説明を表示しています。

Creates complete AEM components with dialog, HTL template, Sling Model, unit tests, and clientlibs. Supports extending Core Components and project components. When a Figma design URL is provided, fetches the design via Figma MCP (get_design_context) and translates it into pixel-perfect HTL, CSS, and JS. Follows Adobe Experience League best practices for AEM Cloud Service and 6.5. Use this skill whenever the user mentions creating, building, generating, or scaffolding an AEM component, or mentions component types like teaser, card, hero, banner, accordion, tabs, carousel, list, navigation, breadcrumb, or any custom AEM component. Also trigger when the user wants to extend a Core Component, create a component dialog, add a Sling Model, or convert a Figma design into an AEM component.

日本語の概要は準備中です。原文の説明を表示しています。

Generate React Spectrum UI components for Adobe Experience Cloud Shell SPAs and AEM UI Extensions. Provides patterns for pages, forms, data tables, dialogs, and navigation using @adobe/react-spectrum. Guides ExC Shell integration with @adobe/exc-app including runtime.done(), IMS token passthrough, and shell theming. Guides AEM UI Extension development with @adobe/uix-guest for Content Fragment Console, CF Editor, Universal Editor, and Assets View surfaces. Trigger on: building App Builder UI, React Spectrum components, ExC Shell pages, forms, data tables, dialogs, modals, navigation, theming, web-src, Spectrum design system, @adobe/exc-app, AEM extension, AEM UI extension, Content Fragment Console, Universal Editor extension, uix-guest, @adobe/uix-guest, extension points for AEM, customizing AEM surfaces.

日本語の概要は準備中です。原文の説明を表示しています。

UI 自動化生產總控 SKILL — 從 UI 示意圖、參考圖、Figma snapshot 或既有頁面經驗啟動，串接 proof draft、family-map、MCQ、normalized recipe、task shard、ui-spec 與 CompositePanel / ChildPanel scaffold、靜態驗證、Browser QA 自動調整，直到交付人類驗收。USE FOR: 想把一張新 UI 從「給圖」一路推進到可驗證的 screen package 與 QA 閉環。DO NOT USE FOR: 單純修一個 runtime bug、單一 prefab 微調、純美術資產委託。

日本語の概要は準備中です。原文の説明を表示しています。

Seed minimal agent harness v0 — manifest, eval checks stub, governance. AUTO-INVOKED after project-setup or retroactive-project-setup when docs/harness/manifest.json is missing. Also triggers on: generate harness, scaffold agents, agent bootstrap, first time agents in this repo, new project agent setup, set up agent harness, agent onboarding files, missing agent configuration, agent instructions setup, make agents read project rules, agent reliability setup, agents not configured. Pairs with project-setup. Evolution is harness-evolution.

日本語の概要は準備中です。原文の説明を表示しています。

Orchestrator for agent harness work — the setup that makes AI agents follow project rules and improve when they fail. FIRES PROACTIVELY when agents misbehave, repeat mistakes, ignore instructions, skip skills, or when AGENTS.md exists but docs/harness/manifest.json is missing. Also triggers on: harness engineering, agent scaffold, agent keeps failing, agent not following instructions, make agents reliable, agents going off rails, agent forgot context, improve agent setup, self-improving agents, agents keep making mistakes, why is my agent bad, agent quality, agent setup broken, agents ignore skills, same mistake again, fix agent behavior, tune agent instructions, set up agent infrastructure, after project setup agents still bad. Routes bootstrap vs evolution. Not multi-agent topology — agent-builder.

日本語の概要は準備中です。原文の説明を表示しています。

Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

日本語の概要は準備中です。原文の説明を表示しています。

Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk/Aldridge filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.

日本語の概要は準備中です。原文の説明を表示しています。

Performs ML-based protein-ligand pose prediction and scoring using DiffDock-L (diffusion-based), Boltz-1 / Boltz-2 (foundation model with affinity), Chai-1, AlphaFold3 ligand, EquiBind, TANKBind, NeuralPLexer, and hybrid workflows (DiffDock pose + GNINA rescore + PoseBusters QC). Explicit handling of when ML beats classical docking, when classical beats ML, the PB-invalid pose problem, and rescoring as the standard production hybrid. Use when modern docking is needed: foundation-model ligand-pose prediction, AI rescoring of classical poses, or scaffold-hopping in cross-docking scenarios.

日本語の概要は準備中です。原文の説明を表示しています。

Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.

日本語の概要は準備中です。原文の説明を表示しています。

Performs molecular similarity searching using Tanimoto, Tversky, Dice, and cosine coefficients on bit/count fingerprints with explicit choice rules for symmetric vs asymmetric measures, scaffold-hopping vs lead-optimization regimes, activity-cliff diagnosis, and large-library nearest-neighbor methods (BulkTanimoto, Annoy MHFP6, USRCAT). Use when ranking compounds by structural resemblance to a query, clustering libraries, finding analogs, or diagnosing activity cliffs.

日本語の概要は準備中です。原文の説明を表示しています。

Initialize a new Convex project from scratch or add Convex to an existing app. Use when starting a new project with Convex, scaffolding a Convex app, or integrating Convex into an existing frontend.

日本語の概要は準備中です。原文の説明を表示しています。

Создать пустой внешний отчёт 1С (scaffold XML-исходников)

日本語の概要は準備中です。原文の説明を表示しています。