894 件 ・ 関連度順
概要と使いどころ
Quick-reference card for all ponytail modes, skills, and commands. One-shot display, not a persistent mode. Trigger: /ponytail-help, "ponytail help", "what ponytail commands", "how do I use ponytail".
日本語の概要は準備中です。原文の説明を表示しています。
Write the executable feature specification — the WHAT and WHY artifact that agents and reviewers treat as source of truth. Owns both /specify and /clarify modes. Load when the user asks to write a feature spec, write a specification, write an executable spec, define functional requirements, capture acceptance criteria as Given/When/Then, or when the spec-driven-development orchestrator routes here. Also triggers on "feature spec", "executable spec", "/specify", "/clarify", "write the spec for this feature", "specification for", "spec-driven", "machine-readable spec". Output: docs/specs/YYYY-MM-DD-<slug>-feature-spec.md. Hard gate: cannot Approve while [NEEDS CLARIFICATION] markers remain.
日本語の概要は準備中です。原文の説明を表示しています。
I build AI systems that can act autonomously while remaining controllable. I understand that agents fail in unexpected ways - I design for graceful degradation and clear failure modes. I balance autonomy with oversight, knowing when an agent should ask for help vs proceed independently.
日本語の概要は準備中です。原文の説明を表示しています。
Rank and prioritize neoantigen/epitope candidates by likely T-cell response using NeoFox feature annotation, PRIME2.0, BigMHC-IM, the Łuksza/Balachandran fitness model (agretopicity + foreignness), and pVACtools tiering. Encodes the field's hard truths that immunogenicity is the least-solved layer (dedicated scores ~AUROC 0.6-0.7, modest PPV), that scores are valid only for RANKING within one patient (never absolute go/no-go or cross-patient), that DAI has anchor-inflation and WT-denominator traps, and that stacking weak correlated scores into one number is a red flag. Use when ordering a candidate list for a vaccine. Binding lives in mhc-binding-prediction; calling in neoantigen-prediction.
日本語の概要は準備中です。原文の説明を表示しています。
Identifies non-coding RNAs (tRNA, rRNA, snoRNA, snRNA, riboswitches, sRNAs) using Infernal covariance-model search against Rfam, tRNAscan-SE 2.0 for tRNA, barrnap for rRNA, and ARAGORN for tmRNA, plus the small-RNA-seq boundary for miRNA and the transcript-assembly boundary for lncRNA. Covers the structure-conserved-not-sequence-conserved principle (why BLAST fails), GA-threshold and clan-competition correctness, tRNAscan-SE domain modes and pseudogene flags, rDNA copy-number collapse, and why homology annotation is a recall floor. Use when performing genome-wide ncRNA annotation, choosing the right tool for an RNA class, or interpreting ncRNA counts.
日本語の概要は準備中です。原文の説明を表示しています。
Assembles a genome de novo from Illumina short reads with SPAdes (isolate/careful/sc/meta/plasmid/rna modes), MEGAHIT (low-memory, huge datasets), Unicycler (bacterial finishing/hybrid), MaSuRCA (large hybrid), ABySS (Bloom-filter), and Platanus (heterozygous diploids), using multi-k de Bruijn graphs. Covers the repeat-resolution limit, why N50 plateaus at the genome not the depth, GenomeScope2 k-mer profiling first, the heterozygosity/haplotig trap, error-correction erasing rare alleles, GC dropout, and NG50/auN/BUSCO reporting. Use when assembling a bacterial isolate, fungal, small-eukaryotic, single-cell, or metagenome genome from Illumina reads, or when deciding whether short reads can even produce the assembly being asked for.
日本語の概要は準備中です。原文の説明を表示しています。
Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural splines, maSigPro (Nueda 2014 for RNA-seq), ImpulseDE2 with explicit impulse-model failure modes, DREAM for repeated measures via linear mixed models, pseudoreplication avoidance, conditional vs marginal modeling, and trajectory clustering with DPGP, Mfuzz (with Schwämmle 2010 fuzzifier estimation), and splines+k-means. Use when modeling time-course or longitudinal expression, choosing factor vs spline, handling repeated measures from the same subject, avoiding pseudoreplication, clustering temporal trajectories, or selecting between dedicated time-course tools and pairwise+LRT.
日本語の概要は準備中です。原文の説明を表示しています。
Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.
日本語の概要は準備中です。原文の説明を表示しています。
Detect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allele-specific callers. Use when calling CNVs from hybrid-capture panels or exomes, deciding whether CNVkit (depth-only) is the right tool versus an allele-specific caller, building a panel of normals, diagnosing flat-reference false positives, or interpreting log2 ratios into copy-number states.
日本語の概要は準備中です。原文の説明を表示しています。
Calls ChIP-seq peaks with MACS3, MACS2, HOMER, or SPP across narrow (TF) and broad (histone) modes. Handles input control matching, fragment-size modeling vs --nomodel, effective genome size, ENCODE-style IDR vs naive overlap, hyper-ChIPable artifacts, and aligner-specific shifts. Use when calling peaks from ChIP-seq alignments, choosing between narrow vs broad mode for a histone mark, deciding model vs nomodel for low-depth data, applying ENCODE pseudoreplicate IDR, or reconciling MACS vs HOMER vs SPP results.
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill when an inspector requests ELD records during a roadside inspection. Covers the three required transfer methods, what data must be transmitted, and common failure modes.
日本語の概要は準備中です。原文の説明を表示しています。
Discover failure modes in Coval runs, uploaded conversations or local conversation exports using scoped sampling and transcript, audio and trace evidence. Prepare human review without inventing ground truth or launching new runs.
日本語の概要は準備中です。原文の説明を表示しています。
Scaffold recipe for a new authenticated route: SSR shell, DB-derived types, Redux hydration, view sub-pages. Use when creating a new route or page, adding a feature with a sidebar/main layout, adding view modes to a route, or feature types don't match database.types.ts.
日本語の概要は準備中です。原文の説明を表示しています。
Build, test, and debug Hermes Agent RL environments for Atropos training. Covers the HermesAgentBaseEnv interface, reward functions, agent loop integration, evaluation with tools, wandb logging, and the three CLI modes (serve/process/evaluate). Use when creating, reviewing, or fixing RL environments in the hermes-agent repo.
日本語の概要は準備中です。原文の説明を表示しています。
AI-assisted pair programming with multiple modes (driver/navigator/switch), real-time verification, quality monitoring, and comprehensive testing. Supports TDD, debugging, refactoring, and learning sessions. Features automatic role switching, continuous code review, security scanning, and performance optimization with truth-score verification.
日本語の概要は準備中です。原文の説明を表示しています。
Fetch any URL and convert to markdown using Chrome CDP. Supports two modes - auto-capture on page load, or wait for user signal (for pages requiring login). Use when user wants to save a webpage as markdown.
日本語の概要は準備中です。原文の説明を表示しています。
Interactive training for the GitHub Copilot CLI. Guided lessons, quizzes, scenario challenges, and a full reference covering slash commands, shortcuts, modes, agents, skills, MCP, and configuration. Say "cliexpert" to start.
日本語の概要は準備中です。原文の説明を表示しています。
7-agent paper review system on Hermes Agent. 6 modes (full/re-review/quick/methodology-focus/guided/calibration). 5-panel review with editorial decision, revision roadmap, and calibration metrics. Uses delegate_task for each reviewer. Triggers: review paper, peer review, manuscript review, check revisions, calibrate reviewer, 審稿, 同儕審查, 論文審查.
日本語の概要は準備中です。原文の説明を表示しています。
12-agent academic paper writing pipeline on Hermes Agent. 10 modes (full/plan/outline/revision/revision-coach/abstract/lit-review/format-convert/citation-check/disclosure). 6 paper types, 5 citation formats, bilingual abstracts, LaTeX/DOCX/PDF output. Uses delegate_task for each agent. Triggers: write paper, academic paper, guide my paper, parse reviews, AI disclosure, 寫論文, 學術論文, 引導我寫論文, 審查意見.
日本語の概要は準備中です。原文の説明を表示しています。
Tunes GC and memory. GC modes, LOH/POH, Gen0/1/2, Span/Memory deep patterns, ArrayPool.
日本語の概要は準備中です。原文の説明を表示しています。
Architects Blazor apps. Hosting models, render modes, routing, streaming, prerender.
日本語の概要は準備中です。原文の説明を表示しています。
Use when building, testing or previewing site-os — the BUILD_TARGET=stable dist directory, the four verification gates (build, test, env:check, brand:check), the preview servers on :3000 and :3100, and the failure modes that look like bugs but are not.
日本語の概要は準備中です。原文の説明を表示しています。
Static-to-EDS conversion that preserves the original design while making content authorable in Document Authoring. Two modes — page-level (overlay template with slot markers) and block-level (each section becomes an independent EDS block). Use when converting an AI-generated static HTML page (Stardust, Mobirise, Relume, Lovable, v0, Figma-derived hand-coded, etc.) into an Edge Delivery Services page. Triggers on "convert this page to EDS", "static-to-EDS overlay", "convert to EDS blocks", "next experimentation", "next run", "start run", or when a user provides a source URL and asks to make it editable in DA while keeping the original design intact. Do NOT use for canonical EDS block-rewrite migrations — that's the page-import skill.
日本語の概要は準備中です。原文の説明を表示しています。