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Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

日本語の概要は準備中です。原文の説明を表示しています。

Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

日本語の概要は準備中です。原文の説明を表示しています。

Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.

日本語の概要は準備中です。原文の説明を表示しています。

Estimate SNP heritability and partition it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

日本語の概要は準備中です。原文の説明を表示しています。

Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about getting/maintaining motor carrier operating authority — USDOT number, MC number, BOC-3 process agent, insurance filing (MCS-90, BMC-91/91X), Unified Carrier Registration (UCR), International Registration Plan (IRP), International Fuel Tax Agreement (IFTA), state-level permits (NY HUT, KY weight distance, OR weight-mile, NM weight distance), new entrant safety audit, intra vs interstate, for-hire vs private. Cite 49 CFR 365, 387, 390.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a carrier is evaluating ELD / telematics / dashcam platforms and needs an objective comparison of Samsara, Motive (formerly KeepTruckin), and Geotab. Covers ELD compliance, AI dashcams, driver scoring, integrations, pricing structure, and which fleet profile suits which platform.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a driver or carrier asks about trucker mental health — depression, isolation, stress, fatigue, suicide risk, addiction, EAP programs, or wellness benefits. Covers evidence-based programs, hotlines, carrier-side EAP design, and how mental health affects safety and retention.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to understand the value and limits of CVSA decals. Covers when they apply, what they signal, and inspector discretion.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when a driver needs to extend the 14-hour duty window using the 16-hour exception under § 395.1(o). Covers eligibility, frequency limits (once per 7 days), return-to-terminal requirement, and documentation.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a carrier asks about fuel-card vendor selection (Comdata, EFS, WEX, RTS, Pilot Flying J, Love's Connect), discount levels, fraud control, driver authorization PINs, IFTA reporting features, cash advance, money codes, or how the card fits into payroll/settlement workflows.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about CDL driver wellness, retention strategies, what causes driver turnover, common health issues (obesity, hypertension, sleep apnea, mental health), benefits packages, home-time policies, and how to build a culture that keeps drivers. Reference ATA Workforce Development + FMCSA Wellness Initiative.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about Electronic Logging Device (ELD) compliance under 49 CFR 395.20-38 — ELD mandate, AOBRD vs ELD transition, ELD exemptions, ELD malfunctions, 8-day paper backup, ELD certification on FMCSA registered list, data file integrity, edits + annotations, driver portability, and how to handle ELD failures at roadside. Cite 49 CFR 395.20-395.38.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to understand the FMCSA cargo securement standards. Covers § 393.100-§ 393.136 general rules, tiedown requirements, working load limits.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to calculate Working Load Limits for cargo tiedowns. Covers manufacturer ratings, deration, and total tiedown WLL.

日本語の概要は準備中です。原文の説明を表示しています。

Apply rapport-based elicitation to resistant or semi-cooperative humans and agents. Use when coercive prompting or brittle handoffs damage cooperation. NOT for routine cooperative tasks, pure technical debugging, or already reliable exchanges.

日本語の概要は準備中です。原文の説明を表示しています。

Build low-fidelity wireframes, screen mockups, and user-flow diagrams in Frame0 (the hand-drawn Balsamiq-style wireframing tool) through its connected MCP server. Use when asked to wireframe a screen, sketch a UI, make a low-fi mockup, lay out an app's screens, or diagram a user flow with clickable links. Triggers: "wireframe", "frame0", "low-fi mockup", "sketch a screen", "user flow", "lo-fi", "rough out the UI". NOT for high-fidelity visual design, brand systems, or color/typography polish (use web-design-expert / Figma); NOT for production UI code (use frontend skills).

日本語の概要は準備中です。原文の説明を表示しています。

Designs, reconciles, and reviews an end-to-end Drydock program for safely staging agent runtimes: immutable worktree provenance, disposable VM containment, typed effect brokerage, global body accounting, resurrection, subscription-capacity economics, context compaction, operator control, evidence, and promotion. Use when several Drydock contracts must compose into one architecture, implementation hypertree, diagram set, or release plan. NOT for launching Port Daddy, running an untrusted subject, replacing focused containment/resurrection/capacity audits, or treating a design packet as runtime authority.

日本語の概要は準備中です。原文の説明を表示しています。

Refute-before-prove research discipline: automated counterexample sweeps before any formalization, meter-integrity audits for information-bound experiments, mutation-tested model checkers, pre-registered commit-or-cut gates for speculative directions, wrong-turn reporting, and numeric-claim provenance. Use when validating any new theorem, bound, equilibrium, or security claim; when building or trusting a checker, simulator, or experiment; or when deciding whether a speculative research direction lives or dies. NOT for exploratory brainstorming, product prioritization, writing style, or literature review.

日本語の概要は準備中です。原文の説明を表示しています。

Operationalizing an expungement website — user intake flows, document generation pipelines, court filing integrations, payment processing, state-by-state workflow variations, customer support for sensitive populations, and the handoff between automated systems and human legal review. Activate on 'expungement operations', 'legal tech SaaS', 'court filing integration', 'document automation pipeline', 'expungement business', 'legal service workflow', 'multi-state legal operations'. NOT for expungement law itself (use national-expungement-expert), web design (use legal-tech-web-design), or legal document drafting (use recovery-app-legal-terms).

日本語の概要は準備中です。原文の説明を表示しています。

Aesthetic assessment and design scoring across 6 dimensions. Use for UI critique, design review, visual quality assessment, remix suggestions. Activate on "design critique", "aesthetic review", "UI assessment", "visual quality", "design score", "remix this design". NOT for implementation (use frontend-developer), accessibility-only audits (use color-contrast-auditor), or brand identity creation.

日本語の概要は準備中です。原文の説明を表示しています。

Expert in developer tool documentation as a product. Activate on: docs site, getting started guide, API reference, developer documentation, Docusaurus, Mintlify, Nextra, ReadMe, migration guide, troubleshooting page, docs information architecture, documentation testing, llms.txt. NOT for: marketing copy (use seo-content-blogging), API design itself (use api-architect), general technical writing (use technical-writer).

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Designs and audits data retention and file compaction for an embedded SQLite datastore in a long-lived service — a unified retention registry (one declared policy per table), TTL / absolute-age / row-count-cap policies, a fail-loud coverage guard, WAL/checkpoint tuning, and auto_vacuum/incremental-vacuum so pruning actually shrinks the file. Use when a SQLite DB grows unbounded, a table has an index but no DELETE, a pruned DB never shrinks on disk, metrics are stored as raw events forever, or a new table needs bounding. Keywords retention policy, TTL, reaper, prune, VACUUM, auto_vacuum, incremental_vacuum, WAL checkpoint, freelist, DB bloat, row cap, per-tenant quota. NOT for Postgres/MySQL/server-DB partitioning or TTL, log-line rate-limiting/sampling, backup/replication, schema migrations, or query-performance indexing.

日本語の概要は準備中です。原文の説明を表示しています。