「ods」の検索結果

Performs molecular similarity searching using Tanimoto, Tversky, Dice, and cosine coefficients on bit/count fingerprints with explicit choice rules for symmetric vs asymmetric measures, scaffold-hopping vs lead-optimization regimes, activity-cliff diagnosis, and large-library nearest-neighbor methods (BulkTanimoto, Annoy MHFP6, USRCAT). Use when ranking compounds by structural resemblance to a query, clustering libraries, finding analogs, or diagnosing activity cliffs.

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Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

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Use this skill when the user asks about CMV maintenance program requirements under 49 CFR 396.3 — what records must be kept, retention periods (12-18 months on vehicle file + 1 year after disposal), what counts as systematic inspection/repair/maintenance, preventive maintenance scheduling, brake adjustment records, and what auditors look for in vehicle files. Cite 49 CFR 396.3 + 396.21.

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Use this skill to understand record retention requirements for currently-employed drivers. Covers DQF, HOS, vehicle records, and D&A specific periods.

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Use this skill to understand how IFTA quarterly mileage is calculated. Covers measurement methods, manual vs ELD-derived, and verification.

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Use this skill when an inspector requests ELD records during a roadside inspection. Covers the three required transfer methods, what data must be transmitted, and common failure modes.

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Use this skill to track recent and upcoming SMS methodology changes from FMCSA. Covers proposed rule changes, comment periods, and implementation timelines.

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Use this skill when the user asks about Driver Qualification Files (DQF) — what must be in a DQ file under 49 CFR 391, retention periods, what's required pre-hire vs ongoing, document expiration tracking, audit-readiness for driver files, common DQF deficiencies that auditors find, or how to handle missing documents on existing drivers. Always cite the specific subsection of 49 CFR 391.

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Generates Test Data Builder and Object Mother patterns for PHP 8.5. Creates fluent builders with sensible defaults and factory methods for test data creation.

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Detects leaky abstractions in PHP code. Identifies implementation details exposed in interfaces, concrete returns from abstract methods, framework leakage into domain, and infrastructure concerns in application layer.

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Analyzes PHP codebase for test coverage gaps. Detects untested classes, methods, branches, exception paths, and edge cases. Provides actionable recommendations.

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Date and time formatting for OneKey applications. Use when displaying dates, timestamps, or formatting time in UI components. Always use OneKey utilities instead of native JS date methods. Triggers on date, time, timestamp, formatDate, formatTime, toLocaleDateString, toLocaleString, dateUtils, locale, format, display date, show time, datetime, calendar.

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Use when you need to review, improve, or refactor Java code for generics quality — including avoiding raw types, applying the PECS (Producer Extends Consumer Super) principle for wildcards, using bounded type parameters, designing effective generic methods, leveraging the diamond operator, understanding type erasure implications, handling generic inheritance correctly, preventing heap pollution with @SafeVarargs, and integrating generics with modern Java features like Records, sealed types, and pattern matching. Part of the skills-for-java project

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Use this skill when building analytics dashboards with nuxt-ui-tools as a package consumer. Covers schema and view functions (defineDashboardSchema, defineDashboardView) that take their context as typed params, useDashboard with a getter that rebuilds on input change, typed injection (useDashboardView, injectDashboard, InferDashboard, InferDashboardView), filters declared inline with the f builder and synced with the URL, memory, or an external store (one value per key across views), headless filters, filter controls and the shipped UI (UiDashboardPage, UiDashboardFilters, UiDashboardFilter, UiDashboardViewTabs) with slot overrides, remote paginated pickers and remoteTableOptions, staged queries (essential / background / deferred) with select and dependent requires, lazy enabled conditions on views, queries, and filters (blocks of disabled queries hidden, grids closing up), derived values, views (tabs), query-scoped filters, number formats (presets, Intl options, useDashboardFormat), and the dashboard blocks (stats with trends, goals, and comparisons, stat groups, gauges, unovis charts with highlights, value labels, and totals, lists with progress rings, bars, funnel, alerts, activity feeds, sortable tables, custom widgets) with their automatic loading, error, empty, and refresh states, card menus, header and footer actions, row actions, drill-down and selected state, card tabs, split cards, comparison periods, auto-refresh, and data freshness.

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Parameter-efficient fine-tuning for LLMs using LoRA, QLoRA, and 25+ methods. Use when fine-tuning large models (7B-70B) with limited GPU memory, when you need to train <1% of parameters with minimal accuracy loss, or for multi-adapter serving. HuggingFace's official library integrated with transformers ecosystem.

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Remove refusal behaviors from open-weight LLMs using OBLITERATUS — mechanistic interpretability techniques (diff-in-means, SVD, whitened SVD, LEACE, SAE decomposition, etc.) to excise guardrails while preserving reasoning. 9 CLI methods, 28 analysis modules, 116 model presets across 5 compute tiers, tournament evaluation, and telemetry-driven recommendations. Use when a user wants to uncensor, abliterate, or remove refusal from an LLM.

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Creates and refines Founder Story and brand narrative content for DTC/independent stores selling founder-driven products (e.g. handcrafted leather, artisan sauces, small-batch goods). Use whenever the user mentions founder story, brand story, about page, origin story, artisan brand, handcrafted brand, "who we are" copy, brand voice, mission/vision for a product brand, landing page hero narrative, PDP brand block, or wants to differentiate through authenticity and founder-led storytelling—even if they do not say "founder story" explicitly. Output structured narrative frameworks, placement guidance, and ready-to-use copy aligned with DTC best practices.

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Creates an integration testing plan for .NET data access artifacts during Oracle-to-PostgreSQL database migrations. Analyzes a single project to identify repositories, DAOs, and service layers that interact with the database, then produces a structured testing plan. Use when planning integration test coverage for a migrated project, identifying which data access methods need tests, or preparing for Oracle-to-PostgreSQL migration validation.

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Refactoring using Extract Methods in Java Language

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Look up Microsoft API references, find working code samples, and verify SDK code is correct. Use when working with Azure SDKs, .NET libraries, or Microsoft APIs—to find the right method, check parameters, get working examples, or troubleshoot errors. Catches hallucinated methods, wrong signatures, and deprecated patterns by querying official docs.

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Technology-agnostic prompt generator that creates customizable AI prompts for scanning codebases and identifying high-quality code exemplars. Supports multiple programming languages (.NET, Java, JavaScript, TypeScript, React, Angular, Python) with configurable analysis depth, categorization methods, and documentation formats to establish coding standards and maintain consistency across development teams.

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Parameter-efficient fine-tuning for LLMs using LoRA, QLoRA, and 25+ methods. Use when fine-tuning large models (7B-70B) with limited GPU memory, when you need to train <1% of parameters with minimal accuracy loss, or for multi-adapter serving. HuggingFace's official library integrated with transformers ecosystem.

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Test Data Builder Pattern complete implementation guide. Used when using builder pattern to create maintainable test data or simplify complex object test preparation. Covers fluent interface, semantic methods, default value design, and Builder composition patterns. Keywords: test data builder, builder pattern test, test data builder, object mother, fluent interface, fluent interface, UserBuilder, ProductBuilder, .With(), .Build(), AUser(), test data preparation, complex object creation, semantic testing

日本語の概要は準備中です。原文の説明を表示しています。