412 件 ・ 関連度順
概要と使いどころ
Infer cis-regulatory connections (peak-to-peak co-accessibility) from scATAC-seq using Cicero, ArchR getCoAccessibility, or SCENIC+. Use when linking enhancer accessibility to promoter accessibility, identifying enhancer-gene pairs from chromatin alone (without paired RNA), running gene-regulatory inference combining ATAC + RNA, or comparing predicted regulatory contacts against Hi-C/Micro-C ground truth.
日本語の概要は準備中です。原文の説明を表示しています。
Use when building server-driven UIs with htmx, designing hx-* attribute compositions, choosing swap strategies (innerHTML/outerHTML/morph), wiring out-of-band updates, integrating with form validation, or migrating from a SPA back to server-rendered HTML. Triggers: hx-get/hx-post setup, hx-target + hx-swap interplay, hx-trigger debouncing, OOB swaps for parts of the page outside the request target, response headers like HX-Trigger and HX-Push-Url, integration with Hyperscript or Alpine.js, accessibility considerations on partial updates. NOT for full SPAs (use React/Vue), framework-specific server libraries (use those skills directly), or non-HTML responses.
日本語の概要は準備中です。原文の説明を表示しています。
Work a primary-prevention patient through the 2026 ACC/AHA multisociety dyslipidaemia guideline CPR framework — Calculate (10-year and 30-year PREVENT-ASCVD), Classify (low / borderline / intermediate / high), Personalize (demographic, clinical, biomarker, and reproductive risk enhancers), and Reclassify (coronary artery calcium scoring where appropriate). Use when a clinician asks how to assess ASCVD risk for primary prevention, who needs a statin, borderline risk patient what to do, intermediate risk should I start a statin, risk enhancers to look for, premature family history of ASCVD how does it change risk, pregnancy-related risk factors, PCOS and cardiovascular risk. Grounded in the 2026 ACC/AHA multisociety dyslipidaemia guideline.
日本語の概要は準備中です。原文の説明を表示しています。
Load this skill when building any web feature, reviewing architecture decisions, or evaluating JavaScript dependencies. Under no circumstances build features that break completely when JavaScript is unavailable or fails. Absolutely always start with semantic HTML, layer CSS enhancements, and add JavaScript as the final, optional layer. Prioritize resilience and universal access over cutting-edge features.
日本語の概要は準備中です。原文の説明を表示しています。
Builds a WooCommerce-style AJAX product search select (the selectWoo / wooselect dropdown) — class="wc-product-search" + the data-action attribute pointing to woocommerce_json_search_products (products only) or woocommerce_json_search_products_and_variations (products AND variations, often the right choice). Pre-selected items rendered server-side as <option selected> via wc_get_product() + get_formatted_name(); WC's wc-enhanced-select script auto-enqueued on WC admin screens, explicit enqueue required on non-WC pages. Solves the "load 20k products into a select" antipattern AI assistants commonly emit. Use when adding a product picker meta box, a custom WC admin page selector, or any UI where the user must search and pick from many products. Triggers on wc-product-search, woocommerce_json_search_products, woocommerce_json_search_products_and_variations, selectWoo, wc-enhanced-select, "select2 products in WooCommerce", or product-picker meta box scaffolding.
日本語の概要は準備中です。原文の説明を表示しています。
新しい Web API / CSS の利用追加に対し、Baseline 状態とブラウザ互換性 / progressive enhancement の有無を suggestion で示す。
Upscale and prepare a selected video parent for delivery while preserving provenance and checking that enhancement did not create new defects.
日本語の概要は準備中です。原文の説明を表示しています。
Performs comprehensive FiveM resource security, performance, and compatibility audits. Detects backdoors, RATs, SQL injection, event exploitation, NUI vulnerabilities, dupes, crash/DoS vectors, npm and build-chain supply chain attacks, and malware patterns across ESX, QBCore, QBox, ox_lib, and ND_Core frameworks, on both GTA V Legacy and Enhanced builds. Use whenever a FiveM/cfx resource is being reviewed — even if not explicitly asked — including: audit FiveM script, review FiveM security, optimize FiveM resource, check FiveM performance, FiveM code review, review Lua script security, audit ESX resource, audit QBCore resource, audit QBox resource, check for exploits, FiveM vulnerability scan, GTA V Enhanced migration check, resmon optimization, or asking whether a leaked, cracked, nulled or unknown-origin script is safe to run.
日本語の概要は準備中です。原文の説明を表示しています。
Enhanced architecture guidance for voice-first Brazilian fintech applications. Use when designing voice interfaces, implementing PIX/Boletos, optimizing financial systems, or making technology stack decisions for Brazilian market applications. Integrates with docs/ content, MCP tools for Brazilian market research, enhanced validation scripts, and comprehensive Brazilian compliance patterns.
日本語の概要は準備中です。原文の説明を表示しています。
Build enhancer-driven gene regulatory networks (eGRNs) by integrating single-cell RNA-seq and ATAC-seq using SCENIC+, CellOracle base GRNs, Pando, FigR, DIRECT-NET, TRIPOD, and scMEGA. Covers the accessibility-defines-enhancers principle, peak-to-gene linking and its cell-composition confound, the paired-vs-unpaired decision, and TF-region-gene eRegulon triplets. Use when analyzing 10x multiome or paired/unpaired scRNA+scATAC to infer cis-regulatory GRNs. For RNA-only regulons see scenic-regulons; for in silico TF perturbation see perturbation-simulation.
日本語の概要は準備中です。原文の説明を表示しています。
Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CTCF-only/DNase-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.
日本語の概要は準備中です。原文の説明を表示しています。
Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.
日本語の概要は準備中です。原文の説明を表示しています。
Infer cis-regulatory connections (peak-to-peak co-accessibility) from scATAC-seq using Cicero, ArchR getCoAccessibility, or SCENIC+. Use when linking enhancer accessibility to promoter accessibility, identifying enhancer-gene pairs from chromatin alone (without paired RNA), running gene-regulatory inference combining ATAC + RNA, or comparing predicted regulatory contacts against Hi-C/Micro-C ground truth.
日本語の概要は準備中です。原文の説明を表示しています。
Implement React Server Actions in Next.js 14+ for secure, progressively enhanced form handling and server mutations without API routes. Use when handling form submissions, performing server-side mutations, implementing progressive enhancement, creating actions that work without JavaScript, validating data on the server, revalidating cached data after mutations, handling file uploads server-side, implementing optimistic UI updates, or building forms that gracefully degrade without client-side JavaScript.
日本語の概要は準備中です。原文の説明を表示しています。
Build enhancer-driven gene regulatory networks (eGRNs) by integrating single-cell RNA-seq and ATAC-seq using SCENIC+, CellOracle base GRNs, Pando, FigR, DIRECT-NET, TRIPOD, and scMEGA. Covers the accessibility-defines-enhancers principle, peak-to-gene linking and its cell-composition confound, the paired-vs-unpaired decision, and TF-region-gene eRegulon triplets. Use when analyzing 10x multiome or paired/unpaired scRNA+scATAC to infer cis-regulatory GRNs. For RNA-only regulons see scenic-regulons; for in silico TF perturbation see perturbation-simulation.
日本語の概要は準備中です。原文の説明を表示しています。
Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.
日本語の概要は準備中です。原文の説明を表示しています。
Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CTCF-only/DNase-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.
日本語の概要は準備中です。原文の説明を表示しています。
Infer cis-regulatory connections (peak-to-peak co-accessibility) from scATAC-seq using Cicero, ArchR getCoAccessibility, or SCENIC+. Use when linking enhancer accessibility to promoter accessibility, identifying enhancer-gene pairs from chromatin alone (without paired RNA), running gene-regulatory inference combining ATAC + RNA, or comparing predicted regulatory contacts against Hi-C/Micro-C ground truth.
日本語の概要は準備中です。原文の説明を表示しています。
CLI modernization and hooks system enhancement for claude-flow v3. Implements interactive prompts, command decomposition, enhanced hooks integration, and intelligent workflow automation.
日本語の概要は準備中です。原文の説明を表示しています。
A presentation system for agent-made PPTs — born for the talk, not just the template. It turns raw material into an AST (audience-state-transfer) outline with per-page visual-enhancement decisions (image / SVG diagram / video), hands a production brief to a downstream renderer (HTML-PPT skills or native PPTX), then runs a capped 3-round presentation checkup (演讲体检) on the rendered deck. It never renders slides itself. Use before generating PPT/HTML slides from raw material, and after rendering when the user says things like "给这份 deck 做演讲体检" or "PPT 渲染质检". If all you want is one beautiful template page with no outline and no checkup, a rendering skill alone is enough.
日本語の概要は準備中です。原文の説明を表示しています。
Improve image and screenshot quality by enhancing resolution, sharpness, and clarity for professional presentations and documentation.
日本語の概要は準備中です。原文の説明を表示しています。
Upscale and enhance image and video resolution using AI super-resolution models hosted on fal.ai.
日本語の概要は準備中です。原文の説明を表示しています。
Improve prompts with design specs and UI/UX vocabulary. Useful for design-to-code workflows and clarifying requests for visual output.
日本語の概要は準備中です。原文の説明を表示しています。
MCP server optimization and transport layer enhancement for claude-flow v3. Implements connection pooling, load balancing, tool registry optimization, and performance monitoring for sub-100ms response times.
日本語の概要は準備中です。原文の説明を表示しています。