263 件 ・ 関連度順
概要と使いどころ
Capture a user's real writing voice from 5-20 prior samples, store a local voice.yaml fingerprint, and enforce it on newsjack drafts so AI tells disappear. Measures voice with named stylometry lenses (Burrows's Delta function-word vector, MATTR lexical diversity, sentence-length burstiness, Biber Dimension-1 register, opener-POS profile, punctuation rates) and gates drafts against the fingerprint as bands, not vibes.
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Self-coaching analysis of your own behavior across meetings — talk-time ratio, filler words, hedging language, monologue length, energy patterns, and (when meetings are tagged via /minutes-tag) what your behavior in winning meetings looks like vs losing ones. Use this whenever the user says "how did I do", "review my last meeting", "mirror", "self-review", "show my patterns", "coach me", "where am I weak", "talk time", "am I improving", "what do I do in meetings I win", "feedback on me", or asks for any kind of personal feedback on their own meeting behavior. This is the rare skill that gives the user a mirror to their own habits — surface it whenever they show curiosity about their own performance, even if they don't use the word "mirror".
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Apply the CV conventions of the country where the job is: length, photo, personal details, date and name order, spelling, paper size and the documents expected alongside. Use when asked what a CV looks like in Germany, Japan, China, the UK, the US, France, India, the Gulf or Australia, should I put a photo on my CV, convert my US resume to a UK CV, or make a 简历, 履歴書 or Lebenslauf. Produces the country rules as a checklist, the CV converted to them, and the personal details that must be removed or added, with the legal reason where there is one.
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Use when asked 公开课怎么准备, 帮我写说课稿, 优质课比赛, 评优课, 教研课, 汇报课, 青年教师赛课, 试讲, or prepare an observed lesson in a Chinese school. Produces a 公开课 preparation pack in Chinese: a 说课稿 (说教材, 说学情, 说教学目标, 说重难点, 说教法学法, 说教学过程, 说板书) timed to the required length, the lesson's highlights (亮点) and how observers will see them, a rehearsal and 磨课 plan, contingency plans, and answers to likely 评课 questions.
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Optimize an article for Answer Engine Optimization (AEO) so AI engines like ChatGPT, Perplexity, and Claude can extract, quote, and cite it. Use when asked to AEO-optimize, make content AI-readable, improve AI citation chances, or adapt an article for answer engines. Produces an AEO-optimised rewrite with question headings, 50–80 word answer capsules, a paragraph-length audit, and flagged trust signals.
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Use when targeting Geology (GSA) or deciding whether a short, high-impact geoscience research letter fits this venue. Encodes the journal's broad-significance-in-tight-length fit, the novelty and rapid-communication bar, GSA house style, official-submission re-check, and desk-reject heuristics.
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Use when revising an American Economic Review: Insights (AER: Insights) short-format manuscript to lead with the result, fit the hard word cap (7,000 words minus 200 per exhibit), and write the ≤100-word abstract. Enforces the length budget and the lead-with-the-result arc; it does not change the analysis.
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Use when deciding which robustness checks belong in the few in-text words of an American Economic Review: Insights (AER: Insights) short-format manuscript versus the online Supplemental Appendix. Triages checks against the length cap; it does not design the identification (see aeri-identification).
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Use when running the final pre-submission preflight for the American Economic Journal: Macroeconomics (AEJ: Macro) via the AEA submission system — membership-scaled fee, JEL codes, PDF and length rules, ≤100-word abstract, disclosure statements, and data/code readiness. Final checks; it does not draft content.
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Use when polishing the prose of an Advanced Materials manuscript for Wiley house style, concision, precise materials nomenclature and units, and readability across materials subfields. Polishes language; does not restructure the advance or manage the length budget.
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Use when running the final pre-submission preflight for an Academy of Management Review (AMR) manuscript — ScholarOne portal, AOM format and length, abstract, anonymization for review, references, ethics/originality, and required files. Theory-only journal; there is no data-availability or replication step.
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Use for the pre-submission preflight to 《会计研究》 (Accounting Research) — checking footnote (当页下注) conventions, the 著者—出版年制 reference style, abstract/keyword limits, article length, the online-only submission system via the Accounting Society of China site, double-blind anonymity, and document hygiene. Use right before submitting; verify every rule against the journal's current 投稿指南.
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Use when polishing the prose of an Accounting, Organizations and Society (AOS) manuscript — sustained argumentative writing that carries theory and evidence together, a self-contained abstract, disciplined length despite the absence of a hard cap, and full anonymization for double-anonymized review. Polishes prose; it does not run the submission preflight (aos-submission).
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Generate an instrumental music bed via ElevenLabs Music, ROUTED THROUGH THE elevenlabs-proxy so it bills the Ads agent. Trims any sparse intro, loudnorm, fades the tail. Prompt + length from the template recipe. Use for the music layer of any video-ad format.
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Phases small variants, SVs, and methylation from Oxford Nanopore and PacBio long reads (read-backed/physical phasing) with WhatsHap, LongPhase, or HiPhase, and haplotags the BAM (HP/PS tags) for allele-resolved downstream analysis. Covers why phase blocks break at het-sparse gaps (read length x heterozygosity), why phasing the VCF is useless until the BAM is haplotagged, the GT-pipe/PS and read HP/PS tag spec, reporting block N50 with switch error, the diploid-assumption/CNV/haploid-region traps, trio phasing as the gold standard, and the boundary to statistical panel phasing. Use when phasing long-read variants, haplotagging reads for allele-specific methylation/expression or phased SVs, choosing WhatsHap vs LongPhase vs HiPhase, trio phasing, or assessing phasing quality.
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Predict peptide-MHC class I binding and natural presentation with MHCflurry, NetMHCpan-4.1, and MixMHCpred to nominate candidate CD8 T-cell epitopes. Covers the binding-affinity (BA) vs eluted-ligand (EL/presentation) distinction, why %Rank beats raw nM for cross-allele work, the MS abundance bias that misranks low-expression neoantigens, allele-coverage inequity, and length bias. Use when scanning a protein or peptide set for class I epitopes, scoring neoantigen candidates, or choosing a binding predictor. For CD4/HLA class II see mhc-class-ii-prediction.
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Quality control for flow, spectral, and mass cytometry - time-based anomaly cleaning (flowAI, flowCut, PeacoQC, flowClean), margin/boundary event removal, signal-drift detection, dead-cell exclusion, CyTOF Gaussian/DNA/event-length checks, instrument calibration/standardization (MESF, CS&T, peak-2), and batch-level outlier flagging. Use when assessing acquisition quality, choosing a cleaning tool, ordering QC relative to compensation, deciding margin removal before density-based steps, or flagging problematic samples before clustering or differential analysis.
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Detects and removes doublets/aggregates from flow, spectral, and mass cytometry before clustering or quantification. Covers FSC-A vs FSC-H singlet discrimination (the Area-Height non-proportionality, not a 1D area gate), FSC-W/SSC width gating, CyTOF Gaussian discrimination parameters (Center/Offset/Width/Residual/Event_length) and DNA intercalator gating, and the residual heterotypic conjugates that survive scatter gating and masquerade as double-positive populations. Use when filtering aggregates before phenotyping, choosing a doublet method for flow vs CyTOF, or diagnosing a suspicious double-positive cluster.
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Assesses genetic health of populations for conservation with Ne estimation across time horizons (LDNe NeEstimator V2 option-file API + SNeP physical-linkage correction; recent trajectory via GONE/GONE2; deep history via Stairway Plot 2 / dadi / fastsimcoal2 / PSMC), F-statistics, runs of homozygosity binned by length class to date inbreeding, genetic-load decomposition (Bertorelle 2022 realized vs masked), the modern 100/1000 Ne rule (Frankham 2014), Ne/Nc 2-6 orders of magnitude in marine fish (Hauser & Carvalho 2008), tree-sequence forward simulations (SLiM 4 + pyslim + tskit), and the Sukumaran-Knowles caveat against MSC methods for management-unit definition. Use when estimating Ne by time horizon, detecting inbreeding via F_ROH, decomposing genetic load, justifying conservation thresholds, distinguishing ESU/MU/DPS, configuring NeEstimator V2, or correcting LDNe physical linkage.
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Assesses the quality and completeness of a genome annotation with BUSCO (conserved single-copy ortholog recovery), OMArk (proteome completeness, consistency, and contamination), CheckM2 (prokaryotic completeness/contamination), and a gene-set sanity panel (gene count, mono-exonic fraction, protein-length distribution, mRNA:gene ratio, coding density). Covers the assembly-BUSCO-vs-proteome-BUSCO diagnostic, what BUSCO-Duplicated really means, why gene count is a vanity metric, and the QC of transferred annotations. Use when judging whether an annotation is good enough to publish or submit, diagnosing a suspect annotation, or comparing annotation completeness across pipelines.
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Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.
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Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.
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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.
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Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CA-CTCF/CA-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.
日本語の概要は準備中です。原文の説明を表示しています。