239 件 ・ 関連度順
概要と使いどころ
Score every decision point with a Thoroughness Rating (1-10). AI makes the marginal cost of doing things properly near-zero — pick the higher-rated option every time. Includes scope checks to distinguish contained vs unbounded work.
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Create a spacing scale from a base unit with rules for when each step applies. Use when standardising padding and margins. For page-level columns and gutters, use `layout-grid`.
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Define a responsive grid — columns, gutters, margins, and breakpoint behaviour. Use when establishing page structure. For the spacing scale inside components use `spacing-system`; for cross-device behaviour use `responsive-design`.
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Establishes whether the business makes money on each customer or unit — contribution margin, acquisition cost, payback period, lifetime value, and the cohort behavior underneath. Use this to assess whether growth is profitable, evaluate a channel or segment, support a pricing decision, judge how fast the business can afford to grow, or diagnose why revenue growth is not producing profit.
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Use when evaluating Benjamin Graham-style deep value: net-nets, working capital bargains, margin of safety, statistical cheapness, and balance-sheet protection.
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Use when evaluating a business through Buffett-style ownership, owner earnings, durable moat, management quality, capital allocation, and margin-of-safety judgment.
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Use when evaluating Seth Klarman-style deep value and distressed opportunities: extreme margin of safety, forced sellers, liquidity discounts, complexity, downside protection, and patience.
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Generator economic dispatch and cost optimization for power systems. Use when minimizing generation costs, computing optimal generator setpoints, calculating operating margins, or working with generator cost functions.
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When provisioning, setting a limit, or committing an estimate under uncertainty, size a buffer to residual error and the cost of breach—not to the optimistic edge.
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Build Godot 4.7 user interfaces with Control nodes: anchors and offsets for responsive layout, Container nodes (VBox/HBox/Grid/Margin) for automatic arrangement, Theme resources for consistent styling, and keyboard/gamepad focus navigation. Use when laying out a HUD, menu, or UI in a Godot project, working with Control/Container nodes, anchors, themes, or focus in a .tscn.
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Use when the marginal contribution of an American Economic Journal: Applied Economics (AEJ: Applied) manuscript is fuzzy or undersold and must be staked precisely against prior applied-micro work. Positions the contribution; it does not fix the identification (aeja-identification) or the prose (aeja-writing-style).
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Use when the contribution of an American Economic Journal: Macroeconomics (AEJ: Macro) manuscript relative to the macro frontier is fuzzy, contested, or undersold. Frames the marginal contribution against quantitative-theory and identified-empirical literatures; it does not fix the identification or the model itself.
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Compare gene co-expression and regulatory networks between biological conditions to find rewired relationships using DiffCorr, DiffCoEx, DINGO/iDINGO, and CoDiNA. Covers the differential-connectivity-is-not-differential-expression distinction, the pairwise multiple-testing explosion, marginal vs partial (direct) rewiring, and the underpowered-rewiring failure mode. Use when comparing co-expression networks between disease vs control, treatment, or developmental stages, or finding hub genes that rewire without changing mean expression. For single-condition modules see coexpression-networks; for differential expression of means see differential-expression/de-results.
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Decides whether and how to polish a draft genome assembly to raise consensus accuracy (QV) with read-type-matched tools - Racon and medaka (ONT consensus), dorado polish, Polypolish and pypolca (Illumina, repeat-aware), Pilon (legacy short-read), NextPolish/NextPolish2, Hapo-G (haplotype-aware), ntEdit, and DeepPolisher/PEPPER-Margin-DeepVariant for human. Covers the do-not-polish-HiFi rule, the medaka basecaller-model footgun, held-out Merqury QV as the only honest stop signal, and the haplotype-collapse trap. Use when correcting homopolymer indels or residual SNPs in a long-read assembly, deciding if a HiFi assembly needs polishing, or choosing an ONT vs hybrid vs short-read polishing chain.
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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.
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Build weighted gene co-expression networks to identify modules of co-regulated genes, relate them to phenotypes, and find hub genes using WGCNA, hdWGCNA, MEGENA, CEMiTool, and Gaussian graphical models. Covers signed-network choice, soft-threshold selection, module preservation, and the marginal-vs-partial-correlation distinction. Use when finding co-expression modules, identifying hub genes, relating gene networks to clinical or experimental traits, or building single-cell co-expression networks. For directed TF-target inference see scenic-regulons and grn-inference; for condition rewiring see differential-networks.
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Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural splines, maSigPro (Nueda 2014 for RNA-seq), ImpulseDE2 with explicit impulse-model failure modes, DREAM for repeated measures via linear mixed models, pseudoreplication avoidance, conditional vs marginal modeling, and trajectory clustering with DPGP, Mfuzz (with Schwämmle 2010 fuzzifier estimation), and splines+k-means. Use when modeling time-course or longitudinal expression, choosing factor vs spline, handling repeated measures from the same subject, avoiding pseudoreplication, clustering temporal trajectories, or selecting between dedicated time-course tools and pairwise+LRT.
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Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.
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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.
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Analyze financial data, calculate financial ratios, and generate analysis reports. Use when the user asks about revenue, costs, profits, margins, ROI, financial metrics, or needs financial analysis of a company or project.
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E-commerce growth strategy advisor. Diagnoses current business health using unit economics (CAC, LTV, AOV, contribution margin), identifies the highest-impact growth opportunities across 5 levers (traffic, conversion, AOV, retention, expansion), and builds a prioritized 90-day growth roadmap. Uses the Ansoff Matrix adapted for e-commerce to evaluate market penetration, channel expansion, product expansion, and new market entry. Includes multichannel readiness assessment (Amazon, Walmart, TikTok Shop, Etsy, DTC/Shopify/Shopify) and product line expansion analysis. No API key required. Use when: (1) planning next phase of e-commerce growth, (2) deciding whether to expand to new channels or products, (3) diagnosing why growth has stalled, (4) prioritizing what to fix or build next.
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Product research for dropshipping businesses. Identify profitable products with reliable suppliers, healthy margins, and manageable competition. Evaluates shipping times, return risk, and marketing viability.
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Build an evidence-based competitive pricing strategy for ecommerce products. Use when a seller asks how to position a price against competitors, set regular and promotional prices, protect contribution margin, design bundles or price tiers, respond to competitor moves, or coordinate prices across Amazon, Shopify, TikTok Shop, Walmart, eBay, or other channels. Do not use for automated repricing implementation or claims of a mathematically proven optimal price without sufficient data.
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Compare and optimize shipping rates across carriers and fulfillment methods. UPS, FedEx, USPS, DHL rate comparison, zone optimization, and shipping strategy to maximize margins.
日本語の概要は準備中です。原文の説明を表示しています。